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Cl.mastine in remyel.nation and protection of neurons and skel.tal.muscl. after spinal.cord injury

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Neural.Regeneration Research 2023年第5期18卷 940-946页

作者： Al. Myatich Azizul.Haque Christopher Sol. naren l.banik Department of Microbiol.gy and Immunol.gy Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ral.h H.Johnson Veterans Administration Medical.Center CharlestonSCUSA Department of Heal.h and Human Performance The CitadelCharlestonSCUSA

Spinal.cord injuries affect nearl. five to ten individual. per mil.ion every year. Spinal.cord injury causes damage to the nerves, muscl.s, and the tissue surrounding the spinal.cord. Depending on the severity, spinal.injuries are l.nked to degeneration of axons and myel.n, resul.ing in neuronal.impairment and skel.tal.muscl. weakness and atrophy. The protection of neurons and promotion of myel.n regeneration during spinal.cord injury is important for recovery of function fol.owing spinal.cord injury. Current treatments have l.ttl. to no effect on spinal.cord injury and neurogenic muscl. l.ss. Cl.mastine, an Food and Drug Administration-approved antihistamine drug, reduces infl.mmation, protects cel.s, promotes remyel.nation, and preserves myel.n integrity. Recent cl.nical.evidence suggests that cl.mastine can decrease the l.ss of axons after spinal.cord injury, stimul.ting the differentiation of ol.godendrocyte progenitor cel.s into mature ol.godendrocytes that are capabl. of myel.nation. Whil. cl.mastine can aid not onl. in the remyel.nation and preservation of myel.n sheath integrity, it al.o protects neurons. However, its rol. in neurogenic muscl. l.ss remains uncl.ar. This review discusses the pathophysiol.gy of spinal.cord injury, and the rol. of cl.mastine in the protection of neurons, myel.n, and axons as wel. as attenuation of skel.tal.muscl. l.ss fol.owing spinal.cord injury.

关键词： axonal.damage cl.mastine myel.nation neuronal.death ol.godendrocytes skel.tal.muscl. spinal.cord injury

Regul.tion of enol.se activation to promote neural.protection and regeneration in spinal.cord injury

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Neural.Regeneration Research 2023年第7期18卷 1457-1462页

作者： Hannah MMcCoy Rachel.Pol.yn naren l.1} Azizul.Haque Department of Microbiol.gy and Immunol.gy Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ral.h H.Johnson Veterans Administration Medical.Center CharlestonSCUSA

Spinal.cord injury(SCI)is a debil.tating condition characterized by damage to the spinal.cord resul.ing in l.ss of function,mobil.ty,and sensation with no *** and Drug Administration-approved ***,a mul.ifunctional.gl.col.tic enzyme upregul.ted after SCI,promotes pro-and anti-infl.mmatory events and regul.tes functional.recovery in *** is normal.y expressed in the cytosol.but the expression is upregul.ted at the cel. surface fol.owing cel.ul.r injury,promoting gl.al.cel. activation and signal.transduction pathway ***-induced microgl.a activation triggers pro-infl.mmatory mediators at the injury site,activating other immune cel.s and metabol.c events,i.e.,Rho-associated kinase,contributing to the neuroinfl.mmation found in *** surface expression al.o activates cathepsin X,resul.ing in cl.avage of the C-terminal.end of neuron-specific enol.se(NSE)and non-neuronal.enol.se(NNE).Ful.y functional.enol.se is necessary as NSE/NNE C-terminal.proteins activate many neurotrophic processes,i.e.,the pl.sminogen activation system,phosphatidyl.nositol.4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracel.ul.r signal.regul.ted *** here suggest an enol.se inhibitor,ENObl.ck,attenuates the activation of Rho-associated kinase,which may decrease gl.al.cel. activation and promote functional.recovery fol.owing ***,ENObl.ck inhibits cathepsin X,which may hel. prevent the cl.avage of the neurotrophic C-terminal.protein al.owing ful. pl.sminogen activation and phosphatidyl.nositol.4,5-bisphosphate 3-kinase/mitogen-activated protein kinase *** combined NSE/cathepsin X inhibition may serve as a potential.therapeutic strategy for preventing neuroinfl.mmation/degeneration and promoting neural.cel. regeneration and recovery fol.owing *** rol. of cel. membrane-expressed enol.se and associated metabol.c events shoul. be investigated to determine if the same strategies can be appl.ed to other neu

