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Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

Chinese Journal of Chemical Engineering 2024年第4期68卷 65-75页

作者： Xuwei Liu Wei Chen Yufei Xia Guanghui Ma Reiji noda Wei Ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering ***,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly *** gap in knowledge holds significant potential for enhancing vaccine *** study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell *** transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case *** factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion *** simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport ***,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single *** study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering *** insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug ***,the desired transport efficiency varies depending on the specific *** instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词： Pickering emulsion Skeletal muscular cells Transport phenomena Dissipative particle dynamics Drug delivery

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Reconsideration of So-Called “Invasive” Meningioma

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Open Journal of Modern Neurosurgery 2015年第4期5卷 118-123页

作者： Tomu Okada Kazuhiko Fujitsu Teruo Ichikawa Kousuke Miyahara Shin Tanino Uriu Yasuhiro Yuusuke Tanaka Yuusuke Tsuchiya naoyuki noda Hitoshi Niino Saburou Yagishita Department of Neurosurgery National Hospital Organization Yokohama Medical Center Yokohama Japan Department of Pathology National Hospital Organization Yokohama Medical Center Yokohama Japan

For the purpose of histopathological diagnosis, so-called “invasive meningioma” is defined as a meningioma that has infiltrated the cerebral parenchyma, and such cortical infiltration raises the risk of recurrence. However, as the definition of “invasive” remains far from clear, we have attempted to redefine it. Tumors that were completely removed from 32 patients between April 2005 and September 2015 and that had been diagnosed as so-called “invasive meningioma” were classified by World Health Organization grade (Group I–III), and then further classified as: true invasion, involving invasion of the brain with breakdown of the pia mater;and pseudo-invasion, involving encroachment into the brain with the pia mater still intact. We then investigated recurrence rates in the brain or dura mater for each group. Rate of recurrence in the brain or dura mater was significantly higher for Group I meningioma classified as true invasion compared to that of the same group classified as pseudo-invasion. We redefined so-called “invasive meningioma” as Group I meningioma exhibiting true invasion, and considered that, when possible, wide resection of the areas of adhesion to the dura mater in addition to tumor extirpation along with the cerebral parenchyma increased the success rate for curative treatment.

关键词： Invasive Meningioma True Invasion Pseudo-Invasion Surgical Margin Recurrence Rate

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Tumor size discrepancy between endoscopic and pathological evaluations in colorectal endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 136-147页

作者： Takeshi Onda Osamu Goto Toshiaki Otsuka Yoshiaki Hayasaka Shun Nakagome Tsugumi Habu Yumiko Ishikawa Kumiko Kirita Eriko Koizumi Hiroto noda Kazutoshi Higuchi Jun Omori Naohiko Akimoto Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolGraduate School of MedicineBunkyo-ku 113-8603TokyoJapan Endoscopy Center Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Hygiene and Public Health Nippon Medical SchoolBunkyoku 113-8603TokyoJapan Center for Medical Education Nippon Medical SchoolBunkyo-ku 113-8603TokyoJapan

BACKGROUND Tumor size impacts the technical difficulty and histological curability of colorectal endoscopic submucosal dissection(ESD);however,the preoperative evaluation of tumor size is often different from histological *** influential factors on failure to obtain an accurate tumor size evaluation could help prepare optimal conditions for safer and more reliable *** This was a retrospective study conducted at a single institution.A total of 377 lesions removed by colorectal ESD at our hospital between April 2018 and March 2022 were *** first assessed the difference in size with an absolute per-centage of the scaling ***,we compared the clinicopatho-logical characteristics of the correct scaling group(>-33%and33%),which was further subdivided into the underscaling group(-33%or less of the discrepancy)and overscaling group(33%or more of the discrepancy),*** secondary outcome measures,parameters on size estimation were compared between the underscaling and correct scaling groups,as well as between the overscaling and correct scaling ***,multivariate analysis was performed in terms of the following relevant parameters on size estimation:Pathological size,location,and possible influential factors(P<0.1)in the univariate *** The mean of absolute percentage in the scaling discordance was 21%,and 91 lesions were considered to be incorrectly estimated in *** incorrect scaling was significantly remarkable in larger lesions(40 mm vs 28 mm;P<0.001)and less experience(P<0.001),and these two factors were influential on the underscaling(75 lesions;P<0.001).Conversely,compared with the correct scaling group,16 lesions in the overscaling group were significantly small(20 mm vs 28 mm;P<0.001),and the small lesion size was influential on the overscaling(P=0.002).CONCLUSION Lesions indicated for colorectal ESD tended to be underestimate

关键词： Endoscopic submucosal dissection Colorectal tumor Tumor size Size estimation Size discrepancy

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Molecular dynamics simulations of ovalbumin adsorption at squalene/water interface

