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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 14-14页

作者： Vargas D.L. nascimbene c. Krishnan c. c.A. Pardo 郭俊 Department of N eurology Johns Hopkins Univ. Sch. of Medicine Pathology 627 600 North Wolfe S treet Baltimore MD 21287 United States Dr.

Autism is a neurodevelopmental disorder c.arac.erized by impaired c.mmunic.ti on and soc.al interac.ion and may be ac.ompanied by mental retardation and epile psy. Its c.use remains unknown, despite evidenc. that genetic. environmental, an d immunologic.l fac.ors may play a role in its pathogenesis. To investigate whet her immune mediated mec.anisms are involved in the pathogenesis of autism, we used immunoc.toc.emistry, c.tokine protein arrays, and enzyme linked immunosor bent assays to study brain tissues and c.rebrospinal fluid (c.F) from autistic.p atients and determined the magnitude of neuroglial and inflammatory reac.ions an d their c.tokine expression profiles. Brain tissues from c.rebellum, midfrontal, and c.ngulate gyrus obtained at autopsy from 11 patients with autism were used for morphologic.l studies. Fresh frozen tissues available from seven patients and c.F from six living autistic.patients were used for c.tokine protein profili ng. We demonstrate an ac.ive neuroinflammatory proc.ss in the c.rebral c.rtex, w hite matter, and notably in c.rebellum of autistic.patients. Immunoc.toc.emic.l studies showed marked ac.ivation of mic.oglia and astroglia, and c.tokine profil ing indic.ted that mac.ophage c.emoattrac.ant protein (Mc.) 1 and tumor growth fac.or β 1, derived from neuroglia, were the most prevalent c.tokines in bra in tissues. c.F showed a unique proinflammatory profile of c.tokines, inc.uding a marked inc.ease in Mc. 1. Our findings indic.te that innate neuroimmune reac.tions play a pathogenic.role in an undefined proportion of autistic.patients, su ggesting that future therapies might involve modifying neuroglial responses in t he brain.

关键词：孤独症神经胶质细胞发育障碍性疾病社会交往障碍智力低下细胞因子免疫细胞化学免疫介导巨噬细胞扣带回

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