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Transcriptomic analysis of Andrias davidianus meat and experimental validation for exploring its bioactive components as functional foods

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Food Science and Human Wellness 2024年第1期13卷 166-172页

作者： Changge Guan Zhenglin Tan Shucheng Li Yi Wang naoyuki Yamamoto Chong Zhang Songjun Wang Junjie Chen Xinhui Xing Key Laboratory for Industrial Biocatalysis Ministry of Education of ChinaDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Life Science and Technology Tokyo Institute of TechnologyYokohama 226-0026Japan Sensing System Research Center National Institute of Advanced Industrial Science and TechnologyTsukuba 305-8565Japan Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Henan Giant Salamander Protection and Development Association Luoyang 471000China Intelligent Computing Research Center Harbin Institute of TechnologyShenzhen 518071China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518067China

Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in ***,the progress of functional peptides mining was slow due to lack of reference genome and protein sequence *** this study,we illustrated full-length transcriptome sequencing to interpret the proteome of CGS meat and obtain 10703 coding DNA *** functional annotation and amino acid composition analysis,we have discovered various genes related to signal transduction,and 16 genes related to *** have also found vast variety of functional peptides through protein coding sequence(CDS)analysis by comparing the data obtained with the functional peptide ***-Pro-Ile predicted by the CDS analysis was released from the CGS meat through enzymatic hydrolysis,suggesting that our approach is *** study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat,thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.

关键词： Chinese giant salamander Transcriptomic analysis Bioactive components Functional peptides mining

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A Multi-Center International Survey Related to the Nutritional Support after Hematopoietic Stem Cell Transplantation Endorsed by the ASIA Pacific Blood and Marrow Transplantation (APBMT)

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Food and Nutrition Sciences 2012年第3期3卷 417-421页

作者： Shigeo Fuji Takehiko Mori Vincent Lee Jessica Cheng Natalie Linton Albert Lie Navin Khattry Akio Shigematsu naoyuki uchida Tetsuya Eto Nguyen Duy Thang Yi-Chang Liu Deok-Hwan Yang Jin Seok Kim Joon Ho Moon Dae-Young Kim Minako Iida Ritsuro Suzuki Yoshihisa Kodera Sung-Won Kim Department of Hematology and Hematopoietic Stem Cell Transplantation National Cancer Center Hospital Tokyo Japan. Department of Hematology and Oncology Chonnam National University Hwasun Hospital Jeollanam-do Korea Department of Hematology and Oncology Hokkaido University Hospital Hokkaido Japan Department of Hematology and Oncology Kaohsiung Medical University Hospital Taiwan (China) Department of Hematology and Oncology Kyungpook National University Hospital Daegu Korea (South) Department of Hematology Asan Medical Center Seoul Korea (South) Department of Hematology Hamanomachi Hospital Fukuoka Japan Department of Hematology Toranomon Hospital Tokyo Japan Department of Hematology University Hospital Wuerzburg Wuerzburg Germany Department of HSCT Data Management and Biostatistics School of Medicine Nagoya University Nagoya Japan Department of Medical Oncology Tata Memorial Center Mumbai India Department of Medicine Queen Mary Hospital Hong Kong (China) Department of Nutrion Services St Vincent’s Hospital Sydney Sydney Australia Department of Pediatrics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong (China) Department of Promotion for Blood and Marrow Transplantation School of Medicine Aichi Medical University Nagakute Japan Division of Hematology Keio University Hos- pital Tokyo Japan Division of Hematology Yonsei University College of Medicine Severance Hospital Seoul Korea (South) Hue Regional Hematology and Blood Transfusion Center Hue Central Hospital Hue City Vietnam

Background: The nutritional support after hematopoietic stem cell transplantation (HSCT) has not been well established due to the scarcity of clinical trials. To conduct international clinical trials in Asia, we performed the questionnaire survey to investigate the current standard of nutritional support after HSCT. Method: We sent the questionnaire to the physicians nominated by the Asia Pacific Blood and Marrow Transplantation (APBMT) members of each country/ region. Result: We received 15 responses from 7 different countries/regions. The target calorie amount is 1.0 - 1.3 × basal energy expenditure (BEE) in 11 institutes when partial parenteral nutrition is used. When total parenteral nutrition (TPN) is used, the target calorie amount is 1.0 - 1.3 × BEE in 9 institutes and 1.3 - 1.5 × BEE in 4 institutes. Lipid emulsion is routinely used in 12 institutes. Multivitamins and trace elements are routinely added to TPN used in most institutes. It is still uncommon to use the immunonutrition. Blood glucose levels are routinely monitored in all institutes, but the target range varies (<110 in 2 institutes, <150 in 4 institutes, and <200 in 8 institutes). Conclusions: Basic nutritional support is similar in participating institutes. However, the target glucose level varies and the use of immunonutrition is rather rare. These points can be the theme of future clinical trials.

