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The completed macronuclear genome of a model ciliate Tetrahymena thermophila and its application in genome scrambling and copy number analyses

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Science China(Life Sciences) 2020年第10期63卷 1534-1542页

作者： Yalan Sheng Lili Duan Ting Cheng Yu Qiao naomi AStover Shan Gao Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266003China Department of Biology Bradley UniversityPeoriaIllinois 61625USA

The ciliate Tetrahymena thermophila has been a powerful model system for molecular and cellular ***,some investigations have been limited due to the incomplete closure and sequencing of the macronuclear genome assembly,which for many years has been stalled at 1,158 scaffolds,with large sections of unknown sequences(available in Tetrahymena Genome Database,TGD,http://***/).Here we completed the first chromosome-level Tetrahymena macronuclear genome assembly,with approximately 300×long Single Molecule,Real-Time reads of the wild-type SB210 cells—the reference strain for the initial macronuclear genome sequencing *** 181 chromosomes were capped with two telomeres and gaps were entirely *** completed genome shows significant improvements over the current assembly(TGD 2014)in both chromosome structure and sequence *** majority of previously identified gene models shown in TGD were retained,with the addition of 36 new genes and 883 genes with modified gene *** new genome and annotation were incorporated into *** new genome allows for pursuit in some underexplored areas that were far more challenging previously;two of them,genome scrambling and chromosomal copy number,were investigated in this *** expect that the completed macronuclear genome will facilitate many studies in Tetrahymena biology,as well as multiple lines of research in other eukaryotes.

关键词： Tetrahymena thermophila macronuclear genome 181 chromosomes DNA scrambling copy number

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2011年

作者： (英) naomi Simmons

本套书共4册, 每册由15个单元。书中内容涉及天气、颜色、动植物、学校、数字课等课程标准中提到的话题。本册是小学五年级。

ISBN: (纸本)9787513510707;9787894788351

本套书共4册, 每册由15个单元。书中内容涉及天气、颜色、动植物、学校、数字课等课程标准中提到的话题。本册是小学五年级。

关键词：英语课

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From micro-to macroevolution:brood parasitism as a driver of phenotypic diversity in birds

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Current Zoology 2020年第5期66卷 515-526页

作者： Iliana Medina Rebecca M.Kilner naomi E.Langmore School of BioSciences University of MelbourneVictoria3010Australia Department of Zoology University of CambridgeCambridgeCB23EJUK Division of Ecology and Evolution Australian National UniversityCanberraACT 2600Australia

A fun dame ntal question in biology is how diversity evolves and why some clades are more diverse than *** diversity has often been shown to result from morphological adaptation to different *** role of behavioral interactions as a driver of broadscale phenotypic diversity has received comparatively less *** interactions,however,are a key agent of natural *** behavioral interactions with predators or with parasites can have significant fitness consequences,and hence act as strong evolutionary forces on the phe no type of species,ultimately gen erating diversity betwee n species of both victims and *** obligate brood parasites lay their eggs in the nests of other species,their hosts,and this behavioral interaction between hosts and parasites is often considered one of the best examples of coevolution in the natural *** this review,we use the coevolution between brood parasites and their hosts to illustrate the potential of behavioral interactions to drive evolution of phenotypic diversity at different taxonomic *** provide a bridge between behavioral ecology and macroevolution by describing how this interaction has increased avian phenotypic diversity not only in the brood parasitic clades but also in their hosts.

关键词： brood parasitism coevolution diversity phenotypic variation macroevolution

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Highly-Ordered Ferroelectric Photonic Crystals

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光学学报 2003年第S1期23卷 149-150页

作者： naomi Matsuura Harry E. Ruda Center for Advanced Nanotechnology University of Toronto Toronto Ontario M5S 3E3 CanadaCenter for Advanced Nanotechnology University of Toronto Toronto Ontario M5S 3E3 Canada

Highly-ordered, ferroelectric, Pb-doped Ba0.7Sr0.3TiO3, inverse opal thin films were fabricated using a sol-gel spin coating technique. The excellent crystal quality is evident from the SEM images and the good agreeme... 详细信息

关键词： were be SEM into high Highly-Ordered Ferroelectric Photonic Crystals Figure from of BST view or Pb that

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Treatment for superficial non-ampullary duodenal epithelial tumors

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World Journal of Gastroenterology 2014年第35期20卷 12501-12508页

作者： naomi Kakushima Hideyuki Kanemoto Masaki Tanaka Kohei Takizawa Hiroyuki Ono Division of Endoscopy Shizuoka Cancer Center Division of Hepato-Biliary-Pancreatic Surgery Shizuoka Cancer CenterShizuoka Cancer Center

Because of the low prevalence of non-ampullary duodenal epithelial tumors(NADETs),standardized clinical management of sporadic superficial NADETs,including diagnosis,treatment,and follow-up,has not yet been *** studies have revealed certain endoscopic findings suggestive of *** adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive *** use of endoscopic treatment including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),for the treatment for superficial NADETs is *** requires multiple sessions to achieve complete remission and repetitive endoscopy is needed after *** provides an excellent complete resection rate,however it remains a challenging method,considering the high risk of intraoperative or delayed *** invasive surgery such as wedge resection and pancreas-sparing duodenectomy are beneficial for superficial NADETs that are technically difficult to remove by endoscopic *** remains a standard surgical procedure for treatment of duodenal cancer with submucosal invasion,which presents a risk of lymph node *** or surgical treatment outcomes of superficial NADETs without submucosal invasion are *** an endoscopic diagnostic tool to differentiate superficial NADETs between adenoma and cancer as well as between mucosal and submucosal cancer is required to select the most appropriate treatment.