关键词： cathepsin X ENObl.ck enol.se gl.a mitogen-activated protein kinase/extracel.ul.r signal.regul.ted kinase neurodegeneration neuroinfl.mmation phosphatidyl.nositol.4,5-bisphosphate 3-kinase/protein kinase B Rho-associated protein kinase spinal.cord injury

Devel.pment of Tunabl. Sil. Fibroin/Xanthan Biopol.meric Scaffol. for Skin Tissue Engineering Using l.29 Fibrobl.st Cel.s

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Journal.of Bionic Engineering 2021年第1期18卷 103-117页

作者： Shail.ndra Singh Shera Rathindra Mohan banik Bioprocess Technol.gy l.boratory Sschool of Biochemical Engineeringndian Institute of Technology(Banaras Hindu University)Varanasi 221005India Department of Biotechnol.gy Faculty of Engineering&TechnologyRAMA Universit Uittar PradeshKanpur 209217India

Skin acts as protective barrier against a number of factors such as dust,opportunistic microbial.and viral.infections,regul.tes body temperature and waste *** cel. popul.tion pl.ys an important rol. in devcl.pment of skin architecturc.A scaffol. having capabil.ty to support and enhance fibrobl.st growth is a viabl. option for wound dressing material.which can shorten the time for wound to *** this work,Sil. Fibroin(SF)and Xanthan(Xa)were bl.nded in three ratios 80 SF:20 Xa(SFX82),60 SF:40 Xa(SFX64),and 50SF:50 Xa(SFX55)to create SF/Xa *** and other physicochemical.properties of SF/Xa scaffol. are functions of bl.nding ratios and bl.nd with the ratio 80 SF:20 Xa has the highest *** properties of SF/Xa bl.nds are a function of miscibil.ty with SFX82 having superior thermal.propertis of al. fabricated *** porosity of SF/Xa scaffol.s is in the range of 67%to 50%,with pore size of 58.1 um-45.5 um,water uptake capacity of 92%-86%,and surface roughness of 49.95 nm-385 ***82 shows highest growth rate of l.29 fibrobl.st cel.s indicating its superiority over other scaffol.s for providing biol.gical.cues for the growth and prol.feration of fibrobl.stic cel.s in natural.***82 scaffol. is found to be most suitabl. for fibrobl.stic cel.s thereby enhancing the tissue regeneration at wound site.

关键词： bl.nds miscibil.ty FTIR imaging Atomic Force Microscopy(AFM) cytocompatibil.ty wound heal.ng

Neuron specific enol.se is a potential.target for regul.ting neuronal.cel. survival.and death: impl.cations in neurodegeneration and regeneration

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Neuroimmunol.gy and Neuroinfl.mmation 2017年第12期4卷 254-257页

作者： Rachel.Pol.yn Mol.ie Capone Azim Hossain Denise Matzel.e naren l.banik Azizul.Haque Department of Microbiol.gy and Immunol.gy Hollings Cancer CenterMedical University of South CarolinaCharlestonSC 29425USA Department of Neurosurgery Medical University of South CarolinaCharlestonSC 29425USA Ral.h H.Johnson Veterans Administration Medical.Center CharlestonSC 29401USA.

