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Computational Molecular Bioscience 2023年第2期13卷 21-34页

作者： Elizabeth Cagle Brent Lake Anasua banerjee Jazmine Cuffee narendra banerjee Darla Gilmartin Makaiyah Liverman Shennel Brown Erik Armstrong Santanu Bhattacharya Somiranjan Ghosh Tanmoy Mandal Hirendra banerjee Department of Natural Health and Human Sciences Elizabeth City State University Campus of The University of North Carolina Elizabeth NC USA Department of Biochemistry and Molecular Biology Mayo College of Medicine and Science Jacksonville FL USA Department of Physiology and Biomedical Engineering Mayo College of Medicine and Science Jacksonville FL USA Departments of Pediatrics and Child Health College of Medicine Howard University Washington DC USA

Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.

关键词： Triple Negative Breast Cancer Epithelial to Mesenchymal Transition Core Canonical Pathways

A Study of Differential Gene Expression and Core Canonical Pathways Involved in Rhenium Ligand Treated Epithelial Mesenchymal Transition (EMT) Induced A549 Lung Cancer Cell Lines by INGENUITY Software System

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Computational Molecular Bioscience 2022年第1期12卷 12-19页

作者： Christopher Krauss Chelsey Aurelus Kayla Johnston Joseph Hedley Satyendra banerjee Sarah Wisniewski Quentin Reaves Khadimou Dia Shenell Brown Victoria Bartlet Sheritta Gavin Jazmine Cuffee narendra banerjee Kuldeep Rawat Santosh Mandal Zahidur Abedin Somiranjan Ghosh Hirendra banerjee Department of Natural Sciences and Department of Health and Human Studies Elizabeth City State University University of NC Elizabeth City NC USA Department of Chemistry Morgan State University Baltimore MD USA PrimBio Research Institute LLC Exton PA USA Department of Pediatrics and Child Health Howard University Medical School Washington DC USA

Rhenium compounds have shown anti-cancer properties against many different types of cancer cell lines;however, the cellular signaling mechanisms involved in the cytotoxic properties of rhenium-based compounds were never deciphered or reported. In this manuscript, we report the results of an investigation done by RNA sequencing of rhenium treated A549 lung cancer cell lines along with an untreated vehicular control, analyzed by the Ingenuity Pathway Analysis (IPA) software system to decipher the core canonical pathways involved in rhenium induced cancer cell death. A549 EMT lung cancer cell lines were treated with rhenium ligand (Tricarbonylperrhenato(bathocuproine)rhenium(I), PR7) for seven days along with vehicular control. RNA was isolated from the treated and control cells and sequenced by a commercial company (PrimBio Corporation). The RNA sequencing data was analyzed by the INGNUITY software system and the core canonical pathways involved with differential gene expression were identified. Our report is showing that there are several cellular pathways involved in inducing cell death by rhenium-based compound PR7.

关键词： Rhenium Compounds Lung Cancer Epithelial

Improved Dynamic Johnson Sequencing Algorithm(DJS)in Cloud Computing Environment for Efficient Resource Scheduling for Distributed Overloading

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 391-424页

作者： Anurag Sinha Pallab banerjee Sharmistha Roy Nitasha Rathore narendra Pratap Singh Mueen Uddin Maha Abdelhaq Raed Alsaqour Department of Computer Science Engineering ICFAI Tech SchoolICFAI UniversityJharkhandRanchi834004India Department of Computer Science Engineering Amity UniversityJharkhandRanchi835303India Department of Computing and Information Technology Usha Martin UniversityRanchi835103India Department of Information Technology Bharti Vidyapeeth’s College of EngineeringPaschim ViharNew DelhiIndia Department of CSE Delhi UniversityNew DelhiIndia College of Computing and Information Technology University of Doha for Science and TechnologyDoha24449Qatar Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdurrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Technology College of Computing and InformaticsSaudi Electronic University93499RiyadhSaudi Arabia

