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Journal of Renewable Materials 2019年第12期7卷 1279-1293页

作者： narsimha pandi Shirish H.Sonawane Sarang P.Gumfekar Anand Kishore Kola Pramod H.Borse Swapnil B.Ambade Sripadh Guptha Muthupandian Ashokkumar Department of Chemical Engineering National Institute of TechnologyWarangalTelanganaIndia Department of Chemical and Materials Engineering University of AlbertaEdmontonCanada International Advanced Research Centre for Powder Metallurgy and New Materials Balapur POHyderabadTelanganaIndia Department of Organic and Nano Engineering Hanyang University 222Wangsimni-roSeongdong-guSeoulKorea Department of Chemistry University of MelbourneVictoriaAustralia.

The present study deals with the intensified synthesis of starch-polyaniline(starch-PANI)nanocomposite using an ultrasound-assisted *** is a key component in this nanocomposite,which acts as a backbone of the nucleation of *** Electrochemical property of the nanocomposite arises due to the addition of *** is one of green approach for the synthesis of bio nanocomposite using *** crystallinity of the composite is evaluated using the Scherrer *** starch-PANI nanocomposite was characterized by XRD,FT-IR,Raman,XPS and *** composite nanoparticles show spherical *** elemental composition of starch-PANI showed O 1s peak at 546 eV,N 1s peak at 416 eV,C 1s peak at 286 eV and S 1s peak at 176 *** electrochemical studies of the starch-PANI electrodes are evaluated by cyclic voltammetry(CV),galvanostatic charge/discharge(GCD),and electrochemical impedance spectroscopy(EIS).Starch-PANI electrode has shown the maximum specific capacitance of 499.5 F/g at 5 mV/s scan rate.

关键词： Starch polyaniline sonochemical synthesis ultrasound biocomposite electrochemical analysis supercapacitor

Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress

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Nano Research 2024年第10期17卷 9031-9043页

作者： narsimha Mamidi Michael Poellmann Kaila Javius-Jones KiChang Nam Seungpyo Hong Wisconsin Center for NanoBioSystems University of Wisconsin-MadisonMadisonWI 53705USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Department of Medical Engineering College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Pharmacy Yonsei UniversityIncheon 21983Republic of Korea Lachman Institute for Pharmaceutical Development University of Wisconsin-MadisonMadisonWI 53705USA

Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical ***,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a major *** response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side *** address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target *** review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response ***,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are *** also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关键词： cancer immunotherapy drug delivery hydrogels immunotherapeutic agents immune modulation clinical outcomes

Microbial Populations,Activity and Gene Abundance in Tropical Vertisols Under Intensive Chemical Farming

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Pedosphere 2016年第5期26卷 725-732页

作者： Kopparapu APARNA Desiraju Lakshmi narsimha RAO Dananjeyan BALACHANDAR Indian Institute of Soil Science Nabi BaghBhopal 462038(India) Tamilnadu Agricultural University Coirnbatore 641003(India)

There are increasing concerns on the environmental impacts of intensive chemical agriculture. The effect of high agrochemical inputs used in intensive chemical farming was assessed on soil microbiological, molecular and biochemical properties in tropical Vertisols in India. Farm field sites under normal cultivation of arable crops using high inputs of fertilizers and pesticides in chili （Capsicum annum L., 5.0× dose for fertilizers and 1.5× dose for pesticides over normal inputs） and black gram （Vigna mungo L. Hepper, 2.2× dose for fertilizers and 2.3× dose for pesticides over normal inputs） were compared with adjacent sites using normal recommended doses. Organic carbon and basal respiration showed no response to high inputs of fertilizers and pesticides in soils of both crops. Labile carbon decreased by 10% in chili soils and increased by 24% in black gram soils under high input farming system. The proportion of soil labile carbon as a fraction of soil organic carbon was unaffected by high inputs. The labile carbon mineralization coefficient （qMLc） increased by 50.0% in chili soils, indicating that the soil microorganisms were under stress due to high agochemical inputs, whereas qMLc decreased by 36.4% in black gram soils. Copiotrophs increased due to high inputs in soils of both chili （63.1%） and black gram （47.1%）. Oligotrophs increased by 10.8% in black gram soils but not in chili soils. The abundance of amoA gene reduced by 39.3% in chili soils due to high inputs and increased significantly by 110.8% in black gram soils. β-Glucosidase also increased by 27.2% and 325.0%, respectively. Acid phosphatase activity reduced by 29.2% due to high inputs in chili soils and increased by 105.0% in black gram soils. The use of high agrochemical inputs thus had adverse consequences on biological health in chili but not in black gram soils. In soils cultivated with black gram, the moderating effect of cultivating legumes and their beneficial effect on soil health were eviden

关键词： amoA gene copiotrophs high agrochemical input legumes oligotrophs soil enzymes

Electrospun Aloe Vera Extract Loaded Polycaprolactone Scaffold for Biomedical Applications:A Promising Candidate for Corneal Stromal Regeneration

