检索结果-南通市图书馆

The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Breast Cancer Research 2013年第3期2卷 60-65页

作者： Yu Koyama Hiroshi Ichikawa Jun Sakata Eiko Sakata Kumiko Tatsuda Miki Hasegawa Chie Toshikawa naoko manba Mayuko Ikarashi Toshifumi Wakai Division of Digestive & General Surgery Niigata University Graduate School of Medical & Dental Sciences Niigata Japan

Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.

关键词： Breast Cancer Sentinel Lymph Node Molecular Subtypes Ki-67 Labeling Index

Analyzing Disaster Mitigation Policies in Japan and China from an Eco-DRR Perspective:A Comparative Study of Shanghai and Tokyo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Architectural Research and Development 2024年第1期8卷 14-19页

作者： Minghui Tang naoko Fujita Art and Design University of TsukubaTsukuba 3058577IbarakiJapan

Global climate change-induced natural disasters require international efforts and the adoption of Eco-Disaster Risk Reduction(Eco-DRR)policies for sustainable *** study examines the status of Eco-DRR in disaster prevention policies through word cloud analysis,providing insights for policymakers to enhance disaster prevention amid increasing climate-related *** and Japan prioritize soft aspects,while Shanghai and China emphasize engineering for flood prevention,revealing a gap in Eco-DRR *** these differing approaches,the shared focus on water-related disasters indicates a shift towards urban *** research should assess policy effectiveness and the impact of Eco-DRR on disaster risk reduction and ecosystem protection.

关键词： Disaster Policy Eco-DRR Word-cloud

Characterization of Pyrolytic Lignin Extracted from Bio-oil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2010年第6期18卷 1018-1022页

作者： JIANG Xiaoxiang naoko Ellis ZHONG Zhaoping Thermoenergy Engineering Research Institute Southeast University Nanjing 210096 China Department of Chemical and Biological Engineering University of British Columbia Vancouver Canada

Bio-oil is a new liquid fuel produced by fast pyrolysis,which is a promising technology to convert bio-mass into liquid. Pyrolytic lignin extracted from bio-oil,a fine powder,contributes to the instability of bio-oil. The paper presents the structural features of three kinds of pyrolytic lignin extracted from bio-oil with different methods(WIF,HMM,and LMM) . The pyrolytic lignin samples are characterized by Fourier transform infrared spectrometer(FTIR) and X-ray photoelectron spectroscopy(XPS) . FTIR data indicate that the three pyrolytic lignin samples have similar functional groups,while the absorption intensity is different,and show characteristic vibra-tions of typical lignocellulosic material groups O H(3340-3380 cm-1) ,C H(2912-2929 cm-1) and C O(1652-1725 cm-1) . Comparison in the region(3340-3380 cm-1) indicates that WIF has more O H stretch groups than HMM and LMM. The carbon spectra are fitted to four peaks:C1,C C or C H,BE 283.5 eV;C2,C OR or C OH,BE 284.5-285.8 eV;C3,C O or HO C OR,BE 286.10-287.10 eV;C4,O C O,BE 287.5-287.7 eV. The absence of C1,C C or C H indicates the dominant polymerization structure of aro-matic carbon in pyrolytic lignin samples. For HMM and WIF,C2a and C2b can not be separated,so there is no free hydroxyl group in the samples. The oxygen peaks are also fitted to four peaks:O1,OH,BE = 530.3 eV;O2,RC O,BE 531.45-531.72 eV;O3,O C O,BE = 532.73-533.74 eV;O4,H2O,BE 535 eV. The absence of O1 and O4 indicates that little hydroxyl groups and adsorbed water are present in the samples.

关键词：快速热解生物油木质素 X射线光电子能谱傅立叶变换红外光谱仪提取表征影响因子

Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第6期13卷 979-980页

作者： naoko Niimi Kazunori Sango Diabetic Neuropathy Project Department of Sensory and Motor Systems Tokyo Metropolitan Institute of Medical Science

Diabetic peripheral neuropathy（DPN）is one of the most common and intractable complications of diabetes *** irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and depression;whereas its progression to more advanced stages can result in serious consequences,such as lower limb amputations and lethal arrhythmias.

