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Soft electrostatic trapping in nanofluidics

Microsystems & Nanoengineering 2017年第1期3卷 27-36页

作者： Michael A.Gerspach nassir mojarad Deepika Sharma Thomas Pfohl Yasin Ekinci Swiss Nanoscience Institute Basel 4056Switzerland Laboratory for Micro and Nanotechnology Paul Scherrer InstitutVilligen 5232Switzerland Chemistry Department University of BaselBasel 4056Switzerland Nanotechnology Group ETH ZürichRüschlikon 8803Switzerland Biozentrum University of BaselBasel 4056Switzerland Biomaterials Science Center University of BaselAllschwil 4123Switzerland ABB Switzerland Ltd. SemiconductorsLenzburg 5600Switzerland Institute of Physics University of FreiburgFreiburg 79104Germany

Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical *** report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane(PDMS)-based *** trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects,called geometry-induced electrostatic(GIE)*** gold nanoparticles as probes,we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps,and compare the results with numerical *** trapping 100 nm particles,we observe potential depths of up to Q≅24 k_(B)T that provide stable trapping for many *** advantage of the soft material properties of PDMS,we actively tune the trapping strength and potential depth by elastically reducing the device channel height,which boosts the potential depth up to Q~200 k_(B)T,providing practically permanent contactfree *** to a high-throughput and low-cost fabrication process,ease of use,and excellent trapping performance,our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids.

关键词： contact-free electrostatic nanoparticle trapping PDMS nanofluidic devices high-throughput fabrication single nano-object manipulation soft-lithography

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Sirtuins and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第46期22卷 10084-10092页

作者： Fatiha nassir Jamal A Ibdah Research Service Harry S Truman Memorial VA Hospital University of Missouri Department of Medicine Division of Gastroenterology and Hepatology University of Missouri

Mammalian sirtuins are seven members belonging to the silent information regulator 2 family, a group of Class Ⅲ histone/protein deacetylases. Sirtuins(SIRT 1-7) have different subcellular localization and function and they regulate cellular protein function through various posttranslational modifications. SIRT1 and 3, the most studied sirtuins, use the product of cellular metabolism nicotinamide adenine dinucleotide as a cofactor to post-translationally deacetylate cellular proteins and consequently link the metabolic status of the cell to protein function. Sirtuins have been shown to play a key role in the development and rescue of various metabolic diseases including non-alcoholic fatty liver disease(NAFLD). NAFLD is currently the most chronic liver disease due mainly to high-calorie consumption and lower physical activity. No pharmacological approach is available to treat NAFLD, the current recommended treatment are lifestyle modification such as weight loss through calorie restriction and exercise. Recent studies have shown downregulation of sirtuins in human as well as animal models of NAFLD indicating an important role of sirtuins in the dynamic pathophysiology of NAFLD. In this review, we highlight the recent knowledge on sirtuins, their role in NAFLD and their unique potential role as novel therapeutic target for NAFLD treatment.

关键词： SIRT1 SIRT3 Sirtuins Non-alcoholic fatty liver disease

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Role of mitochondria in alcoholic liver disease

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World Journal of Gastroenterology 2014年第9期20卷 2136-2142页

作者： Fatiha nassir Jamal A Ibdah Division of Gastroenterology and Hepatology Department of Internal Medicine University of Missouri School of Medicine Columbia MO 65212 United States

Alcohol abuse is the leading cause of liver related morbidity and *** or binge alcohol drinking causes hepatic steatosis which can develop to steatohepatitis,cirrhosis and ultimately hepatocellular *** pathogenesis of alcoholic liver disease(ALD)is poorly characterized,however several recent studies point to a major role of mitochondria in this *** play a crucial role in cellular energy metabolism and in reactive species *** treatment causes mitochondrial DNA damage,lipid accumulation and oxidative *** in both animal models and in humans showed that alcohol administration causes changes in the mitochondrial morphology and function suggesting a role of these changes in the pathogenesis of *** review recent findings on mechanisms by which alcohol negatively impacts mitochondrial biogenesis and function and we will discuss the specific intracellular pathways affected by alcohol ***,recent findings indicate that a large number of mitochondrial proteins are acetylated and that mitochondrial proteins acetylation and sirtuins are modulated by ***-derstanding the mechanisms behind alcohol mediated impaired mitochondrial biogenesis and function may help identify potential therapeutic targets for treating ALD in humans.

