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The Influence of Kidney Stones and Salivary Uric Acid on Dental Calculus Formation and Periodontal Status among Some Saudi Patients Aged 25 - 70 Years

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International Journal of Clinical Medicine 2020年第10期11卷 565-578页

作者： Mohammed M. A. Abdullah Al-Abdaly Fayez Saud Thlaab Alharbi Ali Mohammed Almoalem nasser Ahmed Taib Awaji Periodontics and Community Dental Sciences Department College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia

Background: The formation of kidney stones is considered a complicated process. Consequently, there are many questions about the link between kidney stones formation and level of salivary uric acid and calculus formation on the teeth surfaces. Objectives: To evaluate the correlation between the level of salivary uric acid and kidney stones formation and their influence on dental calculus and periodontal status among Saudi patients aged 25 - 70 years. Materials and Methods: 120 Saudi male patients were examined (60 of Kidney stones patients and 60 patients of non-kidney stones patients) for clinical evaluation of plaque index (PLI), gingival index (GI), calculus index of oral hygiene (CI) and clinical attachment loss (CAL). Moreover, lab assessment of uric acid level in the collected salivary samples was done. The findings were analyzed using of ANOVA test and Tukey’s test. Results: There were statistically significant differences in clinical parameters among kidney stones patients and non-kidney stones patients (p Conclusion: At the end of this study, we concluded that there was a relationship between dental calculus formation, kidney stones formation, and an increase in the level of salivary uric acid.

关键词： Dental Calculus Kidney Stones Uric Acid Periodontal Status

Chemical Composition,Cytotoxic and Anti-arthritic Activities of Hexane Extracts of Certain Schinus Species

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Journal of Pharmacy and Pharmacology 2021年第11期9卷 378-386页

作者： Heba A.S.El-Nashar Nada M.Mostafa Omayma A.Eldahshan Abdel nasser B.Singab Department of Pharmacognosy Faculty of PharmacyAin Shams UniversityAbbassiaCairoEgypt Center for Drug Discovery Research and Development Faculty of PharmacyAin Shams UniversityCairoEgypt

The genus Schinus(Anacardiaceae)comprises about 29 species that are utilized in both traditional and current medicine to alleviate various disorders such as rheumatism,bronchial infections,stomach upset,menstrual disturbance,bronchitis,and *** this study we aimed to investigate the chemical composition of hexane extracts obtained from Schinus polygamous and Schinus terebinthifolius leaves as well as their cytotoxic and anti-arthritic *** GC-MS analysis of *** leaves revealed identification of fifty-five components:being betulin(6.54%),phytol acetate(5.27%),lupeol(3.96%),palmitic acid methyl ester(3.58%)and heptacosane(3.25%).While,seventeen compounds were identified in *** leaves,predominately characterized by phytol(14.70%),lupeol(13.33%),linolenic acid methyl ester(11.17%),palmitic acid methyl ester(7.74%),and 28-oxours-12-en-3-yl acetate(7.44%).Both extracts showed moderate cytotoxic activities against hepatocellular carcinoma cells with IC_(50) values of 102.65 and 65.55μg/mL,*** colorectal carcinoma cell line presented IC_(50) values of 217.78 and 83.55μg/mL,***,both extracts provided moderate anti-arthritic effects(IC_(50):80.12 and 63.09μg/mL,respectively)using protein denaturation test,compared to diclofenac sodium(IC_(50)=15.12μg/mL).

关键词： Schinus polygamous Schinus terebinthifolius Betulin Phytol Cytotoxic Anti-arthritic

Immune microenvironment of medulloblastoma:The association between its molecular subgroups and potential targeted immunotherapeutic receptors

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World Journal of Clinical Oncology 2023年第3期14卷 117-130页

作者： Maher Kurdi nasser Mulla Husam Malibary Ahmed K Bamaga Motaz M Fadul Eyad Faizo Sahar Hakamy Saleh Baeesa Department of Pathology Faculty of MedicineKing Abdulaziz UniversityRabigh 213733Saudi Arabia Neuromuscular Unit King Fahad Medical Research CenterKing Abdulaziz UniversityJeddah 213733Saudi Arabia Department of Internal Medicine Faculty of MedicineTaibah UniversityMedina 213733Saudi Arabia Department of Internal Medicine Faculty of MedicineKing Abdulaziz UniversityJeddah 213733Saudi Arabia Department of Paediatrics Faculty of MedicineKing Abdulaziz UniversityJeddah 213733Saudi Arabia Division of Neurosurgery Department of SurgeryFaculty of MedicineTabuk UniversityTabuk 213733Saudi Arabia Neurmuscular Unit Center of Excellence of Genomic MedicineJeddah 21423Saudi Arabia Department of Neuroscience King Faisal Specialist Hospital and Research CenterJeddahSaudi Arabia

