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Pharmacology & Pharmacy 2017年第1期8卷 1-14页

作者： Sumit Bhatt Gajendra singh Sanjeev Kumar Rachna paliwal Jeet singh Jangwan Chandra pal singh Department of Chemistry SRT Campus Badshahi Thaul Tehri Garhwal University Campus of HNB Garhwal Central University Shrinagar (Uttarakhand) India Sahu Jain P.G. College Najibabad Department of Chemistry MJP Rohilkhand University Bareilly (Uttar Pradesh) India Hindu College Moradabad Department of Chemistry MJP Rohilkhand University Bareilly (Uttar Pradesh) India

A series of sulpha/substituted derivatives of phenyl azo-1,2-diazole have been synthesized and tested as an anti-inflammatory and anti-bacterial activity in mature albino rats hind paw by taking Diclofenac sodium as standard. N1-(4-hydroxy benzoyl)-3-methyl-5-phenyl-4(N-4-chlorophenylazo)-1,2-diazole is synthesized by a two-step process. In the first step, synthesis of N1-4-chlorophenyl hydrazono-1-methyl-3-phenyl propane-1,3-dione by the reciprocal action of 1-methyl-5-phenylpropane-1,3-dione and diazonium salt solution of phenyl-chloride interacts with 4-hydroxybenzoic acid hydrazide to form the final compound. These diazoles, the heterocyclic compounds which contained electron withdrawing groups, were screened for analgesic activity by acetic acid induced writing method, and for anti-inflammatory activity carried on carrageenan-induced paw edema. The synthesized substituted Chlorophenylazo-1,2-diazole nucleus exhibited significant anti-bacterial, anti-cancer, anti-inflammatory activity, muscle relaxing and moderate activity in anti-proliferative studies.

关键词： 1 2-Diazole Diuretic Activity Muscle Relaxing Anti-Inflammatory Analgesic Antibacterial Activity Anti-Proliferative Studies

Prediction of Antagonistic Activity of β-Carboline and Its Derivatives Using Topological Descriptors

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Open Journal of Applied Sciences 2021年第5期11卷 577-584页

作者： Anil Kumar Soni Gajendra pal singh Vishnu Kumar Sahu Department of Chemistry Shia Post Graduate College Lucknow India Department of Chemistry Bareilly College Bareilly India Department of Chemistry Maharani Lal Kunwari Post Graduate College Balrampur India

Prediction of antagonistic activity of β-carboline and its thirteen derivatives has been made using topological descriptors viz, connectivity index, and kappa shape index of different orders. For evaluation of values of descriptor, molecular modeling and geometry optimization of all the compounds were carried out with CAChe Pro software by opting semiempirical PM3 method using MOPAC 2002. For prediction of activity multiple linear regression analysis (MLR) was performed. MLR analysis has been made by Project Leader Software associated with CAChe by using the above descriptors as independent variables and biological activity as dependent variables. We were performed leave-one-out methods and the result reflected a direct relationship between biological activity and connectivity index of zero order, while indirect relationship with connectivity index of second order and thus connectivity index is a reliable descriptor to predict the biological activity of β-carboline and its various derivatives.

关键词： β–carboline antagonistic activity PM3 connectivity index and kappa shape index

Treating morbid obesity in cirrhosis: A quest of holy grail

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World Journal of Hepatology 2015年第28期7卷 2819-2828页

作者： Naveen Kumar narendra singh Choudhary Department of Transplant Hepatology Medanta Liver Institute Medanta the Medicity

The problem of obesity is increasing worldwide in epidemic proportions; the situation is similarly becoming more common in patients with cirrhosis which negatively affect the prognosis of disease and also makes liver transplantation difficult especially in the living donor liver transplantation setting where low graft to recipientweight ratio negatively affects survival. Treatment of obesity is difficult in cirrhosis due to difficulty in implementation of lifestyle measures, limited data on safety of anti-obesity drugs and high risk of surgery. Currently approved anti-obesity drugs have limited data in patients with cirrhosis. Bariatric surgery remains an option in selected compensated cirrhotic patients. Endoscopic interventions for obesity are emerging and are quite promising in patients with cirrhosis as these are minimally invasive. In present review, we briefly discuss various modalities of weight reduction in obese patients and their applicability in patients with cirrhosis.