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Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： Amin Orash Mahmoud Salehi Mohammad Rafienia narsimha Mamidi Saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research Center Isfahan University of Medical SciencesIsfahan81746-73461Iran Wisconsin Center for NanoBioSystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research Center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/Polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human Stromal Keratocyte Cells(HSKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract Polycaprolactone Electrospinning

Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs

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World Journal of Gastroenterology 2007年第23期13卷 3199-3205页

作者： Meghna R Adhvaryu narsimha Reddy Minoo H Parabia Bapalal Vaidya Botanical Research Centre Department of Biosciences Veer Narmad South Gujarat University

AIM: To evaluate and compare the hepatoprotective and immunomodulatory effects of Curcuma longa (CL), Ocimum sanctum (OS), Tinospora cordifolia (TC) and Zizyphus mauritiana (ZM) on liver injury and immunosuppression induced by Isoniazid (INH), Rifampicin (RIF) and Pyrazinamide (PZA). METHODS: Duncan Hartley guinea pigs, weighing 700-1050 g, were treated orally with 50 mg/kg of INH, 100 mg/kg of RIF and 300 mg/Kg of PZA for 21-d. 200 mg/kg (bw) of each herb crude extract was administered to the herb control group and 2-h previous to INH + RIF + PZA (AKT) doses to the Herb + AKT groups. Serum alanine aminotransferase (ALT), aspertate aminotransferase (AST) bilirubin and Alkaline Phosphatase (ALP) were assessed on d 0 and 21 in all the groups. Phagocytic % (P%), Phagocytic Index (PI) and Chemotactic Index (CI) were also measured as immunologic parameters. Histological analysis was carried out to assess injury to the liver. RESULTS: The AKT treated control group showed hepatotoxicity as judged by elevated serum AST 5-fold, AST/ALT ratio 4-fold, ALP 2-fold and hepatological changes, such as focal necrosis, portal triaditis and steatosis. Immune function was suppressed as judged by decreased P% (51.67 ?1.68 vs 40.61 ?1.28, P < 0.01), PI (2.0725±0.05 vs 0.61±0.05, P < 0.001) and CI (1.8525±0.04 vs 0.695±0.07, P < 0.001). All four herb treated groups showed normal liver histology, enzyme levels and increased P%, while PI and CI were enhanced in the TC and ZM treated groups, respectively. CL + AKT, TC + AKT and ZM + AKT showed nearly normal histology with minimal inflammation and microvesicular steatosis, while OS + AKT showed partial protection. Hepatotoxicity was prevented by restricting the rise of AST by 2-fold in CL + AKT and TC + AKT groups and by 3-fold in OS + AKT and ZM + AKT groups, AST/ALT by 2-fold and ALP to normal levels in all four groups. All four herb + AKT groups showed normal to enhanced neutrophil function. CONCLUSION: All four herbs showed hepatoprotecti

关键词： Isoniazid Rifampicin Pyrazinamide Hepatotoxicity Curcuma longa Ocimum sanctum Tinospora cordifolia Zizyphus mauritiana Hepatoprotective Immunomodulatory

Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach

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World Journal of Gastroenterology 2008年第30期14卷 4753-4762页

作者： Meghna R Adhvaryu narsimha M Reddy Bhasker C Vakharia Bapalal Vaidya Botanical Research Centre Department of Biosciences Veer Narmad South Gujarat University Shree Gurudev Sarvajanik Charitable Trust Mobile Clinic Ramnagar Rander Road

AIM： To evaluate the ability of Curcuma Ionga （CL） and Tinospora cordifolia （TC） formulation to prevent anti-tuberculosis （TB） treatment （ATT） induced hepatotoxicity. METHODS： Patients with active TB diagnosis were randomized to a drug control group and a trial group on drugs plus an herbal formulation. Isoniazid, rifampicin, pyrazinamide and ethambutol for first 2 mo followed by continuation phase therapy excluding Pyrazinamide for 4 mo comprised the anti-tuberculous treatment. Curcumin enriched （25%） CL and a hydro-ethanolic extract enriched （50%） TC 1 g each divided in two doses comprised the herbal adjuvant. Hemogram, bilirubin and liver enzymes were tested initially and monthly till the end of study to evaluate the result. RESULTS： Incidence and severity of hepatotoxicity was significantly lower in trial group （incidence： 27/192 vs 2/316, P 〈 0.0001）. Mean aspartate transaminase （AST）（195.93 ± 108.74 vs 85 ± 4.24, P 〈 0.0001）, alanine transaminase （ALT）（75.74 ± 26.54 vs 41 ± 1.41, P 〈 0.0001） and serum bilirubin （5.4 ±3.38 vs 1.5 ±0.42, P 〈 0.0001）. A lesser sputum positivity ratio at the end of 4 wk （10/67 vs 4/137, P = 0.0068） and decreased incidence of poorly resolved parenchymal lesion at the end of the treatment （9/152 vs 2/278, P = 0.0037） was observed. Improved patient compliance was indicated by nil drop-out in trial vs 10/192 in control group （P 〈 0.0001）. CONCLUSION： The herbal formulation prevented hepatotoxicity significantly and improved the disease outcome as well as patient compliance without any toxicity or side effects.