This study introduces an innovative approach to optimize cloud computing job distribution using the Improved Dynamic Johnson Sequencing Algorithm(DJS).Emphasizing on-demand resource sharing,typical to Cloud Service Providers(CSPs),the research focuses on minimizing job completion delays through efficient task *** Johnson’s rule from operations research,the study addresses the challenge of resource availability post-task *** advocates for queuing models with multiple servers and finite capacity to improve job scheduling models,subsequently reducing wait times and queue *** Dynamic Johnson Sequencing Algorithm and the M/M/c/K queuing model are applied to optimize task sequences,showcasing their efficacy through comparative *** research evaluates the impact of makespan calculation on data file transfer times and assesses vital performance indicators,ultimately positioning the proposed technique as superior to existing approaches,offering a robust framework for enhanced task scheduling and resource allocation in cloud computing.

关键词： First come first served(FCFS)scheduling round robin task scheduling queuing model Johnson scheduling algorithm

Additive friction stir deposition of AZ31B magnesium alloy

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Journal of Magnesium and Alloys 2022年第9期10卷 2404-2420页

作者： Sameehan S.Joshi Shreyash M.Patil Sangram Mazumder Shashank Sharma Daniel A.Riley Shelden Dowden Rajarshi banerjee narendra B.Dahotre Department of Materials Science and Engineering University of North Texas3940 N Elm StDentonTX 76207USA Center for Agile and Adaptive Additive Manufacturing University of North Texas3940 N Elm StDentonTX 76207USA

The current work explored additive friction stir deposition of AZ31B magnesium alloy with the aid of MELD?***31B magnesium bar stock was fed through a hollow friction stir tool rotating at constant velocity of 400 rpm and translating at linear velocity varied from 4.2 to 6.3 mm/s.A single wall consisting of five layers with each layer of 140×40×1 mm^(3)dimensions was deposited under each processing ***,phase,and crystallographic texture evolutions as a function of additive friction stir deposition parameters were studied with the aid of scanning electron microscopy including electron back scatter diffraction and X-ray *** feed material and additively produced samples consisted of theα-Mg *** additively produced samples exhibited a refined grain structure compared to the feed *** feed material appeared to have a weak basal texture,while the additively produced samples experienced a strengthening of this basal *** additively produced samples showed a marginally higher hardness compared to the feed *** current work provided a pathway for solid state additive manufacturing of Mg suitable for structural applications such as automotive components and consumable biomedical implants.

关键词： Additive friction stir deposition Magnesium alloys Additive manufacturing Thermomechanical processing Materials processing Solid state additive manufacturing

Triaxial strength behaviour of rockmass satisfying Modified Mohr-Coulomb and Generalized Hoek-Brown criteria

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International Journal of Mining Science and Technology 2018年第6期28卷 901-915页

作者： Saurav Rukhaiyar narendra Kumar Samadhiya Department of Civil Engineering Indian Institute of Technology Roorkee

The triaxial strength of twenty rockmass types was predicted using two non-linear triaxial strength criteria for rockmass i.e. Modified Mohr-Coulomb(MMC) criterion and Generalized Hoek-Brown(GHB)criterion. Four different rockmass classification systems were used for the calculation of MMC criterion parameters while only GSI classification system has been used for calculation of GHB parameters. The representative value of the uniaxial compressive strength and elastic modulus of rockmass have been estimated using probabilistic approach. A hypothetical case of an unsupported tunnel has been analyzed considering both MMC and GHB criteria. The analysis was done using the convergence-confinement method with two different approaches. The first approach predicts the tunnel response using GHB criterion directly. The second approach predicts the tunnel response using equivalent Mohr-Coulomb parameters obtained by linearization of triaxial data points obtained from MMC and GHB criteria. The tunnel response has been estimated in terms of radius of plastic zone, tunnel convergence and tunnel convergence strain. For very poor rockmasses the tunnel response predicted by MMC criterion is less than that predicted by GHB criterion. For poor and fair rockmass, the tunnel response estimated considering both the criteria are comparable except for few cases. Squeezing condition in rockmass has been also evaluated.

