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Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

引用

Cellular & Molecular Immunology 2010年第3期7卷 227-234页

作者： Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki narumi hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling Department of Neurosurgery XuanWu HospitalCapital University of Medical ScienceBeijingChina Department of Oncology Chinese PLA General HospitalBeijingChina Department of Stem Cell Biology and Regenerative Medicine Graduate School of Medical ScienceKansai Medical UniversityOsakaJapan Department of Blood Transfusion Chinese PLA General HospitalBeijingChina Department of Obstetrics and Gynecology Faculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Biomedical Research Center Division of Analytical ScienceFaculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Anesthesiology Faculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Immunogenetics Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan

Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and ***,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum *** pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 *** current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th *** the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in *** addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 *** exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 *** findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.

关键词： bisphenol A dendritic cells Th1/2 human

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