Medulloblastoma(MB)is considered the commonest malignant brain tumor in *** treatments consisting of surgery,radiation,and chemotherapy have improved patients’***,the recurrence occurs in 30%of *** persistent mortality rates,the failure of current therapies to extend life expectancy,and the serious complications of non-targeted cytotoxic treatment indicate the need for more refined therapeutic *** MBs originating from the neurons of external granular layer line the outer surface of neocerebellum and responsible for the afferent and efferent ***,MBs have been segregated into four molecular subgroups:Wingless-activated(WNT-MB)(Group 1);Sonichedgehog-activated(SHH-MB)(Group 2);Group 3 and 4 *** molecular alterations follow specific gene mutations and disease-risk *** current treatment protocols and ongoing clinical trials against these molecular subgroups are still using common chemotherapeutic agents by which their efficacy have improved the progression-free survival but did not change the overall ***,the need to explore new therapies targeting specific receptors in MB microenvironment became *** immune microenvironment of MBs consists of distinctive cellular heterogeneities including immune cells and none-immune *** associate macrophage and tumour infiltrating lymphocyte are considered the main principal cells in tumour microenvironment,and their role are still under *** this review,we discuss the mechanism of interaction between MB cells and immune cells in the microenvironment,with an overview of the recent investigations and clinical trials.

关键词： Medulloblastoma Tumour microenvironment Tumour associated macrophages Tumour infiltrating lymphocyte Immunotherapies

锆—钽—钛种植材料的表面性质对抗菌活性的影响

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锆—钽—钛种植材料的表面性质对抗菌活性的影响

作者：查松海（Juaim Akram nasser Hussien）中南大学

学位级别：硕士

钛及其合金Ti6Al4V是牙科和骨科植入物中最常用的合金,具有优异的机械性能和生物相容性,但是仍存在许多问题,如它们的弹性模量显著高于骨骼,可能导致植入物周围的应力屏蔽效应和骨质流失;合金中铝和钒释放可引起细胞毒性和过敏反应,而... 详细信息