关键词： Triaxial strength Modified Mohr-Coulomb criterion Generalised Hoek-Brown criterion Convergence-confinement method

Strength behaviour of sandstone subjected to polyaxial state of stress

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International Journal of Mining Science and Technology 2017年第6期27卷 889-897页

作者： Rukhaiyar Saurav Samadhiya narendra Kumar Department of Civil Engineering Indian Institute of Technology Roorkee Roorkee 247667 India

The paper presents an experimental investigation on the strength behaviour of natural rock subjected to polyaxial state of stress. The polyaxial tests were conducted on cubical specimens of sandstone obtained from the Shivpuri district in Madhya Pradesh state of India, The specimens having nominal dimensions of100 mm x 100 mm x 100 mm were tested using a polyaxial testing machine. Twenty-five combinations of intermediate and minor principal stresses were applied and the specimens were loaded till failure occurs. It was observed that the intermediate principal stress has a substantial effect on the strength of the Shivpuri sandstone. A database of rock strength under various combinations of σ_2 and σ_3 was obtained for the Shivpuri sandstone. The database was used to study the predictability of five most commonly used strength criterion. Root mean square error(RMSE), average absolute relative error percentage(AAREP) and coefficient of accordance(COA) were used as indices for the measure of goodness of fit. It was observed that the least error in the prediction was shown by modified Mohr Coulomb criterion followed by modified Weibols and Cook criterion. A probability analysis of the error in prediction was also done.

关键词： Polyaxial testing Sandstone Strength criterion Modified Mohr-Coulomb criterion Modified Weibols and Cook criterion

Recent advances in catalytic combustion of AP-based composite solid propellants

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Defence Technology（防务技术） 2021年第3期17卷 1013-1031页

作者： narendra Yadav Prem Kumar Srivastava Mohan Varma Department of Space Engineering&Rocketry India Department of Chemistry Birla Institute of TechnologyMesraRanchiIndia

Composite solid propellants(CSPs) have widely been used as main energy source for propelling the rockets in both space and military applications. Internal ballistic parameters of rockets like characteristic exhaust velocity, specific impulse, thrust, burning rate etc., are measured to assess and control the performance of rocket motors. The burn rate of solid propellants has been considered as most vital parameter for design of solid rocket motors to meet specific mission requirements. The burning rate of solid propellants can be tailored by using different constituents, extent of oxidizer loading and its particle size and more commonly by incorporating suitable combustion catalysts. Various metal oxides(MOs),complexes, metal powders and metal alloys have shown positive catalytic behaviour during the combustion of CSPs. These are usually solid-state catalysts that play multiple roles in combustion of CSPs such as reduction in activation energy, enhancement of rate of reaction, modification of sequences in reaction-phase, influence on condensed-phase combustion and participation in combustion process in gas-phase reactions. The application of nanoscale catalysts in CSPs has increased considerably in recent past due to their superior catalytic properties as compared to their bulk-sized counterparts. A large surface-to-volume ratio and quantum size effect of nanocatalysts are considered to be plausible reasons for improving the combustion characteristics of propellants. Several efforts have been made to produce nanoscale combustion catalysts for advanced propellant formulations to improve their energetics. The work done so far is largely scattered. In this review, an effort has been made to introduce various combustion catalysts having at least a metallic entity. Recent developments of nanoscale combustion catalysts with their specific merits are discussed. The combustion chemistry of a typical CSP is briefly discussed for providing a better understanding on role of co

关键词： Composite solid propellants Burn rate modifier Metallic nano-catalysts Catalytic combustion Thermal decomposition

Challenges,opportunities,and advances related to COVID-19 classification based on deep learning

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Data Science and Management 2023年第2期6卷 98-109页

作者： Abhishek Agnihotri narendra Kohli Department of Computer Science and Engineering Harcourt Butler Technical UniversityKanpur208002India

