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Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication

World Journal of Gastroenterology 2013年第47期19卷 8986-8995页

作者： Sang-Ho Park napapan kangwan Jong-Min Park Eun-Hee Kim Ki Baik Hahm CHA Cancer Prevention Research Center CHA Cancer InstituteCHA UniversitySeoul 135-081South Korea

Although the International Agency for Research on Cancer declared Helicobacter pylori(H.pylori)as a definite human carcinogen in 1994,the Japanese Society for Helicobacter Research only recently(February 2013)adopted the position that H.pylori infection should be considered as an indication for either amelioration of chronic gastritis or for decreasing gastric cancer mortality.Japanese researchers have found that H.pylori eradication halts progressive mucosal damage and that successful eradication in patients with non-atrophic gastritis most likely prevents subsequent development of gastric cancer.However,those who have already developed atrophic gastritis/gastric atrophy retain potential risk factors for gastric cancer.Because chronic perpetuated progression of H.pylori-associated gastric inflammation is associated with increased morbidity culminating in gastric carcinogenesis,a non-microbial approach to treatment that provides long-term control of gastric inflammation through nutrients and other interventions may be an effective way to decrease this morbidity.This non-microbial approach might represent a new form of prerequisite"rescue"therapy that provides a quicker path to the prevention of gastric cancer as compared to simple eradication.

关键词： Helicobacter pylori Gastric cancer Prevention Atrophic gastritis Non-microbial approach

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Quality of healing of gastric ulcers: Natural products beyond acid suppression

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World Journal of Gastrointestinal Pathophysiology 2014年第1期5卷 40-47页

作者： napapan kangwan Jong-Min Park Eun-Hee Kim Ki Baik Hahm CHA Cancer Prevention Research Center CHA Cancer InstituteCHA University College of Pharmacy CHA University Department of Gastroenterology CHA University Bundang Medical Center

Gastric ulcer is a chronic disease featured with unexpected complications, including bleeding, stenosis and perforation, as well as a high incidence of recurrence. Clinical treatments for gastric ulcer have allowed the rapid development of potent anti-ulcer drugs during the last several decades. Gastric ulcer healing is successful with conventional treatments including H2-receptor antagonists, and proton pump inhibitors(PPIs) have been essential for ulcer healing and prevention of complications. Additionally, Helicobacter pylori eradication therapy is effective in reducing ulcer recurrence and leads to physiological changes in the gastric mucosa which affect the ulcer healing process. However, in spite of these advancements, some patients have suf-fered from recurrence or intractability in spite of continuous anti-ulcer therapy. A new concept of the quality of ulcer healing(QOUH) was initiated that considers the reconstruction of the mucosal structure and its function for preventing ulcer recurrence. Although several gastroprotection provided these achievements of the QOUH, which PPI or other acid suppressants did not accomplish, we found that gastroprotection that originated from natural products, such as a newer formulation from either Artemisia or S-allyl cysteine from garlic, were very effective in the QOUH, as well as improving clinical symptoms with fewer side effects. In this review, we will introduce the importance of the QOUH in ulcer healing and the achievements from natural products.

关键词： Quality of ulcer healing Natural products Gastric ulcers Acid suppression S-allyl cysteine Artemisia isopropanol extract

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