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Outcomes of early versus late irrigation and debridement of pediatric open long bone fractures

World Journal of Orthopedics 2024年第6期15卷 539-546页

作者： Riya Savla Yen-Hong Kuo nasim ahmed Department of Surgery and Trauma Hackensack Meridian School of MedicineNutleyNJ 07110United States Department of Medical Sciences Hackensack Meridian School of medicineNutleyNJ 08753United States Office of Research Administration Hackensack Meridian Health Research InstituteNutleyNJ 077110United States Department of Surgery Department of Trauma and Surgical Critical CareJersey Shore University Medical CenterNeptuneNJ 07754United States Department of Surgery Department of Trauma and Surgical Critical CareHackensack Meridian School of MedicineNutleyNJ 07110United States

BACKGROUND Open long bone fractures are a major concern for pediatric patients due to the risk of surgical site infection(SSI).Early studies have recommended irrigation and debridement of open fractures within 6 hours-8 hours for the prevention of *** to the American College of Surgeons(ACS)Best Practice Guidelines,in 2015,irrigation and debridement should be done within 24 *** To identify whether early irrigation and debridement,within 8 hours,vs late,between 8 hours and 24 hours,for pediatric open long bone fractures impacts rate of *** Using retrospective data review from the National Trauma Data Bank,Trauma Quality Improvement Project(TQIP)of *** database is own by the ACS and it is the largest database for trauma quality program in the *** matching analysis was performed for the *** There were 390 pediatric patients with open long bone fractures who were incl-uded in the *** completing propensity score matching,we had 176 patients in each category,irrigation and debridement within 8 hours and irrigation and debridement between 8 hours and 24 *** found no significant differences between each group for the rate of deep SSI which was 0.6%for patients who received surgical irrigation and debridement within 8 hours and 1.1%for those who received it after 8 hours[adjusted odd ratio(AOR):0.5,95%CI:0.268-30.909,P>0.99].For the secondary outcomes studied,in terms of length of hospital stay,patients who received irrigation and debridement within 8 hours stayed for an average of 3.5 days,and those who received it after 8 hours stayed for an average of 3 days,with no significant difference found,and there were also no sig-nificant differences found between the discharge dispositions of the *** Our findings support the recommendation for managing open long bone fractures from the ACS:Complete surgical irrigation and debridement within 24 hours.

关键词： Pediatric trauma Open tibia fracture Irrigation and debridement Timing of intervention Surgical site infection

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Changes in trends of orthopedic services due to the COVID-19 pandemic: A review

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World Journal of Orthopedics 2022年第11期13卷 955-968页

作者： Eunice Obamiro Radhika Trivedi nasim ahmed Department of Surgery Division of Trauma&Surgical Critical CareJersey Shore University Medical CenterNeptuneNJ 07754United States Department of Surgery Hackensack Meridian School of MedicineNutleyNJ 07110United States

As of June 10,2022,the World Health Organization has recorded over 532 million documented coronavirus disease 2019(COVID-19)[(Coronavirus)SARS-CoV-2]cases and almost 6.3 million deaths worldwide,which has caused strain on medical specialties *** aim of this review is to explore the impact that COVID-19 has had on orthopedic *** observed a rapid decline in the number of orthopedic patients’admissions due to cancellation of elective procedures;however,emergent cases still required *** observational studies,case reports,and clinical trials were collected through a PubMed database *** sources were found through *** search was refined to publications in English and between the years of 2019 and *** keywords used were“COVID-19”and/or“Orthopedic Injuries”.Thirty-seven studies were *** pandemic brought on significant changes to the mechanism of injury,number of admissions,type of injuries,and patient *** rates significantly increased particularly amongst patients with hip fractures and *** traffic injuries remained a common cause of injury and domestic injuries became more prevalent with *** isolation negatively affected mental health resulting in several orthopedic *** services and separation for COVID-positive and COVID-negative patients benefited both patients and *** hospitals and medical facilities are still facing COVID-19 case surges,it is important to understand how this pandemic has impacted preparation,care,and opportunities for prevention education and ongoing care.