The novel coronavirus disease,or COVID-19,is a hazardous *** is endangering the lives of many people living in more than two hundred *** directly affects the *** general,two main imaging modalities,i.e.,computed tomography(CT)and chest x-ray(CXR)are used to achieve a speedy and reliable medical *** the coronavirus in medical images is exceedingly difficult for diagnosis,assessment,and *** is demanding,time-consuming,and subject to human *** biological disciplines,excellent performance can be achieved by employing artificial intelligence(AI)*** a subfield of AI,deep learning(DL)networks have drawn considerable attention than standard machine learning(ML)*** models automatically carry out all the steps of feature extraction,feature selection,and *** study has performed comprehensive analysis of coronavirus classification using CXR and CT imaging modalities using DL ***,we have discussed how transfer learning is helpful in this ***,the problem of designing and implementing a system using computer-aided diagnostic(CAD)to find COVID-19 using DL approaches highlighted a future research possibility.

关键词： Classification COVID-19 Coronavirus Deep learning CAD system

Battery energy storage-based system damping controller for alleviating sub-synchronous oscillations in a DFIG-based wind power plant

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Protection and Control of Modern Power Systems 2023年第2期8卷 260-277页

作者： Neevatika Verma narendra Kumar Rajeev Kumar Department of Electrical Engineering Delhi Technological UniversityNew DelhiIndia Electrical Engineering Department Jamia Millia IslamiaNew DelhiIndia Electrical and Electronics Engineering Department KIET Group of InstitutionsGhaziabadIndia

This paper presents the issue of the Sub-synchronous resonance(SSR)phenomenon in a series compensated DFIG-based wind power plant and its alleviation using a Battery Energy Storage-based Damping Controller(BESSDCL).A supplementary damping signal is developed considering the angular speed deviation and is incorporated into the BESS control ***-area Measurement System data is used to determine the angular speed deviation.A lin-earized system model is developed to perform eigenvalue analysis,and to detect and examine unstable SSR *** variation of wind speed and three-phase fault are also taken into consideration to validate the robustness of the *** further verify the efficacy of the proposed damping controller,time-domain simulations are performed using MATLAB/*** application of the proposed BESSDCL stabilizes all the unstable system modes effectively at wind speeds of 7 m/s,9 m/s,and 11 m/s,and at 40%,50%,and 60%series compensation levels,as well three-phase fault conditions.

关键词： Battery energy storage system Damping controller Doubly-fed induction generator(DFIG) Series

Understanding the effects of intramuscular injection and feed withdrawal on Salmonella Typhimurium shedding and gut microbiota in pullets

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Journal of Animal Science and Biotechnology 2022年第1期13卷 123-137页

作者： Nitish narendra Joat Samiullah Khan Kapil Chousalkar School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Background:Gut microbiota plays a key role in health,immunity,digestion,and production in *** such as environment,diet,diseases,stress,and flock management significantly affect gut microbiota;however,it is not known how potential stressors such as intramuscular injections or feed withdrawal alter the composition of gut microbiota that result in increased the shedding level of foodborne *** the current study,the effects of intramuscular corticosterone injection and feed withdrawal were evaluated to understand their role in Salmonella Typhimurium shedding and changes in the composition of gut microbiota in ***:Salmonella shedding was observed for 8 weeks *** was a significant increase in Salmonella Typhimurium count after intramuscular injection and feed *** Salmonella infected and the negative control groups showed significant differences in the abundance of different genera in gut microbiota at week 1 and up to week 7 post *** infected group showed a significant reduction in alpha diversity of gut *** reduced significantly(P<0.05)after intramuscular injection,while the feed withdrawal groups did not cause any significant changes in Proteobacteria-Firmicutes ***,intramuscular injection resulted in a significant change in alpha diversity of gut ***:Exposure of chicks to relatively low dose of Salmonella Typhimurium can lead to persistent shedding in *** Salmonella Typhimurium infection disrupted the gut microbiota composition immediately after *** potential stress of intramuscular injection and feed withdrawal significantly increased the Salmonella Typhimurium count in *** intramuscular injection also resulted in a significant alteration of the Proteobacteria-Firmicutes ratio,which could increase the risk of dysbiosis.

关键词： Corticosterone injection Feed withdrawal stress Gut microbiota composition Layer chicken Salmonella Typhimurium infection