关键词： DPN Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration NGF NCV AR PNS

A fate model of pathogenic viruses in a composting toilet based on coliphage inactivation

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2011年第7期23卷 1194-1198页

作者： Shinobu Kazama Narue Tameike naoko Nakagawa Masahiro Otaki Department of Human Environmental Science Ochanomizu University INAX Co. 1-23-6 Yoshino-cho Kita-ku Satiama 331-0811 Japan Department of Civil and Environmental Engineering Tokyo Metropolitan University 1-1 Minamiosawa Hachioji City Tokyo 192-0397 Japan

A composting toilet using sawdust as a matrix has the potential to trap pathogens that might occasionally be contained in human feces. Therefore, care should be taken when handling the sawdust. It should also be noted that pathogenic viruses tend to have stronger tolerance than pathogenic bacteria. The fates of several species of coliphages, T4, λ, Qβ and MS2, in sawdust were investigated as a viral model. The fates of coliphages were significantly different among them, and they changed in response to temperature and the water content of the sawdust. As the results, T4 coliphage had the strongest tolerance and Qβ had the weakest one in sawdust. It was estimated the days required to decrease virus to a safe level based on a risk assessment. According to the rates of Qβ and T4, 15 days and 167 days were required respectively for a safe level of infection risk based on actually operated composting toilet condition. Thus, it was significantly different depending on the species and sawdust conditions.

关键词： composting toilet viral indicator coliphage risk assessment

Field survey of a sustainable sanitation system in a residential house

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2006年第6期18卷 1088-1093页

作者： naoko NAKAGAWA Masahiro OTAKI Shinji MIURA Hironobu HAMASUNA Katsuyoshi ISHIZAKI Department of Human Environmental Sciences Ochanomizu University2-1-1OtsukaBunkyo-KuTokyo 112-8610Japan. City Maintenance Technical Research Center 2-9-23ShinjuShinjuku-KuTokyo 160-0023Japan Nagasaki Institute of Applied Science 536Abama-choNagasaki-shiNagasaki Pref.851-0123Japan Research Institute for a Sustainable Future Waseda University513 Tsurumaki-ChouWasedaShinjuku-KuTokyo 169-8050Japan

Sustainable sanitation is an approach for more ecological and sustainable water resources management. In this paper, we proposed one of the new integrated waste treatment systems： an ＂sustainable sanitation system＂ that includes separation of the black water from water system by a non-flushing toilet （bio-toilet）, and a gray water treatment based on a biological and ecological concept. Sustainable sanitation system also converts the domestic waste to soil conditioners and fertilizers, for farmland use. As one of the case studies, Environmentally Symbiotic Housing in which people actually live using the bio-toilet for the black water treatment and the household wastewater treatment facility for the gray water was introduced. The availability of this system was investigated by analyzing the sawdust used in the bio-toilet and the quality of the effluent in the household wastewater treatment facility. As the result, the water content of the sawdust did not exceed 60% in any of the sampling points and the BOD and COD of the effluent of the household wastewater treatment facility were below 10 and 20 mg/L respectively, due to the low loading. Compared to the pollution load on the water environment created by the conventional system, it was found that the effluent of the house has a lower load than the tertiary treatment and the volume of the water consumption is 75% of the conventional system.

关键词： bio-toilet pollution load sustainable sanitation system water consumption

Structure properties of pyrolytic lignin extracted from aged bio-oil

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2011年第14期56卷 1417-1421页

作者： JIANG XiaoXiang naoko Ellis ZHONG ZhaoPing Thermoenergy Engineering Research Institute Southeast University Nanjing 210096 China Department of Chemical and Biological Engineering University of British Columbia Vancouver V6T 1Z3 Canada

Fast pyrolysis is a promising technology that can convert biomass into ***-oil is one such product,known not only as a greenhouse gas-neutral energy source,but also an opportunity to reduce reliance on fossil *** lignin,a fine homogeneous powder,is the water-insoluble fraction of bio-oil and it contributes to the instability of ***,pyrolytic lignin can be used in commercial materials such as adhesives in the wood-based panel *** paper presents the structural characterization of pyrolytic lignin extracted from aged bio-oil and the relationship between its properties and the treatment temperature of the aged *** lignin samples were characterized by Fourier transform infrared spectroscopy,gel permeation chromatography,differential scanning calorimetry,thermogravimetric analysis and proton nuclear magnetic resonance *** average molecular weight of pyrolytic lignin increased from 700 to 1000 g/mol with increasing aging temperature (6-50°C).Differential scanning calorimetry showed that the glass transition temperature of pyrolytic lignin increases with lower heating rate and higher treatment temperature of *** increase in the initial decomposition temperature and the temperature at 95 wt% weight loss of the aged pyrolytic lignin in thermogravimetry were observed for the bio-oil aged at higher *** increase in residue weight of aged pyrolytic lignin was found in bio-oil aged at higher temperatures.