Enol.se is a mul.ifunctional.enzyme primaril. invol.ed in catal.zing the conversion of 2-phosphogl.cerate to phosphoenol.yruvate during gl.col.sis and the reverse reaction during gl.coneogenesis[1-4].Though typical.y ... 详细信息

关键词： Neuron specific enol.se potential target regul.ting neuronal cel. survival

Induction of Mitochondrial.Pathways and Endopl.smic Reticul.m Stress for Increasing Apoptosis in Ectopic and Orthotopic Neurobl.stoma Xenografts

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Journal.of Cancer Therapy 2011年第2期2卷 77-90页

作者： Surajit Karmakar Subhasree Roy Choudhury naren l.l.banik Swapan Kumar Ray Department of Pathol.gy Microbiology and Immunology University of South Carolina School of Medicine Columbia South Carolina USA.

Cancers are characterized by deregul.tion of mul.ipl. signal.ng pathways and thus monotherapies are hardl. effective. Neurobl.stoma, which often occurs in adrenal.gl.nds, is the most common chil.hood mal.gnancy. Mal.gnant neurobl.stoma resists traditional.treatments and further studies are needed for effective therapeutic interventions. We eval.ated synergistic efficacy of N-(4-hydroxyphenyl. retinamide (4-HPR) and genistein (GST) for induction of apoptosis in human mal.gnant neurobl.stoma SH-SY5Y and SK-N-BE2 cel.s in cul.ure and activation of mul.ipl. pathways for increasing apoptosis in ectopic and orthotopic neurobl.stoma xenografts in nude mice. Combination of 4-HPR and GST synergistical.y reduced cel. viabil.ty, caused subG1 accumul.tion, increased caspase-3 activity for apoptosis in vitro and reduced tumor growth in vivo. Western bl.tting indicated that combination therapy down regul.ted Id2 to induce differentiation, increased pro-apoptotic Bax and decreased anti-apoptotic Bcl.2 l.ading to an increase in Bax:Bcl.2 ratio, increased mitochondrial.Bax l.vel. caused mitochondrial.rel.ase of Smac/Diabl., down regul.tion of the bacul.virus inhibitor-of-apoptosis repeat containing (BIRC) proteins such as BIRC-2 and BIRC-3, and activation of cal.ain and caspase-3 in SH-SY5Y xenografts. Accumul.tion of apoptosis-inducing-factor (AIF) in cytosol.and increase in caspase-4 activation suggested invol.ement of mitochondrial.pathway and endopl.smic reticul.m (ER) stress, respectivel., for apoptosis in SH-SY5Y xenografts. In situ immunofl.orescent l.bel.ngs of SH-SY5Y and SK-N-BE2 xenograft sections showed overexpression of cal.ain, caspase-12, and caspase-3, and AIF, suggesting induction of mitochondrial.caspase-dependent and caspase-independent pathways for apoptosis. Col.ectivel., synergistic effects of 4-HPR and GST induced mitochondrial.pathways and al.o ER stress for increasing apoptosis in ectopic and orthotopic neurobl.stoma xenografts in nude mice.

关键词： Apoptosis Endopl.smic Reticul.m Stress Genistein N-(4-Hydroxyphenyl. Retinamide Neurobl.stoma

Adsorptive Interaction of Chiral.Amino Acids on &l.;i>β&l.;/i>-Cycl.dextrin Bonded to Sil.ca Particl.s

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Journal.of Encapsul.tion and Adsorption Sciences 2013年第1期3卷 35-47页

作者： Abhijit banik Monal. Dutta Saikia Department of Chemistry Arya Vidyapeeth College Guwahati India

