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Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第7期19卷 1407-1408页

作者： naomi Hartopp Andrea Markovinovic Christopher CJ Miller Patricia Gomez-Suaga Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceLondonUK Universidad de Extremadura.Departamento de Bioquímica y Biología Molecular y Genética Facultad de Enfermería y Terapia OcupacionalCáceresSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos Ⅲ(CIBER-CIBERNED-ISCⅢ) MadridSpain Instituto Universitario de Investigación Biosanitaria de Extremadura(INUBE) CáceresSpain

Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron *** is currently no cure and approximately 90% of cases are *** shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile *** and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).

关键词： senile sclerosis

Classification of musical hallucinations and the characters along with neural-molecular mechanisms of musical hallucinations associated with psychiatric disorders

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World Journal of Psychiatry 2024年第9期14卷 1386-1396页

作者： Xin Lian Wei Song Tian-Mei Si naomi Zheng Lian Department of Radiology and Biomedical Imaging Shanxi Bethune HospitalShanxi Academy of Medical SciencesTaiyuan 030032Shanxi ProvinceChina Department of Psychiatry and Behavioral Neurosciences McMaster UniversityHamilton L8S 4L8ONCanada Department of Psychopharmacology Peking University Sixth HospitalBeijing 100191China Department of Psychiatry Hartford HealthCareSt Vincent’s Medical CenterWestportCT 06088United States

BACKGROUND Musical hallucinations(MH)involve the false perception of music in the absence of external stimuli which links with different *** pathomechanisms of MH encompass various *** etiological classification of MH is of particular importance and offers valuable insights to understand MH,and further to develop the effective treatment of *** the recent decades,more MH cases have been reported,revealing newly identified medical and psychiatric causes of *** imaging studies reveal that MH activates a wide array of brain *** up-to-date analysis on MH,especially on MH comorbid psychiatric conditions is *** To propose a new classification of MH;to study the age and gender differences of MH in mental disorders;and neuropathology of *** Literatures searches were conducted using keywords such as“music hallucination,”“music hallucination and mental illness,”“music hallucination and gender difference,”and“music hallucination and psychiatric disease”in the databases of PubMed,Google Scholar,and Web of *** cases were collected and categorized based on their *** t-test and ANOVA were employed(P<0.05)to compare the age differences of MH different etiological *** neuroimaging studies of neural networks regulating MH and their possible molecular mechanisms were *** Among the 357 yielded publications,294 MH cases were *** average age of MH cases was 67.9 years,with a predominance of females(66.8%females vs 33.2%males).MH was classified into eight groups based on their etiological *** analysis of MH cases indicates varying associations with psychiatric *** We carried out a more comprehensive review of MH *** the first time according to our knowledge,we demonstrated the psychiatric conditions linked and/or associated with MH from statistical,biological and molecular point of view.

关键词： Pathomechanism Etiological factors Classification Gender difference Neuropathway Psychotic musical hallucination and non-psychotic musical hallucination Neuropathway Biological and molecular mechanism

From germline genome to highly fragmented somatic genome:genome-wide DNA rearrangement during the sexual process in ciliated protists

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Marine Life Science & Technology 2024年第1期6卷 31-49页

作者： Liping Lyu Xue Zhang Yunyi Gao Tengteng Zhang Jinyu Fu naomi A.Stover Feng Gao Key Laboratory of Evolution&Marine Biodiversity(Ministry of Education) and Institute of Evolution&Marine BiodiversityOcean University of ChinaQingdao 266003China Department of Biology Bradley UniversityPeoriaIL 61625USA Laoshan Laboratory Qingdao 266237China

Genomes are incredibly dynamic within diverse eukaryotes and programmed genome rearrangements(PGR)play important roles in generating genomic ***,genomes and chromosomes in metazoans are usually large in size which prevents our understanding of the origin and evolution of *** expand our knowledge of genomic diversity and the evolutionary origin of complex genome rearrangements,we focus on ciliated protists(ciliates).Ciliates are single-celled eukaryotes with highly fragmented somatic chromosomes and massively scrambled germline *** in ciliates occurs extensively by removing massive amounts of repetitive and selfish DNA elements found in the silent germline genome dur-ing development of the somatic *** report the partial germline genomes of two spirotrich ciliate species,namely Strombidium *** and Halteria grandinella,along with the most compact and highly fragmented somatic genome for *** provide the first insights into the genome rearrangements of these two species and compare these features with those of other *** analyses reveal:(1)DNA sequence loss through evolution and during PGR in *** has combined to produce the most compact and efficient nanochromosomes observed to date;(2)the compact,transcriptome-like somatic genome in both species results from extensive removal of a relatively large number of shorter germline-specific DNA sequences;(3)long chromosome breakage site motifs are duplicated and retained in the somatic genome,revealing a complex model of chromosome fragmentation in spirotrichs;(4)gene scrambling and alternative pro-cessing are found throughout the core spirotrichs,offering unique opportunities to increase genetic diversity and regulation in this group.

