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Poten.ial Biomarkers of Schizophren.a from MEG Restin.-State Fun.tion.l Con.ectivity n.tworks: Prelimin.ry Data

Journ.l of Behavioral an. Brain.Scien.e 2015年第1期5卷 1-11页

作者： Susan.M. Bowyer Klevest Gjin. Xiao Zhu Lawren.e Kim John.E. Moran.Syeda U. Rizvi Valen.in. Gumen.uk n.rman.Tepley nash n. boutros Departmen. of n.urology Henry Ford Hospital Detroit USA Departmen. of n.urology Wayne State University Detroit USA Departmen. of n.urosurgery Seton Brain and Spine Institute Austin USA Departmen. of Psychiatry University of Missouri Kansas City USA

Previous studies examin.n. coheren.e an. con.ectivity deviation. in.schizophren.a patien.s relied on.stan.ard coheren.e measures between.recordin. sites (at the sen.or level). A coheren.e source imagin. (CSI) methodology where coheren.e is assessed within.imaged brain.structures (at the source level) was developed recen.ly by our group an. applied successfully for detectin. coheren. areas in.the cortical n.tworks of patien.s with epilepsy. We applied this Magn.toen.ephalography (MEG)-CSI techn.que to measure n.rmal an. pathological pattern. of brain.oscillation. (biomarkers) in.n.rmal subjects an. patien.s diagn.sed with schizophren.a. Twelve patien.s diagn.sed with schizophren.a an. twelve healthy con.rol subjects were studied. A ten.min.te restin. state MEG brain.scan.was performed with eyes open. MEG-CSI an.lysis was performed to iden.ify the cortical areas that in.eracted stron.ly within.the 3 - 50 Hz frequen.y ran.e. Statistically sign.fican. in.reased region. of coheren.e were detected in.schizophren.a patien.s compared to con.rols in.the right in.erior fron.al gyrus (BA 47—pars orbitalis), left superior fron.al gyrus (BA9— dorsolateral prefron.al cortex), right middle fron.al gyrus (BA 10—an.erior prefron.al cortex & BA 46—dorsolateral prefron.al cortex), an. right cin.ulate gyrus (BA 24—ven.ral an.erior cin.ulate cortex). These areas are in.olved in.lan.uage, memory, decision.makin., empathy, executive an., higher cogn.tive fun.tion.n.. We con.lude that MEG-CSI can.detect imagin. biomarkers from restin. state brain.activity in.schizophren.a patien.s that deviates from n.rmal con.rol subjects in.several behaviorally salien. brain.region.. An.lysis with MEG-CSI can.provide biomarkers of abn.rmalities in.the restin.-state. The fin.in.s an. procedures described can.be used to probe the pathophysiology of schizophren.a an. possibly detect subtypes.

关键词： Magn.toen.ephalography (MEG) Coheren.e Schizophren.a Fun.tion.l Restin. State Brain n.tworks

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cardiGAn.A gen.rative adversarial n.twork model for design.an. discovery of multi prin.ipal elemen. alloys

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Journ.l of Materials Scien.e & Techn.logy 2022年第30期125卷 81-96页

作者： Z.Li W.T.nash S.P.O’Brien.Y.Qiu R.K.Gupta n.Birbilis College of En.in.erin. an. Computer Scien.e The Australian National UniversityA.C.T.Acton 2601Australia Departmen. of Materials Scien.e an. En.in.erin. Monash UniversityClaytonVictoria 3800Australia Departmen. of Materials Scien.e an. En.in.erin. North Carolina State UniversityRaleighNC 27695USA

Multi-prin.ipal elemen. alloys(MPEAs),in.lusive of high en.ropy alloys(HEAs),con.in.e to attract sign.fican. research atten.ion.owin. to their poten.ially desirable *** MPEAs remain.un.er exten.ive research,tradition.l(***)alloy production.an. testin. are both costly an. timecon.umin.,partly due to the in.fficien.y of the early discovery process which in.olves experimen.s on.a large n.mber of alloy *** is in.uitive to apply machin. learn.n. in.the discovery of this n.vel class of materials,of which on.y a small n.mber of poten.ial alloys have been.probed to *** this work,a proof-of-con.ept is proposed,combin.n. gen.rative adversarial n.tworks(GAn.)with discrimin.tive n.ural n.tworks(n.s),to accelerate the exploration.of n.vel *** applyin. the GAn.model herein.it was possible to directly gen.rate n.vel composition. for MPEAs,an. to predict their *** verify the predictability of the model,alloys design.d by the model are presen.ed an. a can.idate produced-as *** suggests that the model herein.offers an.approach that can.sign.fican.ly en.an.e the capacity an. efficien.y of developmen. of n.vel MPEAs.

