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Health 2013年第1期5卷 62-69页

作者： Riad El Kebbaj Soufiane El Kamouni Hammam I.El Hajj Pierre Andreoletti Joseph Gresti Norbert Latruffe M’Hammed Said El Kebbaj Joseph Vamecq Gerard Lizard Boubker nasser Mustapha Cherkaoui-Malki Universitede Bourgogne Laboratoire BioPeroxIL EA7270DijonFrance Laboratoir de Biochimie et Neurosciences Facultedes Sciences et TechniquesUniversite Hassan ISettatMorocco Universitede Bourgogne Centre de Recherche INSERMDijonFrance Laboratoire de Recherche sur les Lipoproteines et l’Atherosclerose Facultedes Sciences Ben M’sikUniversite Hassan II-MohammediaCasablancaMorocco INSERM and HMNO CBPCHRU LilleLilleFrance

Pseudo-neonatal adrenoleukodystrophy (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subsequent impairment of peroxisomal fatty acid β-oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in peroxisome abundance. Increase in peroxisome number has been previously suggested to improve peroxisomal disorders, and in this perspective, the present work was aimed at exploring whether modulation of peroxisomes abundance could be achieved in P-NALD fibroblasts. Here we showed that treatment with the natural Argan oil induced peroxisome proliferation in P-NALD fibroblasts. This induction was independent on activations of both nuclear receptor PPARα and its coactivator PGC-1α. Lipopolysaccharides (LPS) treatment, which caused inflammation, induced also a peroxisome proliferation that, in contrast, was dependent on activations of PPARα and PGC-1α. By its ability to induce peroxisome proliferation, Argan oil is suggested to be of potential therapeutic use in patients with P-NALD.

关键词： Acyl-CoA Oxidase 1 Argan Oil LPS PGC-1a Peroxisome Proliferation P-NALD PPARa

Modeling and Predictive Analytics of Breast Cancer Using Ensemble Learning Techniques:An Explainable Artificial Intelligence Approach

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Computers, Materials & Continua 2024年第12期81卷 4033-4048页

作者： Avi Deb Raha Fatema Jannat Dihan Mrityunjoy Gain Saydul Akbar Murad Apurba Adhikary Md.Bipul Hossain Md.Mehedi Hassan Taher Al-Shehari nasser A.Alsadhan Mohammed Kadrie Anupam Kumar Bairagi Computer Science and Engineering Discipline Khulna UniversityKhulna9208Bangladesh Information and Communication Engineering Noakhali Science and Technology UniversityNoakhali3814Bangladesh School of Computing Sciences and Computer Engineering University of Southern MississippiHattiesburgMS 39401USA Computer Skills Department of Self-Development SkillCommon First Year DeanshipKing Saud UniversityRiyadh11362Saudi Arabia Computer Science Department College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia

Breast cancer stands as one of the world’s most perilous and formidable diseases,having recently surpassed lung cancer as the most prevalent cancer *** disease arises when cells in the breast undergo unregulated proliferation,resulting in the formation of a tumor that has the capacity to invade surrounding *** is not confined to a specific gender;both men and women can be diagnosed with breast cancer,although it is more frequently observed in *** detection is pivotal in mitigating its mortality *** key to curbing its mortality lies in early ***,it is crucial to explain the black-box machine learning algorithms in this field to gain the trust of medical professionals and *** this study,we experimented with various machine learning models to predict breast cancer using the Wisconsin Breast Cancer Dataset(WBCD)*** applied Random Forest,XGBoost,Support Vector Machine(SVM),Multi-Layer Perceptron(MLP),and Gradient Boost classifiers,with the Random Forest model outperforming the others.A comparison analysis between the two methods was done after performing hyperparameter tuning on each *** analysis showed that the random forest performs better and yields the highest result with 99.46%*** performance evaluation,two Explainable Artificial Intelligence(XAI)methods,SHapley Additive exPlanations(SHAP)and Local Interpretable Model-Agnostic Explanations(LIME),have been utilized to explain the random forest machine learning model.