钛及其合金Ti6Al4V是牙科和骨科植入物中最常用的合金,具有优异的机械性能和生物相容性,但是仍存在许多问题,如它们的弹性模量显著高于骨骼,可能导致植入物周围的应力屏蔽效应和骨质流失;合金中铝和钒释放可引起细胞毒性和过敏反应,而且这些材料的抗菌活性不足以预防植入物周围感染。为解决抗菌问题,研究通常采用表面修饰添加铜和银等抗菌元素或使用具有光敏活性的材料来改善植入物的抗菌活性,但这些技术存在细胞毒性、短期效应、不稳定性和高成本等缺点。为克服这些缺点,本研究采用等离子烧结技术制备了新合金Zr-30Ta和Zr-25Ta-5Ti,它们由对人体友好、无毒、不引起过敏反应的锆、钽和钛元素组成,具有良好的生物相容性,其弹性模量显著低于Ti及其合金(Zr-30Ta为99GPa,Zr-25Ta-5Ti为73GPa)。前期研究已证实了它们具有良好的机械性能和成骨活性。研究证实细菌直接与材料表面相互作用,但材料的表面性能因素,如元素组成、氧化膜形成、表面粗糙度、接触角和表面电荷等如何影响细菌附着和生长目前尚不清楚。因此本研究选择与种植体周围感染有关的变形链球菌和牙龈卟啉单胞菌,探索Zr-30Ta和Zr-25Ta-5Ti材料的抗菌活性和机制。1.材料与方法1.1.材料选择:前期对Zr-Ta合金研究发现Zr-30Ta合金具有最佳的机械性能和生物相容性,又发现向合金中添加钛后,Zr-25Ta-5Ti合金的机械性能显著提高,弹性模量降低。还发现这两种合金都具有优异的生物相容性和成骨活性。因此,选择Zr-30Ta和Zr-25Ta-5Ti合金进行抗菌评估。1.2.材料制备:使用放电等离子烧结粉末冶金技术制备Zr-30Ta和Zr-25Ta-5Ti合金样品,烧结过程在等离子烧结系统中进行,温度/压力为1600°C/40MPa。在本研究中,所用样品尺寸为10mm×10mm×2 mm,用同样参数制备的工业纯钛(CP-Ti)作为对照组。1.3.材料性能评估:1.3.1.材料显微结构评估:使用扫描电子显微镜在次级电子和背散射模式下分析Zr-30Ta和Zr-25Ta-5Ti合金表面形貌和相组成。采用能量色散谱(EDS)定量分析合金表面元素分布。1.3.2.电化学腐蚀评估:实验所用样品尺寸为6 mm×6 mm×6mm,利用三电极系统中的电化学工作站对其进行测试(图2-2)。为稳定其表面电位,将样品浸于Fusayama人工唾液(腐蚀液)中5小时后进行测试,采用电位动力学极化测试评估Zr-30Ta和Zr-25Ta-5Ti合金的抗腐蚀性,以商业纯钛作为对照组。使用扫描电子显微镜评估腐蚀后的表面形貌,并采用EDS分析确定元素组成以评估腐蚀液对合金表面的影响。1.3.3.表面粗糙度评估:使用Dektak XT探针式轮廓仪评估纳米级粗糙度。在实验之前,样品经过抛光、清洁和干燥处理,测量长度为3 mm。1.3.4.表面润湿性评价:使用DSA100滴形分析仪,通过静置法测量静态接触角以评价表面润湿性。于室温(22℃)和大气压下,将一滴水(d HO)置于样品表面,5秒后记录液滴形态。1.3.5.表面电荷评价:使用Surpass电化学分析仪,采用p H扫描法测量Zeta电位。实验所用样品尺寸为20 mm×10 mm×1 mm,测试溶液为0.001-M的氯化钾(KCl)电解质溶液,测试液的p H值在2.8-8.2之间,利用0.05-M的盐酸(HCl)和0.05 M的氢氧化钠(Na OH)调控。1.4.抗菌评价:评估Zr-30Ta和Zr-25Ta-5Ti样品对与口腔种植体周围感染相关细菌--变形链球菌、牙龈卟啉单胞菌的抗菌活性,CP-Ti为对照。细菌浓度均为1×10 CFU/孔。1.4.1.抑菌圈法:采用Kirby-Bauer抑菌圈试验改进法评估样品对细菌生长的影响。将细菌接种在含样品的琼脂平板上,标准条件下培养1天(变形链球菌)或7天(牙龈卟啉单胞菌),在所设时间内测量样品周围所形成的抑菌区。1.4.2.平板计数法:采用平板计数法评估样品对细菌附着和存活的影响。首先将细菌与样品在脑心浸液肉汤(Brain heart infusion broth(BHI))培养基中标准条件下孵育1天和3天,然后将样品上细菌分离至溶液中,10倍稀释后接种于琼脂平板上。根据中国标准GB/T4789.2-2010计数琼脂平板上的细菌菌落数,并计算Zr-30Ta和Zr-25Ta-5Ti样品的抗菌率(R),以CP-Ti为对照。1.4.3.活死染色法:采用活死染色法直接观察样品对细菌存活的影响。将细菌与样品在BHI液培养基中孵育1天和3天,将细菌溶液废弃后,PBS洗涤样品,并根据生产商说明使用细菌活力检测试剂盒染色。SYTO9将活细菌染成绿色,碘化丙啶(PI)将死亡细菌染成红色。去除多余染料后,使用倒置荧光显微镜观察染色样品。

关键词：锆钽钛种植体周围炎抗菌活性氧抗粘附

Studies on free-radical scavenging activity and identification of active ingredients of different plant crude extracts of Mentha piperita collected from Sur,Sultanate of Oman

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Journal of Coastal Life Medicine 2014年第10期 805-810页

作者： Mohammad Amzad Hossain Aqeela Said Hamed AL Orimi Afaf Mohammed Weli Qasim Al-Riyami Jamal nasser Al-Sabahi School of Pharmacy College of Pharmacy and NursingUniversity of NizwaP.O.Box 33Postal Code 616NizwaSultanate of Oman Central Instrument Laboratory College of Agricultural and Marine SciencesSultan Qaboos UniversitySultanate of Oman