关键词： Liver Alcoholic liver disease Mitochondria Alcohol Sirtuins

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Do migrant remittances matter for financial development in Kenya?

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Financial Innovation 2019年第1期5卷 541-565页

作者： Roseline Nyakerario Misati Anne Kamau Hared nassir Research Department Central Bank of KenyaNairobi 60000-00200Kenya African Institute for Remittances Nairobi 52448-00200Kenya

The paper analyzes the relationship between remittances and financial development using Kenyan quarterly data from 2006 to *** different indicators of financial development are used:credit to the private sector as a share of GDP,the number of mobile transactions,the value of these mobile transactions,the number of mobile agents,and the number of bank *** results from using an autoregressive distributed lag demonstrate a strong,positive relationship between remittances and financial development in long-run *** suggests that higher levels of remittances provide opportunities for recipients to open bank accounts,enhance their savings,and access financial systems,in addition to exposing the previously unbanked to both new and existing financial *** results also confirm the potential advantage of embracing modern and advanced technology to facilitate international mobile *** international remittance transfers through mobile technology reduces costs by eliminating the need for physical branches and personnel to attend to walk-in *** from offering convenience and safety for remittance actors,this method also dominates traditional remittance business ***,a policy window exists for the government to leverage on remittances as a tool of financial inclusion and depth,and particularly through the continued expansion of regulatory space to accommodate the wider use of international mobile remittance transfer ***,given the strong,positive relationship between remittances and credit to the private sector as indicated by its share of GDP and number of bank accounts,commercial banks and other players in the remittance market may also find it useful to develop customized products for migrants to access their *** example,financial intermediaries can consider providing better deposit interest rates for diaspora deposits compared to deposits made in the local ***,these institut

关键词： Remittances Financial inclusion Technology

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Medi-Block Record Secure Data Sharing in Healthcare System:Issues,Solutions and Challenges

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Computer Systems Science & Engineering 2023年第12期47卷 2725-2740页

作者： Zuriati Ahmad Zukarnain Amgad Muneer Nur Atirah Mohamad nassir Akram A。Almohammedi Faculty of Computer Science and Information Technology University Putra MalaysiaSeri Kembangan43400Malaysia Department of Computer and Information Sciences Universiti Teknologi PETRONASSeri Iskandar32160Malaysia Centre for Research in Data Science(CeRDaS) Universiti Teknologi PETRONASSeri Iskandar32610Malaysia Automobile Transportation Department South Ural State UniversityChelyabinsk454080Russia Electrical and Electronics Engineering Department Karabük UniversityKarabük78050Turkey

With the advancements in the era of artificial intelligence,blockchain,cloud computing,and big data,there is a need for secure,decentralized medical record storage and retrieval *** cloud storage solves storage issues,it is challenging to realize secure sharing of records over the ***-block record in the healthcare system has brought a new digitalization method for patients’medical *** centralized technology provides a symmetrical process between the hospital and doctors when patients urgently need to go to a different or nearby *** enables electronic medical records to be available with the correct authentication and restricts access to medical data ***-block record is the consumer-centered healthcare data system that brings reliable and transparent datasets for the medical *** study presents an extensive review of proposed solutions aiming to protect the privacy and integrity of medical data by securing data sharing for Medi-block *** also aims to propose a comprehensive investigation of the recent advances in different methods of securing data sharing,such as using Blockchain technology,Access Control,Privacy-Preserving,Proxy Re-Encryption,and Service-On-Chain ***,we highlight the open issues and identify the challenges regarding secure data sharing for Medi-block records in the healthcare systems.

