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Journal of Pharmaceutical Analysis 2012年第4期2卷 298-305页

作者： M.Mathrusri Annapurna Chitaranjan Mohapatro A.narendra Department of Pharmaceutical Analysis & Quality Assurance GITAM Institute of PharmacyGITAM University Department of Pharmaceutical Analysis & Quality Assurance Roland Institute of Pharmaceutical Sciences

A stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Letrozole in tablet dosage forms. Reversed-phase chromatography was performed on Shimadzu Model LC-Class-Vp with Lichrocart/Lichrosphere 100 C-18 (250 mm 4.6 mm, 5 mm particle size) column with methanol: tetra butyl ammonium hydrogen sulfate (80:20V/V) as mobile phase at a flow rate of 1 mL/min with UV detection at 240 nm. Linearity was observed in the concentration range of 0.5-150 mg/mL (R 2 0.9998) with regression equation y 102582xt43185. The limit of quantitation (LOQ) and limit of detection (LOD) were found to be 0.043 and 0.012 mg/mL respectively. The forced degradation studies were performed by using HCl, NaOH, H 2 O 2 , thermal and UV radiation. Letrozole is more sensitive towards alkaline conditions and very much resistant towards acidic, oxidative and photolytic degradations. The method was validated as per ICH guidelines. The RSD for intra-day (0.78-0.97) and inter-day (0.86-0.96) precision were found to be lesser than 1%. The percentage recovery was in good agreement with the labeled amount in the pharmaceutical formulations and the method is simple, specific, precise and accurate for the determination of Letrozole in pharmaceutical formulations.

关键词： Letrozole Liquid chromatography Stability-indicating

Susceptibility of northern corn rootworm Diabrotica barberi （Coleoptera： Chrysomelidae） to mCry3A and eCry3.1Ab Bacillus thuringiensis proteins

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Insect Science 2016年第6期23卷 913-917页

作者： Isaac O. Oyediran Phillip Matthews narendra Palekar Wade French Jared Conville Tony Burd Syngenta Crop Protection LLC Research Triangle Park NC 27709 USA USDA ARS North Central Agricultural Research Laboratory Brookings SD 57006 USA

The susceptibility of the northern corn rootworm Diabrotica barberi （Smith ＆ Lawrence） to mCry3A and eCry3.1Ab proteins derived from Bacillus thuringiensis （Bt） was determined using a diet bioassay. Northern corn rootworm neonates were exposed to different concentrations of mCry3A and eCry3.1Ab, incorporated into artificial diet. Larval mortality was evaluated after 7 d. The mCry3A and eCry3.1 Ab proteins were found to be toxic to the northern corn rootworm larvae. The LCs0 and LC99 values for mCry3A were 5.13 and 2482.31 μg/mL, respectively. For eCry3.1Ab, the LC50 and LC99 values were 0.49 and 213.01 μg/mL. Based on the estimated lethal concentrations, eCry3, lab protein was more efficacious to northern corn rootworm larvae than mCry3A. These lethal concentration values will be used as diagnostic doses for routine annual monitoring for change in susceptibility of field collected northern corn rootworm to mCry3A, and eCry3.1Ab toxins.

关键词： Bacillus thuringiensis Diabrotica barberi eCry3.1Ab mCry3A susceptibility

Preparation of NiFe_2O_4 nanopowder via EDTA precursor and study of its properties

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Particuology 2012年第1期10卷 29-34页

作者： Amit B.Rajput Subhenjit Hazra Niharika B.Krishna Pavani Chavali Sneha Datla narendra Nath Ghosh Nano-Materials Lab Department of Chemistry BITS-Pilani K.K. Birla Goa Campus

An ethylene diamine tetra acetic acid （EDTA） precursor-based chemical method is reported for prepar- ing single-phase nickel ferrite （NiFe204） nanopowder. The synthesized powder was characterized by thermogravimetric analysis, differential scanning calorimetric analysis, X-ray diffraction, particle size analysis and scanning electron microscopy. DC electrical resistivity and magnetic property of the synthesized NiFe204 were measured by using a two-probe method and a vibrating sample magnetometer respectively. The DC resistivity behaviour of the NiFe204 nanopowder was correlated with the change of microstructure, during sintering. This EDTA precursor-based method is capable of producing nanos- tructured single-phase NiFe204 powder at a comparatively low calcination temperature and offers the potential of a simple and cost-effective route, including the preparation of other ferrite nanoparticles.