关键词： Breast cancer prediction machine learning models explainable artificial intelligence random forest hyperparameter tuning

政治文体中的中国特色词汇及其阿拉伯语的表现

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阿拉伯研究论丛 2016年第2期 205-218页

作者：纳赛尔·阿卜杜阿勒埃及艾因夏姆斯大学语言学院中文系

随着中国社会各项事业的快速发展，越来越多的中国特色词汇出现在政治文献当中。语言随着时代的进步而不断发展，翻译必须反映语言的这种变化。汉语和阿拉伯语都是古老的语言，具有文化含义丰富的语言。两种语言的词汇系统有区别，尤其... 详细信息

随着中国社会各项事业的快速发展，越来越多的中国特色词汇出现在政治文献当中。语言随着时代的进步而不断发展，翻译必须反映语言的这种变化。汉语和阿拉伯语都是古老的语言，具有文化含义丰富的语言。两种语言的词汇系统有区别，尤其是两种语言的文化特色不同。本文以中国政府工作报告为例来分析和说明政治文献中的中国特色词汇的特点。主要的目的是如何让学习汉语的阿拉伯学习者把握并正确使用政治文献中的中国特色词汇。在这些文献的翻译中，译者要注意具有新含义的词汇、文化差异和时代特色等方面。分析和解释政治文献中的中国特色词汇对从事汉语教学的阿拉伯语学习者，尤其对译者，是有帮助的。

关键词：汉语阿拉伯语政治文体中国特色词汇

波氏假阿利什菌(尖端赛多孢子菌)引起的真菌性角膜炎1例(英文)

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国际眼科杂志 2008年第8期8卷 1530-1532页

作者： Mohammad nasser Hashemian Mehrdad Shamshiri Firoozeh Rahimi Mohammad Taher Rajabi Seyed All Tabatabaee Mohammad Reza Salari 德黑兰大学医学院眼科伊朗德黑兰

我们报道成功治疗波氏假阿利什菌引发的真菌性角膜炎1例,患者只留有很小的角膜瘢痕。一位71岁女性患者,有疼痛、红肿和异物感病史,来到我们第三眼科中心就诊。最初角膜刮片显示有真菌成分,2d后真菌培养为阳性,5d后显示生长物为波氏假阿... 详细信息

我们报道成功治疗波氏假阿利什菌引发的真菌性角膜炎1例,患者只留有很小的角膜瘢痕。一位71岁女性患者,有疼痛、红肿和异物感病史,来到我们第三眼科中心就诊。最初角膜刮片显示有真菌成分,2d后真菌培养为阳性,5d后显示生长物为波氏假阿利什菌。患者仅用药物疗法取得临床治愈,留下微小的角膜瘢痕,最终视力为3/10。

关键词：真菌性角膜炎波氏假阿利什菌尖端赛多孢子菌

Evaluation of the Quality and Safety of Hand Sanitizers Marketed in Saudi Arabia

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Health 2022年第5期14卷 523-534页

作者： Ibrahim A. Al Othaim Turki F. Al-Mutari nasser S. Bakiri Khalid M. Bin Shehail Fouza K. Al-Enazi Fahad S. Aldawsari Anwar S. Al Suhaibani Yahya M. Alshehri Reference Laboratory for Medicine and Cosmetics Saudi Food and Drug Authority (SFDA) Riyadh Saudi Arabia National Drug and Cosmetic Control Laboratories Saudi Food and Drug Authority (SFDA) Riyadh Saudi Arabia

Background: Hand sanitizers are an important preventive measure to halt the spread of pathogens, which has become a huge demand during the coronavirus disease (COVID-19). Consequently, their safety and quality are top priorities for regulatory organizations. Methods: Saudi Food & Drug Authority laboratories have analyzed numerous samples of hand sanitizers in order to ensure their safety and efficacy. Active ingredients, as well as hazardous impurities, have been checked according to the pharmacopeia. Results: In this study, we report the results of the analysis of 1409 samples, which represent the majority of products available in the Saudi Arabian market. The results showed that 196 samples (13.9%) did not meet international standards. Specifically, out of 196 failed samples, 75, 12, and 4 products contained hazardous substances such as methanol, 1-propanol, and acetaldehyde, respectively. Additionally, some failed samples contained foreign particles, were improperly labeled, or contained an inadequate concentration of alcohol. Conclusion: The substandard hand sanitizers possess a risk to the community, particularly during pandemics, and hence stringent yet dynamic regulations should be implemented.