关键词： Medi-block record healthcare system Blockchain technology secure data sharing

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The Effect of KRAS and NRAS Variants on the Prognosis of Colorectal Cancer among the Western Saudi Population

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Journal of Biosciences and Medicines 2021年第6期9卷 81-93页

作者： Rami nassir Ghada Esheba Department of Pathology School of Medicine Umm Al-Qura University Makkah Saudi Arabia Department of Pathology Faculty of Medicine Tanta University Tanta Egypt

Colorectal Cancer (CRC) is one of the most common cancer with high mortality rate globally and the second leading cancer in Saudi Arabia. RAS oncogenes play critical roles in the regulation of the cellular function and any mutation in these genes leads to develop CRC. Therefore, we identified the most common mutations in KRAS and NRAS genes by applying next generation sequencing (NGS) then, we assessed the correlation between these mutations and the clinicopathological features. KRAS-mutated carcinoma was significantly associated in patients who were older than 60 years old (83.3% vs 16.7%, P = 0.039) and it was associated with female patients as well, (83.3% vs 30%, P = 0.039). Also, KRAS-mutated carcinoma was significantly associated with mucinous differentiation (85.7% vs 14.3%;P = 0.012) and higher tumor grade (P = 0.014). In addition, the number of KRAS mutations per case was significantly associated with depth of the invasion (p = 0.049). The most common mutation was a missense mutation and it was highly associated with age and gender (both, p = 0.039). Also, it was highly associated with tumor grade and with mucinous differentiation (p = 0.014, p = 0.012), respectively. On the other hand, NRAS mutated carcinoma was associated only with distant metastasis however, this association was not significant (p = 0.064). For overall survival, KRAS-mutated carcinomas had a significantly worse overall survival (p = 0.025). While, no significant association was between NRAS mutation and overall survival (p = 0.985). We believe that KRAS and NRAS genes can be prognostic factors for CRC patients and the information obtained may contribute for better diagnosis and therapeutic effect.

关键词： Colorectal Cancer KRAS NRAS

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A New Technique of Outlier Detection

A New Technique of Outlier Detection

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作者： nassir Abdullah nassir（那西尔）中南大学

学位级别：硕士

孤立点检测是数据挖掘领域一个重要的研究课题,目的是为了发现藏在大数据集中的有用的异常和不规则的模式。孤立点的检测在多种应用领域也备受关注,如信用卡,保险、税务,欺诈监测中、网络安全的问题中入侵检测和其他许多领域。许多数... 详细信息

孤立点检测是数据挖掘领域一个重要的研究课题,目的是为了发现藏在大数据集中的有用的异常和不规则的模式。孤立点的检测在多种应用领域也备受关注,如信用卡,保险、税务,欺诈监测中、网络安全的问题中入侵检测和其他许多领域。许多数据挖掘技术中服务孤立点只是聚类操作的一个副产品。一般而言，这些技术将不在簇内的点定义孤立点。因此,基于聚类的孤立点检测算法的一个主要问题是找到集群和孤立点,而这些孤立点经常被视为噪声而去除,为了得到更多可靠的聚类。本论文通过分析孤立点检测方法,提出了一种有效检测孤立点和数据聚类的新法。该算法的主要思想是在聚类完成后继续进行数据过滤,方法首先利用k-means进行聚类,然后通过阈值是的设定进行孤立点的判别,最后将孤立点去除。为了检验算法的效率和有效性,本文采用用于KDD的Cup1999比赛数据集进行实验。实验结果表明,论文中提出的方法成功检测到了目前数据中的入侵行为,是可行及可靠的。此外,我们还将提出的算法与现有的一些算法在KDD常用数据集上进行实验比较,并得到了更好的孤立点的去除性能。

关键词：数据挖掘孤立点检测聚类 k-means 数据过滤

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Economical and Environmental Effects of Pressure Reducer Valve Substituting by Small Hydro Power-Plants in Gravity Water Transmission Pipelines in Iran

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Journal of Energy and Power Engineering 2012年第2期6卷 209-215页

作者： Amir Bashirzadeh Tabrizi nassir Gifani TOOSSA B Cons ulting Engineers Company Mashhad P.O. Box： 91775-1569 Iran

