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Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel

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World Journal of Clinical Urology 2014年第2期3卷 139-143页

作者： Takumi Endo naoto Kamiya Hiroyoshi Suzuki Ryo Oka Fang-Ching Lee Takanobu Utsumi Masashi Yano Shuichi Kamijima Koji Kawamura Takashi Imamoto Tomohiko Ichikawa Department of Urology Toho University Sakura Medical CenterSakura-shiChiba 285-8741Japan Department of Urology Graduate School of MedicineChiba UniversityChiba-shiChiba 260-8670Japan

AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with ***: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP) and alkaline phosphatase(ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with ***: For the total patient group, the mean ± standard deviation(SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and num-ber of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP(8.2 ng/m L) and ALP(538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P < 0.05).CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.

关键词： Prostate cancer Docetaxel chemotherapy Carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen Alkaline phosphatase Prognostic factor

1.5 Ma以来黄土高原风尘堆积的岩石磁学记录与中更新世气候转型

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海洋地质与第四纪地质 2005年第3期25卷 43-51页

作者：宋友桂方小敏石川尚人鸟居雅之李吉均史正涛强小科符超峰中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710075 兰州大学教育部西部环境重点实验室兰州730000 京都大学综合人间学部冈山理科大学情报学院

通过对黄土高原中部朝那剖面黄土-古土壤序列系统的岩石磁学分析,建立了1.5 Ma以来黄土高原高分辨率岩石磁学指标演化序列.岩石磁学记录表明本区1.5 Ma以来以0.93和0.62 Ma为界经历了3个不同的气候演化阶段.在1.5～0.93和0.62～0 Ma期... 详细信息

通过对黄土高原中部朝那剖面黄土-古土壤序列系统的岩石磁学分析,建立了1.5 Ma以来黄土高原高分辨率岩石磁学指标演化序列.岩石磁学记录表明本区1.5 Ma以来以0.93和0.62 Ma为界经历了3个不同的气候演化阶段.在1.5～0.93和0.62～0 Ma期间各种磁学参数大致呈同步变化趋势,能较好地与深海氧同位素(MIS)曲线相对应,而在0.93～0.62 Ma期间(相当于L9底到L6顶,MIS24-MIS16),尽管磁化率、饱和剩磁强度(Mr)、饱和磁化强度(Ms)与剩磁矫顽力(Bcr)、矫顽力(Bc)曲线的峰谷能与MIS的峰谷相对比,但该阶段的磁学参数变化幅度和形式明显不同于1.5～0.93和0.62 Ma以来的两个演化阶段.磁化率、Mr和Ms在0.93 Ma突然降低,此后变幅很小,反映夏季风较弱且相对稳定,一直维持到0.62 Ma前后.在0.9 Ma前后Bc、Bcr突然增大,可能反映了冬季风突然增强,然后宽幅波动下降.这种变化可能是黄土高原风尘堆积对中更新世气候转型事件的响应.黄土高原岩石磁学记录的中更新世气候转型事件发生于0.93 Ma,结束于0.62 Ma.造成这次气候转型事件的原因除了与全球冰量和太阳辐射变化有关之外,还可能与中更新世青藏高原急剧隆升而激发的亚洲内陆干旱化加剧,从而导致亚洲内陆沙漠的形成与扩张有关.

关键词：岩石磁学黄土-古土壤古气候中更新世气候转型黄土高原

维普期刊数据库

路易体痴呆患者临床症状和纹状体多巴胺转运体活性间的关系

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中华核医学与分子影像杂志 2018年第1期38卷 72-72页

作者：唐军 Soichiro Shimizu Disuke Hirose Nayuta Namioka Hidekazu Kanetaka Kentaro Hirao Hirokuni Hatanaka naoto Takenoshita Yoshitsugu Kaneko Yusuke Ogawa Takahiko Umahara Hirofumi Sakurai Haruo Hanyu 上海交通大学医学院附属苏州九龙医院核医学科 Department of Geriatric Medicine Tokyo Medical University

目的众所周知,路易体痴呆（DLB）患者;I-氟丙基-甲酯基-3β-（4-碘苯丙烷）(FPCIT)SPECT显像时,纹状体内多巴胺转运体（DAT）活性是降低的。该研究分析了临床症状和纹状体内局部DAT活性降低间的关系。方法纳入95例阿尔茨海默病（AD）患... 详细信息

目的众所周知,路易体痴呆（DLB）患者;I-氟丙基-甲酯基-3β-（4-碘苯丙烷）(FPCIT)SPECT显像时,纹状体内多巴胺转运体（DAT）活性是降低的。该研究分析了临床症状和纹状体内局部DAT活性降低间的关系。方法纳入95例阿尔茨海默病（AD）患者和133例DLB患者行;I-FP-CIT SPECT显像,分析DLB患者的相关症状[认知功能减退、运动症状波动、幻视、震颤麻痹和快相睡眠行为异常（RBD）]和纹状体局部DAT活性间的关系。结果比较有和没有运动症状波动、幻视或RBD的DLB患者显像结果,发现两者纹状体内任何部位的DAT活性均无明显差异。与无帕金森病的DLB患者相比,有帕金森病的DLB患者纹状体、壳核或壳核前部的DAT活性明显降低。此外,DLB患者帕金森病的严重程度与整个纹状体内DAT活性的降低呈弱相关。DLB患者纹状体内任何部位的DAT活性降低与认知功能减退无明显相关性。结论就DLB患者而言,仅帕金森病与纹状体内DAT活性的降低有关。

关键词：路易体痴呆帕金森病 I-FP-CIT DAT显像阿尔茨海默病

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乳酸抗性酵母的筛选及其生长特性的研究

氨基酸和生物资源 2000年第3期22卷 1-5页

作者：王昌禄杜连祥顾晓波路福平赵学明饭村穰冈崎直人天津轻工业学院天津大学化工学院天津300071 天津大学化工学院国税厅酿造研究所

以酿酒酵母 (saccharomycesceevisiae)单倍体YNN -2 7(αtep ura )为亲株 ,在含有 4 %乳酸的梯度平板上直接进行紫外线诱变处理 ,筛选到突变株YNN -2 7-2 4。通过对该突变株乳酸抗性产生原因分析、在含有不同浓度的乳酸和潮霉素B(hygrom... 详细信息

以酿酒酵母 (saccharomycesceevisiae)单倍体YNN -2 7(αtep ura )为亲株 ,在含有 4 %乳酸的梯度平板上直接进行紫外线诱变处理 ,筛选到突变株YNN -2 7-2 4。通过对该突变株乳酸抗性产生原因分析、在含有不同浓度的乳酸和潮霉素B(hygromycinB)的YPDL和YPDLH培养基中的重复特性的研究发现 ,该突变株对乳酸和潮霉素B产生的抗性 ,不是因对环境条件的适应而产生 ,而是由基因突变所引起。与突变株YNN2 7-2 4相比 ,乳酸对亲株生长的影响在于延长了其生长的延迟期 ,而其生长速率没有发生改变。用Mini-photo 51 8测定供试菌株在生长过程中的吸光度 ( 660nm)以研究酵母菌的生长特性 ,是一种行之有效的方法 ,具有较高的灵敏度和较好的再现性。

关键词：酿酒酵母乳酸抗性潮霉素B 生长特性

维普期刊数据库

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid