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Determination of ETM, Histamine and Mycotoxins in Garba, a Traditional Ivoirian Meal

American Journal of Analytical Chemistry 2018年第4期9卷 245-256页

作者： Adjo Thérèse Anoman Kouamé Mathias Koffi kouassi narcisse aboua Marina Koussemon Laboratoire Central pour l’Hygiène Alimentaire et l’Agro-industrie LANADA Ministère de l’Agriculture Abidjan C&ocirc te d’Ivoire Laboratoire de Biochimie et Sciences des Aliments Université Félix Houphou&euml t Boigny Abidjan C&ocirc te d’Ivoire Laboratoire des Sciences de l’Environnement Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire UFR Sciences et Technologie des Aliments Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire

The methods of preparation, conservation and sale of Garba, the traditional Ivorian street meal, abundantly consumed in Côte d’Ivoire, can be exposed to various infections resulting in the poisoning of consumers. The aim of this study was to evaluate the hygienic quality of Garba through the analysis and the determination of certain toxic chemicals. In three hundred (300) samples of Garba collected in four districts in Abidjan, toxic metals (cadmium, mercury, lead), biogenic amine (histamine) and mycotoxins (aflatoxins and ochratoxin A) were detected and quantified using official standardized methods. Different toxics analyzed were present at various levels in the Garba. The mercury, lead, cadmium and histamine levels in the Garba were respectively 0.19 mg/kg, 0.19 mg/kg, 0.03 mg/kg and 32.69 mg/kg. The detected mycotoxins included aflatoxins B1, B2, G1, G2 and ochratoxin A, with respective average proportions of 3.44 μg/kg, 1.90 μg/kg, 8.07 μg/kg, 0.56 μg/kg and 0.42 μg/kg. The mycotoxins levels in the Garba are higher than the recommended toxic levels, particularly the ones in aflatoxin B1 and G1. This suggests a sanitary risk associated with the consumption of this meal. Consequently, awareness campaigns and training of the Garba sellers in hygiene and a better regulation of this sector by the competent authorities are required.

关键词： Garba Toxic Metals Biogenic Amine Mycotoxins

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Qualitative Determination of Photodegradation Products of Progesterone and Testosterone in Aqueous Solution

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American Journal of Analytical Chemistry 2016年第1期7卷 22-33页

作者： Ladji Méité Baba Donafologo Soro narcisse kouassi aboua Véronique Mambo Karim Sory Traoré Patrick Mazellier Joseh De Laat Laboratoire des Sciences de l’Environnement Unité de Formation et de Recherche des Sciences et Gestion de l’Environnement Université Nangui Abrogoua Abidjan Cote d’Ivoire CNRS-UMR 5805 EPOC Laboratoire de Physico et Toxico Chimie de l’Environnement Université de Bordeaux Bordeaux France Institut de Chimie des Milieux et Matériaux de Poitiers (UMR CNRS 7285) Equipe Eaux Géochimie Santé Ecole Nationale Supérieure d’Ingénieurs de Poitiers Université de Poitiers Poitiers France

Direct photochemical degradations of progesterone (PR) and testosterone (TR), two naturally produced hormones, have been conducted in non-buffered aqueous solution (pH ranging between 5.5 and 6.0). The irradiation experiments were carried out in a batch reactor upon monochromatic (254 nm) and polychromatic (λ > 290 nm) at 25°C. GLC/MS and LC/UV-DAD/MS analyses were performed to investigate phototransformation products after a solid phase extraction (SPE) step for analytes concentration. For each compound several by-products have been identified and are the same ones under both irradiation conditions. Because of the presence of the same chromophore (α, β-unsaturated group) absorbing UV radiations in both hormones, the majority of chromatographic peaks correspond to by-products formed according to identical mechanisms involving isomerization, enolization, oxidation and hydration to lead to the generation of lumiketone, cyclopentenone, spiro-hydration, oxidation and hydroxylation photoproducts.

关键词： Photoproducts Testosterone Progesterone GLC/MS LC/UV-DAD/MS

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Profile of Patients with Breast Cancer Brain Metastasis in Abidjan

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Advances in Breast Cancer Research 2018年第2期7卷 201-210页

作者： Kouame Konan Yvon kouassi Moctar Touré Evrard narcisse Seka Oumou Kimso Mudasiru Akanji Oseni Bitti Adde Odo Arsène Gaetan Kagambega Innocent Adoubi Oncology Department of the Treichville University Hospital Department of Medicine and Medical Specialties Felix Houphou-et-Boigny University Abidjan Cote d'Ivoire

Patients with breast cancer will develop brain metastases in 15% - 25% of cases. Objective: To identify the profile of patients with breast cancer brain metastasis. Method: Retrospective study over 4 years in the oncology department of Treichville Hospital. All patients with breast carcinoma who had a brain metastasis during their cancer management were included. Results: 41 cases of breast carcinoma brain metastasis were collected. Patients were older than 40 years in 78% of cases. Family history of breast cancer was found in 7% of patients. More than 80% of patients had consulted with T3 and T4 tumor masses, with 100% of cases of node involvement. The brain was the second site of metastasis. The tumors were Triple negative in 48%, Her2 positive in 36% and luminal in 16%. Brain metastases were of late onset in the majority of cases (68%). They were clinically characterized by headaches (100%), most often included in an intracranial hypertension syndrome (52%). They were multiple (60%). Therapeutically, no surgery was performed on the metastases. Three patients received whole brain radiation therapy. All patients received systemic therapy. In terms of response, 30 cases of progression were observed after treatment and 2 cases of complete response were obtained. Survival from onset of brain metastasis was of 75% at 3 months and 2% at 12 months. Patients with longer survival rates were over 40 years old with triple negative breast cancer. Conclusion: Brain metastasis from breast cancer most often occurs in a particular clinical and pathological context in our countries.