In this work, historical background of power generation by small hydro-power plants across the world and specially across the Iran with emphasis on small hydro-power plant utilization as recovery turbine in water transmission pipeline have been attended firstly, and then, three water transmission pipelines from Chah-nemie to Zahedan city, Shirindare dam to Bojnord city and Mokhtaran desert to Birjand city in Iran have been studied as case study samples. According to the sample pipeline characteristics and pipeline topography, reachable energy have been estimated; in the next step, pay attending to reachable energy, initial investment cost, total benefit of operating period, benefit to cost ratio and other economical parameters for small hydro-power plants in case study pipelines have been presented and generated power cost of the same amount via other resources compared to the hydro-power cost. At the end, in agreement with environmental advantages of small hydro-power plants, the methods of generated power utilization, proper solution for optimization of reachable energy in water transmission pipeline and substitution of pressure reducing valve by small hydro-power plant in the pipelines as a major solution for energy recovering in water pipelines have been proposed.

关键词： Water transmission pipeline small hydro power-plant reachable energy renewable energy.

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在环境监控中的人体跟踪研究

在环境监控中的人体跟踪研究

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作者： Yahiaoui nassir 哈尔滨工程大学

学位级别：硕士

这个项目的目的是实现人类探测和跟踪系统，当检测到移动物体，算法将开始工作，目前许多方法，检测和跟踪人类依靠图像，使用颜色，但色彩对比或运动段，要求的目标是在不断的相对运动的背景，往往需要固定相机。背景减法是最常用的技... 详细信息

这个项目的目的是实现人类探测和跟踪系统，当检测到移动物体，算法将开始工作，目前许多方法，检测和跟踪人类依靠图像，使用颜色，但色彩对比或运动段，要求的目标是在不断的相对运动的背景，往往需要固定相机。背景减法是最常用的技术检测对象。背景减法从视频序列中的对象检测技术使用从当前图像中减去背景模型或参考模型的概念。在这个项目中所考虑的方法，使用各种技术，为建立背景模型。有不同的背景减法像帧差分算法，近似的中位数，高斯混合测试这个算法检测多在不同的场景使用固定相机记录的对象，比较他们在速度和内存的要求，选择最好的一个表现。使用卡尔曼滤波，而不需要检测人体运动检测和跟踪移动到背景减法，跟踪后，可以用来定位从这种情况下的背景下移动的物体和段，我们使用光流技术。为简单起见，用户测试我们的算法，我们提出在MATLAB中的图形界面GUI（R2010a版本）用于探测和跟踪过程。

关键词：跟踪系统卡尔曼滤波高斯 MATLAB

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Cooling of the Vulcain Nozzle＇s Divergent Wall

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Journal of Mechanics Engineering and Automation 2015年第8期5卷 459-464页

作者： nassir Chellou Maamar Guendez Abdallah Benarous Department of Mechanical Engineering Faculty of Technology Hassiba Benbouali University of Chlef Chief02000 Algeria LCEMSM (Laboratory of ControL Tests Measures and Mechanical Simulation) UHB Chief02000 Algeria

Rocket engine nozzle is a propelling nozzle used to expand and accelerate the combustion gases produced by burning propellants to supersonic exit velocities. To furnish high performance and thrust, a maximum of the energy which is released inside the combustion chamber due to the reaction of the propellant and the oxidizer has to be converted into kinetic energy. This converted energy emits high heat fluxes that damage the nozzle that is so expansive to realize. For this matter, lots of researches were established to invent multiple cooling techniques in a way to avoid the damage of the nozzle, so recovering it for to be operative again. This work aims to identify the quality of cooling using the method of film injection. A numerical simulation is run on a scale model of a BKE propulsive nozzle. A parietal injection is conducted in the divergent section where the heat fluxes are enormous what allows us to predict the static temperature ＆ pressure on the walls without parietal injection ＆ then we include it in the parameters in order to see the efficiency of the film cooling technique in the nozzles. For this study, we used two different calculation codes： Ansys-Fluent was used to realize the simulation of the supersonic flow ＆ the parietal injection, where Solidworks simulation was used in the thermal study. The effects of the thermal fluxes ＆ pressure after ＆ before the fluidic injection on the wall are discussed.

关键词： Propulsive nozzle fluidic injection heat fluxes.

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