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非生物储存因素互作对储藏土耳其带壳榛子呼吸、干物质损失和黄曲霉毒素B_(1)污染的影响

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粮油食品科技 2021年第6期29卷 16-22页

作者： Kalliopi Mylona Angel Medina naresh magan 英国克兰菲尔德大学环境和农业食品领域学院应用真菌学团队英国克兰菲尔德MK430AL

榛子是一种具重要经济意义、世界各地广泛食用的坚果,易受黄曲霉感染和黄曲霉毒素的污染。以土耳其榛子为研究对象,旨在了解不同的温度和可利用水分下,自然存储的带壳榛子的量化呼吸速率、干物质损失(DML)和黄曲霉毒素B_(1)(AFB_(1))的... 详细信息

榛子是一种具重要经济意义、世界各地广泛食用的坚果,易受黄曲霉感染和黄曲霉毒素的污染。以土耳其榛子为研究对象,旨在了解不同的温度和可利用水分下,自然存储的带壳榛子的量化呼吸速率、干物质损失(DML)和黄曲霉毒素B_(1)(AFB_(1))的污染等情况,以及榛子储存前附加接种黄曲霉对干物质损失和AFB_(1)污染的影响。榛子和相关菌群的最大呼吸作用发生在0.90~0.95水分活度(aw=12.5%~18%水分含量)的潮湿条件下。这导致25和30℃下储存5 d后,榛子损失约10%的DML。储存的带壳榛子+接种黄曲霉在25~30℃和小于0.90 aw下产生类似的最佳呼吸模式。事实上,在测试的最大水分水平0.90 aw的AFB_(1)污染是最高的;这样的污染水平超过了欧盟对这些坚果污染AFB_(1)的法定限制。两组研究中,DML与所有AFB_(1)数据之间的相关性表明,由于干燥或≥0.6%不良储存引起非常小的DML变化,可导致AFB_(1)污染超过欧盟法定限制。因此,有效干燥和安全监控储存对于最大限度地降低这种重要经济商品中AFB_(1)污染风险并避免消费者暴露于此类毒素是十分必要的。

关键词：土耳其榛子储藏呼吸干物质损失黄曲霉毒素B_(1) 黄曲霉法定限制

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Accumulation of the betaine and ectoine in osmotic stress adaptation of biocontrol agents against <i>Fusarium verticillioides</i>in maize

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Agricultural Sciences 2012年第1期3卷 83-89页

作者： Melina Sartori Andrea Nesci naresh magan Miriam Etcheverry Applied Micology Group Cranfield Health Vincent Building Cranfield University Cranfield UK Laboratorio de Ecología Microbiana Departamento de Microbiología e Inmunología Facultad de Ciencias Exactas Físico Químicas y Naturales Universidad Nacional de Río Cuarto Río Cuarto Argentina

The aims of this study was to examine the effect of the osmotic (NaCl) water stress on, growth and accumulation of endogenous compatible solutes of Bacillus amyloliquefaciens and Microbacterium oleovorans, biocontrol agents against Fusarium verticillioides. Triptic soya broth media were modified ionically to 0.99;0.98;0.97 and 0.96 aw with NaCl. The endogenous contents of the intracellular compatible solutes glycine-betaine and ectoine were quantified. Cells grown under ionic solute stress showed accumulation of significant amounts of both amino acids in all treatments. The growth rate of F. verticillioides was decreased significantly by interaction with B. amyloliquefaciens and M. oleovorans physiologically adapted at 0.96 aw. This study have demonstrated the ability to synthesize betaine and ectoine under high-osmolality conditions of B. amyloliquefaciens and M. oleovorans cells. Such ecophysiological manipulation, especially to water stress, may increase the potential for biological control of F. verticillioides at field under wider aw conditions.

关键词： Biological Control Osmotic Adaptation Solute Compatible Fusarium verticillioides Maize

Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3257-3260页

作者： naresh Singh Samantha Sharma Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States

Over the years immunotherapy has demonstrably improved the field of cancer ***,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet *** immunotherapies incor-porating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative ***,substantial gaps remain in the current therapeutic armamentarium for *** recent years,there has been a surge of interest in exploring novel treatment strategies,including the application of light-activated drugs in conjunction with optical *** approach holds promise for achie-ving localized and targeted delivery of cytotoxic agents,such as microtubule-targeting drugs,directly to cancerous cells within the colon.