关键词： Orthopedics Surgery Lockdown Mental health Telehealth COVID-19

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Post-traumatic thrombotic microangiopathy: What trauma surgeons need to know?

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Chinese Journal of Traumatology 2021年第2期24卷 69-74页

作者： Mohammad A.Hossain nasim ahmed Varsha Gupta Ravneet Bajwa Marjan Alidoost Arif Asif Tushar Vachharajani Department of Medicine Hackensack Meridian Health Jersey Shore University Medical CenterNeptuneNJ07753USA Department of Surgery Division of Trauma SurgeryHackensack Meridian Health Jersey Shore University Medical CenterNeptuneNJ07753USA Global Nephrology Glickman Urological&Kidney InstituteCleveland ClinicClevelandOH44103USA

Thrombotic microangiopathy(TMA)is characterized by systemic microvascular thrombosis,target organ injury,anemia and *** thrombocytopenic purpura,atypical hemolytic uremic syndrome and Shiga toxin E-coli-related hemolytic uremic syndrome are the three common forms of ***,TMA is encountered during pregnancy/postpartum period,malignant hypertension,systemic infections,malignancies,autoimmune disorders,***,the patients presenting with trauma have been reported to suffer from *** carries a high morbidity and mortality,and demands a prompt recognition and early intervention to limit the target organ *** trauma surgeons are the first line of defense for patients presenting with trauma,the prompt recognition of TMA for these experts is critically *** treatment of post-traumatic TMA can help improve the patient outcomes,if the diagnosis is made *** treatment of TMA is also different from acute blood loss anemia namely in that plasmapheresis is recommended rather than platelet *** article familiarizes trauma surgeons with TMA encountered in the context of ***,it provides a simplified approach to establishing the diagnosis of *** trauma patients can require multiple transfusions,the development of disseminated intravascular coagulation must be ***,the article also provides different features of disseminated intravascular coagulation and ***,the article suggests practical points that can be readily applied to the management of these patients.

关键词： Trauma Microangiopathy Complement amplifying condition

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Non-invasive diagnosis of H pylori infection: Evaluation of serological tests with and without current infection marker CIM

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World Journal of Gastroenterology 2008年第8期14卷 1231-1236页

作者： Sufi HZ Rahman M Golam Azam M Anisur Rahman MS Arfin M Mahbub Alam Tareq M Bhuiyan nasim ahmed Motiur Rahman Shamsun Nahar MS Hassan Department of Immunology Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh Department of Gastrointestinal Hepatobiliary and Pancreatic Diseases Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh Department of Pathology Ibrahim MedicalCollege Dhaka Bangladesh Laboratory Sciences Division International Centre for Diarrhoeal Diseases Research Bangladesh Dhaka Bangladesh

AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in adult dyspeptic patients. METHODS:Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (AccuBindTM ELISA, Monobind, USA), ICT (Assure H pylori Rapid Test, Genelabs Diagnostics, Singapore), and immunoblot (Helico Blot 2.1, Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIM among other parameters and their performance with and without CIM was evaluated separately. RESULTS:Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of ELISA were 96.7%, 42.8%, 83.1%, 81.8%, and 82.9%, of ICT were 90.1%, 80.9%, 93.2%, 73.9%, and 87.8%, of ICT with CIM were 88.5%, 90.4%, 96.4%, 73.0%, and 89.0%, of immunoblot were 98.3%, 80.9%, 93.7%, 94.4%, and 93.9%, and of immunoblot with CIM were 98.3%, 90.4%, 96.7%, 95.0%, and 96.3%, respectively. CONCLUSION:Immunoblot with CIM had the best performance. ICT with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.

