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Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)

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中国神经肿瘤杂志 2013年第1期11卷 21-21页

作者： Shibui S narita y Mizusawa J Beppu T Ogasawara K Sawamura y Kobayashi H Nishikawa R Mishima K Muragaki y Maruyama T Kuratsu J Nakamura H Kochi M Minamida y yamaki T Kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita y Nakazato y Sato A Fukuda H Nomura K Department of Neurosurgery and Neuro-Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of *** therapy consists of resection with concomitant *** to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT *** study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + *** primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR ***: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in *** median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,*** median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,*** 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse ***: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM.

关键词：星形细胞母细胞随机试验放疗胶质变性化疗 MGMT

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深度学习重建提高了腹部超高分辨力CT的影像质量

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国际医学放射学杂志 2020年第1期 120-121页

作者： M.Akagi y.Nakamura T.Higaki K.narita y.Honda J.Zhou 王雪杰 Diagnostic Radiology Hiroshima University

目的深度学习重建(DLR)是一种新的重建方法,它将深度卷积神经网络引入到重建流程。本研究是为了检验新的DLR算法对于腹部超高分辨力CT(U-HRCT)检查的临

关键词：高分辨力影像质量 CT 深度学习

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MAGNETIC PROPERTy CHANGE IN AN AUSTENITIC STAINLESS STEEL SUBJECTED TO DAMAGE AT ELEVATED TEMPERATURE-MICROSTRUCTURE RESPONSIBLE FOR MAGNETIC PROPERTy

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 387-392页

作者： y.Nagae K.Aoto Japan Nuclear Cycle Development Institute 4002 Narita Oarai Ibaraki 311-1393 JapanJapan Nuclear Cycle Development Institute 4002 Narita Oarai Ibaraki 311-1393 Japan

It has been found that magnetic property changes in austenitic stainless steel subjected to creep at high temperature. The change of magnetic property is mainly due to decrease the chromium concentration in the vicinity of grain boundary and transform into martensite in the area. However this result is for short-term creep. It is necessary to evaluate the long-term creep in order to develop non-destructive technique for plants. Moreover it is important to evaluate the fatigue. The change of magnetic property for those damages at high temperatures is investigated. The transformation into martensite is observed for both the long-term creep and fatigue. The magnetic regions are observed in sever deformed area and near crack. Then the formation of magnetic phases is related to the damage. The damage at high temperature can be universally evaluated.

关键词： creep fatigue high temperature austenitic stainless steel magnetism

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Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication

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World Journal of Gastroenterology 2016年第33期22卷 7569-7578页

作者： Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato yutaka narita yoshio Kanemitsu yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital Department of Hepatology Shonan-East General Hospital Department of Pathology Juntendo University Shizuoka Hospital Department of Gastroenterology Juntendo University School of Medicine

AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus *** In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank *** Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P y higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 *** Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR.

关键词： Human AKR1B10 protein Hepatocellular carcinoma Chronic hepatitis C Immunohistochemistry Risk factor Sustained virological response

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冷喷涂用铝基、钛基、锌基、铁基合金粉末的粉尘爆炸特性

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热喷涂技术 2014年第1期6卷 53-58,39页

作者： K.Sakata K.Tagomori N.Sugiyama S.Sasaki y.Shinya T.Nanbu y.Kawashita I.narita H.Miyahara 郭东海 Fujikikosan Corporation Nissan Motor Co. Ltd. Kyushu University

冷喷涂工艺通常采用较热喷涂更细小粒径的金属粉末,而且粉末颗粒在喷涂中没有经历熔化过程,所以较热喷涂颗粒中的氧化物夹杂少。正因如此,有必要对工业、研发用冷喷涂工艺中的粉尘爆炸和燃烧特性进行研究,这不仅是为了防止粉末在喷涂中... 详细信息

冷喷涂工艺通常采用较热喷涂更细小粒径的金属粉末,而且粉末颗粒在喷涂中没有经历熔化过程,所以较热喷涂颗粒中的氧化物夹杂少。正因如此,有必要对工业、研发用冷喷涂工艺中的粉尘爆炸和燃烧特性进行研究,这不仅是为了防止粉末在喷涂中爆炸或燃烧,更为保护工人的健康和安全。为使冷喷涂在工业上得到很好的应用,有必要在风险评估的基础上对其进行风险管理,然而关于此风险评估的研究鲜有报道。本文依据JIS Z 8818-《可燃粉尘的最低浓度限度测试方法》、IEC61241-2-3(1994-09)第三节-《粉尘/空气混合物的最小点火能量测定方法》和JIS Z 8817-《可燃粉尘的爆炸压力及压力上升速率的测试方法》来测定冷喷涂用铝基、钛基、锌基、铁基合金粉末的粉尘爆炸特性。

