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Relationship between Dysphagia and Serum Substance P Level in Chronic Central Nervous Disease

International Journal of Clinical Medicine 2013年第2期4卷 86-90页

作者： Yoshiyuki Kishida naoto maeda Yoshikazu Murawaki Second Department of Internal Medicine Tottori University School of Medicine Yonago Japan

Purpose: We compared serum substance P (SP) levels in underlying diseases and dysphagia, or its absence, in patients with cerebrovascular disease, neurodegenerative disease or Alzheimer’s disease, to investigate the relationship between dysphagia and serum SP in chronic central nervous disease. Methods: Subjects comprised 94 patients admitted to a hospital or nursing home during the 5 years between April 2007 and April 2012 with central nervous symptoms. Serum SP levels were measured by enzyme immunoassay, and video endoscopy using a nasal endoscope in all subjects to objectively evaluate swallowing function. Results: Serum SP level was very similar in central nervous disease without dysphagia and controls without central nervous disease. Conversely, serum SP level was significantly lower in central nervous disease with dysphagia. When comparing underlying diseases, serum SP was significantly lower in Parkinson’s disease than in other disease groups (cerebrovascular disease, Alzheimer’s disease). Looking at changes in serum SP levels over time after disease onset, SP level was significantly low in subjects without dysphagia at the time of onset who went on to develop dysphagia during the disease course, whereas serum SP level tended to be higher in subjects with dysphagia at the time of onset and improvement during the disease course. With Parkinson’s disease and cerebrovascular disease, serum SP was low, particularly in subjects thought to have severe damage to the basal ganglia. Conclusion: Serum SP is generally thought to decrease in patients with cerebrovascular disease accompanied by dysphagia, but these results suggest that serum SP levels can be expected to improve to some extent, even if dysphagia is present at disease onset, assuming, for example, that some basal ganglia function remains. Positive therapeutic interventions such as swallowing rehabilitation should be promoted in such patients, with the goal of improving swallowing function.

关键词： Substance P Dysphagia Central Nervous Disease

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Algorithm Selection Method Based on Coupling Strength for Partitioned Analysis of Structure-Piezoelectric-Circuit Coupling

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1237-1258页

作者： Daisuke Ishihara naoto Takayama Department of Intelligent and Control Systems Kyushu Institute of TechnologyIizuka820-8502Japan

In this study, we propose an algorithm selection method based on coupling strength for the partitioned analysis ofstructure-piezoelectric-circuit coupling, which includes two types of coupling or inverse and direct piezoelectriccoupling and direct piezoelectric and circuit coupling. In the proposed method, implicit and explicit formulationsare used for strong and weak coupling, respectively. Three feasible partitioned algorithms are generated, namely(1) a strongly coupled algorithm that uses a fully implicit formulation for both types of coupling, (2) a weaklycoupled algorithm that uses a fully explicit formulation for both types of coupling, and (3) a partially stronglycoupled and partially weakly coupled algorithm that uses an implicit formulation and an explicit formulation forthe two types of coupling, *** examples using a piezoelectric energy harvester,which is a typicalstructure-piezoelectric-circuit coupling problem, demonstrate that the proposed method selects the most costeffectivealgorithm.

关键词： Multiphysics coupling strength partitioned algorithm structure-piezoelectric-circuit coupling strongly coupled algorithm weakly coupled algorithm

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Hybrid Strategy of Partitioned and Monolithic Methods for Solving Strongly Coupled Analysis of Inverse and Direct Piezoelectric and Circuit Coupling

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1371-1386页

作者： Daisuke Ishihara Syunnosuke Nozaki Tomoya Niho naoto Takayama Department of Intelligent and Control Systems Kyushu Institute of TechnologyFukuokaJapan

The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy *** strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic *** formulation has its advantages and disadvantages,and the choice depends on the characteristics of each coupled *** study proposes a new option:a coupled analysis strategy that combines the best features of the existing formulations,namely,the hybrid partitioned-monolithic *** analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric and circuit interaction are strongly coupled using a partitioned iterative hierarchical *** a typical benchmark problem of a piezoelectric energy harvester,this research compares the results from the proposed method to those from the conventional strongly coupled partitioned iterative method,discussing the accuracy,stability,and computational *** proposed hybrid concept is effective for coupled multi-physics problems,including various coupling conditions.