Objective:To determine free radical scavenging activity and active chemical ingredients of different plant crude extracts of Mentha piperita(***).Methods:The dried powder leaves of *** were extracted with polar organic solvent by Soxhlet *** crude extract and its fractions of hexane,chloroform,ethyl acetate and butanol crude extracts were *** antioxidant activity of different crude extracts from *** was carried out by DPPH method with minor modification,and the active chemical ingredients of different plant crude extracts of *** were analyzed by gas chromatography-mass spectrometry(GC-MS).Results:Qualitative analysis of different polarities crude extracts by GC-MS found different types of active organic *** antioxidant activity of different crude extracts were found to be in the order of chloroform extract>butanol extract>ethyl acetate extract>hexane extract>methanol *** identified compounds in the plant crude extracts by GC-MS were biologically ***:Therefore,the isolation,purification,identification and characterization of bioactive compounds from various crude extracts of *** might have ecological significance.

关键词： Mentha piperita Lamiaceae Crude extracts Antioxidant activity DPPH Gas chromatography-mass spectrometry analysis

Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson’s Disease

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Journal of Behavioral and Brain Science 2024年第5期14卷 135-160页

作者： Fayda Protásio Carlos Alberto Bezerra Tomaz Joaquim Brasil-Neto Pedro Brandão nasser Allam Maria Clotilde Henriques Tavares Laboratory of Neuroscience and Behavior Department of Physiological Sciences Institute of Biology University of Braslia Braslia Brazil Master Program in Environment University CEUMA So Lus MA and Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil NA Neurologistas Associados Braslia Brazil

Introduction: In the last thirty years, brain neuromodulation techniques have been used as an alternative to pharmacological treatment of neurological disorders. Parkinson’s disease (PD) is a neurodegenerative disorder leading to bradykinesia, rest tremor, postural changes, and non-motor symptoms such as depression, anxiety, sleep disorders, pain, and cognitive decline that compromises executive functions (EFs), responsible for the orderly execution of behaviors and tasks of daily life and intentional and directed actions. To this date, a few studies with transcranial direct current stimulation (tDCS) have shown beneficial effects in PD patients concerning specific motor and non-motor symptoms, targeting the motor cortex and/or prefrontal regions. Objective: The main objective of this study was to evaluate the effects of left prefrontal tDCS across a broad spectrum of motor and non-motor symptoms of PD using established validated scales. Method: Single-blind randomized clinical trial with 18 volunteers with PD, aged between 45 and 80 years (66.1 ± 9.65), who met inclusion and exclusion criteria. Participants were submitted to assessments of motor and non-motor functions employing psychometric scales and tests to evaluate EFs and were randomly divided into two groups: control (sham stimulation) and experimental (active stimulation). All participants were involved in three separate tDCS sessions. The anode was positioned over the left dorsolateral prefrontal cortex and the cathode over the right supraorbital region, with a direct current intensity of 2 mA, lasting 20 minutes. At the end of the three sessions, all participants were reassessed. Results: Significant effects of tDCS on non-motor functions were observed for cognition (verbal fluency of actions, clock copy test, appointment by visual confrontation, and verbal memory with immediate free recall) and subjective assessment of sleep quality (overall restlessness and discomfort in the arms and legs at night, leg

关键词： Parkinson’s Disease Neuromodulation Transcranial Direct Current Stimulation—tDCS Movement Disorders Mood Sleep Cognition

Hepatocellular Carcinoma: The Final Moments of Life

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Journal of Cancer Therapy 2013年第2期4卷 377-383页

作者： Rodrigo Martins Abreu Camila Silva Ferreira Paulo Dominguez nasser Luciana Oba Onishi Kikuchi Flair José Carrilho Suzane Kioko Ono Department of Gastroenterology Clinical Division Hepatology Branch University of Sao Paulo School of Medicine Sao Paulo Brazil

Hepatocellular carcinoma (HCC) is a wide world prevalent hepatic disease, being the third greater cancer related death cause and most of the patients are not eligible for liver transplant. Palliative care is an option for, in average, half of hepatocellular carcinoma diagnosed patients and only recently the molecular targeted drug, Sorafenib, has been introduced among the therapeutic options for these patients. The physical pain comes frequently associated with progression disease (metastasis). Patients may be very fragile, with immobility, loss of interest in food and beverage intake, as well as weakness and drowsiness. Therefore, it is important that health professionals start planning care with patients and their relatives, before the end-stage disease. Informing the patient about therapeutic options guarantee a doctor patient relationship improvement and more belief on the health team.

关键词： Hepatocellular Carcinoma Liver Cancer Palliative Care Terminally Ill Death