关键词： Hepatoprotection Anti-tuberculous treatment Curcumin Ionga Tinospora cordifolia

Sorghum germplasm from West and Gentral Africa maintained in the ICRISAT genebank: Status,gaps,and diversity

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The Crop Journal 2017年第6期5卷 518-532页

作者： Hari Deo Upadhyaya Kothapally narsimha Reddy Mani Vetriventhan Mohammed Irshad Ahmed Gumma Murali Krishna Mulinti Thimma Reddy Shailesh Kumar Singh Genebank International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Patancheru 502324 Telangana India Department of Agronomy Kansas State University Manhattan KS 66506 USA The UWA Institute of Agriculture The University of Western Australia Crawley WA 6009 Australia Remote Sensing and GIS Unit International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Patancheru 502324Telangana India

The genebank at ICRISAT maintains 8020 accessions of sorghum from 16 West and Central African countries. Geographical gaps and diversity were assessed in the collection. Using the passport data of 3991 accessions for which georeferenced data were available, a total of386 districts(gaps) located in 11 West and Central African countries were identified as geographical gaps. Burkina Faso with 140 and Nigeria with 118 districts were identified as countries with major geographical gaps. The collection of 43 accessions of wild species represented only three species belonging to Sorghum bicolor ssp. drummondii and ***, S. hevisonii, and S. macrochaeta, highlighting the need for collection missions aimed exclusively at enriching the collection of wild relatives. Accessions having characterization data(7630) were used to assess diversity. The first three principal components contributed to >60% of variation. Maximum diversity was observed in the collection from Nigeria for both qualitative and quantitative traits. Mean values indicated significant differences between basic and intermediate races for the traits studied. Among the races, accessions of guinea-caudatum for qualitative traits and those of caudatum for quantitative traits were highly diverse. The low intensity of the sorghum collection and the many geographical gaps in the collection underline the importance of launching collection missions to fill the gaps, particularly in regions of predominantly guinea *** of possible duplicate accessions is needed to identify duplicates in the collection. It is suggested that all passport information including georeferenced data of collection sites should be collected when samples are collected in gaps.

关键词： Collection Diversity Gaps Germplasm Landraces Sorghum

An Asymptotic-Fitted Method for Solving Singularly Perturbed Delay Differential Equations

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Applied Mathematics 2012年第8期3卷 895-902页

作者： Awoke Andargie Yanala narsimha Reddy Bahir dar University Bahir dar Ethiopia

In this paper, we presented an asymptotic fitted approach to solve singularly perturbed delay differential equations of second order with left and right boundary. In this approach, the singularly perturbed delay differential equations is modified by approximating the term containing negative shift using Taylor series expansion. After approximating the coefficient of the second derivative of the new equation, we introduced a fitting parameter and determined its value using the theory of singular Perturbation;O’Malley [1]. The three term recurrence relation obtained is solved using Thomas algorithm. The applicability of the method is tested by considering five linear problems (two problems on left layer and one problem on right layer) and two nonlinear problems.

关键词： Asymptotic-Fitted Scheme Delay-Differential Equations Singular Perturbation Boundary Layer

Two Initial Value Problems Approach for Solving Singular Perturbations Problems

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American Journal of Computational Mathematics 2012年第3期2卷 213-216页

作者： Awoke Andargie Yanala narsimha Reddy Department of Mathematics Bahir dar University Bahir dar Ethiopia National Institute of Technology Warangal India

In this paper, we presented an initial value approach for solving singularly perturbed two point boundary value problems with the boundary layer at one end (left or right). By employing asymptotic power series expansion, the given singularly perturbed two-point boundary value problem is replaced by two first order initial value problems. To demonstrate the applicability of the present method three linear and two nonlinear problems with left end boundary layer are considered. It is observed that the present method approximates the exact solution very well.

关键词： Singular Perturbation Initial Value Problems Asymptotic Power Series Expansions

Genomics in medicine: A new era in medicine

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World Journal of Methodology 2021年第5期11卷 231-242页

作者： Vishwanath Pattan Rahul Kashyap Vikas Bansal narsimha Candula Thoyaja Koritala Salim Surani Division of Endocrinology Wyoming Medical CenterCasperWY 82601United States Department of Anesthesiology and Peri-operative Medicine Mayo ClinicRochesterMN 55905United States Hospital Medicine University Florida HealthJacksonvilleFL 32209United States Hospital Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Internal Medicine Texas A&M UniversityCorpus ChristiTX 78405United States

The sequencing of complete human genome revolutionized the genomic ***,the complex interplay of gene-environment-lifestyle and influence of non-coding genomic regions on human health remain largely *** medicine has great potential for diagnoses or disease prediction,disease prevention and,targeted ***,many of the promising tools of genomic medicine are still in their infancy and their application may be limited because of the limited knowledge we have that precludes its use in many clinical *** this review article,we have reviewed the evolution of genomic methodologies/tools,their limitations,and scope,for current and future clinical application.

关键词： Genomic medicine Medical genetics Gene sequencing DNA sequencing RNA sequencing Clustered regularly interspaced short palindromic repeat Gene based therapy Genomic tools Genome editing