关键词： Breast Cancer Brain Metastasis Abidjan

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Metastatic(Advanced)Prostate Cancer Resistant to Castration:The Time before Resistance Development and Therapeutic Measures Undertaken in Cote d’Ivoire

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Journal of Cancer Therapy 2018年第12期9卷 955-961页

作者： kouassi Kouame Konan Yvon Toure Moctar Seka Evrard narcisse Oumou Kimso Traore Kadjatou Odo Bitti Adde Traore Asmaho Danielle Kagambega Arsene Gaetan Adoubi Innocent Oncology Department of the Treichville University Hospital AbidjanCote d’Ivoire

Objective: Contribute to improving care for prostate cancer patients in Cote d’Ivoire by identifying the average time before the development of the hormone-resistance and inherent therapeutic strategies. Patients and Method: It was a retro and prospective study over three years performed at the University Teaching Hospital of Treichville in Abidjan. 84 patients with metastatic prostate adenocarcinoma and resistant to hormone therapy were involved in the study. The analysis of clinical records enabled us to integrate different parameters in our study. Results: Our patients were relatively young (an average age of 61 years) and most of them belonged to the middle socio-economic class (50%). The resistance occurred within an average period of 9 months. The mixing of Docetaxel and Prednisone chemotherapy was the most used method of treatment (70% of cases). However, few patients (9.5%) received Abiraterone Acetate. Digestive and hematologic toxicities were noticed but they could be controlled by inherent treatment or disappear spontaneously. After nine months of treatment, 54.24% of patients who received specific treatment were alive, but high rates of mortality were observed as for patients who were only treated symptomatically. Conclusion: The relatively short average time before the development of hormone-resistance shows the aggressiveness of prostate adenocarcinoma from black Africans. The main therapeutic standard in our context remains Taxane-based chemotherapy with a good and fair tolerance.

关键词： Cancer Prostate Occurrence Time Resistance

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Non-Small Cell Lung Cancer:Therapeutic and Evolutionary Aspects in Cote d’Ivoire

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Advances in Lung Cancer 2018年第1期7卷 1-8页

作者： TouréMoctar kouassi KouaméKonan Yvon Séka Evrard narcisse TraoréKadjatou TraoréAsmaho Danielle Odo Bitti Addé Oumou Kimso Kagambega Arsène Gaetan Adoubi Innocent Oncology Department of the Treichville University Hospital AbidjanCote d’Ivoire

Non-small cell lung cancer (NSCLC) is a heterogeneous group of malignancies including squamous cell carcinoma, adenocarcinoma, bronchioloalveolar carcinoma and large cell carcinoma. They are known to be of poor prognosis, despite a better understanding of bronchial oncogenesis. This descriptive retrospective study carried out over three years (January 2013 to December 31st, 2016) at the Oncology Department of the Treichville University Hospital in Abidjan was aimed to assess the efficacy of new treatments for NSCLC in Cote d’Ivoire and to specify their benefit in terms of quality of life, comfort and overall survival. This 77 patients study, found that NSCLC, the most frequent of which is squamous cell carcinoma, occurs in relatively young subjects, smokers (91%) diagnosed at a locally advanced or metastatic stage (89%). Cisplatin base multi-drug chemotherapy was mostly used (71%). Combined all treatments, there was a significant clinical gain. However, no complete response was observed. Hematological and digestive toxicities were seen in more than 30% of cases. Overall survival was of 9 months on average. This study is an advocate to optimize primary prevention policies for a cancer with poor prognosis despite the development of new treatments such as target therapies.

关键词： Non-Small Cell Lung Cancer Treatment Evolution

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Benefit of Targeted Therapies in Metastatic Colon Cancer in the Ivorian Context

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Journal of Cancer Therapy 2017年第8期8卷 785-792页

作者： Touré Moctar kouassi Kouamé K. Yvon Séka E. narcisse Traoré Kady Kimso Oumou Niang D. Rokhaya Odo B. Adde Oseni Jelili Adoubi Innocent Department of Oncology University Hospital of Treichville Abidjan Cote d’Ivoire

In our daily practice, the use of targeted therapies (Bevacizumab and rarely Cetuximab) in metastatic colic cancers is recent. Very few patients benefit from these therapies because of their high cost. In a cohort of 68 patients who received these therapies, a retrospective and prospective study was conducted over three years period (1 January 2013 to 31 December 2015) to evaluate their benefit in terms of quality of life, tolerance and overall survival. These targeted therapies provided a significant clinical and biological gain with acceptable toxicities (most often resolving spontaneously). Moreover, they have allowed a significant improvement in overall survival in first line metastatic treatment. The limiting factor remains their extremely high cost and therefore inaccessibility to the majority of our patients.

关键词： Cancer-Colon-Metastasis-Targeted Therapy

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