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Efficiency of combining pomegranate juice with low-doses of cisplatin and taxotere on A549 human lung adenocarcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 19-24页

作者： nasser Mohamad Hijazi Akram Sayed Ahmad Bouchra Jamal Eddine Zeinab Ibrahim Sajida Rammal Hassan Al Rekaby Abd-El-Ameer nasser mouhamad Doctoral School of Science and Technology Research Platform for Environmental Science (PRASE) Lebanese University Université Fédérale de Toulouse Midi-Pyrénées INP-ENSIACET Laboratoire de Chimie Agro-industrielle Al Mustansiriya University College of Science Department of Biology American University of Beirut

Objective: To test the coalescence effect of two chemotherapy drugs at low effective dose(cisplatin and taxotere) combined with pomegranate juice on A549 cancer cells. Methods: Infrared spectroscopy method is a qualitative test that was performed to ensure the existence of the phytochemicals providing the antioxidant activity through the presence of the hydroxyl group(-OH). The viability of A549 cell line and normal MCs was tested using the neutral red uptake, Clonogenic survival, XTT and Cell migration assays. Results: Our results showed that this combination firstly led to a greater decrease in the viability of cells comparing to those treated with chemotherapy drugs alone, and secondly led to a significant reduction in cell migration. Conclusions: These data suggest a synergistic effect between the pomegranate and cisplatin which makes probably this combination a powerful option for treating lung adenocarcinoma and in parallel minimizing the systemic side effects.

关键词： Lung cancer Chemotherapy Cisplatin Taxotere Pomegranate A549 cells

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Indolent lung opacity: Ten years follow-up of pulmonary inflammatory pseudo-tumor

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World Journal of Clinical Cases 2017年第2期5卷 61-66页

作者： Jad A Degheili Nadim A Kanj Salwa A Koubaissi mouhamad J nasser Division of General Surgery Department of Surgery American University of Beirut-Medical Center Division of Pulmonary Critical Care and Sleep Medicine Department of Internal Medicine American University of Beirut-Medical Center Department of Internal Medicine American University of Beirut-Medical Center

Inflammatory pseudotumor(IPT) has always been considered a diagnostic challenge. Its rarity and resemblance to other more common pathological entities imposes that neither clinical nor radiological characteristics can lead to a definitive diagnosis. The surgical excision of the lesion is the ultimate approach for accurate diagnosis and cure. Moreover the true nature of IPT, its origin as a neoplastic entity or an overreactive inflammatory reaction to an unknown trigger, has been a long debated matter. Surgery remains the treatment of choice. IPT is mostly an indolent disease with minimal morbidity and mortality. Local invasion and metastasis predict a poor prognosis. We hereby present a unique case of pulmonary IPT that was surgically excised, but recurred contralaterally, shortly thereafter. Despite no medical or surgical treatment for ten years, the lesion has remained stable in size, with neither symptoms nor extra-pulmonary manifestations.

关键词： Inflammatory pseudotumor Anaplastic lymphoma kinase Inflammatory myofibroblastic tumor Plasma cells granuloma IgG4-related sclerosing disease

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