关键词： Alternative processing Ciliates Gene scrambling Genome rearrangement Germline genome Somatic genome

Comparison of Body Composition Two Months after High Caloric-Tofu Intake and Body Composition Six Months after the Experiment—In the Case of Elderly People

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Journal of Health Science 2019年第3期7卷 166-175页

作者： naomi katayama Yui Nakayama Shoko Kondo Nagoya Women’s University Nagoya City 4678610Japan Graduate School of Nagoya Women’s University Nagoya City 4678610Japan Watanabe Hospital Mihama TownChita-gun 4703235Japan

Japan becomes the super aged society. It is expected from now on that the population of the elderly person increases more and more. Therefore, disease prevention such as sarcopenia and frailty in the elderly person is required. This study tried the improvement of meal contents by taking in soy protein using caloric-tofu in daily life. The ten elderly people (one man, 9 women: from age 55 years old to 83 years old) who submitted the written consent of the subject participated in this study. We performed the gene analysis (β3AR, UCP1,β2AR) of the subject. The subject lived a normal life every day. The subject had eaten two high caloric-tofu a day. A caloric-tofu has 100 kcal. The subject participated in a study for two months. As for the subject, body composition was measured on the first day and two months after the start of the experiment, and six months after the end of the experiment. As a result, skeletal muscle rates of five people increased slightly, and body fat rate decreased slightly. However, five people changed into neither the skeletal muscle rate nor the body fat rate. Six months after the end of the experiment, the pair composition results were kept almost the same as at the end of the experiment. It can be highly appreciated that in the effective group, the pair composition could be maintained in a better condition than at the beginning of the experiment. For elderly people, the effective group, it is significant that intake of high caloric-tofu is effective in increasing the rate of skeletal muscle, and the effect is maintained even after half a year.

关键词： Elderly person gene analysis caloric-tofu skeletal muscle rate body fat rate

Changes in the Amount of Ingestion Nutrients in Meals before and after Ingesting High Caloric-Tofu—For Elderly People

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Journal of Health Science 2019年第3期7卷 185-192页

As katayama et al. reported in the past, it has been shown with a 50-70% probability that increases in skeletal muscle rate and decreases in body fat rate will occur in elderly people by taking high caloric-tofu for two months. Participants measured body composition before and after the experiment, and the results were statistically processed to confirm significant differences. Therefore, we decided to clarify how the amount of nutrient intake changed before and after taking high caloric-tofu for two months. The participants self-reported a 3-day meal record before entering the experiment. Similarly, participants performed a self-administered meal intake record for 3 days before the end of the high caloric-tofu intake two months. Food intake recording was performed using nutrition calculation software, and the results were recorded. The nutrition calculation software used the Excel eiyou-kun version 8 manufactured by Kenpaku. The calculated nutrients were 13 items: energy, protein, lipid, carbohydrate, dietary-fiber, calcium, iron, equivalent of retinol, vitamin D, vitamin B1, vitamin B2, vitamin C, equivalent of salt. As a result of statistically processing the nutrition of the participants, in both groups (effective group and not effective group) lipid intake increased with statistical significance. However, protein intake did not differ statistically. In the future, it will be necessary to conduct more detailed interviews with many participants.

关键词： Elderly person gene analysis caloric-tofu skeletal muscle rate body fat rate

Relationship between Walking Speed and Exercise Habits of Elderly People

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Journal of Health Science 2019年第3期7卷 193-197页

作者： naomi katayama Miki Kamijyo Shoko Kondo Nagoya Women’s University Nagoya City 4678610Japan Graduate School of Nagoya Women’s University Nagoya City 4678610Japan Watanabe Hospital Mihama TownChita-gun 4703235Japan

Japan becomes the super aged society. For Japan, the proportion of elderly people aged 65 and over is 27.3%. The Ministry of Health, Labor and Welfare estimates that in 2060, the proportion of the elderly people aged 75 or older to the total population will exceed 26.9%. Japan has nursing problems in a rapidly aging society. Therefore, the long-term care insurance system is being reviewed. The state, prefectures, and local governments are carrying out various campaigns from the perspective of long-term care prevention. One of them is fall prevention. Falling of the elderly often causes bedridden and death. Therefore, in this study, in order to examine the influence of exercise habits of the elderly on gait, the results of questionnaire survey and actual 10 m walking speed were obtained for elderly people who participated in the health class. As a result, walking speed was fast for people with exercise habits. As for exercise, walking speed was faster for those who continued with exercise such as walking than for those who did muscle training. By continuing the light exercise like walking, it might be possible to maintain the muscles of the lower limbs and cultivate a sense of balance or lead to the fall prevention of the elderly.