关键词：快速热解木质素生物油年龄结构特性提取差示扫描量热法傅立叶变换红外光谱

Deciphering Starch Quality of Rice Kernels Using Metabolite Profiling and Pedigree Network Analysis

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2012年第2期5卷 442-451页

作者： Miyako Kusano Atsushi Fukushima naoko Fujita Yozo Okazaki Makoto Kobayashi naoko Fujita Oitome Kaworu Ebana Kazuki Saito RIKEN Plant Science Center Tsurumi Yokohama 230-0045 Japan KIHARA Institute for Biological Research Yokohama City University Totsuka Yokohama 244-0813 Japan Department of Biological Production Akita Prefectural University Akita 010-0195 Japan National Institute of Agrobiological Sciences 2-1-2 Kannondai Tsukuba Ibaraki 305-8602 Japan Graduate School of Pharmaceutical Sciences Chiba University Chiba 260-8675 Japan

The physiological properties of rice grains are immediately obvious to consumers. High-coverage metabolomic characterization of the rice diversity research set predicted a negative correlation between fatty acid and lipid levels and amylose/total starch ratio （amylose ratio）, but the reason for this is unclear. To obtain new insight into the relationships among the visual phenotypes of rice kernels, starch granule structures, amylose ratios, and metabolite changes, we investigated the metabolite changes of five Japonica cultivars with various amylose ratios and two knockout mutants （e 1, a Starch synthase Ilia （SSIIla）-deficient mutant and the SSIIla/starch branching enzyme （BE） double-knockout mutant 4019） by using mass spectrometry-based metabolomics techniques. Scanning electron microscopy clearly showed that the two mutants had unusual starch granule structures. The metabolomic compositions of two cultivars with high amylose ratios （Hoshiyutaka and Yumetoiro） exhibited similar patterns, while that of the double-knockout mutant, which has an extremely high amylose ratio, differed. Rice pedigree network analysis of the cultivars and the mutants provided insight into the association between metabolic-trait properties and their underlying genetic basis in rice breeding in Japan. Multidimensional scaling analysis revealed that the Hoshiyutaka and Yumetoiro cultivars were Indica-like, yet they are classified as Japonica subpopulations. Exploring metabolomic traits is a powerful way to follow rice genetic traces and breeding history.

关键词： starch quality traits amylose ratio metabolite profiling pedigree networks rice.

Reading impairment after neonatal hypoglycemia with parietotemporo-occipital injury without cortical blindness:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第16期11卷 3899-3906页

作者： naoko Kurahashi Shunsuke Ogaya Yuki Maki Norie Nonobe Sumire Kumai Yosuke Hosokawa Chikako Ogawa Keitaro Yamada Koichi Maruyama Kiyokuni Miura Miho Nakamura Department of Pediatric Neurology Central HospitalAichi Developmental Disability CenterKasugai 480-0392AichiJapan Department of Pediatrics Nagoya University Graduate School of MedicineNagoya 466-8560AichiJapan Division of Neonatology Center for Maternal-Neonatal Care Nagoya University HospitalNagoya 466-8560AichiJapan Department of Pediatrics Tokyo Metropolitan Fuchu Medical Center for the DisabledFuchu 183-0042TokyoJapan Department of Functioning and Disability Institute for Developmental ResearchAichi Developmental Disability CenterKasugai 480-0392AichiJapan Okazaki Medical Center for Child Development Okazaki 444-0011AichiJapan

BACKGROUND Perinatal brain injury may lead to later neurodevelopmental disorders,whose outcomes may vary due to neuroplasticity in young *** neuroimaging studies have shown that the left parietotemporal area(which includes the left inferior parietal lobe)is associated with phonological awareness and decoding skills,which are essential skills for reading acquisition in ***,the literature on the effect of perinatal cerebral injury on the development of phonological awareness or decoding ability in childhood is *** SUMMARY We report the case of an 8-year-old boy who presented with reading difficulty following a perinatal injury in the parieto-temporal-occipital *** patient was born at term and was treated for hypoglycemia and seizures during the neonatal ***-weighted brain magnetic resonance imaging on postnatal day 4 revealed cortical and subcortical hyperintensities in the parieto-temporo-occipital *** the age of 8 years,physical examination was unremarkable,aside from mild *** occipital lobe injury,the patient had adequate visual acuity,normal eye movement,and no visual field ***-scale intelligence quotient and verbal comprehension index on Wechsler Intelligence Scale for Children-Fourth Edition were 75 and 90,*** assessment revealed adequate recognition of Japanese Hiragana ***,he had significantly slower reading speed in the Hiragana reading test than control *** phonological awareness test revealed significant errors(standard deviation+2.7)in the mora reversal *** Patients with perinatal brain injuries in the parietotemporal area require attention and may benefit from additional reading instructions.

关键词： Brain diseases Hypoglycemia Dyslexia Long-term care Education Case report