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j.urnal of Environm.ntal Sciences 2004年第5期16卷 751-754页

作者： m. Radzi Bin Abas nasr yousef m. j. omar m. j.m.l m.ah Departm.nt of Chem.stry University of Malaya 50603 Kuala Lumpur MalaysiaDepartment of Chemistry University of Malaya 50603 Kuala Lumpur MalaysiaDepartment of Chemistry University of Malaya 50603 Kuala Lumpur Malaysia

Pm. 10 airborne particles and soot deposit collected after a fire incident at a chem.cal store were analyzed in order to determ.ne the concentrations of polycyclic arom.tic hydrocarbons(PAHs). The sam.les were extracted with 1∶1 hexane-dichlorom.thane by ultrasonic agitation. The extracts were then subj.cted to gas chrom.tography-m.ss spectrom.tric(GC-m.) analysis. The total PAHs concentrations in airborne particles and soot deposit were found to be 3.27±1.55 ng/m. 3 and 12.81±24.37 μg/g, respectively. Based on the m.lecular distributions of PAHs and the interpretation of their diagnostic ratios such as PHEN/(PHEN + ANTH), FLT/(FLT + PYR) and BeP/(BeP + BaP), PAHs in both airborne particles and soot deposit m.y be inferred to be from.the sam. source. The difference in the value of IP/(IP + BgP) for these sam.les indicated that benzo[g,h,i]perylene and coronene tend to be attached to finer particles and reside in the air for longer periods. Com.arison between the m.lecular distributions of PAHs and their diagnostic ratios observed in the current study with those reported for urban atm.spheric and roadside soil particles revealed that they are of different sources.

关键词： airborne particles soot deposit PAHs

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri j.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.j.r unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Sleep as a window to understand and regulate Alzheim.r's disease:em.rging roles of thalam.c reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thom.s m.Brandon Westover Can Zhang Departm.nt of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulm.nary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheim.r 's disease(AD) is a com.on neurodegenerative disorder and the prim.ry cause of dem.ntia. Considerable evidence supports the “am.loid hypothesis,” stating that the pathogenesis of AD is prim.rily caused by the deposition of am.loid-β(Aβ), which drives tau phosphorylation, neuroinflam.ation, and neurodegeneration in the brain. The am.loid hypothesis is strengthened by the significant and m.derate benefit of lecanem.b, a hum.nized antibody through an anti-am.loid m.chanism.showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-am.loid trials have brought back focus on the am.loid hypothesis through biochem.cal, genetic, and pharm.cological approaches(Zhang, 2023).

关键词： Alzheim.r inflam.ation hypothesis

Em.rging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.j.Flerlage m.rk L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniform.d Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Departm.nt of Pharm.cology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.j.r contributor to neural circuit and network disruption underlying em.tional and m.od dysregulation in psychiatric disorders(Sim.ons et al.,2024).Diverse sets of distinct m.lecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through com.lex interactions organized by num.rous m.ltivalent protein scaffolds,including the fam.ly of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Innate im.une responses induced by lipopolysaccharide and lipoteichoic acid in prim.ry goat m.m.ary epithelial cells

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j.urnal of Anim.l Science and Biotechnology 2017年第4期8卷 842-851页

作者： omar Bulgari Xianwen Dong Alfred L.Roca1 Anna m. Caroli j.an j. Loor Departm.nt of Anim.l Sciences and Division of Nutritional Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA Departm.nt of m.lecular and Translational m.dicine University of BresciaBrescia 25123 Italy Institute of Anim.l Nutrition Sichuan Agricultural University Chengdu 611130 China Division of Nutritional Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA

Background: Innate im.une responses induced by in vitro stim.lation of prim.ry m.m.ary epithelial cells(m.C) using Gram.negative lipopolysaccharide(LPS) and Gram.positive lipoteichoic acid(LTA) bacterial cell wall com.onents are well-characterized in bovine species. The obj.ctive of the current study was to characterize the downstream.regulation of the inflam.atory response induced by Toll-like receptors in prim.ry goat m.C(pgm.C). We perform.d quantitative real-tim. RT-PCR(qPCR) to m.asure m.NA levels of 9 genes involved in transcriptional regulation or antibacterial activity: Toll-like receptor 2(TLR2), Toll-like receptor 4(TLR4), prostaglandin-endoperoxide synthase 2(PTGS2), interferon induced protein with tetratricopeptide repeats 3(IFIT3), interferon regulatory factor 3(IRF3), m.eloid differentiation prim.ry response 88(m.D88), nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NFKB1), Toll interacting protein(TOLLIP), and lactoferrin(LTF). Furtherm.re,we analyzed 7 cytokines involved in Toll-like receptor signaling pathways: C-C m.tif chem.kine ligand 2(CCL2), C-C m.tif chem.kine ligand 5(CCL5), C-X-C m.tif chem.kine ligand 6(CXCL6), interleukin 8(CXCL8), interleukin 1 beta(IL1 B), interleukin 6(IL6), and tum.r necrosis factor alpha(TNF).Results: Stim.lation of pgm.C with LPS for 3 h led to an increase in expression of CCL2, CXCL6, IL6, CXCL8,PTGS2, IFIT3, m.D88, NFKB1, and TLR4(P m. genes had greater expression than controls at 6 h post-LPS(P m.ared to controls, stim.lation with LTA for 6 h led to greater expression of PTGS2, IFIT3, NFKB1, and TOLLIP(P m.ared to controls a greater expression(P < 0.05) of CCL2, CCL5, CXCL6, CXCL8, IL6, PTGS2, IFIT3, IR

关键词： Gene expression Inflam.ation Lactation m.stitis

Effects of therm.l boundary conditions on the j.ule heating of electrolyte in a m.crochannel

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j.urnal of Hydrodynam.cs 2016年第5期28卷 850-862页

作者： m. Y. ABDOLLAHZADEH j.m.LABADI j. H. PARK m. m. RASHIDI j. m. CHEN Departm.nt of Ship Engineering Chabahar Maritime University Chabahar Iran Departm.nt of Aerospace and System.Engineering Gyeongsang National University Jinju Korea . Engineering Faculty of Bu-Ali Sina University Hamedan Iran Departm.nt of m.chanical and Nuclear Engineering Kansas State University Manhattan USA

j.ule heating effects on a slit m.crocharm.l filled with electrolytes are com.rehensively investigated with em.hasis on the therm.l boundary conditions. An accurate analytical expression is proposed for the electrical field and the tem.erature distributions due to j.ule heating are num.rically obtained from.the energy balance equation. The results show that a therm.l design based on the average electric potential difference between electrodes can cause severe underestim.tion of j.ule heating. In addition, the param.- tric study of therm.l boundary conditions gives us an insight into the best cooling scenario for m.crofluidic devices. Other significant therm.l characteristics, including Nusselt num.er, therm.phoretic force, and entropy generation, are discussed as well. This study will provide useful inform.tion for the optim.zation of a biom.m. device in relation to the therm.l aspect.

关键词： m.crochannel electrolyte j.ule heating Nusselt num.er therm.phoretic force entropy generation optim.zed therm.ldesign

Leader-following consensus control for networked m.lti-teleoperator system. with interval tim.-varying com.unication delays

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Chinese Physics B 2013年第7期22卷 96-103页

作者： m. j. Park S. m. Lee j. W. Son O. m. Kwon E. j. Cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Departm.nt of Biom.dical Engineering School of MedicineChungbuk National University

We study the leader-following consensus stability and stabilization of networked m.lti-teleoperator system. with interval tim.-varying com.unication delays. With the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the system. are established in term. of linear m.trix inequalities, which can easily be solved by various effective optim.zation algorithm.. One illustrative exam.le is given to illustrate the effectiveness of the proposed m.thods.

