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Bioactive Materials 2022年第6期7卷 71-84页

作者： Deepti Rana Ajoy Kandar nasim salehi-nik Ilyas Inci Bart Koopman Jeroen Rouwkema Department of Biomechanical Engineering Technical Medical CentreFaculty of Engineering TechnologyUniversity of Twente7500AEEnschedethe Netherlands Izmir Democracy University Vocational School of Health ServicesDepartment of Dentistry ServicesDental Prosthetics TechnologyIzmir35140Turkey

Spatiotemporally controlled growth factor(GF)delivery is crucial for achieving functional vasculature within engineered ***,conventional GF delivery systems show inability to recapitulate the dynamic and heterogeneous nature of developing tissue’s biochemical ***,an aptamer-based programmable GF delivery platform is described that harnesses dynamic affinity interactions for facilitating spatiotemporal control over vascular endothelial GF(VEGF165)bioavailability within gelatin methacryloyl *** platform showcases localized VEGF165 sequestration from the culture medium(offering spatial-control)and leverages aptamer-complementary sequence(CS)hybridization for triggering VEGF165 release(offering temporal-control),without non-specific ***,extensive 3D co-culture studies(human umbilical vein-derived endothelial cells&mesenchymal stromal cells),in bi-phasic hydrogel systems revealed its fundamentally novel capability to selectively guide cell responses and manipulate lumen-like microvascular networks via spatiotemporally controlling VEGF165 bioavailability within 3D *** platform utilizes CS as an external biochemical trigger for guiding vascular morphogenesis which is suitable for creating dynamically controlled engineered tissues.

关键词： Aptamers Vascular endothelial growth factor Spatiotemporal release Co-culture Vascularization Biomaterials Tissue engineering

Outcomes of early versus late irrigation and debridement of pediatric open long bone fractures

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World Journal of Orthopedics 2024年第6期15卷 539-546页

作者： Riya Savla Yen-Hong Kuo nasim Ahmed Department of Surgery and Trauma Hackensack Meridian School of MedicineNutleyNJ 07110United States Department of Medical Sciences Hackensack Meridian School of medicineNutleyNJ 08753United States Office of Research Administration Hackensack Meridian Health Research InstituteNutleyNJ 077110United States Department of Surgery Department of Trauma and Surgical Critical CareJersey Shore University Medical CenterNeptuneNJ 07754United States Department of Surgery Department of Trauma and Surgical Critical CareHackensack Meridian School of MedicineNutleyNJ 07110United States

BACKGROUND Open long bone fractures are a major concern for pediatric patients due to the risk of surgical site infection(SSI).Early studies have recommended irrigation and debridement of open fractures within 6 hours-8 hours for the prevention of *** to the American College of Surgeons(ACS)Best Practice Guidelines,in 2015,irrigation and debridement should be done within 24 *** To identify whether early irrigation and debridement,within 8 hours,vs late,between 8 hours and 24 hours,for pediatric open long bone fractures impacts rate of *** Using retrospective data review from the National Trauma Data Bank,Trauma Quality Improvement Project(TQIP)of *** database is own by the ACS and it is the largest database for trauma quality program in the *** matching analysis was performed for the *** There were 390 pediatric patients with open long bone fractures who were incl-uded in the *** completing propensity score matching,we had 176 patients in each category,irrigation and debridement within 8 hours and irrigation and debridement between 8 hours and 24 *** found no significant differences between each group for the rate of deep SSI which was 0.6%for patients who received surgical irrigation and debridement within 8 hours and 1.1%for those who received it after 8 hours[adjusted odd ratio(AOR):0.5,95%CI:0.268-30.909,P>0.99].For the secondary outcomes studied,in terms of length of hospital stay,patients who received irrigation and debridement within 8 hours stayed for an average of 3.5 days,and those who received it after 8 hours stayed for an average of 3 days,with no significant difference found,and there were also no sig-nificant differences found between the discharge dispositions of the *** Our findings support the recommendation for managing open long bone fractures from the ACS:Complete surgical irrigation and debridement within 24 hours.

关键词： Pediatric trauma Open tibia fracture Irrigation and debridement Timing of intervention Surgical site infection

Clinical implications of single cell sequencing for bladder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： REZA YADOLLAHVANDMIANDOAB MEHRSA JALALIZADEH FRANCIELE APARECIDA VECHIA DIONATO KEINI BUOSI PATRÍCIA A.F.LEME LUCIANA S.B.DAL COL CRISTIANE F.GIACOMELLI ALEX DIAS ASSIS nasim BASHIRICHELKASARI LEONARDO OLIVEIRA REIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per *** this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA *** searched PubMed,CENTRAL,Embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February *** included original studies that used at least one single-cell technology to study bladder ***-one publications were included in the ***-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition *** studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine *** remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell ***-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer *** nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

