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ADAPTATION LUMINANCE OF THE COMPLEX LUMINANCE DISTRIBUTION:DIRECTIONALITY AND ADDITIVITY OF THE ADAPTATION LUMINANCE INCREASE

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ADAPTATION LUMINANCE OF THE COMPLEX LUMINANCE DISTRIBUTION:D...

Positive influence of aspirin on coronary endothelial function: Importance of the dose

26th Session of the CIE

作者： IKEGAMI Yoko HARA naoya INOUE Youko Kansai University Kansai University Nara Women’s University

＜正＞Visibility is determined by the effective luminance difference and visual *** effective luminance differences of various target size and figuration are derived by effective luminance *** sensitivity under the visual fields with complex luminance distribution is not clarified *** relationship of luminance distribution and visual sensitivity will be able to contribute a designing of the visual environment. Adaptation luminance which represents the visual sensitivity under the visual fields with complex luminance distribution,is considered as the summation of adaptation luminance increases which caused by luminance of divided parts of visual field. In this paper it is examined whether adaptation luminance increases by every divided parts of visual field has additivity and directionality.

关键词： Adaptation luminance Visibility Luminance threshold Additivity Directionality

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World Journal of Cardiology 2013年第11期5卷 426-433页

作者： Hiroki Teragawa naoya Mitsuba Ken Ishibashi Satoshi Kurisu Yasuki Kihara Department of Cardiovascular Medicine Hiroshima General Hospital of West Japan Railway Company Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical Sciences

AIM: To investigate the effects of different doses of aspirin on coronary endothelial function. METHODS: The study included 139 Japanese subjects(mean age, 60 years; 53 women) with angiographically normal coronary arteries. Patients were distributed into GroupⅠ(n = 63), who was administered aspirin and Group Ⅱ(n = 76), the control, who were not administered aspirin. GroupⅠwas further divided into GroupⅠa(n = 50, low-dose aspirin, 100 mg) and GroupⅠb(n = 13, high-dose aspirin, 500 mg). After a routine coronary angiography, acetylcholine(ACh; 3 and 30 μg/min successively) and nitroglycerin(NTG) were infused into the left coronary ostium over 2 min. The change in the diameter of the coronary artery in response to each drug was expressed as the percentage change from baseline ***: The patient characteristics did not differ between the two groups. The change in coronary diameter in response to ACh was greater in GroupⅠthan in Group Ⅱ(P = 0.0043), although the NTG-induced coronary vasodilation was similar between groups. ACh-induced dilation was greater in GroupⅠa than in GroupⅠb(P = 0.0231). Multivariate regression analysis showed that a low-dose of aspirin(P = 0.0004) was one of the factors associated with ACh-induced dilation at 30 μg/***: In subjects with angiographically normal coronary arteries, aspirin only had a positive influence on coronary endothelial function at the low dose of 100 mg. This improvement of coronary endothelial function may be involved in the preventive effect of aspirin against future coronary events.

关键词： Acetylcholine Aspirin Coronary endothelial function Quantitative coronary angiography

PGJIFs, new mitochondrial PGJ2 target factors, regulate cell proliferation

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Journal of Biosciences and Medicines 2013年第3期1卷 11-15页

作者： Makoto Umeda Tatsuya Uebi naoya Maekawa Hiroshi Handa Takeshi Imai Department of Aging Intervention National Center for Geriatrics and Gerontology (NCGG) Obu Japan Faculty of Bioscience and Biotechnology Tokyo Institute of Technology Yokohama Japan

Our previous study showed that prostaglandin J2 (PGJ2) interacting factor (PGJIF) was purified and identified with magnetic nanobeads. Farther analysis of PGJ2 function shows that PGJ2 inhibits cell proliferation and rhodamine 123 incorporation. Using PGJ2- immobilized nanobeads, two target proteins were also purified and identified as PGJIF1 and PGJIF2. PGJIF1 genetic analysis showed that PGJIF1 regulates cell proliferation as well as rhodamine 123 incorporation in mitochondria, indicating that PGJIF1 is one of the PGJ2 target proteins. The other target protein, PGJIF2, changes its intracellular localization in PGJ2-dependent manner. Using nanobeads technology, two PGJ2 target factors were purified and identified.