Acoustical properties of a 3D printed honeycomb structure filled with nanofillers:Experimental analysis and optimization for emerging applications

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Defence Technology（防务技术） 2024年第5期35卷 248-258页

作者： Jeyanthi Subramanian Vinoth kumar Selvaraj Rohan Singh Ilangovan S naresh Kakur Ruban Whenish School of Mechanical Engineering Vellore Institute of TechnologyChennai600127Tamil NaduIndia Department of Mechanical Engineering SRM Institute of Science and TechnologyRamapuramChennai600089India Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos Angeles90089USA Advanced Materials Research Centre Technology Innovation InstituteAbu Dhabi9639UAE Center for Biomaterials Cellular and Molecular TheranosticsVellore Institute of TechnologyVellore632014Tamil NaduIndia

The novelty of this research lies in the successful fabrication of a 3D-printed honeycomb structure filled with nanofillers for acoustic properties,utilizing an impedance tube setup in accordance with ASTM standard E *** Creality Ender-3,a 3D printer,was used for printing the honeycomb structures,and polylactic acid(PLA)material was employed for their *** organic,inorganic,and polymeric compounds within the composites were identified using fourier transformation infrared(FTIR)*** structure and homogeneity of the samples were examined using a field emission scanning electron microscope(FESEM).To determine the sound absorption coefficient of the 3D printed honeycomb structure,numerous samples were systematically developed using central composite design(CCD)and analysed using response surface methodology(RSM).The RSM mathematical model was established to predict the optimum values of each factor and noise reduction coefficient(NRC).The optimum values for an NRC of 0.377 were found to be 1.116 wt% carbon black,1.025 wt% aluminium powder,and 3.151 mm distance between parallel ***,the results demonstrate that a 3Dprinted honeycomb structure filled with nanofillers is an excellent material that can be utilized in various fields,including defence and aviation,where lightweight and acoustic properties are of great importance.

关键词： 3D printing Honeycomb structure Acoustics Field emission scanning electron microscope Response surface methodology

Bio-analysis of Saliva Using Paper Devices and Colorimetric Assays

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Journal of Analysis and Testing 2024年第1期8卷 114-132页

作者： Adhan Narasimhan Harshil Jain Kowshika Muniandy Raja Chinnappan naresh Kumar Mani Microfluidics Sensors and Diagnostics(μSenD)LaboratoryCentre for MicrofluidicsBiomarkersPhotoceutics&Sensors(μBioPS)Department of BiotechnologyManipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India College of Medicine Alfaisal UniversityRiyadh 11533SaudiArabia Tissue/Organ Bioengineering&BioMEMS Lab Organ Transplant Centre of ExcellenceTransplant Research&Innovation DepartmentKing Faisal Specialist Hospital and Research CentreRiyadhSaudi Arabia

In light of the evolving nature of various diseases,time becomes a crucial factor in diagnosis and identifying the underlying causes.A point-of-care device provides a rapid diagnosis of a disease without using complex and advanced instruments,which are costly and difficult to transport.A paper-based device is a relatively frugal solution wherein the paper is used as a substratum in which the reactions are carried *** methods are non-invasive,and the sample collection is relatively *** is one such body fluid in which various biomarkers are present for numerous *** of saliva has attracted more attention recently due to its non-invasiveness and *** the discovery of clinical biomarkers from salivary analysis has the potential to revolutionize the healthcare sector by providing crucial information to monitor the health status of individuals and disease progression which enables personalized *** review provides the limitation of the traditional methods in clinical applications and highlights the significance of saliva as a non-invasive biological fluid that is a source of multiple biomarkers associated with various *** also provides insights into the different paper-based colorimetric microfluidic devices developed against salivary biomarkers in the past *** major challenges in the point-of-care application and the future prospects have been discussed as ***,we also emphasize the importance of this approach in dental disease diagnosis which is least explored and holds potential applications.

关键词： Paper-based assay Salivary analysis Non-invasive Point-of-care Body fluids Biomarkers Qualitative detection

Accumulation of the betaine and ectoine in osmotic stress adaptation of biocontrol agents against Fusarium verticillioides in maize

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Disordered Structure and Reversible Phase Transformation from K-Birnessite to Zn-Buserite Enable High-Performance Aqueous Zinc-lon Batteries

Agricultural Sciences（农业科学） 2012年第1期

作者： Melina Sartori Andrea Nesci naresh magan Miriam Etcheverry

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Energy & Environmental Materials 2024年第3期7卷 100-111页

作者： Nibagani naresh Suyoon Eom Sang Jun Lee Su Hwan Jeong Ji-Won Jung Young Hwa Jung Joo-Hyung Kim Department of Materials Engineering and Convergence Technology Gyeongsang National University(GNU)Jinju 52828South Korea School of Material Science and Engineering(Ceramic Engineering) Gyeongsang National University(GNU)Jinju 52828South Korea School of Materials Science and Engineering University of Ulsan(UOU)Ulsan 44776South Korea PLS-ⅡBeamline Division Pohang Accelerator Laboratory(PAL)Pohang 37673South Korea

The layeredδ-MnO_(2)(dMO)is an excellent cathode material for rechargeable aqueous zinc-ion batteries owing to its large interlayer distance(~0.7 nm),high capacity,and low cost;however,such cathodes suffer from structural degradation during the long-term cycling process,leading to capacity *** this study,a Co-doped dMO composite with reduced graphene oxide(GC-dMO)is developed using a simple cost-effective hydrothermal *** degree of disorderness increases owing to the hetero-atom doping and graphene oxide *** is demonstrated that layered dMO and GC-dMO undergo a structural transition from K-birnessite to the Zn-buserite phase upon the first discharge,which enhances the intercalation of Zn^(2+)ions,H_(2)O molecules in the layered *** GC-dMO cathode exhibits an excellent capacity of 302 mAh g^(-1)at a current density of 100 mAg^(-1)after 100 cycles as compared with the dMO cathode(159 mAhg^(-1)).The excellent electrochemical performance of the GC-dMO cathode owing to Co-doping and graphene oxide sheets enhances the interlayer gap and disorderness,and maintains structural stability,which facilitates the easy reverse intercalation and de-intercalation of Zn^(2+)ions and H_(2)O ***,GC-dMO is a promising cathode material for large-scale aqueous ZIBs.