Oxidative desulfurization of model and real oil samples using Mo supported on hierarchical alumina–silica: Process optimization by Box–Behnken experimental design

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2759-2770页

作者： nasim Ghorbani Gholamreza Moradi Catalyst Research Center Department of Chemical EngineeringFaculty of EngineeringRazi UniversityKermanshahIran

The catalytic performance of Mo supported on hierarchical alumina–silica(Si/Al = 15) with Mo loadings of 3, 6 and 15 wt% was investigated for the oxidative desulfurization(ODS) of model and real oil samples. Hierarchical alumina–silica(h Al–Si) was synthesized by economical and ecofriendly silicate-1 seed-induced route using cetyltrimethylammonium bromide(CTAB) as mesoporogen. The effect of CTAB on the structure of catalyst was studied by characterization techniques. The results revealed that 6%Mo/h Al–Si had the highest sulfur removal compared to the other catalyst loadings. The effect of operating parameters was evaluated using Box–Behnken experimental design. The optimal desulfurization conditions with the 6%Mo/h Al–Si catalyst were determined at oxidation temperature of 67 ℃, oxidation time of 42 min, H2O2/S molar ratio of 8 and catalyst dosage of 0.008 g·ml^-1 for achieving a conversion of 95%. Under optimal conditions, different sulfur-containing compounds with initial concentration of 1000 ppm, Dibenzothiophene(DBT), Benzothiophene(BT) and Thiophen(Th), showed the catalytic oxidation reactivity in the order of DBT > BT>Th. According to the regeneration experiments, the 6%Mo/h Al–Si catalyst was reused 4 times with a little reduction in the performance. Also, the total sulfur content of gasoline and diesel after ODS process reached 156.6 and 4592.2 ppm, respectively.

关键词： Oxidative desulfurization Hierarchical alumina–silica Silicate-1 seed-induced route Box–Behnken experimental design

Geochemistry of Tertiary sandstones from southwest Sarawak,Malaysia: implications for provenance and tectonic setting

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Acta Geochimica 2016年第3期35卷 294-308页

作者： nasim Ferdous Atikul Haque Farazi Department of Geology University of Malaya

Tertiary sandstones collected from southwest Sarawak, Malaysia, were analyzed to decipher their provenance, weathering, and tectonic setting. The studied sandstones have a sublitharenite composition and are dominantly composed quartz with little mica and feldspar, and a small amount of volcanic fragments. These sand- stones were generally derived from quartz-rich recycled orogenic sources. They have relatively high SiO2 content with low Na20, CaO, MnO, and MgO contents. Values of Chemical Index of Alteration （CIA） of these rock samples vary from 71 to 93, with an average of 81, implying intense chemical alteration during weathering. A felsic igneous source is suggested by a low concentration of TiO2 com- pared to CIA, enrichment of Light Rare Earth Elements, depletion of Heavy Rare Earth Elements, and negative Eu anomalies. A felsic origin is further supported by a Eu/Eu＊ range of 0.65-0.85 and high Th/Sc, La/Sc, La/Co, and Th/ Co ratios. This work presents the first reported geochemical data of Tertiary sandstones of the Sarawak Basin. These data led us to conclude that the sandstones were dislodged from recycled orogenic sources and deposited in a slowly subsiding rifted basin in a passive continental tectonic setting.

关键词： Geochemistry Tertiary sandstone Provenance Tectonic setting SW Sarawak Malaysia

A review of high-strength nanolaminates and evaluation of their properties

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Journal of Materials Science & Technology 2020年第15期47卷 215-244页

作者： Mohammad nasim Yuncang Li Ming Wen Cuie Wen School of Engineering RMIT UniversityMelbourneVictoria3001Australia State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Kunming Institute of Precious MetalsKunming650106China

Nanolaminates are composed of nanoscale-thick alternating layers of different materials and their properties are dependent on the individual layers,the layer thickness and the interfaces between the *** composed of cubic crystal structured metals are usually ductile compared to nanolaminates containing hexagonal crystal structured *** properties such as strength and hardness of nanolaminates increase with a decrease in individual layer thickness down to a few nanometers and they become independent when the thickness of individual layers is less than a couple of *** review provides a detailed analysis of the effects of individual layer thickness and the interface structures on the strength and the strengthening mecha nisms of nanolaminates,their ductility and fracture behavior in terms of structural variations including grain morphologies,nanotwins,amorphous phases and crystal structures of the *** principles for designing nanolaminates with exceptionally high mechanical and physical properties and their fabrication are also *** contradictory issues such as strengthening mechanisms,elastic modulus dependency on individual layer thickness and the effect of a thin amorphous layer on the strength are *** review also provides future research directions in designing the high-strength nanolaminates that will facilitate practical engineering applications through analyzing up-to-date research efforts.

关键词： Nanolaminates Mechanical properties Physical properties Deformation mechanisms

Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality

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Bioactive Materials 2023年第11期29卷 214-229页

作者： Yuting Zheng Avijit Baidya nasim Annabi Department of Chemical and Biomolecular Engineering University of Californi1Los AngelesLos AngelesCA90095United States Department of Bioengineering University of Californi1Los AngelesLos AngelesCA90095United States

Designing adhesive hydrogels with optimal properties for the treatment of injured tissues is challenging due to the tradeoff between material stiffness and toughness while maintaining adherence to wet tissue surfaces. In most cases, bioadhesives with improved mechanical strength often lack an appropriate elastic compliance, hindering their application for sealing soft, elastic, and dynamic tissues. Here, we present a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe^(3+) ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ/m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 s of gentle pressing and deform to support physiological tissue function over time under wet conditions. While Alg-NHS provides covalent bonding with the tissue surfaces, the catechol moieties of TA molecules synergistically adopt a mussel-inspired adhesive mechanism to establish robust adherence to the wet tissue. The strong adhesion of the engineered bioadhesive patch is showcased by its application to rabbit conjunctiva and porcine cornea. Meanwhile, the engineered bioadhesive demonstrated painless detachable characteristics and in vitro biocompatibility. Additionally, due to the molecular interactions between TA and Fe3+, antioxidant and antibacterial properties required to support the wound healing pathways were also highlighted. Overall, by tuning various molecular interactions, we wer

关键词： Molecular engineering Tough hydrogel Bioadhesive Multifunctionality

nasim Mahmmud's View on the Belt and Road Initiative

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International Understanding 2023年第4期4卷 65-66页

作者： nasim Mahmmud

The historic Third Belt and Road Forum(BRF-2023)for International Cooperation was held in Beijing on October 17-18,2023 which has opened the gate to a new opportunity for global development and potential *** Belt and ... 详细信息

关键词： Road peace Belt

Seismic analysis of diagrid structural frames with shear-link fuse devices

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Earthquake Engineering and Engineering Vibration 2013年第3期12卷 463-472页

作者： nasim S. Moghaddasi B. Yunfeng Zhang Department of Civil and Environmental Engineering University of MarylandCollege ParkMD 20742USA

This paper presents a new concept for enhancing the seismic ductility and damping capacity of diagrid structural frames by using shear-link fuse devices and its seismic performance is assessed through nonlinear static and dynamic analysis. The architectural elegancy of the diagrid structure attributed to its triangular leaning member configuration and high structural redundancy make this system a desirable choice for tall building design. However, forming a stable energy dissipation mechanism in diagrid framing remains to be investigated to expand its use in regions with high seismicity. To address this issue, a diagrid framing design is proposed here which provides a competitive design option in highly seismic regions through its increased ductility and improved energy dissipation capacity provided by replaceable shear links interconnecting the diagonal members at their *** structural characteristics and seismic behavior （capacity, stiffness, energy dissipation, ductility） of the diagrid structural frame are demonstrated with a 21-story building diagrid frame subjected to nonlinear static and dynamic analysis. The findings from the nonfinear time history analysis verify that satisfactory seismic performance can be achieved by the proposed diagrid frame subjected to design basis earthquakes in California. In particular, one appealing feature of the proposed diagrid building is its reduced residual displacement after strong earthquakes.

关键词： diagrid structure nonlinear analysis seismic behavior shear link steel structure

Alleviation of nickel stress by halophilic bacteria in mungbean(Vigna radiata)

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应用与环境生物学报 2018年第3期24卷 465-469页

作者： Maryum Fakhar Anjum nasim Sabri Department of Microbiology and Molecular Genetics University of the Punjab

Mungbean is an important, short-duration legume crop with high nutritive value for poor families, where protein and micronutrient scarcity are most pervasive. In developing countries, like Pakistan, where mungbean is one of the greatest sources of protein for underprivileged people, salinity and metal stresses are drastically limiting its yield. Therefore, it is necessary to explore the ways for promoting the growth of mungbean under stressed conditions. This study provides the basis for the use of two previously isolated halophilic and nickel-resistant bacteria [Bacillus subtilis and Halomonas aquamarina (1)] in promoting the growth of mungbean plant under nickel-stressed environments. These bacterial strains were previously found to improve the growth of plants under salinity because of their good biofilm-forming abilities. We hypothesized that these two halophilic and nickel-resistant biofilm-forming bacteria can help the plants to grow under nickel-stressed environments by promoting soil aggregation as they were previously reported to resist salinity and nickel stress, as well as were found to promote plant growth under saline environments. The results revealed that under nickel stress, both bacteria promote plant growth by facilitating the formation of soil aggregates through an increase in their extra polymeric substance (EPS) production.

关键词：环境生物学环境保护生物技术环境卫生