关键词： Magnetic materialsChemical synthesisX-ray diffractionMagnetic properties

The effect of calcination temperature on the capacitive properties of WO3-based electrochemical capacitors synthesized via a sol-gel method

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Frontiers of Materials Science 2013年第4期7卷 370-378页

作者： Diah SUSANTI Rizky narendra Dwi WIBAWA Lucky TANANTA Hariyati PURWANINGSIH Rindang FAJARIN George Endri KUSUMA Materials and Metallurgical Engineering Department Faculty of Industrial Technology nstitut Teknologi Sepuluh Nopember (ITS) Kampus ITS Keputih Sukolilo Surabaya 60111 Indonesia Mechanical Engineering Department Surabaya State Shipbuilding Polytechnic Kampus PPNS Jalan Teknik Kimia ITS Surabaya 60111 Indonesia

Electrochemical capacitor （EC） is a promising energy storage device which can be hybridized with other energy conversion or energy storage devices. One type of ECs is pseudocapacitor made of metal oxides. WO3 is an inexpensive semiconductor metal oxide which has many applications. However the application of WO3 as an EC material was rarely reported. Therefore in this research EC was prepared from WO3 nanomaterial synthesized by a sol-gel process. The WO3 gel was spin-coated on graphite substrates and calcined at various temperatures of 300~C, 400℃, 500℃ and 600℃ for 1 h. Cyclic voltammetry （CV） measurements were used to observe the capacitive property of the WO3 samples. SEM, XRD, FTIR and Brunauer-Emmett-Teller （BET） analyses were used to characterize the material structures. WO3 calcined at 400~C was proved to have the highest capacitance of 233.63 Fo g^-1 （1869 mFo cm-2） at a scan rate of 2 mVo s-1 in 1 mol/L H2SO4 between potentials -0.4 and 0.4 V vs. SCE. Moreover it also showed the most symmetric CV curves as the indication of a good EC. Hence WO3 calcined at 400℃ is a potential candidate for EC material of pseudocapacitor type.

关键词： electrochemical capacitor (EC) WO3 nanomaterial sol-gel process calcination

Structural Design and Numerical Analysis of a Novel Biodegradable Zinc Alloy Stent

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 17-28页

作者： Kun Peng Aike Qiao Makoto Ohta narendra Kurnia Putra Xinyang Cui Yongliang Mu Hitomi Anzai College of Life Science and Bioengineering Beijing University of TechnologyNo.100PingleyuanChaoyang DistrictBeijing100022China Institute of Fluid Science Tohoku UniversitySendaiMiyagi980-85777 Japan Institute of Metallurgical Research Northeastern UniversityShenyangLiaoning110819China

Biodegradable zinc alloy stents are a prospective solution for complications caused by the incompatibility between artery and permanent ***,insufficient scaffolding has limited the clinical application of biodegradable zinc alloy ***,in this study,a new stent concept was designed to improve the *** mechanical performances of the new and a traditional design stent were investigated and compared using finite element analysis(FEA).The new and traditional design stent were expanded to the intended radial displacement of 0.24 mm under the expansion pressure of 0.58 MPa and 0.45 MPa,***,a pressure load of 0.35 MPa was exerted on the outer surfaces of the two stents to compress *** results showed that the radial recoiling ratio were 45.3%and 83.3%for the new and the traditional stent,*** simulations demonstrate that the biodegradable zinc alloy stent offers enhanced support because of the new structural *** study implies that biodegradable zinc alloy stent can be a new competitive intervention device for the future clinical cardiovascular application.