关键词： Structure-piezoelectric-circuit interaction energy harvesting partitioned method monolithic method hybrid method

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Natural Convection Melting in a Rectangular Heat Storage Tank of Carbon Nanotube Dispersed Latent Heat Storage Material

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Journal of Thermal Science 2024年第3期33卷 847-855页

作者： Shin-ichi MORITA Tomoya SAITO Kazunori TAKAI Yasutaka HAYAMIZU naoto HARUKI Division of Mechanical and Electrical Engineering Kitami Institute of Technology165 Koen-choKitami-shiHokkaido090-8507Japan National Institute of Technology Yonago College4448 Hikona-cyoYonago-shiTottori683-8502Japan Okayama Prefectural University 111 KubokiSoja-shiOkayama719-1197Japan

A dispersion system fluid can convect even if the dispersoid is a solid ***,heat exchange performance can be improved while maintaining fluidity using a material with high thermal conductivity as the *** study presents the melting performance evaluation results of a latent heat storage material with a carbon nanotube(CNT)dispersion system with high thermal conductivity,which enhances the thermal conductivity of the latent heat storage material and does not limit free *** the thermal conductivity and enhancing the melting convection of the heat storage material result in increased latent heat storage *** this study,the thermal conductivity of the latent heat storage material was successfully increased by dispersing CNTs in the *** 0.1%(in mass)of multi-wall CNT(MWCNT)was dispersed in a paraffin-based latent heat storage material,the shear stress increased by 1.5 times at a shear rate of 500 s^(-1),while taking into account the potential effects of convective ***,a latent heat storage experiment was conducted in a rectangular heat storage tank using the CNT dispersion composition ratio as a parameter.A rectangular vessel with a heated vertical surface was used for the latent heat storage *** melting speed was determined by comparing the amount of latent heat stored in a CNT-dispersed latent heat storage material and a single-phase latent heat storage material *** experimental results show that the time required for the latent heat storage material to completely melt in the heat storage tank was the shortest for the single-phase latent heat storage material ***,the fastest melting progress was observed for the sample with 0.02%(in mass)MWCNT content in the melting rate range of up to approximately 40%in the *** results indicate that this phenomenon is caused by the difference in the melting rates in the upper part of the *** generated data are useful for det

关键词： latent heat storage phase change carbon nano tube free convection heat transfer

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电子非厄米系统中的拓扑自旋图样

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Science Bulletin 2024年第9期69卷 325-333页

作者：张骁骁 naoto Nagaosa RIKEN Center for Emergent Matter Science(CEMS) WakoSaitama 351-0198Japan Department of Applied Physics University of TokyoTokyo 113-8656Japan

Non-Hermitian systems have been discussed mostly in the context of open systems and *** experimental progress is much from optical,cold-atomic,and classical platforms due to the vast tunability and clear identification of ***,their counterpart in solid-state electronic systems in equilibrium remains unmasked although highly desired,where a variety of materials are available,calculations are solidly founded,and accurate spectroscopic techniques can be *** demonstrate that,in the surface state of a topological insulator with spin-dependent relaxation due to magnetic impurities,highly nontrivial topological soliton spin textures appear in momentum *** spin-channel phenomena are delicately related to the type of non-Hermiticity and correctly reveal the most robust non-Hermitian features detectable ***,the distinct topological soliton objects can be deformed to each other,mediated by topological transitions driven by tuning across a critical direction of doped *** results not only open a solid-state avenue to exotic spin patterns via spin-and angle-resolved photoemission spectroscopy,but also inspire non-Hermitian dissipation engineering of spins in solids.

关键词： Non-Hermitian system Topological spin texture Magnetic impurity Surface state ARPES

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电子非厄米系统中的拓扑自旋图样（英文）

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Science Bulletin 2024年第3期 325-333页

作者：张骁骁 naoto Nagaosa RIKEN Center for Emergent Matter Science (CEMS) Department of Applied Physics University of Tokyo

Non-Hermitian systems have been discussed mostly in the context of open systems and *** experimental progress is much from optical, cold-atomic, and classical platforms due to the vast tunability and clear identification of observables. However, their counterpart in solid-state electronic systems in equilibrium remains unmasked although highly desired, where a variety of materials are available, calculations are solidly founded, and accurate spectroscopic techniques can be applied. We demonstrate that, in the surface state of a topological insulator with spin-dependent relaxation due to magnetic impurities, highly nontrivial topological soliton spin textures appear in momentum *** spin-channel phenomena are delicately related to the type of non-Hermiticity and correctly reveal the most robust non-Hermitian features detectable spectroscopically. Moreover, the distinct topological soliton objects can be deformed to each other, mediated by topological transitions driven by tuning across a critical direction of doped magnetism. These results not only open a solid-state avenue to exotic spin patterns via spin-and angle-resolved photoemission spectroscopy, but also inspire non-Hermitian dissipation engineering of spins in solids.