关键词： Stem Cell Transplantation Nutritional Support Asia Pacific Blood and Marrow Transplantation

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Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

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World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki Hidekazu Tamai Takahiro Fukuyama Yoko Sagara Ryutaro Hidaka Aira uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

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A Case Report of Kissing Molars Class II

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Open Journal of Stomatology 2024年第5期14卷 249-254页

作者： Toshiyuki Inou Keiichi uchida Keiko Kaneko Anna Fuji Nina Wakimoto Tatsuo Takaya Hiroyuki Kitamura Hiroshi Mori Yuji Kurihara Department of Oral Diagnostics and Comprehensive Dentistry Matsumoto Dental University Hospital Shiojiri Japan Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University Shiojiri Japan

Kissing molars (KMs) is a condition of occlusal molar surfaces in a single follicular space with roots extending in opposite directions. Here, we have reported a case of KMs in a 58-year-old woman. The patient complained of pain in the right mandibular molar region and was diagnosed with KMs consisting of the right mandibular second and third molars. Because of the patient’s pain having subsided at the time of the visit and her unwillingness to undergo tooth extraction, the patient was followed up. KMs is classified into three classes (I-III) and is either true-KMs or pseudo-KMs and presents with or without cystic variants of dental follicles. The presents as true-KMs class II without a cystic variant. With reference to the literature and based on our analysis, the mean age of patients affected by this specific case of KMs is 31.7 years and unilateral KMs is relatively more common (85.7%). Histopathological findings of dentigerous cysts are more often indicated (42.9%). The treatment policy for KMs should therefore be based on the classification of KMs. Importantly, the focus should be on preserving the first and second molars as much as possible. The treatment approach, such as the employment of surgical removal or orthodontics, should be determined by considering the associated factors such as the crowns, tissues, and age of the patient.

关键词： Kissing Molars Mandibular Second Molar Mandibular Third Molar Cone-Beam Computed Tomography

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Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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Psychological potential field and human eye fixation on binary line-drawing images: A comparative experimental study

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Computational Visual Media 2020年第2期6卷 205-214页

作者： naoyuki Awano Yuki Hayashi Osaka University of Economics OsakaOsaka533-8533Japan Osaka Prefecture University SakaiOsaka599-8531Japan

Quantitatively evaluating the psychological and perceptual effects of objects is an important issue,but is difficult. In cognitive studies, the psychological potential field(PPF), which represents psychological intensities in vision and can be calculated by applying computational algorithms to digital images, may help with this issue. Although studies have reported using the PPF to evaluate psychological effects, such as impressions, detailed investigations on how the PPF represents psychological perception and its limitations have not yet been performed. Another relevant tool is the fixation map, which visualizes human eye fixations;this map is generated from actual measurements acquired by eye-tracking and does not represent psychological effects directly. Although the PPF and the fixation map are based on visual imaging, they have never been compared. In this paper, we do so for the first time, using psychological and perceptual properties of line-drawing images. The results demonstrate the difference between these methods, including their representation of different properties with respect to visual perception. Moreover, the similarity between the two methods highlights the possibility of assessing perceptual phenomena such as categorization and cognition of objects based on human vision.

关键词： psychological potential field(PPF) eye fixation eye-tracking visual perception line drawing

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Hepatic clearance measured with ^(99m)Tc-GSA single-photon emission computed tomography to estimate liver fibrosis

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World Journal of Gastroenterology 2014年第44期20卷 16714-16720页

作者： Masahiko Taniguchi Atsutaka Okizaki Kenji Watanabe Koji Imai Koichiro uchida Takahiro Einama Noriyuki Shuke naoyuki Miyokawa Hiroyuki Furukawa Division of Gastroenterologic and General Surgery Department of Surgery Asahikawa Medical College Department of Radiology Asahikawa Medical College Department of Pathology Asahikawa Medical College

AIM: To evaluate the clinical utility of hepatic clearance(HC) measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin(99mTc-GSA) single-photon emission computed tomography(SPECT) to estimate the degree of liver ***:Seventy-eight consecutive patients who underwent initial hepatectomy due to hepatocellular carcinoma were enrolled in this *** green clearance(ICG R15),quantitative indices estimated by 99mTc-GSA[the receptor index(LHL15 and HH15)and HC via SPECT analysis],and conventional liver function tests were performed before *** among the quantitative indices for liver functional reserve,conventional liver function tests,andthe degree of liver fibrosis were ***:The degree of liver fibrosis was correlated with ICG R15,HH15,LHL15,and *** showed the best correlation with conventional liver function *** to multivariate analysis,HC and LHL15 were significant independent predictors of severe *** was the most valuable index for predicting severe ***:HC measured with 99mTc-GSA SPECT is a reliable index for assessing liver fibrosis before hepatectomy.