关键词： Prostaglandin J2 Nanobeads Mitochondria

Protein phosphatase 4 is involved in the late development of <i>Dictyostelium discoideum</i>

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Open Journal of Molecular and Integrative Physiology 2013年第2期3卷 49-53页

作者： Ichiro Kamei Kozo Takamoto naoya Sakuragi Eiji Tanesaka Motonobu Yoshida Department of Agricultural Science Kinki University Nara Japan

A cDNA clone SSJ337 (accession no. AF161253) of 1230 bp, encoding a catalytic subunit of protein phosphatase 4, was selected as one of the clones expressed specifically in prestalk cells from a cDNA library of D. discoideum slugs. Cells transformed with a knockout construct of SSJ337 showed an aberrant and tiny fruiting-body formation with a short stalk. A knockout mutant, SSJ337KO was allowed to develop much slower than a wild-type AX2 after the post-aggregation stage. This suggested that the SSJ337 cDNA clone has played an important role especially in the later development of Dictyostelium discoideum. Results from Northern blotting, analysis showed that transcripts for SSJ337 were accumulated at 16 h to 24 h after starvation began.

关键词： Dictyostelium Protein Phosphatase Fruiting-Body Formation Knockout Mutant

Syntheses, Crystal Structure and Photoluminescence Properties of Piperidinium Tetrakis (1,3-Diphenyl-1,3-Propanedionato) Europate(III) Complex and Its Two Different Crystals

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Crystal Structure Theory and Applications 2017年第4期6卷 57-66页

作者： Tetsuji Moriguchi naoya Kitou Daisuke Yakeya Akihiko Tsuge Kenji Yoza Venkataprasad Jalli Department of Applied Chemistry Faculty of Engineering Kyushu Institute of Technology Kitakyushu Japan Japan Bruker AXS K.K. Yokohama Japan Sankar Foundation Research and Development Division Visakhapatnam India

Treatment of 1,3-diphenyl-1,3-propanedione 1a with europium (III) chloride in the presence of piperidine results in the halide ligands exchange giving newly piperidinium tetrakis (1,3-diphenyl-1,3-propanedionato)europate(III) complex 2a. The complex was characterized by 1H-NMR, positive FAB-mass, and Elemental Analysis. The exact molecular structure of 2a was determined by single crystal X-ray diffraction with the monoclinic space group Cc (centrosymmetric, No.13). The large cavity sizes of the complex 2a facilitated the inclusion of water and benzene solvate molecules. The other two different crystals 2b, 2c having two water molecules and one benzene moleculewere obtained by the crystallization in different solvents and the exact molecular structures were determined by single crystal X-ray diffraction analysis with space groups P21/n (centrosymmetric, No.14), and P21/n (centrosymmetric, No.14), respectively. The eight coordinate structures of the complexes in the three crystals were slightly different due to the crystal packing and the existence of the solvent molecule(s). The photoluminescence studies indicated that four β-diketone ligands acted as strong antenna ligands and transferred the absorbed energy to europium (III) ion, consequently red luminescence was observed. These strong emissions wereattributed to the 5D0 → 7F2 transition of Europium (III) ions under UV excitation. The photoluminescence spectrum of the three crystals was almost same in solid as well as in solution.