关键词： Hand Sanitizer COVID-19 US FDA Ethanol Methanol

Effect of non-alcoholic beer,diet and exercise on endothelial function,nutrition and quality of life in patients with cirrhosis

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World Journal of Hepatology 2020年第12期12卷 1299-1313页

作者： Ricardo U Macias-Rodriguez Astrid Ruiz-Margain Berenice M Roman-Calleja May E Espin-nasser Nayelli CFlores-Garcia Aldo Torre Gretel Galicia-Hernandez Silvia L Rios-Torres Gabriela Fernandez-del-Rivero Arturo Orea-Tejeda Oscar A Lozano-Cruz Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiranMexico City 14080Mexico Liver Fibrosis and Nutrition Lab(LFN-Lab) MICTLÁN Network:Mechanisms of Liver InjuryCell Death and Translational Nutrition in Liver Diseases-Research NetworkMexico City 14080Mexico Department of Cardiology Instituto Nacional de Enfermedades RespiratoriasMexico City 14080Mexico Department of Internal Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiranMexico City 14080Mexico

BACKGROUND The implementation of nutritional strategies targeting several variables at once could benefit patients with ***-alcoholic beer has different compounds that exert antioxidant,anti-inflammatory and nutritional *** To evaluate the effect of diet+exercise and non-alcoholic beer on nutritional status,endothelial function and quality of life in patients with *** In this randomized open clinical trial,patients with cirrhosis were randomized into two groups:The intervention(non-alcoholic beer+diet+exercise)and control(water+diet+exercise)*** consisted of 330 mL nonalcoholic beer/day or the same amount of water,plus an individualized dietary plan and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/d and>2500 above the baseline during 8 *** function(flow-mediated dilation,plethysmography),biochemical and nutritional variables and quality of life(CLDQ)were *** Forty-three patients were included in the study,21 in the control group and 22 in the intervention *** mean age was 53.5±7.8 years,60%were women,the median MELD score was 8(7-10)and most patients were Child-Pugh A(88%).Adherence to the interventions was>90%in both groups,there were no adverse events and all biochemical parameters remained stable in both *** function improved in both *** measured nutritional parameters improved in the intervention group,compared to only 2 in the control group and quality of life improved in both groups;however,more domains improved in the intervention *** The intervention consisting of non-alcoholic beer,diet and exercise seems to be safe and well tolerated in patients with cirrhosis,and shows improvement in nutritional status,endothelial function,and quality of *** results need to be further confirmed.

关键词： Hops Portal hypertension Sarcopenia Diet Cirrhosis Antioxidants

伊朗德黑兰959例眼外伤流行病学的研究(英文)

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国际眼科杂志 2008年第10期8卷 1975-1979页

作者： Mehdi Nili-Ahmadabadi Syed-Jafar Oskouee Mohammad-nasser Hashemian Mohammad-Bagher Abbaszadeh Ramak Rouhipour Mohammad-Taher Rajabi 德黑兰大学医学院眼科伊朗德黑兰 Farabi眼科医院德黑兰大学眼科研究中心南开利开尔

目的:回顾过去1a,德黑兰转诊眼科中心穿通性眼外伤的发病特征,并发症和流行病学。方法:调查2002年伊朗德黑兰Farabi眼科医院的959例眼外伤住院患者的医疗记录,记录信息包括人口统计资料(年龄,性别和所从事职业),受伤原因,伤口类型,最初... 详细信息