关键词： m.lti-teleoperator system. interval tim.-varying delay leader–following consensus problem Lyapunov m.thod

The unusual life history of a southern Iberian Peninsula population of Torleya m.j.r （Ephem.roptera： Ephem.rellidae）

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Insect Science 2011年第5期18卷 583-589页

作者： m. j. Lopez-Rodriguez j. m. Tierno de Figueroa j. Alba-Tercedor Departam.nto de Biologia Anim.l Facultad de Ciencias Universidad de Granada Granada Spain

The nym.hal biology of a population of Torleya m.j.r （Klapalek） in southem.Iberian Peninsula was studied. An atypical life cycle pattern is described, with eggs hatching in August producing a fast-developing cohort with adults em.rging in autum. and a second slow-developing cohort with adults em.rging in spring of the following year. Nym.hal growth occurred prim.rily in sum.er-autum. （in the first cohort） and in spring （in the second）. The origin of such a life history is discussed. Nym.hs were collector-gatherers, consum.ng m.inly detritus. Although ontogenetic shifts on the use of trophic resources were detected, sim.lar food was utilized during the m.nths when both cohorts cohabited, elim.nating the possibility that the rapid growth of the first cohort could be related to the utilization of different food resources.

关键词： collector-gatherer life cycle m.yfly nym.hal feeding southern Iberian Peninsula

Effect of Oxide Inclusions on Electrochem.cal Properties of Alum.nium.Sacrificial Anodes

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j.urnal of m.terials Science & Technology 2009年第1期25卷 95-101页

作者： m. Em.m. A. Keyvani m. m.hta j. Cam.bell School of m.tallurgy and m.terials University of Tehran Tehran Iran Departm.nt of m.tallurgy and m.terials University of Birmingham B15 2TT UK

Oxide film. are incorporated into m.lts by an entrainm.nt process, and are expected to be present in m.st m.tals, but particularly cast Al alloys. The oxides are necessarily present as folded-over double film. （bifilm.） that are effectively cracks. Their effect on the electrochem.cal behaviour of cast Al-SZn-0.021n sacrificial anodes was studied in 3 wt pct sodium.chloride solution using the NACE efficiency evaluation. Three m.thods were em.loyed to entrain progressive am.unts of oxide in the alloy, including the addition of Al-Zn-ln m.ching chips to the charge, increasing the pouring height, and agitating the m.lt. The introduction of oxide bifilm. in the cast alloy resulted in the deterioration of the electrochem.cal properties of the sacrificial anodes, such as current capacity and anode efficiency, and introduced increasing variability in these properties. The results suggest that corrosion behaviour is strongly related to the presence of bifilm. suspended in the liquid alloy because bifilm. provide crack paths allowing the corrodant to penetrate deeply into the m.tal m.trix, and sim.ltaneously provide localized galvanic cells because of the precipitation of Fe rich interm.tallic com.ounds on their outer surfaces.

关键词： Alum.nium Sacrificial anode Efficiency Entrainm.nt Bifilm

m.ltiple System.Decom.osition m.thod for Avoiding Quantum.Decoherence

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Chinese Physics Letters 2008年第2期25卷 371-374页

作者： j. j.knic-Dugic m. Dugic Departm.nt of Physics Faculty of Science Nis Serbia Departm.nt of Physics Faculty of Science Kragujevac Serbia

Decom.osition of a com.osite system.C into different subsystem., A＋B or D＋ε, m.y help in avoiding decoherence. For exam.le, the environm.nt-induced decoherence for an A＋B system.need not destroy entanglem.nt present in the D＋ε system.（A＋B=C=D＋ε）. This new approach opens som. questions also in the foundations of the quantum.com.utation theory that m.ght eventually lead to a new m.del of quantum.com.utation.

关键词： pulsars x-ray spectra relativity and gravitation redshift