关键词： Fibrosis Technetium-99m-diethylenetri-aminepenta-acetic acid-galactosyl human serum albu-min Single-photon emission computed tomography Hepatic clearance Liver resection

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Finite element polycrystal model simulation of cold rolling textures in deformation processed two-phase Nb/Al metal-metal composites

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中国有色金属学会会刊：英文版 2005年第1期15卷 64-71页

作者：陈礼清 KANETAKE naoyuki Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan

The finite element polycrystal model (FEPM) was extended and applied to simulate the development of the cold rolling textures of matrix aluminum in deformation processed two-phase 10% and 20%Nb/Al(in volume fraction) metal-metal composites on the basis of slip deformation of individual grains. This simulation method can assure the continuity of stress and displacement at the boundary during heterogeneous deformation and take arbitrary boundary conditions into consideration. The starting hot-extruded textures, as initial input condition, were taken into account in the FEPM simulation. The simulation results show that the main texture components and their evolution after various cold rolling reductions in 10% and 20%Nb/Al metal-metal composites are well qualitatively in agreement with the experimental ones. The initially extruded textures are rather weak, so they have no much influence on the simulated final cold rolling textures of the matrix aluminum for Nb/Al composites.

关键词： metal-matrix composites FEPM Nb/Al composite texture rolling

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IMPLEMENTATION OF 3-VALUED PARACONSISTENT LOGIC PROGRAMMING TOWARDS DECISION MAKING SYSTEM OF AGENTS

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Journal of Systems Science and Systems Engineering 2018年第3期27卷 322-339页

作者： Yuki Goto Megumi Fujita naoyuki Nide Graduate School of System Informatics Kobe University (Until Mar. 2018) Faculty of Science and Engineering Kindai University Faculty Division of Human Life and Environmental Sciences Nara Women's University

Due to the rapid development of applications of artificial intelligence and robotics in recent years, the necessity of reasoning and decision making with uncertain and inaccurate information is increasing. Since robots in the real world are always exposed to behavioral inaccuracies and uncertainty arising from recognition methods, they may occasionally encounter contradictory facts during reasoning on action decision. Paraconsistent logic programming is promising to make appropriate action decisions even when an agent is exposed to such uncertain information or contradictory facts, but there has been no implementation of this programming to the best of our knowledge. We propose a resolution algorithm for the 3-valued paraconsistent logic programming system QMPT0 and its implementation on SWI-Prolog. We also describe an application of the 3-valued paraconsistent logic programming regarding agent decision making.

关键词： Agent-based modelling for complex systems paraconsistent logic programming solver implementation declarative programming application for agents

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Scene word recognition from pieces to whole

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Frontiers of Computer Science 2019年第2期13卷 292-301页

作者： Anna ZHU Seiichi uchida SCST Wuhan University of Technology Wuhan 430000 China ISEE-AIT Kyushu University Fukuoka 819-0395 Japan

Convolutional neural networks (CNNs) have had great success with regard to the object classification problem. For character classification, we found that training and testing using accurately segmented character regions with CNNs resulted in higher accuracy than when roughly segmented regions were used. Therefore, we expect to extract complete character regions from seene images. Text in natural scene images has an obvious contrast with its attachments. Many methods attempt to extract characters through different segmentation techniques. However, for blurred, occluded, and complex background cases, those methods may result in adjoined or over segmented characters. In this paper, we propose a scene word recognition model that integrates words from small pieces to entire after-cluster-based segmentation. The segmented connected components are classified as four types: background, in dividual character proposals, adjoined characters, and stroke proposals. Individual character proposals are directly inputted to a CNN that is trained using accurately segmented character images. The sliding window strategy is applied to adjoined character regions. Stroke proposals are considered as fragments of entire characters whose locations are estimated by a stroke spatial distribution system. Then、the estimated characters from adjoined characters and stroke proposals are classified by a CNN that is trained on roughly segmented character images. Finally, a lexicondriven integration method is performed to obtain the final word recognition results. Compared to other word recognition methods, our method achieves a comparable performance on Street View Text and the ICDAR 2003 and ICDAR 2013 benchmark databases. Moreover, our method can deal with recognizing text images of occlusion and improperly segmented text images.

关键词： text recognition convolutional neural networks cluster-based segmentation character integration

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