目的:回顾过去1a,德黑兰转诊眼科中心穿通性眼外伤的发病特征,并发症和流行病学。方法:调查2002年伊朗德黑兰Farabi眼科医院的959例眼外伤住院患者的医疗记录,记录信息包括人口统计资料(年龄,性别和所从事职业),受伤原因,伤口类型,最初视力,受损部位,伴随症状和体征以及所采取的治疗方式。结果:患者的平均年龄是(22.6±16.4)a,男性患者的年龄峰值为21～25a,女性患者为小于5a。男女性别比例为4.2∶1。62.4%的患者为穿通伤,33.9%的患者为钝挫伤,3.7%的患者为混合伤或化学烧伤。金属物是造成眼球穿通伤的最常见原因,与之相比,石块是眼钝挫伤最为常见的原因。在23.4%的病例中发现了异物,最常见的破裂部位为角膜(46.7%)。结论:本研究认为,穿通伤较钝挫伤常见,年轻人更易发生眼外伤,角膜是最常见的损伤部位。

关键词：流行病学眼外伤眼球穿通伤钝挫伤

新型高掺铥硅酸盐玻璃光纤及其光纤激光的研究

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红外与激光工程 2021年第9期50卷 178-183页

作者：张钧翔史伟史朝督房强付士杰盛泉朱秀山 Peyghambarian N 姚建铨天津大学精密仪器与光电子工程学院激光与光电子研究所天津300072 天津大学光电信息技术教育部重点实验室天津300072 山东海富光子科技股份有限公司山东威海264209 天津欧泰激光科技有限公司天津300384 亚利桑那大学光学科学学院美国亚利桑那州85721

具有高稀土离子掺杂浓度的有源光纤一直以来是高性能单频光纤激光器的核心,选用硅酸盐玻璃材料制作高掺杂有源光纤可以有效提升光纤增益。通过高温熔融工艺制备了铥离子掺杂浓度为8 wt.%的高掺杂硅酸盐玻璃,测试了其光谱特性和荧光寿命... 详细信息

具有高稀土离子掺杂浓度的有源光纤一直以来是高性能单频光纤激光器的核心,选用硅酸盐玻璃材料制作高掺杂有源光纤可以有效提升光纤增益。通过高温熔融工艺制备了铥离子掺杂浓度为8 wt.%的高掺杂硅酸盐玻璃,测试了其光谱特性和荧光寿命,并根据McCumber理论计算玻璃的受激发射截面。采用管棒法制备光纤预制棒,拉制出尺寸为7/125μm的高掺铥硅酸盐玻璃光纤。基于低损耗的异质光纤熔接,测试了该光纤的增益特性,并分别采用2 cm和8 cm的新型掺铥光纤搭建线形腔光纤激光器,获得百毫瓦的1 950 nm激光输出。研究表明,在8 wt.%的高浓度掺杂下,铥离子在文中的新型硅酸盐光纤基质中具备良好的发光能力,这种国产高掺杂玻璃光纤在实现高性能单频光纤激光器方面具有明显优势。

关键词：高掺铥硅酸盐玻璃光纤受激发射截面荧光寿命线形腔光纤激光器

应用免疫学和分子遗传学方法合理设计抗结核病疫苗

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国际结核病与肺部疾病杂志 2007年第1期2卷 60-70页

作者： S. H. E. Kaufmann S. Baumann A. nasser Eddine 张宗德（译）屠德华（校）张立兴（审） Department of Immunology Max Planck Institute for Infection Biology Berlin Germany 不详

罗伯特.柯霍(RobertKoch)因对结核病(TB)的贡献荣获诺贝尔奖已过去100年,Albert Calmette和Camille Guerin制备了减毒疫苗株——牛分枝杆菌卡介苗(BCG)也已过去85年,但是,至今仍然没有有效预防TB的方法。然而,21世纪的最初十年将会见证... 详细信息