关键词： Biodegradable stent design finite element analysis

Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection:A study from northern India

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World Journal of Gastroenterology 2008年第10期14卷 1498-1503页

作者： Ashish Saxena Kashi Nath Prasad Uday Chand Ghoshal Monty Roshan Bhagat narendra Krishnani Nuzhat Husain Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014 India Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014 India Department of Gastroenterology CentralCommand Hospital Lucknow 226002 India Department of Pathology Sanjay GandhiPostgraduate Institute of Medical Sciences Lucknow 226014India Department of Pathology Chhatrapati Shahu Ji Maharaj Medical University Lucknow 226001 India

AIM: To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non- ulcer dyspepsia (NUD). METHODS: We enrolled 348 adult patients (62 gastric adenocarcinoma, 45 PUD and 241 NUD) undergoing upper gastrointestinal endoscopy at two referral centers between September, 2002 and May, 2007. H pylori infection was diagnosed when any of the four tests (RUT, culture, histopathology and PCR) were positive. Genotyping for -765G > C polymorphism of COX-2 was performed by PCR-RFLP analysis. RESULTS: Frequency of C carrier had significantassociation with gastric adenocarcinoma as compared to NUD [77.4% vs 29%, P C COX-2 polymorphism with or without H pylori could be a marker for genetic susceptibility to gastric adenocarcinoma. COX-2 polymorphism in presence of H pylori infection might be useful in predicting the risk of PUD.

关键词： COX-2 polymorphism Gastric adenocarcinoma Peptic ulcer disease Helicobacter pylori infection

Chylous ascites after pancreatico-duodenectomy

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 416-419页

作者： Mansoor Ahmed Madanur narendra Battula Muhammad Omar Azam Nigel Heaton Mohamed Rela Institute of Liver Studies Kings College Hospital Denmark HillLondon SE5 9RSUK

BACKGROUND:Chylous ascites(CA) following pancreatico-duodenectomy(PD) is a rare complication secondary to disruption of the lymphatics during extended retroperitoneal lymph node dissection. The majority of cases do not develop CA,possibly due to patency of the proximal thoracic duct and good collaterals. CA may be due to a consequence of occult obstruction of the proximal thoracic duct by malignant infiltration or tumor embolus. This study was to report the incidence of CA and its outcomes of management. METHODS:A retrospective search of our liver database was performed using the 'pancreatico-duodenectomy','chylous ascites' from January 2000 to December 2005. The medical records of CA patients and their management and outcome were reviewed. RESULTS:In 138 patients who had undergone PD in our centre for pancreatic malignancy,3 were identified with CA and managed by abdominal paracentesis. CA resolved in 2 patients with low fat medium chain triglyceride diet alone and 1 patient had total parenteral nutrition(TPN) for persistent CA. Resolution of CA occurred in these 3 patients at a median follow-up of 4 weeks(range 4-12 weeks). Histologically,resected specimen confirmed pancreatic adenocarcinoma in all the patients. Two patients developed loco-regional recurrences at a median follow up of 8 months(range 6-10 months). And the other was currently disease free at a 10-month follow up. CONCLUSIONS:CA as an uncommon postoperative complication requires frequent paracentesis,prolonged hospital stay,and delayed adjuvant chemotherapy. CA istreated with low fat medium chain triglyceride diet or occasionally TPN is required.