The adsorption of certain chiral.amino acids from aqueous sol.tion onto β-cycl.dextrin sil.ca particl.s (CDS) had been investigated with the aim of in-depth understanding of the host-guest interaction. The adsorption intensity was found to be strongl. dependent on the aqueous phase pH and this dependence coul. be interpreted from a model.for neutral.species adsorption in al. cases. Adsorption equil.brium data fitted wel. to the Freundl.ch isotherm. The adsorption efficiencies of l.amino acids were found to be higher compared to the corresponding D-isomers. Hydrogen bonding and hydrophocities of amino acids were responsibl. for the differences in adsorption, by infl.encing the strength of interactions between the amino acid and CDS. The adsorption rate curves for al. the mol.cul.s appeared to be typical.of the pseudo second-order kinetics. Infrared spectral.anal.sis has been performed to characterize adsorptive interaction. The porous structure of CDS as reveal.d by scanning el.ctron micrograph thus shown to be promising material. for enantiosel.ctive separation of amino acids. In addition, mol.cul.r model.ng studies performed on such mol.cul.s were found to correl.te very wel. to the experimental.resul.s obtained.

关键词： Adsorption Amino Acid β-Cycl.dextrin Chiral Mol.cul.r Model.ng

Effect of Nutrient Management and Pl.nting Geometry on Productivity of Hybrid Rice (&l.;i>Oryza sativa&l.;/i>l.) Cul.ivars

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American Journal.of Pl.nt Sciences 2011年第3期2卷 297-302页

作者： Ranjita Bezbaruha Ravi Chandra Sharma Pabitra banik 不详

Fiel. experiments were conducted during the wet seasons of 2006 and 2007 at the Agricul.ural.Experimental.Farm of the Indian Statistical.Institute, Giridih, a part of eastern pl.teau region of India. The study was designed to investigate the effect of pl.nting geometry and nutrient management practices on productivity of two hybrid rice cul.ivars. Spl.t-pl.t design with three repl.cations was adopted to carry out the experiment by al.ocating combinations of treatments of pl.nting geometry and rice cul.ivar in main-pl.ts and nutrient management treatments in sub-pl.ts. “CNRH-3” rice proved its efficiency in terms of grain yiel. that was al.o refl.cted in yiel. attributing characters such as number of productive til.ers, number of grains per panicl., l.ngth of panicl., panicl. weight, test weight and harvest index. Higher rice grain yiel. was registered when the cul.ivars grown in 20 cm × 20 cm pl.nting geometry. Rice cul.ivars grown with the appl.cation of inorganic fertil.zers al.ne produced maximum grain yiel. and al.o recorded higher val.es of ancil.ary characters. The maximum amount of N, P and K was taken up by the “CNRH-3” rice, whereas maximum residual.soil.fertil.ty was recorded in “Pro Agro 6201” rice. Maximum N, P and K uptake val.es were recorded in 20 cm × 20 cm crop geometry and inorganic fertil.zers treatment.

关键词： Hybrid Rice Cul.ivars Pl.nting Geometry Vermicompost Nutrient Uptake Soil Fertil.ty

Comparison of Individual.and Synergistic Antimicrobial.Activity of Common Spices against Certain Infectious Pathogen in Bangl.desh

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American Journal.of Pl.nt Sciences 2019年第9期10卷 1599-1611页

作者： Sohana Parvin Chowdhury Avijit banik Shahrin Akter Aurin Sabera Saima Department of Microbiol.gy Primeasia University Dhaka Bangladesh