罗伯特.柯霍(RobertKoch)因对结核病(TB)的贡献荣获诺贝尔奖已过去100年,Albert Calmette和Camille Guerin制备了减毒疫苗株——牛分枝杆菌卡介苗(BCG)也已过去85年,但是,至今仍然没有有效预防TB的方法。然而,21世纪的最初十年将会见证若干新型候选疫苗的临床试验。这些候选疫苗分为二类:1)亚单位疫苗旨在强化由BCG初免诱导的免疫反应,2)改进的重组BCG取代现有的疫苗株。分别使用合适的佐剂、递送系统的蛋白质和DNA疫苗、重组病毒载体如重组的改良疫苗病毒安卡拉(Ankara),用于强化免疫,现正在试验中。已经开发出重组卡介苗(rBCG)用于初免,这些疫苗株具有很高的免疫原性,或者主要抗原的高表达。这些候选疫苗会在2006年底前通过Ⅰ期临床试验。今后的目标是试验这些新候选疫苗的不同组合以促进最佳免疫接种方案的形成。

关键词： BCG 巨噬细胞 T细胞疫苗

Road safety data collection systems in Iran: A comparison based on relevant organizations

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Chinese Journal of Traumatology 2020年第5期23卷 265-270页

作者： Homayoun Sadeghi-Bazargani Sakineh Sharifian Davoud Khorasani-Zavareh Raana Zakeri Mehdi Sadigh Mina Golestani Mousa Amiri Reza Masoudifar Farzad Rahmani nasser Mikaeeli Javad Namvaran Khalil Pour-Ebrahim Mahdi Rezaei Babak Arabzadeh Bahram Samadirad Aliashraf Seyffarshad Fariba Mirza-Mohammadi-Teimorloue Shahin Kazemnezhad Soudabe Marin Saeede Sheikhi Reza Mohammadi Research Center for Evidence-Based Medicine Tabriz University of Medical SciencesTabrizIran Department of Health in Emergencies and Disasters School of Public Health and SafetyShahid Beheshti University of Medical SciencesTehranIran Workplace Health Promotion Research Center(WHPRC) Department of Health in Emergencies and DisastersShahid Beheshti University of Medical SciencesTehranIran Department of Health Services Management Iranian International Safe Community Support CenterTabriz University of Medical SciencesTabrizIran Road Traffic Injury Research Center Tabriz University of Medical SciencesTabrizIran Iranian Traffic Police TehranIran University of Tabriz Islamic Azad TabrizIran Department of Emergency Medicine Road Traffic Injury Research CenterTabriz University of Medical SciencesTabrizIran Iranian Traffic Police TabrizIran Payame Noor University(PNU) TehranIran Karafarin Insurance TabrizIran Legal Medicine Research Center Legal Medicine OrganizationTehranIran Shohada Medical Research and Training Hospital Tabriz University of Medical SciencesTabrizIran Department of Biostatistics and Epidemiology School of HealthTabriz University of Medical SciencesTabrizIran Department of Neurobiology Care Sciences and Society(NVS)H1Division of Family Medicine and Primary CareHuddingeSweden

Purpose:Various organizations and institutions are involved in road traffic injury(RTI)and crash registration such as police,forensic medicine organization,hospitals and emergency medical *** there is a substantial uncertainty in interpreting the data,duplicated data collection and missing data in relation to RTI in most *** study aims to identify data sources for RTI surveillance in Iran and to explore traffic safety data source domains,data elements and detailed information by each data ***:This is a qualitative study which was conducted in 2017 in *** were collected employing semi-structured interviews with informants in road safety organizations in relation to traffic safety including Police,Ministry of Health and Medical Education as well as Forensic Medicine Organization and other *** completing the preliminary extraction information,the minimum data set was used and compared in each ***:Eight different organizations relevant to road traffic safety were *** main domain of data provided by each one consists of Emergency Medical System form,Police KAM114 form,Ministry of Transport and Road Administration,Red Crescent Organization/Disaster Management Information System,Ministry of Health and Medical Education,Forensic Medicine Organization,Insurance Company and Ministry of *** system has its own database,based upon its scope and mainly at crash and postcrash status and little on pre-crash ***:All current registry systems are not surveillance systems for RTI *** data have been collected in various registry systems in Iran,but most of the collected variables are duplicated in each *** the other hand,some variables like alcohol and substance abuse,child seat belt,helmet use in relation to RTI prevention are missed in all ***,it is a critical need to integrate and establish a comprehensive surveillance system,with focus on the

关键词： Accidents,traffic Integrated surveillance system Prevention and control