关键词： pancreatico-duodenectomy chylous ascites delayed adjuvant chemotherapy

Spontaneous closure of stoma

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Gastroenterology Report 2016年第4期4卷 325-327,I0003页

作者： narendra Pandit Harjeet Singh Hemanth Kumar Rajesh Gupta G.R.Verma Division of Surgical Gastroenterology Department of General Surgery Post Graduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Intestinal loop stoma is a common surgical procedure performed for various benign and malignant abdominal problems,but it rarely undergoes spontaneous closure,without surgical *** male patients presented to our emergency surgical department with acute abdominal *** of them was diagnosed as having rectosigmoid perforation and underwent diversion sigmoid loop colostomy after primary closure of the *** other was a known case of carcinoma of the rectum who had already undergone low anterior resection with covering loop ileostomy;the patient underwent second loop ileostomy,this time for complicated intestinal *** our surprise,both the loop colostomy and ileostomy closed spontaneously at 8 weeks and 6 weeks,respectively,without any *** stoma closure is a rare and interesting *** exact etiology for spontaneous closure remains unknown,but it may be hypothesized to result from slow retraction of the stoma,added to the concept of a tendency towards spontaneous closure of enterocutaneous fistula.

关键词： ileostomy colostomy spontaneous closure of stoma

Review of studies on land use and land cover change in Nepal

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Journal of Mountain Science 2016年第4期13卷 643-660页

作者： Basanta PAUDEL ZHANG Yi-li LI Shi-cheng LIU Lin-shan WU Xue narendra Raj KHANAL Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBering 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Central Department of Geography Tribhuvan UniversityKirtipurKathmandu 44613Nepal

Land use and land cover(LULC) in Nepal has undergone constant change over the past few decades due to major changes caused by anthropogenic and natural factors and their impacts on the national and regional environment and *** comprehensive review of past and present studies of land use and land cover change(LUCC) in Nepal concentrates on cropland, grassland, forest, snow/glacier cover and urban areas. While most small area studies have gathered data from different sources and research over a short period, across large areas most historical studies have been based on aerial photographs such as the Land Resource Mapping Project in 1986. The recent trend in studies in Nepal is to focus on new concepts and techniques to analyze LULC status on the basis of satellite imagery, with the help of geographic information system and remote sensing tools. Studies based on historical documents, and historical and recent spatial data on LULC, have clearly shown an increase in cropland areas in Nepal,and present results indicating different rates and magnitudes. A decrease in forest and snow/glacier coverage is reported in most studies. Little information is available on grassland and urban areas from past research. The unprecedented rate of urbanization in Nepal has led to significant urban land changes over the past 30 years. Meanwhile, long term historical LUCC research in Nepal is required for extensive work on spatially explicit reconstructions on the basis of historical and primary data collection, including LULC archives and drivers for future change.

关键词： Land use Land cover Geographic information system Remote sensing Nepal

Slumping in the Upper Jurassic Baisakhi Formation of the Jaisalmer Basin, western India: Sign of synsedimentary tectonics?

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Journal of Palaeogeography 2017年第4期6卷 321-332页

作者： Matthias Alberti Dhirendra K.Pandey Jitendra K.Sharma narendra K.Swami Alfred Uchman Institut für Geowissenschaften Christian-Albrechts-Universitt zu Kiel Department of Geology University of Rajasthan Earth & Planetary Sciences Group/Palaeontology Manipal Center for Natural Sciences Manipal University Institute of Geological Sciences Jagiellonian University

A spectacularly exposed slump is described from a 120-m-long road cut between the villages of Kanod and Deva in the northeastern Jaisalmer Basin of Rajasthan,*** Upper Jurassic part of the sediments at the outcrop was formed in a near-shore setting and belongs to the Ludharwa Member of the Baisakhi *** 3-m-thick unit shows a number of asymmetric folds and thrust faults leading to an imbrication of partly lithified sandstone *** deformation structures allow the reconstruction of a movement towards the *** agrees well with the basin configuration that shows a deepening into this *** the determination of a specific trigger mechanism is difficult for soft-sediment deformation structures,an earthquake caused by synsedimentary tectonics in the basin seems to be the most likely explanation.

关键词： Sedimentology Mass movements Slumping Soft-sediment deformation structures Jaisalmer Basin Jurassic