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Non-alcoholic steatohepatitis and influence of age and gender on histopathologic findings

World Journal of Gastroenterology 2010年第33期16卷 4169-4175页

作者： Nargess ebrahimi daryani nasser ebrahimi daryani Seyed Moayed Alavian Ali Zare Seyed-Mohammad Fereshtehnejad Mohammad Reza Keramati Mohammad Reza Pashaei Peiman Habibollahi Department of Gastroenterology and Hepatology Tehran University of Medical Sciences Center for Gastroenterology and Liver Disease Baqiatallah University of Medicine and Tehran Hepatitis Center Department of Pathology Firouzgar HospitalIran Uni- versity of Medical Sciences Gastrointestinal & Liver Disease Research Center(GILDRC) Iran University of Medical Sciences Department of Surgery Iran University of Medical Sciences

AIM:To characterize the histopathologic specifications of non-alcoholic steatohepatitis(NASH)according to age and ***:An analytical cross-sectional study was conducted in two private gastroenterology clinics on biopsy proven patients suffering from *** histopathologic findings as well as demographic and laboratory data of the patients at the time of biopsy were gathered retrospectively from clinical *** grading and staging of histopathologic findings were performed according to the Brunt method after reevaluation of the slides by a *** were divided into two groups according to age(belowand above 55 years).Mean quantitative grade of all pathologic findings were also calculated according to Brunt scoring ***:A total number of 77 NASH patients,consisting of 58 males(75.3%)and 19(24.7%)females with a mean age of 41.99±11.80 years(range,18-70 years),were *** mean age(48.72±13.99 years vs 39.74±10.16 years,P=0.004)and aspartate aminotransferase level(75.11±29.68 U/L vs 52.78± 25.00 U/L,P=0.002)was significantly higher in female *** quantitative grade of hepatosteatosis was significantly higher in females(2.00±0.82 vs 1.59 ±0.68,P=0.031)compared to *** four percent(34/65)of young patients had mild hepatosteatosis (GradeⅠ)while only one patient(11.2%)in the older group had gradeⅠ*** aged≥55 had significantly more severe hepatosteatosis(GradeⅢ) (44.4%vs 9.5%,P=0.007)and the mean quantitative grade of hepatosteatosis was significantly higher among them(2.33±0.71 vs 1.56±0.67,P=0.002).Multivariate analysis after omitting the confounding role of age revealed a higher grade of hepatosteatosis in female patients(P=0.010).CONCLUSION:These findings point toward the possible influence of age in the severity of steatohepatitis,portal and lobar inflammation in patients suffering from NASH while gender independently might contribute to the level of steatohepatitis.

关键词： Non-alcoholic steatohepatitis Age Gender Histopathologic findings

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Immunogenicity of recombinant hepatitis B virus vaccine in patients with and without chronic hepatitis C virus infection:A case-control study

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World Journal of Gastroenterology 2007年第2期13卷 294-298页

作者： Naser ebrahimi daryani Mohsen Nassiri-Toosi Armin Rashidi Iman Khodarahmi Department of Gastroenterology Medical School Tehran University of Medical Sciences Tehran Iran

AIM： To compare the response of standard hepatitis B virus （HBV） vaccination between patients with chronic hepatitis C virus （HCV） infection and healthy individuals. METHODS： This is a prospective case-control study. A total of 38 patients with chronic HCV infection and 40 healthy controls were included. Vaccination was performed by injection of 20μg recombinant HBsAg into the deltoid muscle at mo 0,1 and 6. Anti-HBs concentration was determined 3 mo after the last dose and compared between the two groups. The response pattern was characterized as （1） high-response when the anti-HBs antibody titer was 〉 100 IU/L, （2） low-response when the titer was 10-100 IU/L. and （3） no-response when the titer was 〈 10 IU/L. RESULTS： In the patient group, there were 10/38 （26.3%） non-responders, 8/38 （21.1%） Iow-responders and 20/38 （52.6%） high-responders. The corresponding values in the control group were 2/40 （5.0%）, 7/40 （17.5%） and 31/40 （77.5%）, respectively. The response pattern was statistically different between the two groups. In multivariate analysis, smoking was a significant confounder, while HCV infection lost its significant correlation with lower antibody response. CONCLUSION： Patients with chronic HCV infection tend to respond weakly to HBV vaccination compared to healthy individuals, though this correlation is not independent according to multivariate analysis.

关键词： Immunogenicity Hepatitis B Vaccine Hepatitis C Antibody response

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