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SARS-CoV-2 spike protein and RNA dependent RNA polymerase as targets for drug and vaccine development: A review

Biosafety and Health 2021年第5期3卷 249-263页

作者： Yusuf Muhammed Abduljalal Yusuf Nadabo Mkpouto Pius Bashiru Sani Jafar Usman nasir anka garba Jaafaru Mohammed Sani Basit Opeyemi Olayanju Sunday Zeal Bala Musa garba Abdullahi Misbahu Sambo Department of Biochemistry Federal UniversityGusauNigeria Faculty of Pharmaceutical Sciences Ahmadu Bello University ZariaNigeria Department of Medical Genetics University of CambridgeCB21TNUnited Kingdom Department of Microbiology Federal University of LafiaNigeria Department of Biochemistry Kaduna State UniversityNigeria Department of Chemistry and Biochemistry Florida International UniversityFL 33199USA Department of Biochemistry Bayero University KanoNigeria Faculty of Pharmaceutical Sciences Kaduna State UniversityNigeria Department of Biochemistry Abubakar Tafawa Balewa University BauchiNigeria

The present pandemic has posed a crisis to the economy of the world and the health ***,the race to expand research to understand some good molecular targets for vaccine and therapeutic development for SARS-CoV-2 is *** newly discovered coronavirus 2019(COVID-19)is a positive sense,single-stranded RNA,and enveloped virus,assigned to the beta CoV *** virus(SARS-CoV-2)is more infectious than the previously detected coronaviruses(MERS and SARS).Findings from many studies have revealed that S protein and RdRp are good targets for drug repositioning,novel therapeutic development(antibodies and small molecule drugs),and vaccine *** such as chloroquine,convalescent plasma,monoclonal antibodies,spike binding peptides,and small molecules could alter the ability of S protein to bind to the ACE-2 receptor,and drugs such as remdesivir(targeting SARS-CoV-2 RdRp),favipir,and emetine could prevent SASR-CoV-2 RNA *** novel vaccines such as mRNA1273(Moderna),3LNP-mRNAs(Pfizer/BioNTech),and ChAdOx1-S(University of Oxford/Astra Zeneca)targeting S protein have proven to be effective in combating the present *** exploration of the potential of S protein and RdRp is crucial in fighting the present pandemic.

关键词： SARS-CoV-2 Spike protein(S protein) RNA dependent RNA polymerase(RdRp) Drug repositioning SARS-CoV-2-vaccines

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