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Ascorbic acid and curcumin alleviate abnormal estrous cycle and morphological changes in cells induced by repeated ultraviolet B radiations in female Wistar rats

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Asian pacific Journal of Reproduction 2020年第3期9卷 142-147页

作者： Gayatri Rai narendra namdev Payal Mahobiya Department of Zoology Dr Harisingh Gour(A Central University)VishwavidhyalayaSagar(M.P.)India

Objective: To study the protective effect of ascorbic acid and curcumin against the abnormal estrous cycle and morphological changes in cells induced by repeated ultraviolet B(UVB)radiation in female Wistar ***: Sixteen female sexually mature Wistar rats weighing 130-150 g and aged 12-16 weeks were randomly divided into four *** control group received normal food and water ad *** UVB group was exposed to a dose of 280 nm of UVB radiation for 2 h *** UVB+curcumin group received a dose of 280 nm of UVB radiation for 2 h daily and also an oral dose of curcumin(25 mg/kg body weight)*** UVB+ascorbic acid group received a dose of 280 nm of UVB radiation for 2 h daily and also an oral dose of ascorbic acid(250 mg/kg body weight)*** the treatments last for 15 consecutive *** and ovary weight and gonadosomatic index were *** stages(proestrus,estrus,metaestrus and diestrus)of the estrous cycle were determined by the cell types observed in the vaginal ***: UVB radiation caused irregular alterations on the estrous cycle and morphological changes of the female Wistar rat as compared with the control *** acid and curcumin protected UVB-induced estrous phases and their *** curcumin showed greater protection than ascorbic ***: Ascorbic acid and curcumin at low doses can alleviate abnormal estrous cycle and morphological changes in cells induced by UVB radiations in female Wistar rats.

关键词： Estrous cycle Ultraviolet-B radiation Vaginal smear Ascorbic acid Curcumin

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