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Chinese Journal of Chemical Engineering 2022年第10期50卷 369-378页

作者： Qingxia Xiong Ying Ren Yufei Xia Guanghui Ma Reiji noda Wei Ge State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

The adsorption of protein molecules to oil/water(O/W)interface is of critical importance for the product design in a wide range of technologies and industries such as biotechnology,food industry and pharmaceutical *** this work,with ovalbumin(OVA)as the model protein,the adsorption conformations at the O/W interface and the adsorption stability have been systematically studied via multiple simulation methods,including all-atom molecular dynamic(AAMD)simulations,coarse-grained molecular dynamic(CGMD)simulations and enhanced sampling *** computational results of AAMD and CGMD show that the hydrophobic tail of OVA tends to be folded under long time relaxation in aqueous phase,and multiple adsorption conformations can exist at the interface due to heterogeneous interactions raising from oil and water *** further study the adsorption sites of the protein,the adsorption kinetics of OVA at the O/W interface is simulated using metadynamics method combined with CGMD simulations,and the result suggests the existence of multiple adsorption conformations of OVA at interface with the head-on conformation as the most stable *** all,this work focuses on the adsorption behaviors of OVA at squalene/water interface,and provides a theoretical basis for further functionalization of the proteins in emulsion-based products and engineering.

关键词： Molecular dynamicssimulation Metadynamics Protein adsorption Structural stability Ovalbumin

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Liquid biopsy leads to a paradigm shift in the treatment of pancreatic cancer

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World Journal of Gastroenterology 2022年第46期28卷 6478-6496页

作者： Fumiaki Watanabe Koichi Suzuki Hiroshi noda Toshiki Rikiyama Department of Surgery Saitama Medical CenterJichi Medical UniversitySaitama 330-8503Japan

Pancreatic ductal adenocarcinoma(PDAC)is one of the most *** 5-year survival rate is very *** recent induction of neoadjuvant chemotherapy and improvements in chemotherapy for patients with pancreatic cancer have resulted in improved survival ***,the prognosis of pancreatic cancer is still *** dramatically improve the prognosis,we need to develop more tools for early diagnosis,treatment selection,disease monitoring,and response rate ***,liquid biopsy(circulating free DNA,circulating tumor DNA,circulating tumor cells,exosomes,and microRNAs)has caught the attention of many researchers as a new biomarker that is minimally invasive,confers low-risk,and displays an overall state of the ***,liquid biopsy does not employ the traditional difficulties of obtaining tumor samples from patients with advanced PDAC to investigate their molecular biological *** addition,it allows for long-term monitoring of the molecular profile of tumor *** could help in identifying tumor-specific alterations that use the target structure for tailor-made *** this review,we highlighted the latest discoveries and advances in liquid biopsy technology in pancreatic cancer research and showed how it can be applied in clinical practice.

关键词： Pancreatic cancer Cell-free DNA Circulating tumor DNA Circulating tumor cells Exosomes MicroRNAs

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Recent developments in two-dimensional (2D) correlation spectroscopy

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Chinese Chemical Letters 2015年第2期26卷 167-172页

作者： Isao noda Department of Materials Science & Engineering University of Delaware

Recent noteworthy developments in the field of two-dimensional（2D） correlation spectroscopy are reviewed.2D correlation spectroscopy has become a very popular tool due to its versatility and relative ease of *** technique utilizes a spectroscopic or other analytical probe from a number of selections for a broad range of sample systems by employing different types of external perturbations to induce systematic variations in intensities of *** spectral intensity variations are then converted into2 D spectra by a form of correlation analysis for subsequent *** different types of 2D correlation approaches have been *** particular,2D hetero-correlation and multiple perturbation correlation analyses,including orthogonal sample design scheme,are discussed in this *** references to other important developments in the field of 2D correlation spectroscopy,such as projection correlation and codistribution analysis,were also provided.

关键词： Two-dimensional correlation spectroscopy Hetero-correlation Multiple perturbation correlation Orthogonal sample design

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Update on gut microbiota in gastrointestinal diseases

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World Journal of Clinical Cases 2022年第22期10卷 7653-7664页

作者： Atsushi Nishida Kyohei Nishino Masashi Ohno Keitaro Sakai Yuji Owaki Yoshika noda Hirotsugu Imaeda Department of Gastroenterology and Hepatology Nagahama City HospitalNagahama 526-8580Japan