关键词： aqueous zinc-ion batteries birnessite buserite disordered structure phase transformation

An Intelligent Big Data Security Framework Based on AEFS-KENN Algorithms for the Detection of Cyber-Attacks from Smart Grid Systems

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Big Data Mining and Analytics 2024年第2期7卷 399-418页

作者： Sankaramoorthy Muthubalaji naresh Kumar Muniyaraj Sarvade Pedda Venkata Subba Rao Kavitha Thandapani Pasupuleti Rama Mohan Thangam Somasundaram Yousef Farhaoui Department of Electrical and Electronics Engineering CMR College of Engineering&TechnologyHyderabad 501401India Department of Electronics and Communication Engineering Vardhaman College of Engineering KacharamShamshabad 501218India Department of Electronics and Communication Engineering Sreenidhi Institute of Science and TechnologyHyderabad 501301India Department of Electronics and Communication Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Electrical and Electronics Engineering Bharat Institute of Engineering and TechnologyHyderabad 501510India Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidhyapeethamBengaluru 560035India T-IDMS Department of Computer ScienceFaculty of Sciences and TechniquesMoulay Ismail UniversityErrachidia 52000Morocco

Big data has the ability to open up innovative and ground-breaking prospects for the electrical grid,which also supports to obtain a variety of technological,social,and financial *** is an unprecedented amount of heterogeneous big data as a consequence of the growth of power grid technologies,along with data processing and advanced *** main obstacles in turning the heterogeneous large dataset into useful results are computational burden and information *** original contribution of this paper is to develop a new big data framework for detecting various intrusions from the smart grid systems with the use of AI ***,an AdaBelief Exponential Feature Selection(AEFS)technique is used to efficiently handle the input huge datasets from the smart grid for boosting ***,a Kernel based Extreme Neural Network(KENN)technique is used to anticipate security vulnerabilities more *** Polar Bear Optimization(PBO)algorithm is used to efficiently determine the parameters for the estimate of radial basis ***,several types of smart grid network datasets are employed during analysis in order to examine the outcomes and efficiency of the proposed AdaBelief Exponential Feature Selection-Kernel based Extreme Neural Network(AEFS-KENN)big data security *** results reveal that the accuracy of proposed AEFS-KENN is increased up to 99.5%with precision and AUC of 99%for all smart grid big datasets used in this study.

关键词： smart grid Machine Learning(ML) big data analytics AdaBelief Exponential Feature Selection(AEFS) Polar Bear Optimization(PBO) Kernel Extreme Neural Network(KENN)

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer:Unravelling challenges and future directions

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World Journal of Gastroenterology 2024年第13期30卷 1815-1835页

作者： Samantha Sharma naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyrchal Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorectal cancer(CRC)is a complex disease with diverse etiologies and clinical *** considerable progress in development of CRC therapeutics,challenges remain regarding the diagnosis and management of advanced stage metastatic CRC(mCRC).In particular,the five-year survival rate is very low since mCRC is currently rarely *** the past decade,cancer treatment has significantly improved with the introduction of cancer immunotherapies,specifically immune checkpoint *** aimed at blocking immune checkpoints such as PD-1,PD-L1,and CTLA-4 target inhibitory pathways of the immune system,and thereby enhance anti-tumor *** therapies thus have shown promising results in many clinical trials alone or in *** efficacy and safety of immunotherapy,either alone or in combination with CRC,have been investigated in several clinical *** trials,including KEYNOTE-164 and CheckMate 142,have led to Food and Drug Administration approval of the PD-1 inhibitors pembrolizumab and nivolumab,respectively,for the treatment of patients with unresectable or metastatic microsatellite instability-high or deficient mismatch repair ***,these drugs benefit only a small percentage of patients,with the benefits of immunotherapy remaining elusive for the vast majority of CRC *** this end,primary and secondary resistance to immunotherapy remains a significant issue,and further research is necessary to optimize the use of immunotherapy in CRC and identify biomarkers to predict the *** review provides a comprehensive overview of the clinical trials involving immune checkpoint inhibitors in *** underlying rationale,challenges faced,and potential future steps to improve the prognosis and enhance the likelihood of successful trials in this field are discussed.

关键词： Colorectal cancer Immune checkpoint inhibitors Clinical trials Immunotherapy Microsatellite instability Microsatellite stability DNA mismatch repair