关键词： Alloy design Machin. learn.n. Gen.rative adversarial n.twork n.ural n.twork Multi-prin.ipal elemen. alloy High en.ropy alloys

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Metamaterial-based graphen. thermal emitter

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n.n. Research 2018年第7期11卷 3567-3573页

作者： Chen. Shi n.than.H. Mahlmeister Isaac J. Luxmoore Geoffrey R. nash College of En.in.erin. Mathematics and PhysicaI Sciences University of Exeter Exeter EX4 4QF UK

A thermal emitter composed of a frequen.y-selective surface metamaterial layer an. a hexagon.l boron.n.tride-en.apsulated graphen. filamen. is demon.trated. The broadban. thermal emission.of the metamaterial （con.istin. of rin. reson.tors） was tailored in.o two discrete ban.s, an. the measured reflection.an. emission.spectra agreed well with the simulation.results. The high modulation.frequen.ies that can.be obtain.d in.these devices, coupled with their operation.in.air, con.irm their feasibility for use in.application. such as gas sen.in..

关键词： graphen. hexagon.l boron.n.tride thermal emitter in.rared metamaterial

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Is the propen.ity to emit alarm calls associated with health status?

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Curren. Zoology 2020年第6期66卷 607-614页

作者： Austin.L.nash Alexan.ra H.M.Jebb Dan.el T.BLUMSTEIn Departmen. of Ecology an. Evolution.ry Biology University of Colorado265 UCBBoulderCO 80309USA School of Biological Scien.es University of AberdeenZoology BuildingTillydrone AvenueAberdeenAB242TZUK The Rocky Moun.ain.Biological Laboratory Box 519 Crested ButteCO 81224USA Departmen. of Ecology an. Evolution.ry Biology University of California621 Young Drive SouthLos AngelesCA 90095-1606USA

The production.an. structure of an.mal sign.ls may depen. on.an.in.ividual's health status an. may provide more than.on. type of in.ormation.to *** alarm calls are n.t typically viewed as health con.ition.depen.en.,recen. studies have suggested that their structure,an. possibly their propen.ity to be emitted,depen.s on.an.in.ividual,s health con.ition.an. *** asked whether the propen.ity of yellow-bellied marmots(Marmota flaviven.er)to emit calls is in.luen.ced by their immun. logical or parasite status,by quan.ifyin. both trap-elicited an. n.atural callin. rates as a fun.tion.of their n.utrophil-to-lymphocyte(n.)ratio,the presen.e of a blood born. trypan.some,an. the presen.e of several in.estin.l parasites(Eimeria sp.,En.amoeba sp.,an. Ascaris sp.).We fitted mixed effects models to determin. if the health measures we collected were associated with the probability of callin. in.a trap an. with an.ual rates of n.tural alarm *** in.ected with a blood-born. trypan.some were margin.lly more likely to call n.turally an. when.trapped,while those in.ected with the in.estin.l parasite Ascaris were less likely to call when.*** ratio was n.t directly associated with in.trap callin. probability,but males were more likely to call when.they had higher n. ***,health con.ition.,such as parasite in.ection.an. immun. system activation.can.modulate the production.of alarm sign.ls an. poten.ially provide in.formation.to both predators an. prey about the caller's *** experimen.s are required to con.irm if receivers use such in.ormation.

关键词： alarm callin. an.mal commun.cation an.ipredator behavior con.ition.depen.en.e immun. fun.tion parasites

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Hepatocellular carcin.ma in.patien.s with chron.c hepatitis C virus in.ection.without cirrhosis

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World Journ.l of Gastroen.erology 2010年第32期16卷 4061-4065页

作者： Kathryn.L nash Tracy Woodall Ashley SM Brown.Susan.E Davies Graeme JM Alexan.er Departmen. of Hepatology University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom Departmen. of Hepatology Mailpoint 255Southampton General HospitalTremona RoadSouthamptonHampshire SO16 6YDUnited Kingdom Liver Un.t Department of MedicineSt Mary's HospitalPraed StreetLondon W2 1NYUnited Kingdom Departmen. of Histopathology University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom

AIM:To in.estigate an. characterise patien.s with chron.c hepatitis C virus(HCV) in.ection.presen.in. with hepatocellular carcin.ma(HCC) in.the absen.e of ***:Patien.s with chron.c hepatitis C in.ection.without cirrhosis presen.in. with HCC over a 2-year period were *** clin.cal case n.tes,blood test results an. histological specimen. were reviewed to iden.ify whether addition.l risk factors for the developmen. of HCC were ***:Six patien.s(five male,on. female) with chron.c hepatitis C in.ection.without cirrhosis presen.ed to a sin.le cen.re with HCC over a 2-year *** patien.s were treated by surgical resection.an. on. patien. un.erwen. liver *** of gen.rous histological specimen. con.irmed the presen.e of HCC an. the absen.e of cirrhosis in.all *** degree of fibrosis of the backgroun. liver was staged as mild(n.= 1),moderate(n.= 4) or bridgin. fibrosis(n.= 1).Review of the clin.cal case n.tes revealed that all cases had an.addition.l risk factor for the developmen. of HCC(four had eviden.e of past hepatitis B virus in.ection.two had a history of excessive alcohol con.umption.a further patien. had prolon.ed exposure to immun. suppression..COn.LUSIOn.HCC does occur in.patien.s with n.n.cirrhotic HCV in.ection.who have other risk factors for hepatocarcin.gen.sis.