The human gut is a complex microbial ecosystem comprising approximately 100 trillion microbes collectively known as the“gut microbiota”.At a rough estimate,the human gut microbiome contains almost 3.3 million genes,which are about 150 times more than the total human genes present in the human *** vast amount of genetic information produces various enzymes and physiologically active ***,the gut microbiota contributes to the maintenance of host health;however,when healthy microbial composition is perturbed,a condition termed“dysbiosis”,the altered gut microbiota can trigger the development of various gastrointestinal *** gut microbiota has consequently become an extremely important research area in *** is also expected that the results of research into the gut microbiota will be applied to the prevention and treatment of human gastrointestinal diseases.A randomized controlled trial conducted by a Dutch research group in 2013 showed the positive effect of fecal microbiota transplantation(FMT)on recurrent Clostridioides difficile infection(CDI).These findings have led to the development of treatments targeting the gut microbiota,such as probiotics and FMT for inflammatory bowel diseases(IBD)and other *** review focuses on the association of the gut microbiota with human gastrointestinal diseases,including CDI,IBD,and irritable bowel *** also summarize the therapeutic options for targeting the altered gut microbiota,such as probiotics and FMT.

关键词： Inflammatory bowel disease Clostridioides difficile(Clostridium)infection Irritable bowel syndrome Probiotics Fecal microbiota transplantation

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Laser speckle flowgraphy findings in a patient with radiation retinopathy

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 172-174页

作者： Satoru Kase Ayaka Hasegawa Kiriko Hirooka Hiroaki Endo Kousuke noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811Japan

Dear Editor,I am Satoru Kase, from Hokkaido University Hospital, Japan. Choroidal melanoma is a serious intraocular tumor, which threatens patients’ vision and life. Treatments for choroidal melanoma consist of surge... 详细信息

关键词： melanoma surgery intraocular

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Electron transfer governed by light-matter interaction at metal-semiconductor interface

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npj Computational Materials 2020年第1期6卷 1628-1635页

作者： Kenji Iida Masashi noda Department of Theoretical and Computational Molecular Science Institute for Molecular ScienceMyodaijiOkazaki 444-8585Japan Center for Computational Sciences University of Tsukuba1-1-1 TennodaiTsukuba 305-8577Japan

The photoexcitation of heterostructures consisting of metallic nanoclusters and a semiconductor has been extensively investigated in relation to interests in photocatalysis and optical *** optoelectronic functions of the heterostructures originate from localized surface plasmon resonance,which can induce electron and resonance energy *** it is well known that photoinduced electronic interaction between a metallic nanocluster and a semiconductor is responsible for the resonance energy transfer,the electron transfer associated with the photoinduced electronic interaction has not been *** this paper,we elucidate the photoexcitation dynamics of a silver nanocluster/TiO_(2) heterostructure using an original first-principles computational approach that explicitly deals with light–matter *** is shown that the photoinduced silver–TiO_(2) electronic interaction causes excited electrons to be directly transferred from the silver nanocluster to the TiO2 layer without passing through the conduction band of the silver nanocluster.

关键词： silver interaction transfer

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Effects of wing deformation on aerodynamic performance of a revolving insect wing

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Acta Mechanica Sinica 2014年第6期30卷 819-827页

作者： Ryusuke noda Toshiyuki Nakata Hao Liu Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-ku Chiba Japan Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CUICRC) Structure and Motion Laboratory The Royal Veterinary CollegeUniversity of London Hawkshead LaneNorth Mymms Hatfield AL9 7TA United Kingdom

Flexible wings of insects and bio-inspired micro air vehicles generally deform remarkably during flapping flight owing to aerodynamic and inertial forces,which is of highly nonlinear fluid-structure interaction（FSI）*** elucidate the novel mechanisms associated with flexible wing aerodynamics in the low Reynolds number regime,we have built up a FSI model of a hawkmoth wing undergoing revolving and made an investigation on the effects of flexible wing deformation on aerodynamic performance of the revolving wing *** take into account the characteristics of flapping wing kinematics we designed a kinematic model for the revolving wing in two-fold：acceleration and steady rotation,which are based on hovering wing kinematics of hawkmoth,Manduca *** results show that both aerodynamic and inertial forces demonstrate a pronounced increase during acceleration phase,which results in a significant wing *** the aerodynamic force turns to reduce after the wing acceleration terminates due to the burst and detachment of leading-edge vortices（LEVs）,the dynamic wing deformation seem to delay the burst of LEVs and hence to augment the aerodynamic force during and even after the *** the phase of steady rotation,the flexible wing model generates more ver-tical force at higher angles of attack（40°–60°）but less horizontal force than those of a rigid wing *** is because the wing twist in spanwise owing to aerodynamic forces results in a reduction in the effective angle of attack at wing tip,which leads to enhancing the aerodynamics performance by increasing the vertical force while reducing the horizontal ***,our results point out the importance of the fluid-structure interaction in evaluating flexible wing aerodynamics：the wing deformation does play a significant role in enhancing the aerodynamic performances but works differently during acceleration and steady rotation,which is mainly induced by inertial force in accelerati

关键词： Insect flight Flexible wing Revolving wing Fluid-structure interaction

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