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A new index for non-invasive assessment of liver fibrosis

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World Journal of Gastroenterology 2010年第38期16卷 4809-4816页

作者： Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho kato Shiho Kitahara Senju Hashimoto naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka Faculty of Medical Technology School of Health SciencesFujita Health UniversityToyoakeAichi 470-1192Japan Department of Clinical Laboratory Fujita Health University Hospital Department of Liver Biliary Tract and Pancreas DiseasesFujita Health University

AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4.

关键词： Non-invasive fi brosis index Fibro-Stiffness index Chronic hepatitis C Liver stiffness Liver fi brosis

Peak Mating and Breeding Period of the Humpback Whale —(Megaptera novaeangliae) in Okinawa Island, Japan

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Open Journal of Animal Sciences 2016年第3期6卷 169-179页

作者： Nozomi Kobayashi Haruna Okabe Isao Kawazu naoto Higashi Hirokazu Miyahara Hidehiro kato Senzo Uchida Okinawa Churashima Foundation Okinawa Japan Laboratory of Cetacean Biology Tokyo University of Marine Science and Technology Tokyo Japan Okinawa Churaumi Aquarium Okinawa Japan

Although detailed knowledge on breeding ecology of humpback whales is required for developing effective and sustainable whale watching programs in breeding areas, the breeding ecology of this species is still poorly understood. Hence, we examine the migratory timing of humpback whales in Okinawa that is one of their breeding ground, distinguishing the reproductive status (male, female, or female with a calf), group compositions (singleton, pair, or whales more than three) and group types (singer or competitive group) in order to assess the peak period of breeding activities. A total of 1192 days of photo-identification surveys were conducted from 1991 to 2012 and a total of 7366 humpback whales were sighted during the surveys. Among them, 1284 whales were sex-determined (848 males, 147 females and 289 females with a calf), 1138 singletons, 1416 pairs and 710 groups of more than three whales were observed. Females without calves tended to occur from late January to late February, which was the beginning of the breeding season and male-female pairs were observed most frequently during this period. The peak occurrence of competitive group which was considered a mating-related behavior group, formed by females and males, was also observed during this period. These results indicated that humpback whales peak mating period in Okinawa occurred between late January and late February. Females with a calf tended to increase from mid-February toward the end of the breeding season maintaining a high sighting per unit effort (SPUE) value in late March. We, therefore, suggested that the peak time of birthing and newborn care was probably that period in Okinawa. These findings extended our knowledge on the reproductive ecology of humpback whales in Okinawan waters.

关键词： Humpback Whale Mating Birthing Reproductive Status Okinawa

Efficacy of a novel auto-fluorescence imaging system with computer-assisted color analysis for assessment of colorectal lesions

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World Journal of Gastroenterology 2013年第41期19卷 7146-7153页

作者： Hiroko Inomata naoto Tamai Hiroyuki Aihara Kazuki Sumiyama Shoichi Saito Tomohiro kato Hisao Tajiri Department of Endoscopy The Jikei University School of MedicineTokyo 105-8461Japan Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan

AIM:To evaluate the efficacy of computer-assisted color analysis of colorectal lesions using a novel auto-fluorescence imaging(AFI)system to distinguish neoplastic lesions from non-neoplastic lesions and to predict the depth of ***:From January 2013 to April 2013,consecutive patients with known polyps greater than 5 mm in size who were scheduled to undergo endoscopic treatment at The Jikei University Hospital were prospectively recruited for this *** lesions were evaluated using a novel AFI system,and color-tone sampling was performed in a region of interest determined from narrow band imaging or from chromoendoscopy findings without *** green/red(G/R)ratio for each lesion on the AFI images was calculated automatically using a computer-assisted color analysis system that permits real-time color analysis during endoscopic ***:A total of 88 patients with 163 lesions were enrolled in this *** were significant differences in the G/R ratios of hyperplastic polyps(non-neoplastic lesions),adenoma/intramucosal cancer/submucosal(SM)superficial cancer,and SM deep cancer(P0.89 was applied to determine non-neoplastic lesions,the sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy were 83.9%,82.6%,53.1%,95.6%and 82.8%,*** neoplastic lesions,the mean G/R ratio was 0.834±0.080 in adenoma/intramucosal cancer/SM superficial cancer and 0.746±0.045 in SM deep *** G/R ratio of adenoma/intramucosal cancer/SM superficial cancer was significantly higher than that of SM deep cancer(P<0.01).When a G/R ratio cut-off value of<0.77 was applied to distinguish SM deep cancers,the sensitivity,specificity,PPV,NPV,and accuracy were80

关键词： Autofluorescence imaging Computer-aided diagnosis Colon Neoplasia Colonoscopy

Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

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World Journal of Hepatology 2017年第36期9卷 1340-1345页

作者： Yoshinori Ozono Kenji Nagata Satoru Hasuike Hisayoshi Iwakiri Kenichi Nakamura Mai Tsuchimochi Yuri Yamada Yuka Takaishi Mitsue Sueta Tadashi Miike Yoshihiro Tahara Shojiro Yamamoto Kotaro Shide Tomonori Hidaka Yoko Kubuki Kazunori Kusumoto Toshimasa Ochiai Junya kato naoto Komada Shuichi Hirono Kazuo Kuroki Masafumi Shigehira Kazuya Shimoda Department of Gastoroenterology and Hematology Faculty of Medicine University of Miyazaki Department of Liver Disease University of Miyazaki Hospital Department of Internal Medicine Koga General Hospital Department of Internal Medicine National Hospital Organization Miyakonojo Medical Center Department of Internal Medicine Hirono Naika Clinic Department of Internal Medicine Kushima Municipal Hospital Department of Internal Medicine Shigehira Clinic

AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype *** This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age *** The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

关键词： Chronic hepatitis C Sofosbuvir Ledipasvir Sustained virological response Direct acting antivirals

Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

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World Journal of Gastroenterology 2015年第35期21卷 10215-10223页

作者： Keisuke Osakabe Naohiro Ichino Toru Nishikawa Hiroko Sugiyama Miho kato Ai Shibata Wakana Asada naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Takamitsu Kurashita Tomoki Takamura Kentaro Yoshioka Faculty of Medical Technology School of Health SciencesFujita Health University Center of Ultrasound Diagnosis Fujita Health University Hospital Department of Liver Biliary Tract and Pancreas DiseasesFujita Health University

AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis ***: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after ***: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.

关键词： Hepatitis C virus Fibrosis Interferon and ribaviri

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建筑技艺 2010年第5期16卷 92-99页

作者： Yumiko Yamada Rikiya Yamamoto Osamu kato naoto Noguchi Mizuko Kaji Takayuki Hasegawa Louis-Antoine Grego Tetsuo Kondo Matthias Haertel Catarina Canas 朱晓琳 SAPS/Sasaki and Partners B+G Ingenieure Bollinger und Grohmann GmbH Walther Mory Maier Bauingenieure AG BG Ingénieurs Conseils SA Losinger Construction SA

日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA （Sejima And Nishizawa And Associates）是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所，该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验... 详细信息

日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA （Sejima And Nishizawa And Associates）是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所，该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验性质，向人们展示了21世纪人类新的学习方式和交互性影响的意义。作为瑞士洛桑联邦理工学院（EPFL）的一部分，

关键词：学习方式劳力士建筑事务所建筑师设计