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Bone Research 2020年第4期8卷 429-438页

作者： Junich. Kush.oka Takash. Kaito Rintaro Okada h.royuki Ish.guro Zeynep Bal Joe Kodama Ryota Ch.jimatsu Melanie Pye Masah.ro narimatsu Jeffrey LWrana Yasumich. Inoue h.roko Ninomiya Sh.n Yamamoto Takash. Saitou h.deki Yosh.kawa Takesh. Imamura Department of Orth.paedic Surgery Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan Bone and Cartilage Regenerative Medicine The University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-8655Japan Centre for Systems Biology Lunenfeld-Tanenbaum Research InstituteMount Sinai Hospital600 University AveTorontoON M5G 1X5Canada Department of Cell Signaling Graduate School of Pharmaceutical SciencesNagoya City University3-1 Tanabe-doriMizuho-kuNagoyaAichi 467-8603Japan Department of Molecular Medicine for Path.genesis Ehime University Graduate School of Medicine454 ShitsukawaToonEhime 791-0295Japan Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine454 ShitsukawaToonEhime 791-0295Japan Translational Research.Center Ehime University Hospital454 ShitsukawaToonEhime 791-0295Japan

Transforming growth.factor-β(TGF-β)and bone morph.genetic protein(BMP)play important roles in bone *** ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP *** Smurf2 h.s been sh.wn to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism h.s not been th.rough.y *** th. present study,we sough. to evaluate th. role of Smurf2 in BMP/Smad signaling in bone *** collagen sponges containing 3μg of recombinant h.man BMP2(rh.MP2)were implanted in th. dorsal muscle pouch.s of wild type(WT)and Smurf2−/−*** rh.MP2-induced ectopic bone in Smurf2−/−mice sh.wed greater bone mass,h.gh.r mineral apposition and bone formation rates,and greater osteoblast numbers th.n th. ectopic bone in WT *** WT mice,th. ectopic bone consisted of a th.n discontinuous outer cortical sh.ll and scant inner trabecular *** contrast,in Smurf2−/−mice,th. induced bone consisted of a th.ck,continuous outer cortical sh.ll and abundant inner trabecular ***,rh.MP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice sh.wed increased osteogenic ***2 induced th. ubiquitination of Smad1/***/Smad signaling was enh.nced in Smurf2−/−BMSCs stimulated with.rh.MP2,and th. inh.bition of BMP/Smad signaling suppressed osteogenic differentiation of th.se *** findings demonstrate th.t Smurf2 negatively regulates BMP/Smad signaling,th.reby identifying a new regulatory mech.nism in bone metabolism.

关键词： Smurf2 metabolism involvement

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三角纤维软骨的超短回波时间(UTE)定量MR成像:摆位的差异

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国际医学放射学杂志 2019年第4期 505-506页

作者：吴越 A.Fujisaki T.Aoki h.narimatsu C.Kuwah.ra A.Nozaki K.Menuki Department of Radiology University of Occupational and Environmental Health

摘要目的比较分别在中立位、腕部尺骨屈曲和前臂内旋位获得的三角纤维软骨（TFC）超短时间回波（UTE）的T2*值。方法对10名健康志愿者使用8通道膝关节线圈在3T

关键词： UTE 三角纤维软骨回波时间 MR

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日本制订热气机研制计划

船舶工程 1984年第4期 26-31+37+5页

作者： Y.Nakatani h.Mori Y.narimatsu T.Watanabe 董以敏新能源开发组织新能源开发组织 MITI工业科学技术局 MITI工业科学技术局

一、前言在日本,大约占总能耗的66.4％依赖于石油资源,而99％的石油需从产油国进口。因此,为了保证国民经济和生活的稳定进步,需要私人、工业和运输各部门更广泛地进行节能,更多地利用替用能源(非石油)。在过去几年积累的热气机技术的... 详细信息

一、前言在日本,大约占总能耗的66.4％依赖于石油资源,而99％的石油需从产油国进口。因此,为了保证国民经济和生活的稳定进步,需要私人、工业和运输各部门更广泛地进行节能,更多地利用替用能源(非石油)。在过去几年积累的热气机技术的基础上,

关键词：热气机活塞式天然气混合气体加热器研制计划日本

实时前瞻性运动校正（PROMO）对于不合作病人3D T1加权成像脑皮质分割基于体素形态学分析的价值

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国际医学放射学杂志 2017年第5期 620-620页

作者： N.Igata S.Kkeda K.Watenabe A.Nozaki D.Rettmann h.narimatsu 袁涛 Department of Radiology University of Occupational and Environmental Health School of Medicine

摘要目的探讨实时前瞻性运动校正(PROMO)对不合作病人行3D T1加权成像脑皮质分割基于体素形态学(VBM)分析的价值。方法对33例不合作的帕金森病(11

关键词：加权成像 PROMO T1 脑皮质形态学