关键词： Obesity Intragastric balloon Antiobesitydrugs Bariatric surgery Cirrhosis

长丝市场——论当前的旦数细分和应用分支市场

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纺织导报 2009年第7期 67-69页

作者： Suprit pal singh Michael Korobczuk 澳大利亚墨尔本RMIT大学时尚和纺织学院欧瑞康巴马格公司

长丝市场在过去10年已经达到了前所未有的成熟，行业对其已有非常明确的细分。在这篇短文中，笔者将根据现有的市场架构按不同聚合物呈现相关长丝细分市场的一些数据。

关键词：细分市场长丝应用旦数聚合物

Blast Induced Damage to Surrounding Rock Mass in an Underground Excavation

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Journal of Geological Resource and Engineering 2014年第1期2卷 13-19页

作者： Harsh Kumar Verma narendra Kumar Samadhiya Mahendra singh Vilugundam Venkat Ramana Prasad CSIR-Central Institute of Mining and Fuel Research Roorkee 247667 India Department of Civil Engineering Indian Institute of Technology Roorkee 247667 India

Authors have conducted experiments to measure blast induced rock mass damage at L＆T-（Singoli-Bhatwari Hydro-Power Project SBHP） Rudraprayag. Repetitive NX size rock core up to 5.0 m depth were taken from side wall and face with triple tube core barrel drill. CR （core recovery） and RQD （rock quality designation） of the rock cores is computed to evaluate effect of blasting on the surrounding rock mass. RQD and CR values for the initial one meter from the line of excavation in each case reflect maximum damage due to blast. RQD for initial one meter reduced to as high as 40% of the average RQD. The rock samples were also tested using ultrasonic techniques. Ultrasonic tests on NX size core reveal that the 2.0 m of the zone surrounding the opening are adversely affected by the tunnel excavation blasting process. The ultrasonic velocities reduce to approx. 80% of the average values in the initial 0.5 m from the excavation line.

关键词： Blast induced damage ultrasonic velocity RQD and core recovery.

Evaluation of Topical Application of Azadirachta indica(Neem) in Prevention of Gingivitis: A Randomized Control Trial

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Open Journal of Stomatology 2019年第11期9卷 249-259页

作者： Vibha singh Anjani Kumar Pathak Kopal Goel Mahesh pal King George’s Medical University Lucknow India Department of Periodontology Faculty of Dental Sciences King George’s Medical University Lucknow India Sardar Patel Post Graduate Institute of Dental and Medical Sciences Lucknow India Phytochemistry Division CSIR-National Botanical Research Institute Lucknow India

Background: The purpose of the present study was to envisage the anti-plaque and anti-inflammatory properties of neem (Azadirachta) in the form of a mouth gel. Materials and Methods: A total of 60 subjects (33 males and 27 females) from age group 19 - 35 years, suffering from mild to moderate gingivitis were randomly divided into two groups. Group A (n = 30) participants were advised experimental (neem) gel and Group B (n = 30) participants were advised 0.2% chlorhexidine gel. All the clinical parameters (the gingival index by Loe and Silness [1], Plaque index by Silness and Loe [2] and sulcus bleeding index by Muhlemann H. R. and Sen S. [3]) were recorded at baseline, on the 14th day and 21st day by the same clinician in both groups. Results: on intragroup comparison the gingival index, plaque index and sulcus bleeding index decrease significantly in both the groups in all assessed periods. On intergroup comparison the indices did not differ significantly at baseline but after 2nd and 3rd week, the indices in Group B decrease more than the group A, which was statistically significant. Conclusion: Based on the observations of our study, it can be concluded that chlorhexidine gluconate as well as neem gel can be effectively used as an adjunct to mechanical plaque control in prevention of plaque and gingivitis. chlorhexidine gluconate gel has been found to be more effective when antiplaque and anti-inflammatory properties were considered. The effect of neem observed maybe because of its anti-inflammatory action. The antiplaque action of chlorhexidine gluconate is due to its substantivity. Substantivity of neem is required to be further studied.

关键词： Azadirachta Gingivitis. Anti Plaque

Adansonia digitata L.(baobab):a review of traditional information and taxonomic description

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 79-84页

作者： Jitin Rahul Manish Kumar Jain Shishu pal singh Rakesh Kant Kama Anuradha Aliya Naz Anup Kumar Gupta Sujeet Kumar Mrityunjay Centre of Mining Environment Department of Environmental Science&EngineeringIndian School of Mines Department of Botany Dayanand Brajendra Swarup College Centre of Mining Environment Department of Environmental Science&EngineeringIndian School of MinesDhanbad-826004JharkhandIndia