关键词：幽门免疫色谱法测试细菌感染诊断

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Timing of tracheostomy in mechanically ventilated COVID-19 patients

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World Journal of Critical Care Medicine 2021年第6期10卷 345-354页

作者： Nwonukwuru Amadi Radhika Trivedi nasim ahmed Division of Trauma Jersey Shore University Medical CenterNeptuneNJ 07754United States Division of Trauma and Surgical Critical Care Jersey Shore University Medical CenterNepuneNJ 07754United States

According to the World Health Organization as of September 16,2021,there have been over 226 million documented cases of coronavirus disease 2019(COVID-19),which has resulted in more than 4.6 million deaths and approximately 14%develop a more severe disease that requires respiratory assistance such as *** tracheostomy is recommended for patients that are expected to be on prolonged mechanical ventilation;however,supporting data has not yet been provided for early tracheostomies in COVID-19 *** aim of this study was to explore established guidelines for performing tracheostomies in patients diagnosed with *** considered were patient outcomes such as mortality,ventilator-associated pneumonia,intensive care unit length of stay,complications associated with procedures,and risks to healthcare providers that performed *** observational studies,meta-analyses,and systematic reviews were collected through a PubMed Database *** sources were found through *** search was refined to publications in English and between the years of 2003 and *** keywords used were“Coronavirus”and/or“guidelines”and/or“tracheostomy”and/or“intensive care”.Twenty-three studies were *** to the complex presentation of the respiratory virus COVID-19,previously established guidelines for tracheostomies had to be reevaluated to determine if these guidelines were still applicable to these critically ill ventilated *** specifically,medical guidelines state benefits to early tracheostomies in critically ill ventilated non-COVID-19 ***,after having conducted this review,the assumptions about the benefits of early tracheostomies in critically ill ventilated patients may not be appropriate for COVID-19 patients.

关键词： Tracheostomy Timing COVID-19 SARS-CoV-2 Coronavirus

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Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 533-538页

作者： Abu nasim Nizami Md Atiar Rahman Nazim Uddin ahmed Md Shahidul Islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh Department of Biochemistry School of BiochemistryGenetics and MicrobiologyUniversity of KwaZulu-NatalDurban 4000South Africa Bangladesh Council of Scientific and Industrial Research(BCSIR) Chittagong-4220Bangladesh

Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of ***: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic ***(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC *** urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional ***-urolithiatic effect of cystone was significantly(P<0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity ***:The results of this study demonstrated very promising antiurolithiatic effect of *** extract with preventive and therapeutic treatments in this experimental condition.

关键词： Urolithiasis Ethylene glycol Leea macrophylla Urinary parameter Rats

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Comparative studies of elemental composition in leaves and flowers of Catharanthus roseus growing in Bangladesh

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Asian Pacific Journal of Tropical Biomedicine 2016年第1期6卷 50-54页

作者： Shahin Aziz Koushik Saha nasim Sultana Husna Parvin Nur Md.Aminul Ahsan Shamim ahmed Md.Kamal Hossain Chemical Research Division BCSIR Department of Chemistry Jahangirnagar University Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories

Objective:To investigate the elemental composition of the leaves and flowers of Catharanthus roseus(***) due to the plant's wide application in the indigenous medicinal system and its chemical constituents' ***:The atomic absorption spectrophotometer was used for quantitative analysis of various ***:Total 13 important elements were analyzed in leaves and flowers of *** indicated the presence of Na,K,Ca,Mg,Cr,Fe,Zn,Al,Cu,Ni,Pb,Cd and Mn in both leaves and *** most important finding of the work was that,leaves of *** showed high concentration of all elements except K and Zn while flowers of *** showed higher concentration of K and ***:The elemental composition in both leaves and flowers of *** were found to be ***,different parts of this medicinal plant are enriched in some micro and macro nutrients like Fe,Ca,Na,K,Zn,which are very important for biological metabolic system as well as human health.

关键词： Bangladesh Catharanthus roseus Indigenous medicinal systems Atomic absorption spectrophotometer Elemental composition

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