关键词：冷喷涂合金粉末粉尘爆炸特性风险评估

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日本1级和2级高血压相关心血管病所致过早死亡人群归因分值

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中华高血压杂志 2021年第11期29卷 1154-1154页

作者： Hatano y yano y Fujimoto S Sato y Iseki K Konta T Moriyama T yamagata K Tsuruya K narita I Kondo M Kasahara M Shibagaki y Asahi K Watanabe T 袁源(翻译) 郑武洪(审校) 不详

本研究旨在评估高血压相关心血管病所致过早死亡人群归因分值(population-attributable fraction,PAF)是否随高血压的血压阈值变化而变化,血压阈值定义采用2017年美国心脏病学会/美国心脏协会指南标准,从≥140/90降至≥130/80mm Hg(1mm ... 详细信息

本研究旨在评估高血压相关心血管病所致过早死亡人群归因分值(population-attributable fraction,PAF)是否随高血压的血压阈值变化而变化,血压阈值定义采用2017年美国心脏病学会/美国心脏协会指南标准,从≥140/90降至≥130/80mm Hg(1mm Hg=0.133kPa)。方法:纳入日本数据库中2008年起接受国家健康体检参与者510238人,年龄(59.6±8.1)岁,42%为男性。

关键词：美国心脏病学会美国心脏协会心血管病归因分值 2级高血压健康体检过早死亡

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使用同一设备测量的诊室、家庭和动态血压的控制状态不一致

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中华高血压杂志(中英文) 2023年第8期31卷 800-800页

作者： Kario K Hoshide S Tomitani N Nishizawa M yoshida T Kabutoya T Fujiwara T Mizuno H narita K Komori T Ogata y Suzuki D Ogoyama y Ono A yamagiwa K Abe y Nakazato J Nakagawa N Katsuya T Harada N Kanegae H 刘青练桂丽

背景：不同的血压监测设备可导致诊室与非诊室血压检测值不一致。控制血压能减少脑血管疾病风险，并能预防高血压相关疾病，也可显著提升高血压患者的生活质量，延长寿命，减少脑卒中、冠心病、心力衰竭的发生率。方法：本研究采用经过...

背景：不同的血压监测设备可导致诊室与非诊室血压检测值不一致。控制血压能减少脑血管疾病风险，并能预防高血压相关疾病，也可显著提升高血压患者的生活质量，延长寿命，减少脑卒中、冠心病、心力衰竭的发生率。方法：本研究采用经过验证的“一体化（all-in-one）”血压监测设备测量诊室、家庭和动态血压，评估3种血压对血压控制分类（血压控制良好与控制不佳）的一致性。

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HCV感染患者的胰岛素抵抗和胰岛素释放

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 62-62页

作者： narita R. Abe S. Kihara y. M. Otsuki 刘娜 Third Dept.of Internal Medicine Univ.of Occup.and Environ.HealthJapanSch.Med.1-1 IseigaokaY.KitakyushuJapan

Background/Aims Diabetes mellitus (DM) is frequently observed in patients with chronic hepatitis caused by hepatitis C virus infection (CHC). The present study was designed to determine the pathogenic factors responsible for glucose intolerance in CHC patients. Methods A total of 131 patients with CHC were enrolled in this study. Insulin resistance and β-cell function were determined after 75 g oral glucose tolerance tests. Results Glucose intolerance was detected in 27.5% (36/131) of CHC patients; 10 had DM and 26 impaired glucose tolerance. HOMA-R insulin 0× glucose 0/22.5 was greater in patients with both impaired glucose tolerance and DM than in those with normal glucose tolerance (Py lower even in patients with impaired glucose tolerance than in patients with normal glucose tolerance (Pysfunction contribute to glucose intolerance in CHC patients.

关键词：胰岛素释放胰岛素抵抗 HCV感染糖耐量异常空腹胰岛素口服葡萄糖耐量空腹血糖慢性丙型肝炎空腹葡萄糖功能失调

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