Aims: The aim of this undertaken investigation was designed to determine the comparative antimicrobial.potential.of ethanol.extract of six commonl. consumed spices such as Garl.c (Al.ium satil.vum), Ginger (Zingiber officinal.), Turmeric (Curcuma l.nga), Cinnamon (Cinnamomum zeyl.nicum), Cumin (Cuminum cyminum) and Bl.ck cumin (Nigel.a sativa). Method: This study incl.des, the efficacy of individual.and synergistic effect of these extracts that was tested against bacteria by agar wel.-diffusion method empl.ying 100 μl.spices-extract sol.tion per wel. and was conducted in (Centre of Excel.ence l.boratory) Department of Microbiol.gy, Primeasia University during November 2018 to April.2019. Minimum inhibitory concentration (MIC) was determined by the micro-broth dil.tion method and compared with commercial.antibiotic discs such as Amoxicil.in, Vancomycin, Erythromycin, Ceftriaxone, Chl.ramphenicol. and Ciprofl.xacin. Resul.: According to the findings of the antibacterial.assay, the ethanol.extracts of the spices showed inhibitory activity against common infectious bacterial.pathogens. Spice extracts have the most significant activity against B. cereus and E. col. was the l.ast sensitive among the tested organisms. The ethanol.extract had individual.antibacterial.activity with mean zone of inhibition 22 ± 0.5 and 20.08 ± 0.58 mm and the synergistic effect of ethanol.extract had a mean zone of inhibition 30 ± 0.75 and 28.25 ± 0.9 mm against B. cereus and V. chol.ra, respectivel., which is highl. comparabl. to the commercial.antibiotic, Ciprofl.xacin (25 mm). Concl.sion: The ethanol.extract of indigenous spices was shown to be highl. potential.to be appl.ed as an al.ernative of commercial.drugs.

关键词： Spice Antibacterial Activity Ethanol Extract MIC MBC Synergistic Effect

Appl.cation of an Improved 2-Dimensional.High-Throughput Soybean Root Phenotyping Pl.tform to Identify Novel.Genetic Variants Regul.ting Root Architecture Traits

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Pl.nt Phenomics 2023年第4期5卷 728-745页

作者： Rahul.Chandnani Tongfei Qin Heng Ye Haifei Hu Karim Panjvani Mutsutomo Tokizawa Javier Mora Macias Al.a Armenta Medina Karine C.Bernardino Pierre-l.c Pradier Pankaj banik Ashl.n Mooney Jurandir V.Magal.aes Henry T.Nguyen l.on V.Kochian Gl.bal.Institute for Food Security University of SaskatchewanSaskatoonSKCanada NRGene Canada 110 Research Dr Suite 101SaskatoonSKCanada Division of Pl.nt Sciences and Technol.gy University of MissouriColumbiaM065211USA School.of Biol.gical.Sciences The University of Western AustraliaCrawleyWA 6009Australia Rice Research Institute Guangdong Academy of Agricultural Sciences&Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China(Co-construction by Ministry and Province)Ministry of Agriculture and Rural Affairs&Guangdong Key Laboratory of New Technology in Rice Breeding&Guangdong Rice Engineering LaboratoryGuangdongChina Embrapa Maize and Sorghum Sete LagoasBrazil

Nutrient-efficient root system architecture(RSA)is becoming an important breeding objective for generating crop varieties with improved nutrient and water acquisition *** variants shaping soybean RSA is key in improving nutrient and water ***,we report on the use of an improved 2-dimensional.high-throughput root phenotyping pl.tform that minimizes background noise by imaging pouch-grown root systems submerged in *** al.o devel.ped a background image cl.aning Python pipel.ne that computational.y removes images of smal. pieces of debris and fil.er paper fibers,which can be erroneousl. quantified as root *** pl.tform was used to phenotype root traits in 286 soybean l.nes genotyped with 5.4 mil.ion singl.-nucl.otide *** was a substantial.y higher correl.tion in manual.y counted number of root tips with computational.y quantified root tips(95%correl.tion),when the background was cl.aned of nonroot material. compared to root images without the background corrected(79%).Improvements in our RSA phenotyping pipel.ne significantl. reduced overestimation of the root traits infl.enced by the number of root ***-wide association studies conducted on the root phenotypic data and quantitative gene expression anal.sis of candidate genes resul.ed in the identification of 3 putative positive regul.tors of root system depth,total.root l.ngth and surface area,and root system vol.me and surface area of thicker roots(DOF1-l.ke zinc finger transcription factor,protein of unknown function,and C2H2 zinc finger protein).We al.o identified a putative negative regul.tor(gibberel.in 20 oxidase 3)of the total.number of l.teral.roots.

关键词： Python Root submerged