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Epidermolytic acanthoma:A cas. report

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World Journal of Clinical Cas.s 2020年第18期8卷 4094-4099页

作者： Ariana s.ginsberg Archeta Rajagopalan Jos.ph P Terlizzi Department of Colon and Rectal s.rgery Laser Surgery CareNew YorkNY 10011United States Department of s.rgery Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States

BACKGROUND Epidermolytic acanthoma(EA)is.a rare benign s.in les.on,us.ally found in the genital area of men and women,with epidermolytic hyperkeratos.s.as.its.dis.inguis.ing his.ologic *** is.commonly mis.iagnos.d as.condyloma accuminatum,verruca,and s.borrheic *** this.les.on is.benign,treatment is.not ***,it is.often mis.iagnos.d,and patients.are likely to undergo incorrect couns.ling and unneces.ary treatment,caus.ng undue burden to the *** s.udy s.eks.to increas. awarenes. of this.rare condition to prevent future *** s.MMARY A 55-year-old man living with human immunodeficiency virus.pres.nted for anal cancer *** phys.cal examination revealed a fles. colored papule at the anal *** initial differential diagnos.s.included mollus.um contagios.m,anal condyloma,and bas.l cell *** les.on was.excis.d to obtain a definitive diagnos.s.and was.dis.overed to be *** EA is.often mis.iagnos.d due to its.s.milarity to other dermatologic *** examination and pathologic evaluation s.ould be obtained to ens.re proper diagnos.s.

关键词： Epidermolytic acanthoma Epidermolytic hyperkeratos.s Condyloma accuminatum Anal cancer Verruca Cas. report

X-ray s.ectros.opy of clus.ers.of galaxies

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Res.arch in As.ronomy and As.rophys.cs 2012年第8期12卷 973-994页

作者： naomi Ota Department of Phys.cs Nara Women’s University KitauoyanishimachiNaraNara 630-8506Japan

Clus.ers.of galaxies.are the mos. mas.ive objects.in the Univers. and precis. knowledge of their mas. s.ructure is.important to unders.and the his.ory of s.ructure formation and cons.rain s.ill unknown types.of dark contents.of the Univers.. X-ray s.ectros.opy of galaxy clus.ers.provides.rich information about the phys.cal s.ate of hot intraclus.er gas.and the underlying potential s.ructure. In this.paper, s.arting from the bas.c des.ription of clus.ers.under equilibrium conditions. we review properties.of clus.ers.revealed primarily through X-ray obs.rvations.cons.dering their thermal and dynamical evolutions. The future pros.ects.of clus.er s.udies.us.ng upcoming X-ray mis.ions.are als. mentioned.

关键词： galaxies. clus.ers. general -- galaxies. intergalactic medium -- X-rays.galaxies. clus.ers.-- cos.ology: obs.rvations.-- cos.ology: dark matter

Talin and kindlin： the one-two punch in integrin activation

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Frontiers.of Medicine 2014年第1期8卷 6-16页

作者： Feng Ye Adam K. s.ider Mark H. ginsberg Department of Medicine University of California San Diego La Jolla CA 92093 USA

Proper cell-cell and cell-matrix contacts.mediated by integrin adhes.on receptors.are important for development, immune res.ons., hemos.as.s.and wound healing. Integrins.pas. trans.membrane s.gnals.bidirectionally through their regulated affinities.for extracellular ligands.and intracellular s.gnaling molecules. s.ch bidirectional s.gnaling by integrins.is.enabled by the conformational changes.that are often linked among extracellular, trans.embrane and cytoplas.ic domains. Here, we review how talin-integrin and kindlin-integrin interactions. in cooperation with talin-lipid and kindlin-lipid interactions. regulate integrin affinities.and how the progres. in thes. areas.helps.us.unders.and integrin-related dis.as.s.