关键词： Hepatitis C virus Hepatocellular carcin.ma n.n.cirrhotic Screen.n.

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狗在咖啡杯里晕倒了 87个不可思议的狗故事

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丛书名：爱宠物·爱生活

2005年

作者： Bruce nash Allan.Zullo 李媛霞译

本书收集了种种令人匪夷所思的狗故事，它们有：救人危难的英雄狗、惹是生非的淘气狗、助人为乐的热心狗、死里逃生的幸运狗、勇斗歹徒的正义狗、稀奇古怪的神奇狗等等。

ISBN: (纸本)7530640992

关键词：故事作品集世界

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KDE宝典

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丛书名：美国IDG“宝典”丛书

2000年

作者：（美）David nash 李潇漪雷勇等译

本书主要内容包括：KDE的安装、定制，KDE上的一些应用程序，在KDE上使用In.ern.t，基于KDE的一些游戏和新奇的应用软件，最后一部分介绍了用户管理系统时要用到一些基本管理工具。

ISBN: (纸本)7505363832

关键词： Un.X操作系统

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Five Years Follow-Up of Adjustable Con.in.n.e Therapy (ACT) in.the Treatmen. of Recurren. Female SUI

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Open.Journ.l of Urology 2013年第2期3卷 132-137页

作者： n.all T. Galloway Sherif R. Aboseif Pejvak Sassan. Ethan.I. Fran.e Steven.D. nash Joel n. Slutsky Mai Le Tu Peter J. Pommerville n.il H. Baum Suzette E. Sutherlan. Can.Med Clin.cal Research In.. Victoria BC Canada CHUS Flairmon. Quebec City Canada Emory Un.versity School of Medicin. Atlanta USA Kaiser Perman.n.e medical Cen.er Los Angeles USA Kan.as City Urology Care Leawood USA Metro Urology Centers for Continence Care and Female Urology Minneapolis/St Paul USA n.il Baum Urology New Orleans USA Urological Surgeon. Kankakee USA

Purpose/Objective: The primary objective of this FDA study is to evaluate the safety an. efficacy of the ACT device (Adjustable Con.in.n.e Therapy) in.the treatmen. of female recurren. Stress Urin.ry In.on.in.n.e (SUI). The secon.ary objective is to evaluate the difficulty of placemen. an. aspects of device adjustability. Materials an. Methods: The Adjustable Con.in.n.e Therapy (ACT) system (Uromedica, In.., Plymouth, Mn. con.ists of two silicon. balloon. providin. urethral coaption.an. bladder n.ck support. Each balloon.is attached to a titan.um port buried in.the labia allowin. for post-operative adjustmen. of volume. Females with recurren. SUI with or without urethral hypermobility were evaluated at baselin. an. follow-up periods of 6 weeks, 3, 6, 9, 12 mon.hs an. an.ually thereafter in.ludin. urin.lysis, a 3-day voidin. diary, provocative pad weight test, direct visual stress test, Stamey score an. validated question.aires to assess severity of in.on.in.n.e, voidin. dysfun.tion. sexual fun.tion.an. quality of life. Results: Durin. a 5 years period (2002-2007), 162 patien.s were implan.ed (mean.age 67.6, ran.e 31 - 94 years). Of these 162 patien.s 142, 90, 80, 56 an. 31 patien.s completed the 1, 2, 3, 4 an. 5 years follow-up respectively. On. hun.red an. thirty five (83%) had failed at least on. surgery for in.on.in.n.e an. 44% had failed 2 or more procedures prior to ACT implan.ation. Difficulty of ACT placemen. was rated mild in.62%, moderate in.30% an. severe in.9%. Improvemen. in.Stamey score of >1 grade was achieved in.75% (107/142) at 1 year, 76% (68/90) at 2 years, 86% (62/78) at 3 years, 93% (50/54) at 4 years an. 83% (25/30) at 5 years. Dry rate (provocative pad weight 2 gms) was 51%, 62% , 76%, 76% an. 76% at 1 through 5 years, an. >50% improvemen. was achieved in.83%, 86%, 86%, 90% an. 93%,respectively. IQoL improved from 37 at baselin. to 71, 71, 75, 77 an. 74 durin. the study, an. optimal con.in.n.e was achieved with a mean.of 4 adjustmen.s, an. mean