关键词： Tetrakis Europium Complexes Luminescence β-Diketone Ligands

Update on targeted therapy and immune therapy for gastric cancer, 2018

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 365-379页

作者： Yuki Kiyozumi Masaaki Iwatsuki Kohei Yamashita Yuki Koga naoya Yoshida Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityGraduate School of Medical SciencesKumamoto 860-8556Japan

Gastric cancer(GC)remains one of the most common cancers and serious health problems *** unresectable or metastatic advanced gastric cancer,chemotherapy treatment is first *** chemotherapy has improved survival in patients with advanced gastric cancer(AGC),the prognosis of these patients remains *** recent years,some therapies targeting biological molecules have been reported to prolong the survival of patients with *** trastuzumab,a monoclonal antibody that targets HER2,was established as standard therapy for unresectable GC in a HER2-positive patient,many other targets have been reported as new therapy *** molecular targeted therapies,such as HER2,VEGFR or EGFR,have been verified as established standard treatments with or without chemotherapy in clinical ***,immunotherapy is expected to be an effective treatment with promising clinical trial ***,immune checkpoint inhibiters,such as PD-1/PD-L1 or CTLA-4,have demonstrated innovative progression in GC ***,ongoing clinical trials including targeted therapy and immunotherapy have shown promising results in improving clinical outcomes,safety,and *** this article,we review targeting therapies and immunotherapies for GC and summarize future prospective treatments.

关键词： Gastric cancer targeted therapy immunotherapy immune checkpoint inhibitor

Study on Formation Mechanism of Dumping Piles on Dumping Area Stability

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Open Journal of Geology 2014年第4期4卷 161-175页

作者： Donghua Zhang naoya Inoue Takashi Sasaoka Hideki Shimada Akihiro Hamanaka Kikuo Matsui Department of Earth Resources Engineering Faculty of Engineering Kyushu University Fukuoka City Japan

Dumping areas represent a stable hazard. To clarify the formation mechanism of dumping piles on dumping area stability, an investigation in open pit mine was performed. Moreover, experiments with gravel were conducted based on the research site conditions. The geological conditions, dumping operation, and waste particle size distribution were investigated in the Heidaigou open pit mine. Particle size distribution, dumping height, dumping volume, and floor inclination were varied to examine their effects on a single pile formation. The design of blasting can be modified to make the particle size of waste smaller. The volume of the bucket does not have a pronounced effect on dumping pile repose angle, capacity of dumping pile, and dumping area stability. The smaller the floor inclination, the better it is. Two measures are proposed to increase the kinetic force of friction between waste material and floor surface. The interval distance, dumping volume and dumping height were also varied to examine the interaction between the formations of multiple piles. The dumping width should be decided through optimization efficiency of bulldozer and dumping device in bucket wheel excavator-belt-stacker dumping operation and dragline dumping operation. Moreover, the volume of the bucket does not have a pronounced interaction effect. In the dumping operation, the work amount of bulldozer decreases as dumping pile increases. The design of the dumping operation must consider the total efficiency of ground leveling operation and forming dumping the area.

关键词： Open Pit Mine Dumping Pile Formation Mechanism Site Investigation Experiment

Energy barrier in the burst phase folding in wet silica gel

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Energy barrier in the burst phase folding in wet silica gel

ON A CONCEPT OF COLUMN BUCKLING FOR MEMBER PROPORTIONING AND BUCKLING LOAD ESTIMATION OF ELLIPTIC PARABOLOIDAL SINGLE LAYER LATTICE DOMES

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Takahiro Okabe Seiichi Tsukamoto naoya Shibayama Masamichi Ikeguchi Department of Bioinformatics Soka UniversityHachiojiTokyo 192-8577Japan Department of Physiology Division of BiophysicsJichi Medical UniversityShimotsukeTochigi 329-0498Japan

During refolding from the unfolded state,many small globular proteins exhibit the rapid accumulation of intermediates within the dead-time of stopped-flow *** processes are known as burst phases. Although there has been a number of advances in experimental methodologies for studying the early stage of folding so far,it is still difficult to detect the first step of folding reaction.

关键词： protein folding silica gel energy barrier burst phase

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ON A CONCEPT OF COLUMN BUCKLING FOR MEMBER PROPORTIONING AND...