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Determinants of Early Survival of Breast Cancer Patients in Yaoundé-Cameroon

Open Journal of Obstetrics and Gynecology 2024年第3期14卷 487-501页

作者： Um Esther Meka Ngo Junie Annick Metogo Ntsama Kodoumé Motolouze naomi marie laurene ndtoungou schouame Obalemba Etienne Atenguena Claude Cyrille Noa Ndoua Robinson Enow Mbu Faculty of Medicine and Biomedical Sciences The University of Yaoundé 1 Yaoundé Cameroon Yaoundé Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon Hospital Center for Research and Application in Endoscopic Surgery and Human Reproduction Yaoundé Cameroon Yaoundé General Hospital Yaoundé Cameroon

Introduction: Breast cancer is one of the leading causes of death worldwide. We carried out this study with the aim of evaluating the determinants of early survival of women with breast cancer in two hospitals in the city of Yaoundé. Methodology: This was an analytical cross-sectional study with retrospective and prospective data collection of breast cancer patients during 6 years in two Hospitals of Yaoundé from January 2017 to December 2022. We consulted the files in search of epidemiological, clinical, paraclinical, therapeutic and survival variables. We completed the survival data directly from the patients or their relatives after their consent. We analyzed the data using SPSS version 23.0 software. Survival analysis was done using the Kaplan-Meier method and survival curves were compared using the Log Rank test. Factors influencing survival were evaluated using the Cox model. The significance threshold (P value) was set at 0.05 at 95% confidence interval. The study was approved by the ethics committees. Results: We included 500 patients whose ages varied between 22 and 83 years with a mean age of 47.19 ± 11.61 years. The most represented age group was 30 to 45 years old (45.8%). Less than half (41.6%) were postmenopausal. The most frequent reason for consultation was a breast lump (79.9%). The most common clinical stage at presentation was stage-3 (47.6%). Infiltrating ductal carcinoma was the most represented histological type (84.7%). The most represented histological grade was grade 2 (40.2%). Immunohistochemistry was performed in 34.20% of cases. The most represented molecular subtype was triple negative (41.8%) followed by Luminal A (30%). Concerning treatment, 17.2% did not receive any, 45% had surgery, 79.4% had chemotherapy, 34.2% hormone therapy, and 14.6% radiotherapy. The survival of patients with breast cancer at 1, 2, 3, 4 and 5 years was respectively 90.6%;83.1%;74.2%;69.8% and 59.2%. The median survival was not reached;however, the first quartil

关键词： Determinants Early Survival Breast Cancer Yaoundé

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Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins

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Nano Research 2015年第3期8卷 774-789页

作者： Mohammed Jamshad Vinciane Grimard Ilaria Idini Tim J. Knowles Miriam R. Dowle naomi Schofield Pooja Sridhart Yupin Lin Rachael Finka Mark Wheatley Owen R. T. Thomas Richard E. Palmerr Michael Overduin Cedric Govaerts Jean-marie Ruysschaert Karen J. Edler Tim R. Dafforn School of Biosciences University of Birmingham Edgbaston Birmingham B 15 2TT UK Universite Libre de Bruxelles SFMB - CP206/2 Bd. du Triomphe Acces 2 1050 Bruxelles Belgium Department of Chemistry University of Bath Claverton Down Bath BA2 7AY UK School of Cancer Studies University of Birmingham Edgbaston Birmingham B 15 2 TT UK Nanoscale Physics Research Laboratory and PSIBS School of Physics and Astronomy University of Birmingham Edgbaston Birmingham B 15 2TT UK School of Chemical Engineering University of Birmingham Edgbaston Birmingham B 15 2TT UK

在过去几年里，在为稳定包含嵌入的蛋白质的类脂化合物膜的 nanoparticles 的使用有生长。这些 bionanoparticles 由维持类脂化合物 bilayer 必需品到蛋白质完整和活动提供一个解决方案给膜蛋白质隔离的挑战性的问题。我们以前描述了 am... 详细信息

在过去几年里，在为稳定包含嵌入的蛋白质的类脂化合物膜的 nanoparticles 的使用有生长。这些 bionanoparticles 由维持类脂化合物 bilayer 必需品到蛋白质完整和活动提供一个解决方案给膜蛋白质隔离的挑战性的问题。我们以前描述了 amphipathic 聚合物的使用(poly (styrene-co-maleic 酸) ， SMA ) 与包含嵌入的蛋白质的一个类脂化合物 bilayer 核心生产 discoidal nanoparticles。然而， nanoparticle 本身的结构还没是坚定的。这在理解 SMA 怎么稳定包含的 bilayer 并且 bilayer 怎么身体上联系和在结构上到 unencapsulated 类脂化合物 bilayer 离开主要差距。在这份报纸，我们由描述从小角度中子散布使用数据的 SMA 类脂化合物粒子( SMALP )(圣)的结构处理这个问题，电子显微镜学(他们)，稀释全部的思考 Fourier 变换红外线的光谱学( ATR-FTIR )，微分扫描热量测定( DSC )和原子磁性的回声光谱学( NMR )。我们证明粒子是塑造的圆盘包含环绕的一只聚合物手镯类脂化合物 bilayer。在 bilayer 和聚合物以内的单个部件的结构和取向是坚定的证明在 SMA 以内的苯乙烯一半在类脂化合物酰链之间设置。包含的 bilayer 的尺寸也被决定并且匹配为自然的膜测量的那些。一起拿，对 SMALP 的结构的描述在膜蛋白质生产和分析为未来开发和 SMALP 的应用形成基础。

关键词：纳米颗粒结构分析膜蛋白脂质洗涤剂两亲性聚合物 ATR-FTIR 提取

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Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation

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Journal of Molecular Cell Biology 2022年第9期14卷 54-67页

作者： Zhaofei Wu M.Elena Martinez Victoria DeMambro marie Francois Arturo Hernandez MaineHealth Institute for Research Center for Molecular MedicineMaineHealthScarboroughME 04074USA Graduate School of Biomedical Science and Engineering University of MaineOronoME 04469USA naomi Berrie Diabetes Center Division of Molecular GeneticsColumbia University Irving Medical CenterNew YorkNY10032USA Department of Medicine Tufts University School of MedicineBostonMA 02111USA

Thyroid hormone excess secondary to global type 3 deiodinase(DIO3)deficiency leads to increased locomotor activity and reduced adiposity,but also to concurrent alterations in parameters of the leptin-melanocortin system that would predict *** distinguish the underlying contributions to the energy balance phenotype of Dlo3 deficiency,we generated mice with thyroid hormone excess targeted to pro-opiomelanocortin(POMC)-expressing cells via cell-specific DIO3 *** mice exhibit a male-specific phenotype of reduced hypothalamic Pomc expression,hyperphagia,and increased activity in brown adipose tissue,with adiposity and serum levels of leptin and thyroid hormones remained *** male mice also manifest a marked and widespread hypothalamic reduction in the expression of bone morphogenetic receptor 1a(BMPR1A),which has been shown to cause similar phenotypes when inactivated in PoMC-expressing *** results indicate that developmental overexposure to thyroid hormone in PoMC-expressing cells programs energy balance mechanisms in a sexually dimorphic manner by suppressing adult hypothalamic BMPR1A expression.

关键词： thyroid hormone type 3 deiodinase(DIO3) bone morphogenetic receptor 1a(BMPR1A) pro-opiomelanocortin(POMC) hyperphagia brown adipose tissue corticosterone

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