关键词： Duodenal neoplasms Duodenal cancer Pancreaticoduodenectomy Endoscopic surgery Esophagogastroduodenoscopy

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Effects of mixing methods of bifunctional catalysts on catalyst stability of DME synthesis via CO_(2)hydrogenation

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Carbon Resources Conversion 2019年第1期2卷 85-94页

作者： Shoujie Ren Shiguang Li naomi Klinghoffer Miao Yu Xinhua Liang Department of Chemical and Biochemical Engineering Missouri University of Science and TechnologyRollaMO 65409United States Gas Technology Institute 1700 South Mount Prospect RoadDes PlainesIL 60018United States Department of Chemical and Biological Engineering Rensselaer Polytechnic InstituteTroyNY 12180United States

The effects of three different mixing methods of CuO/ZnO/Al_(2)O_(3)(CZA)and HZSM-5 bifunctional catalyst on the stability for dimethyl ether(DME)synthesis from carbon dioxide(CO_(2))hydrogenation were *** the bifunctional catalyst was prepared by method A(mixing powder without pelletization),there was no significant change in DME production and catalyst stability when the HZSM-5 loading was varied between 0.1 g and 0.5 g with a fixed CZA loading of 0.5 g,.When the bifunctional catalysts were prepared by method B(pressed into pellets of CZA and pellets of HZSM-5 and then mixed)and method C(mixed CZA and HZSM-5 powders,then pressed into pellets),the mixing methods did not initially impact CO_(2)conversion and had a minor effect on DME ***,long-term tests(100 h)indicated that the mixing method had a significant influence on the catalyst *** B showed the best stability and the extent of catalyst deactivation followed the sequence of method B

关键词： Dimethyl ether(DME) CO_(2)hydrogenation Bifunctional catalyst Mixing method

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Colonoscopy can miss diverticula of the left colon identified by barium enema

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World Journal of Gastroenterology 2013年第15期19卷 2362-2367页

作者： Ryota Niikura Naoyoshi Nagata Takuro Shimbo Junichi Akiyama naomi Uemura Department of Gastroenterology and Hepatology National Center for Global Health and MedicineShinjukuTokyo 162-8655Japan Department of Clinical Research and Informatics National Center for Global Health and MedicineShinjukuTokyo 162-8655Japan Department of Gastroenterology and Hepatology Kohnodai HospitalNational Center for Global Health and MedicineIchikawaChiba 272-8516Japan

AIM: To identify the diagnostic value of colonoscopy for diverticulosis as determined by barium enema. METHODS: A total of 65 patients with hematochezia who underwent colonoscopy and barium enema were analyzed, and the diagnostic value of colonoscopy for diverticula was assessed. The receiver operating characteristic area under the curve was compared in relation to age (< 70 or ≥ 70 years), sex, and colon location. The number of diverticula was counted, and the detection ratio was calculated. RESULTS: Colonic diverticula were observed in 46 patients with barium enema. Colonoscopy had a sensitivity of 91% and specificity of 90%. No significant differences were found in the receiver operating characteristic area under the curve (ROC-AUC) for age group or sex. The ROC-AUC of the left colon was significantly lower than that of the right colon (0.81 vs 0.96, P=0.02). Colonoscopy identified 486 colonic diverticula, while barium enema identified 1186. The detection ratio for the entire colon was therefore 0.41 (486/1186). The detection ratio in the left colon (0.32, 189/588) was significantly lower than that of the right colon (0.50, 297/598) (P < 0.01). CONCLUSION: Compared with barium enema, only half the number of colonic diverticula can be detected by colonoscopy in the entire colon and even less in the left colon.