关键词： Elderly person walking speed exercise habit gymnastics

Comparison between Eating Habits Improvement by Using the Caloric-Tofu and Gene Analysis Result—For Young People

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Journal of Health Science 2019年第3期7卷 143-150页

作者： naomi katayama Yui Nakayama Shoko Kondo Nobuyuki Horie Nagoya Women’s University Nagoya City 4678610Japan Graduate School of Nagoya Women’s University Nagoya City 4678610Japan Watanabe Hospital Mihama TownChita-gun 470323Japan

The previous paper by naomi katayama et al. reported the effect of high caloric-tofu on elderly people. The body composition was improved by elderly people eating high caloric-tofu for 2 months. Elderly people decreased body fat and increased body protein. Therefore, in this research, we decided to investigate young people who can improve body composition by eating high caloric-tofu for 2 months. The twenty-two young people (19 men, 3 women: from age 19 years old to 22 years old) who submitted the written consent of the subject participated in this study. We performed the gene analysis (β3AR, UCP1,β2AR) of the subject. The subject lived a normal life every day. The subject had eaten two caloric-tofu a day. A caloric-tofu has 100 kcal. The subject participated in a study for two months. As for the subject, body composition was measured on the first day and the last day of the study. A result, skeletal muscle rates of fifteen people increased, and a fat rate decreased. However, five people changed into neither the skeletal muscle rate nor the fat rate. People who were effective by this experiment were the people who had variation in β2AR, and people among whom there was not an effect were the people who had variation in UCP1. This experiment had little number of the data, but it was revealed that an intake of the caloric-tofu was more likely to help the reinforcement of the skeletal muscle mass to a participant with the variation in β2AR gene. It will be necessary to increase the number of participants more, and to examine it in detail in future. We also need to investigate a wide range of age groups. We thought in future that an effect might appear by doing nourishment instruction based on a result of the gene analysis.

关键词： Young person gene analysis caloric-tofu skeletal muscle rate body fat rate.

Results of Body Composition Improvement by High Caloric-Tofu Intake—At the Start of the Experiment, at the End, and Six Months after the End for the Case of Adolescents

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Journal of Health Science 2019年第3期7卷 176-184页

The previous paper by naomi katayama et al. reported the effect of high caloric-tofu on the young people [1] and elderly people [2]. And the body composition was improved by elderly people and young people eating high caloric-tofu for 2 months. In both paper reports, both participates decreased body fat and increased body protein. Therefore, in this research, we decided to investigate young people who can keep their body composition after six months to stop eating high caloric-tofu. The ten young people (9 male, one female: from age 19 years old to 22 years old) who submitted the written consent of the subject participated in this study. We performed the gene analysis (β3AR, UCP1,β2AR) of the subject. The subject lived a normal life every day. The subject had eaten two caloric-tofu a day. A caloric-tofu has 100 kcal. The subject participated in a study for two months. As for the subject, body composition was measured on the first day and the last day of the study. As a result, skeletal muscle rates of eight people increased slightly, and body fat rate decreased slightly. However, two people did not change neither the skeletal muscle rate nor the fat rate. Body composition of the eight participants who were effective by this experiment was not kept after six months to stop this study. Six months after the end of the intervention for the participants, the body composition became worse. In this study, participants could temporarily change their behavior but could not continue this condition. It will be necessary to increase the number of participants more, and to examine it in detail in future. We also need to investigate a wide range of age groups. We thought in future that an effect might appear by doing nourishment instruction based on a result of the gene analysis.

关键词： Young person gene analysis caloric-tofu skeletal muscle rate body fat rate

Effectiveness of ivermectin mass drug administration in the control of soil-transmitted helminth infections in endemic populations: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2024年第1期13卷 1-15页

作者： Brandon Le naomi E.Clarke Nicolas Legrand Susana Vaz Nery The Kirby Institute University of New South WalesLevel 6Wallace Wurth BuildingSydneyNSW2052Australia

Background Current soil-transmitted helminth(STH)control guidelines endorse the use of albendazole or meben-dazole for school-based targeted preventive chemotherapy(PC),yet their reduced efficacy against Strongyloides sterc-oralis and Trichuris trichiura presents significant *** evidence indicates that community-wide PC[or mass drug administration(MDA)]using ivermectin,commonly used in other neglected tropical disease(NTD)control programs,may play an important role in controlling these *** conducted a systematic review and meta-analysis to evaluate the effectiveness of ivermectin PC in reducing STH prevalence in endemic *** We searched Pubmed,EMBASE,and Web of Science on February 14,2023,for studies that investigated the effectiveness of ivermectin PC,either alone or in combination with other anthelmintic drugs,on STH infec-tions,and provided a measure of STH prevalence before and after *** calculated pooled prevalence reductions for each STH using random-effects *** protocol is available on PROSPERO(registration number CRD42023401219).Results A total of 21 were eligible for the systematic review,of which 15 were eligible for *** studies delivered ivermectin through *** pooled prevalence reduction of *** following MDA with ivermec-tin alone was 84.49%(95%CI:54.96-94.66)across five studies and 81.37%(95% CI:61.62-90.96)across seven studies with or without *** prevalence reduction of *** was 49.93%(95%CI:18.23-69.34)across five studies with ivermectin alone,and 89.40%(95%CI:73.66-95.73)across three studies with the addition of *** was high heterogeneity for all syntheses(I^(2)>65%).Conclusions This study underscores the key role of ivermectin-based MDA in addressing limitations in current global STH guidelines in terms of limited efficacy against *** and *** on these findings,revising inter-national STH guidelines to include i

关键词： Soil-transmitted helminths Ivermectin Albendazole Mass drug administration Preventive chemotherapy