关键词： Female Urin.ry In.on.in.n.e Implan. Balloon Adjustmen.s Safety Stamey Score

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Bioin.ormatic Game Theory an. Its Application.to Biological Affin.ty n.tworks

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Applied Mathematics 2013年第10期4卷 92-108页

作者： Bo Den. Brittn.y Hin.s Ximen. Zhen. Etsuko n. Moriyama Departmen. of Mathematics University of Nebraska-Lincoln Lincoln USA School of Biological Scien.es an. Cen.er for Plan. Scien.e In.ovation University of Nebraska-Lincoln Lincoln USA School of Biological Scien.es University of Nebraska-Lincoln Lincoln USA

The exact evolution.ry history of an. set of biological taxa is un.n.wn. an. all phylogen.tic recon.truction. are approximation.. The problem becomes harder when.on. must con.ider a mix of vertical an. lateral phylogen.tic sign.ls. In.this paper we propose a game theoretic approach to con.tructin. biological n.tworks. The key hypothesis is that evolution.is driven.by distin.t mechan.sms that seek to maximize two competin. objectives, taxon.mic con.ervation.an. diversity. On. bran.h of the mathematical theory of games is brought to bear. It tran.lates this evolution.ry game hypothesis in.o a mathematical model in.two-player zero-sum games, with the zero-sum assumption.con.ormin. to on. of the fun.amen.al con.train.s in.n.ture in.mass an. en.rgy con.ervation. We demon.trate why an. how a mechan.stic an. localized adaptation.to seek out greater in.ormation.for con.ervation.an. diversity may always lead to a global nash equilibrium in.phylogen.tic affin.ty. Our game theoretic method, referred to as bioin.ormatic game theory, is used to con.truct n.twork clusters. As an.example, we applied this method to clusterin. of a multidomain.protein.family. The protein.clusters iden.ified were con.isten. with kn.wn.protein.subfamilies, in.icatin. that this game-theoretic approach provides a n.w framework in.biological sequen.e an.lysis, especially in.studyin. gen.-gen.me an. domain.protein.relation.hips.

关键词： Bioin.ormatic Game Theory Biological n.twork Evolution.ry Game Theory nash Dyn.mics Bn. Equation.

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Reducin. n.trogen.Loss in.Subsurface Tile Drain.ge Water with Man.ged Drain.ge an. Polymer-Coated Urea in.a River Bottom Soil

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Journ.l of Water Resource an. Protection 2014年第11期6卷 988-997页

作者： Patrick R. nash Kelly A. n.lson.Peter P. Motavalli Departmen. of Soil Environmental and Atmospheric Sciences University of Missouri Columbia USA Division.of Plan. Scien.es University of Missouri Columbia USA

Poorly-drain.d, river bottom soils can.be high corn.(Zea mays L.) yieldin. en.iron.en.s, but saturated soil con.ition. often.reduce corn.yields. Wabash soils located in.river bottoms in.n.rtheast Missouri have n.t been.tradition.lly tile drain.d due to high clay con.en. which requires n.rrow tile drain.spacin.s. In.reased lan. prices in.the region.have in.reased in.erest in.tile drain.n. poorly-drain.d bottom lan. soils to in.rease corn.yields which could have a deleterious effect on.water quality. The objectives of the three-year study were to determin. whether use of man.ged subsurface drain.ge (MD) in.combin.tion.with a con.rolled release n.fertilizer could reduce the an.ual amoun. of n.3--n.loss through tile drain.ge water compared to free subsurface drain.ge (FD) with a n.n.coated urea application. An.ual n.3--n.loss through tile drain.ge water with FD ran.ed from 28.3 to 90.1 kg·n.ha-1. n.trogen.fertilizer source did n.t affect n.3--n.loss through tile drain.ge water, which was likely due to limited corn.uptake over the three-year study due to adverse weather con.ition.. Averaged over three years, MD reduced tile water drain.d 52% an. n.3--n.loss 29% compared to FD. Reduction.in.n.3--n.loss through tile drain.ge water with MD compared to FD was due to reduced tile flow durin. the n.n.croppin. period. An.ual flow-weighted mean.con.en.ration.of n.3--n.in.the tile water was 5.8 mg·n.L-1 with FD an. 8.1 mg·n.L-1 with MD. Tile drain.n. river bottom soils at this location.for con.in.ous corn.production.may n.t pose a health risk over the evaluated duration.

关键词： Free Drain.ge Man.ged Drain.ge n.trate n.trogen Polymer-Coated Urea Subsurface Tile Drain.ge

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