关键词： Colonoscopic diagnosis Colonic diverticulosis Colonic diverticular bleeding Barium enema Receiver operating characteristic area under the curve

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Physicochemical assessment and treatment of produced water:A case study in Niger delta Nigeria

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Petroleum Research 2023年第1期8卷 87-95页

作者： Kingsley Tamunokuro Amakiri naomi Amoni Ogolo Athanasios Angelis-Dimakis Oshienemen Albert Department of Chemical Engineering University of HuddersfieldQueens GateHuddersfieldEnglandUK Institute of Petroleum Studies University of Port HarcourtRivers StateNigeria School of Art Design and ArchitectureGlobal Disaster Resilience CentreUK

The most important waste stream created during oil and gas production is oilfield-produced *** discharged without treatment,it poses a significant risk of pollution of marine *** adequate treatment before disposal is acceptable,achieving authorized discharge criteria continues to be a problem for the petroleum *** research examined the physicochemical characteristics of produced water at various month intervals before and after *** metal and organic component concentrations in water samples were determined using atomic absorption spectroscopy and gas *** results indicate that produced water from a certain Niger Delta oilfield contains significant amounts of heavy metals and some organic compounds after *** present laws,as well as the measurement of dispersed oil and grease content,have been in place for a long period of time without considerable change,even though most dangerous components in produced water are *** is recommendable for the prospective field developers/operators to consider the dissolved components of produced water and consider the economic consequences of adopting tertiary produced water polishing technologies.

关键词： Nigeria Produced water Environment Oil and Gas Treatment

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Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats

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Journal of Environmental Sciences 2016年第11期28卷 125-130页

作者： Masaki Fujioka Min Gi Satoko Kawachi Kumiko Tatsumi naomi Ishii Kenichiro Doi Anna Kakehashi Hideki Wanibuchi Department of Molecular Pathology Osaka City University Graduate School of Medicine

Arsenic is a well-known human bladder and liver carcinogen, but its exact mechanism of carcinogenicity is not fully understood. Dimethylarsinic acid（DMAV） is a major urinary metabolite of sodium arsenite（i As~Ⅲ） and induces urinary bladder cancers in rats. DMAVand i As~Ⅲare negative in in vitro mutagenicity tests. However, their in vivo mutagenicities have not been determined. The purpose of present study is to evaluate the in vivo mutagenicities of DMAVand i As~Ⅲin rat urinary bladder epithelium and liver using gpt delta F344 ***-week old male gpt delta F344 rats were randomized into 3 groups and administered 0,92 mg/L DMAV, or 87 mg/L i As~Ⅲ（each 50 mg/L As） for 13 weeks in the drinking water. In the mutation assay, point mutations are detected in the gpt gene by 6-thioguanine selection（gpt assay） and deletion mutations are identified in the red/gam genes by Spi-selection（Spi-assay）. Results of the gpt and Spi-assays showed that DMAVand i As~Ⅲhad no effects on the mutant frequencies or mutation spectrum in urinary bladder epithelium or liver. These findings indicate that DMAVand i As~Ⅲare not mutagenic in urinary bladder epithelium or liver in rats.

关键词： Dimethylarsinic acid Sodium arsenite In vivo mutagenicity Urinary bladder epithelium gpt delta rat

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Beyond the synucleinopathies:alpha synuclein as a driving force in neurodegenerative comorbidities

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Translational Neurodegeneration 2019年第1期8卷 346-358页

作者： naomi P.Visanji Anthony E.Lang Gabor G.Kovacs Edmond J.Safra program in Parkinson’s disease and the Morton and Gloria Shulman Movement disorders clinic Toronto Western HospitalTorontoOntarioCanada Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Disease University of TorontoTorontoOntarioCanada Laboratory Medicine Program&Krembil Brain Institute University Health NetworkTorontoOntarioCanada

The fundamental role that alpha-synuclein(aSyn)plays in the pathogenesis of neurodegenerative synucleinopathies,including Parkinson’s disease,dementia with Lewy bodies,and multiple system atrophy,is a well-accepted fact.A wealth of experimental evidence has linked this relatively small but ubiquitously expressed protein to a plethora of cytopathologic mechanisms and suggests that aSyn may be capable of seeding the progressive spread of synucleinopathy throughout the *** the synucleinopathies,the abnormal deposition of aSyn is frequently seen in a variety of other neurodegenerative proteinopathies including Alzheimer’s *** spite of the fact that the frequency of concomitant aSyn pathology in these disorders is such that it can be considered the rule rather than the exception,the potential role that aSyn may have in these disorders has received relatively little *** this article we postulate that aSyn may in fact be a key protein in driving the pathogenic processes in neurodegenerative *** addition to reviewing the frequency of concomitant deposition of aSyn in the neurodegenerative proteinopathies,we also consider our current understanding of the interaction of aSyn with other neurodegenerative disease-associated proteins,including tau,TDP-43,amyloid-βand prion protein,in the context of neuropathologic studies describing the anatomical sites of potential concomitant *** conclude that a growing body of evidence,encompassing neuropathology studies in human brain,animal models of concomitant proteinopathies and studies employing sophisticated methods of probing protein-protein interaction,cumulatively suggest that aSyn is well positioned to exert a strong influence on the pathogenesis of the neurodegenerative *** hope to stimulate research in this emerging field and consider that future studies exploring the contribution of aSyn to the pathogenic processes in neurodegenerative comorbidities may provide critical

关键词： Amyloid-β Alpha-synuclein Alzheimer’s disease Comorbidity Dementia with Lewy bodies Multiple system atrophy Neurodegeneration Parkinson’s disease Prion protein Progressive supranuclear palsy Proteinopathy Tau TDP-43

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