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对吸烟的交感神经反应具有年龄依赖性

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 50-51页

作者： Hering D. Somers V. k. kara T. k. narkiewicz 朱冰坡(译) 刘少伟(校) 不详 Department of Hypertension and Diabetology Akademia Medyczna W Gdansku Debinki 7c 80 - 952 Gdansk Poland

Objective: Smoking is an important risk factor for cardiovascular disease. Sym pathetic responses to cigarette smoking may be implicated in the link between sm oking and cardiovascular disease. We tested the hypothesis that the sympathetic neural responses to smoking are age dependent. Methods: We examined the effects of cigarette smoking and sham smoking on muscle sympathetic nerve activity, bloo d pressure and heart rate in 14 normotensive middle-aged(49±4 years) and 12 yo ung(29±4 years) habitual smokers matched for body mass index(25±2 kg/m2 in bot h groups). Results: Sham smoking had no significant effect on sympathetic drive, blood pressure or heart rate in either group. Cigarette smoking increased heart rate in both middle-aged subjects and young subjects. In comparison to younger subjects, middle-aged smokers showed similar smoking-related increases in sys tolic blood pressure(SBP)[10±3 versus 12±2 mmHg, respectively, not significant (NS)]. Smoking decreased sympathetic nerve activity by 28±12%of baseline value s(Pking in middle-aged subjects(5±8%, NS), despit e the increased blood pressures, which would be expected to inhibit sympathetic activity. By contrast, in young subjects, the heart rate increase(22±2 bpm) was greater than that seen in middle-aged subjects(13±2 bpm, Pking are age dependent. While blood pressure in creases are similar in both groups, young subjects respond to smoking by marked increases in heart rate and suppression of central sympathetic outflow. In middl e-aged subjects, the heart rate increase is less marked, but sympathetic vasoco nstrictor activity is not suppressed.

关键词：交感神经反应年龄依赖性吸烟心血管疾病危险因素交感神经活性显著性差异血压正常受试者

难治性高血压患者的降压药物使用、血压控制及临床特征

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中华高血压杂志 2019年第12期27卷 1136-1136页

作者：刘青(译) 叶鹏(摘/审校) Carcel C Neal B Oparil S Rogers k narkiewicz k Wang JG Schiffrin EL Poulter N Azizi M Chalmers J 不详

研究者评估了难治性高血压(treatment resistant hypertension,TRH)患者的特征以及在一个多国三级专科医疗中心样本中TRH的患病率情况。方法:TRH患者调查研究对西欧、东欧、北美、南美、澳大利亚和亚洲的三级中心医疗记录进行了回顾性... 详细信息

研究者评估了难治性高血压(treatment resistant hypertension,TRH)患者的特征以及在一个多国三级专科医疗中心样本中TRH的患病率情况。方法:TRH患者调查研究对西欧、东欧、北美、南美、澳大利亚和亚洲的三级中心医疗记录进行了回顾性分析。从病历中提取人口统计学、病史和用药数据。基于估计代表人口计算TRH的患病率和发病率。

关键词：难治性高血压降压药物患病率临床特征

左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究

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中华高血压杂志 2014年第10期22卷 934-934页

作者：刘莉叶鹏 kloch-Badelek M knez J Tikhonoff V Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek k Jin Y Malyutina S Casiglia E narkiewicz k Czarnecka D kawecka-Jaszcz k Staessen JA kuznetsova T

确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法：随机抽取316个家庭样本,包... 详细信息

确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法：随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁,

关键词：左心室舒张功能障碍家庭影响因素遗传性人口多普勒指数遗传因素一般人群

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高血压高危患者的去肾交感神经术治疗

中华高血压杂志 2020年第8期28卷 775-775页

作者：刘青(译) 刘莉(校) Mahfoud F Mancia G Schmieder R narkiewicz k Ruilope L Schlaich M Whitbourn R Zirlik A Zeller T Stawowy P Cohen SA Fahy M Bohm M 不详

去肾交感神经术(renal denervation,RDN)治疗难治性高血压的研究正在进行中,对于心血管病风险较高的患者来说,RDN可能是一种具有吸引力的治疗方法。确定基线心血管病风险是否会影响RDN的有效性非常重要。该项研究的目的是评估伴有各种... 详细信息

去肾交感神经术(renal denervation,RDN)治疗难治性高血压的研究正在进行中,对于心血管病风险较高的患者来说,RDN可能是一种具有吸引力的治疗方法。确定基线心血管病风险是否会影响RDN的有效性非常重要。该项研究的目的是评估伴有各种合并症的患者RDN后的血压降低和事件发生率,并验证RDN在这些高风险人群中有效且持久这一假设。

关键词：难治性高血压高风险人群去肾交感神经术高危患者心血管病风险血压降低事件发生率合并症

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

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Translational Neurodegeneration 2019年第1期8卷 290-303页

作者： Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda Fondazione IRCCS Istituto Neurologico Carlo Besta Unit of Neurology 5 and NeuropathologyMilanItaly Fondazione IRCCS Istituto Neurologico Carlo Besta Unit of Neurology I-Parkinson and Movement Disorders UnitMilanItaly Department of Health Sciences Universitàdegli Studi di MilanoOtolaryngology UnitSan Paolo HospitalMilanItaly Department of Neuroscience Scuola Internazionale Superiore di Studi Avanzati(SISSA)Laboratory of Prion BiologyTriesteItaly Fondazione IRCCS Istituto Neurologico Carlo Besta Scientific DirectorateMilanItaly

Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative *** is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain *** diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the *** evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM *** particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and ***:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same ***,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their ***:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-*** studies are required for(i)estimating sensitivity and specificity of the technique and

关键词： RT-QuIC Olfactory mucosa Parkinson’s disease Neurodegenerative parkinsonisms α-Synuclein