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PROPENSITY RULES IN Ar-IMPACT EXCITATION OF H^- IN DOUBLY EXCITED STATES

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原子与分子物理学报 1990年第4期7卷 1571-1574页

作者： naoto Koyama Motoi maeda Michio Matsuzawa Division of Affairs of Foreign Students Department of Applied Physics and ChemistryThe University of Electro-CommunicationsChofu-shiTokyo 182Japan NEC corporationDepartment of Applied Physics and ChemistryThe University of Electro-CommunicationsChofu-shiTokyo 182Japan

We have theoretically investigated excitation processes of H^- ions in the doubly excited states by Ar-impact,using the impulse approximation and employing the hyperspherical *** have found that the H^- ion in the double excited states tends to conserve its initial states as a “floppy linear triatomic molecule” during excitation processes except for the restriction arising from the Pauli exclusion principle for two atomic electrons.

关键词： H^-离子 Ar碰撞激发双激发态

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公共空间公共性的理论研究与分析框架构建

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国际城市规划 2024年第3期39卷 82-90页

作者：蒋敏中岛直人卢峰重庆大学建筑城规学院东京大学工学部都市工学系

当前公共空间建设、管理和运营过程中日益多样的参与主体和灵活的合作模式拓展了公共空间的内涵与边界,这种转变带来一种区别于公私二元对立的新视角。在这样的背景下,将公共性视为一种价值和愿景而非“私”的对立面,从更本质的角度理... 详细信息

当前公共空间建设、管理和运营过程中日益多样的参与主体和灵活的合作模式拓展了公共空间的内涵与边界,这种转变带来一种区别于公私二元对立的新视角。在这样的背景下,将公共性视为一种价值和愿景而非“私”的对立面,从更本质的角度理解公共性的内涵有助于为复杂的利益博弈和权利平衡提供一种价值参照。本文通过研究西方代表性文献,分析了公私二元对立关系的瓦解过程,将公共性的核心价值总结为公开性、异质性和共同性,进而分析了公共空间公共性的价值。在此基础上,受现象学和新行为主义心理学的启发,本文提出将公共空间公共性视为一种主观感知的研究思路,继而融合公共空间的客观特征和使用人群的主观感知构建了一种新的公共空间公共性分析框架,规避了公私的二元对立,实现了评价主体的转变,且有助于反映文脉特征和地域差异,为公共空间公共性的定量研究和机制探索提供新的思路。

关键词：公共空间公共性理论研究公共性感知分析框架

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Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro Kojima Shota Kami Keishiro Aoki Tomoyuki Satake Tatsushi Kobayashi Motokazu Sugimoto Shin Kobayashi Masaru Konishi naoto Gotohda Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report

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Loess magnetic properties in the Ili Basin and their correlation with the Chinese Loess Plateau

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Science China Earth Sciences 2010年第3期53卷 419-431页

作者： naoto Ishikawa Graduate School of Human and Environmental Studies Kyoto University

Over the past two decades, magnetoclimatological studies of loess-paleosol sequences in the Chinese Loess Plateau (CLP) have made outstanding achievements, which greatly promote the understanding of East Asian paleomonsoon evolution, inland aridification of Asia, and past global climate changes. Loess magnetic properties of the CLP have been well studied. In contrast, loess magnetic properties from outside the CLP in China have not been fully understood. We have little knowledge about the magnetic properties of loess in the Ili Basin, an intermontane depression of the Tianshan (or Tien Shan) Mountains. Here, we present the results of rock magnetic measurements of the Ili loess including mass magnetic susceptibility (χ) and anhysteretic remanent magnetization (ARM), high/low temperature dependence of susceptibility (TDS) and hysteresis, as well as X-ray diffraction (XRD) for mineral analysis. Based on the comparison with loess-paleosol sequences in the CLP (hereafter referred to as the Chinese loess), we discuss the possible magnetic susceptibility enhancement mechanism of the Ili loess. The results show that 1) the total magnetic mineral concentration of the Ili loess is far lower than that of the Chinese loess, though they have similar magnetic mineral compositions. The ferrimagnetic minerals in the Ili loess are magnetite and maghemite, and the antiferromagnetic mineral is hematite; XRD analysis also identifies the presence of ilmenite. The ratio of maghemite is lower in the Ili loess than in the Chinese loess, but the ratios of magnetite and hematite are higher in the Ili loess than in the Chinese loess. 2) The granularity of magnetic minerals in the Ili loess, dominated by pseudo-single domain (PSD) and multi-domain (MD) grains, is generally much coarser than that of the Chinese loess. Ultrafine pedogenically-produced magnetic grains have a very limited contribution to the susceptibility enhancement. Rather, PSD and MD particles of magnetite and maghemite are th

关键词： loess magnetic property magnetic susceptibility the Ili Basin the Chinese Loess Plateau

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