Adansonia digitata L.(Malvaceae) is commonly known as baobab tree native to *** is a multi-purpose tree which offers protection and provides food,clothing and medicine as well as raw material for many useful *** fruit pulp,seeds,leaves,***,and bark of baobab are edible and they have been studied by scientists for their useful *** fruit pulp have very high vitamin ***,phosphorus,carbohydrates,fibers,potassium,proteins and lipids content,which can be used in seasoning as an appetizer and also make *** contain appreciable quantities of phosphorus,magnesium,zinc,sodium,iron,manganese,whereas they have high levels of lysine,thiamine,calcium and *** has numerous biological properties including antimicrobial,anti-malarial,diarrhoea,anaemia,asthma,antiviral,anti-oxidant and anti-inflammatory activities amongst *** investigation revealed the presence of *** acids,fatty acids,vitamins and *** review summarizes the information on various aspects of traditional information,taxonomic description,medicinal properties and importantly nutritional value.

关键词： Adansonia digitata Baobab Traditional information Taxonomic description

Structural and Electrical Characteristics of Ba(Fe0.5Nb0.5)O3-SrTiO3Ceramic System

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Materials Sciences and Applications 2011年第11期2卷 1593-1600页

作者： narendra Kumar singh Pritam Kumar Ajay Kumar Sharma Ram Naresh Prasad Choudhary 不详

A complex structure of barium iron niobate, Ba(Fe0.5Nb0.5)O3 (BFN) and strontium titanate SrTiO3 (ST) was fabricated by a solid-state reaction method. The phase formation of Ba(Fe0.5Nb0.5)O3-SrTiO3 was checked using X-ray diffraction (XRD) technique. The X-ray structural analysis of BFN and BFN-ST ceramics, showed the formation of single-phase compound in the monoclinic system, which is a distorted structure of an ideal cubic perovskite. Careful examination of microstructures of the individual compounds of the system was done by the scanning electron micrograph (SEM), and confirms the polycrystalline nature of the systems. Detailed studies of dielectric and electrical impedance properties of the systems in a wide range of frequency (100Hz - 5MHz) and different temperatures (30°C-285°C) showed that these properties are strongly dependent on temperature and frequency.

关键词： Dielectrics Perovskite Oxides X-Ray Diffraction Scanning Electron Micrograph

Effect of Transmission Range on Ad Hoc on Demand Distance Vector Routing Protocol

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Journal of Computer and Communications 2016年第2期4卷 34-46页

作者： Mohammad Izharul Hasan Ansari Surendra pal singh Mohammad Najmud Doja Department of Computer Science & Engineering NIMS University Jaipur India Department of Computer Science & Engineering NIMS University Jaipur India Department of Computer Engineering JMI University New Delhi India

The necessary background as well as the details of simulation was presented to simulate and evaluate the performance of the ad hoc on-demand distance vector routing protocol in mobile ad hoc network with the help of the network simulator NS2 using the common transmission range to deliver the data packets at the destination node. The number of participating nodes played an important role to predict the conditions for the best performance of the protocol with respect to throughput, delay, packet delivery ratio, drop packets, consumed and residual energy of the network. Further, the efforts can be put to control the transmission range dynamically and overheads for reducing the energy consumption in the network and improving its lifetime of the nodes and the lifespan of the network.

关键词： MANET Routing Protocol Network Simulator Transmission Range Throughput Delay Packet Delivery Ratio Energy Consumption Efficiency and Lifetime

Nonunion of coronal shear fracture of femoral condyle

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Chinese Journal of Traumatology 2011年第3期14卷 143-146页

作者： Ajay pal singh Ish Kumar Dhammi Raju Vaishya Anil Kumar Jain Arun pal singh Prashant Modi Punjab Civil Medical Services Mukerian Punjab India Department of Orthopedics UCMS & GTB Hospital Delhi India Department of Orthopedics and Traumatology Indraprastha Apollo Hospital Delhi India S.P.N. Hospital Mukerian Punjab India

Isolated coronal fractures of femoral condyle are rare in adults and nonunion of Hoffa fracture is reported only a few times in the literature. We analyzed six cases of nonunion of Hoffa fractures over a period of three years. Three patients were treated conservatively and three patients had fixation failures. Delay of presentation was 2 months to one year. Treatment protocol consisted of open reduction, excision of pseudoarthrosis, bone grafting and internal fixation along with knee arthrolysis. Union wasachieved in all patients at mean 16 weeks. The treatment of nonunion of Hoffa fractures requires careful preoperative planning and meticulous surgical technique. The literature regarding the controversies in fracture management and surgical technique are reviewed.

关键词： Femoral fracture Fracture ftxation internal Retrospective studies