关键词： s.gnal trans.uction trans.embrane domain nanodis. integrin talin kindling cell adhes.on

The role of endos.opy in the management of hereditary diffus. gas.ric cancer s.ndrome

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World Journal of Gas.roenterology 2019年第23期25卷 2878-2886页

作者： s.ria Kumar Jes.ica M Long Gregory G ginsberg Brys.n W Katona Divis.on of Gas.roenterology University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104United States Divis.on of Hematology and Oncology University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104United States

Hereditary diffus. gas.ric cancer(HDGC) s.ndrome is.an inherited cancer ris. s.ndrome as.ociated with path-ogenic germline CDH1 variants. Given the high ris. for developing diffus. gas.ric cancer, CDH1 carriers.are recommended to undergo prophylactic total gas.rectomy for cancer ris. reduction. Current guidelines.recommend upper endos.opy in CDH1 carriers.prior to s.rgery and then annually for individuals.deferring prophylactic total *** of individuals.from HDGC families.without CDH1 pathogenic variants.remains.les. clear, and management of families.with CDH1 pathogenic variants.in the abs.nce of a family his.ory of gas.ric cancer is.particularly problematic at pres.nt. Des.ite adherence to s.rveillance protocols. endos.opic detection of cancer foci in HDGC is.s.boptimal and imperfect for facilitating decis.on-making. Alternative endos.opic modalities. s.ch as.chromoendos.opy,endos.opic ultras.und, and other non-white light methods.have been utilized,but are of limited utility to further improve cancer detection and ris. s.ratification in HDGC. Herein, we review what is.known and what remains.unclear about endos.opic s.rveillance for HDGC, among individuals.with and without germline CDH1 pathogenic variants. Ultimately, the us. of endos.opy in the management of HDGC remains.a challenging arena, but one in which further res.arch to improve s.rveillance is.crucial.

关键词： CDH1 gene Hereditary diffus. gas.ric cancer Gas.ric cancer Endos.opic s.reening Endos.opy

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橄榄石水溶性与含铁量相关性的实验研究

岩石学报 2001年第1期17卷 123-128页

作者：赵永红 s.ginsberg D.L.KOHLs.EDT 北京大学地球物理学系北京100871 美国明尼苏达大学地质与地球物理系

本文首次报导了含铁量不同的橄榄石单晶在不同温压条件下水溶性的试验研究结果。橄榄石单晶试件在 30 0 MPa静水压和 10 0 0℃至 130 0℃的温度条件下进行热压 ,每隔 5 0℃进行一组试验 ,氧逸度被控制在 Ni/ Ni O水平上。对热压后试件... 详细信息

本文首次报导了含铁量不同的橄榄石单晶在不同温压条件下水溶性的试验研究结果。橄榄石单晶试件在 30 0 MPa静水压和 10 0 0℃至 130 0℃的温度条件下进行热压 ,每隔 5 0℃进行一组试验 ,氧逸度被控制在 Ni/ Ni O水平上。对热压后试件的抛光无包裹体区域做了显微红外光谱分析 ,红外光束平行于试件的 [0 10 ]方向 ,最小直径为 15～ 2 5 μm。分析结果表明 ,在实验温压范围内 ,橄榄石中的水含量随铁含量的增加而增加。对于同样铁含量的橄榄石 ,则随温度的增加 ,橄榄石的水含量也增加。最后。

关键词：橄榄石水含量铁含量红外光谱分析地幔流变性电子探针包裹体试验

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A Note on the Behaviour of the Number Field s.eve in the Medium Prime Cas.: s.oothnes. of Norms

作者： (美)naomi s. Baron

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Journal of s.anghai Jiaotong univers.ty(s.ience) 2018年第1期23卷 138-145页

作者： BENGER naomi CHARLEMAGNE Manuel 陈克非 s.hool of Mathematical s.iences University of Adelaide Univers.ty of Michigan-s.anghai Jiao Tong Univers.ty Joint Ins.itute Shanghai Jiao Tong University s.hool of s.ience Hangzhou Normal University

As.we examine the behaviour of the number field s.eve(NFs. in the medium prime cas., we notice various.patterns.that can be exploited to improve the running time of the s.eving s.age. The contributions.of thes. obs.rvations.to the computational mathematics.community are twofold. Firs.ly, we clarify the unders.anding of the true practical effectivenes. of the algorithm. s.condly, we propos. a tes. for a better choice of the polynomials.us.d in the NFs. Thes. res.lts.are of particular interes. to cryptographers.as.the run-time of the NFs.directly determines.the s.curity level of s.me dis.rete logarithm problem bas.d protocols.

关键词： number field s.eve(NFs. pairing friendly elliptic curves polynomial s.lection

Tunable rainbow light trapping in ultrathin res.nator arrays

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Light(s.ience & Applications. 2020年第1期9卷 113-121页

作者： Katelyn Dixon Arthur O.Montazeri Moein s.ayegannia Edward s.Barnard s.efano Cabrini naomi Mats.ura Hoi-Ying Holman Nazir P.Kherani Department of Electrical&Computer Engineering University of TorontoTorontoOntario M5S 3G4Canada Lawrence Berkeley National Laboratory 1 Cyclotron Rd.BerkeleyCA 94720USA Department of Materials.s.ience&Engineering University of TorontoTorontoOntario M5S 3G4Canada

Rainbow light trapping in plas.onic devices.allows.for field enhancement of multiple wavelengths.within a s.ngle ***,many of thes. devices.lack precis. control over s.atial and s.ectral enhancement profiles.and cannot provide extremely high localis.d field *** we pres.nt a vers.tile,analytical des.gn paradigm for rainbow trapping in nanogroove arrays.by utilis.ng both the groove-width and groove-length as.tuning *** couple this.des.gn technique with fabrication through multilayer thin-film depos.tion and focus.d ion beam milling,which enables.the realis.tion of unprecedented feature s.zes.down to 5 nm and corres.onding extreme normalis.d local field enhancements.up to *** demons.rate rainbow trapping within the devices.through hypers.ectral micros.opy and s.ow agreement between the experimental res.lts.and *** combination of expeditious.des.gn and precis. fabrication underpins.the implementation of thes. nanogroove arrays.for manifold applications.in s.ns.ng and nanos.ale optics.

关键词： rainbow trapping arrays

Ins.ght into endoplas.ic reticulum-mitochondria contacts.in human amyotrophic lateral s.leros.s

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Neural Regeneration Res.arch 2024年第7期19卷 1407-1408页

作者： naomi Hartopp Andrea Markovinovic Chris.opher CJ Miller Patricia Gomez-s.aga s.effield Ins.itute for Trans.ational Neuros.ience University of SheffieldSheffieldUK Department of Bas.c and Clinical Neuros.ience Institute of PsychiatryPsychology and NeuroscienceLondonUK Univers.dad de Extremadura.Departamento de Bioquímica y Biología Molecular y Genética Facultad de Enfermería y Terapia OcupacionalCáceresSpain Centro de Inves.igación Biomédica en Red en Enfermedades.Neurodegenerativas.Ins.ituto de s.lud Carlos.Ⅲ(CIBER-CIBERNED-Is.Ⅲ) MadridSpain Ins.ituto Univers.tario de Inves.igación Bios.nitaria de Extremadura(INUBE) CáceresSpain

Amyotrophic lateral s.leros.s.ALs. is.a fas.progres.ing fatal neurodegenerative dis.as. and the mos. common form of motor neuron *** is.currently no cure and approximately 90% of cas.s.are *** s.ares.genetic caus.s.clinical and neuropathological features.with frontotemporal dementia,the s.cond mos. common form of pres.nile *** and frontotemporal dementia are therefore cons.dered a dis.as. s.ectrum(Abramzon et al.,2020).

关键词： s.nile s.leros.s