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Introduction of Music Therapy Incorporated into Cognitive Remediation: A New Approach to Cognitive Dysfunction in Psychiatric Disorders and a Preliminary Report on Its Effects in Schizophrenia

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Open Journal of Psychiatry 2019年第1期9卷 23-38页

作者： naoko Kosugi Chiaki Oshiyama Naoki Kodama Shin-Ichi Niwa Division of Healthcare Informatics Faculty of Healthcare Tokyo Healthcare University Tokyo Japan National Institute of Advanced Industrial Science and Technology (AIST) Artificial Intelligence Research Center Tokyo Japan Department of Radiological Technology Faculty of Medical Technology Niigata University of Health and Welfare Niigata Japan Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Aim: Cognitive dysfunction and negative symptoms interfere social participation in patients with schizophrenia. Cognitive remediation has proven effective for cognitive deficits. While there are few effective treatments for the negative symptoms of schizophrenia, music therapy is expected to ameliorate negative symptoms. With the goal of improving both cognitive dysfunction and negative symptoms, we originally developed a program of Music Therapy incorporated into Cognitive Remediation (MTCR). We introduce the MTCR program and our preliminary results of conducting MTCR in patients with schizophrenia. Methods: The program was based on the NEAR (neuropsychological educational approach to cognitive remediation) program. The MTCR program uses instrumental performances and ensemble vocal performances to train cognitive functions, which consists of 30 sessions in total, with each session being 60 minutes long (45 minutes of music, 15 minutes of verbal session). The participants attended sessions semiweekly in groups of fewer than 12 members. We measured the participants’ symptoms twice, before the intervention and after the final session. For both measurements, we used the BACS and BPRS. Thirty-six individuals (26 men, 10 women;average age of 42.4 years) with schizophrenia participated in this study. They participated in an average of 28.2 sessions. Results: BACS total scores (p Conclusions: The present study demonstrated that MTCR program can improve both cognitive dysfunction and negative symptoms of patients with schizophrenia, which implies that it can also potentially facilitate the social participation of such patients.

关键词： Schizophrenia Cognitive Remediation Music Therapy Social Participation BACS BPRS

Rendezvous to asteroid with highly uncertain ephemeris: Hayabusa2’s Ryugu-approach operation result

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Astrodynamics 2020年第2期4卷 137-147页

作者： Yuichi Tsuda Hiroshi Takeuchi naoko Ogawa Go Ono Shota Kikuchi Yusuke Oki Masateru Ishiguro Daisuke Kuroda Seitaro Urakawa Shin-ichiro Okumura Hayabusa2 Project Team Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara252-5210Japan Research and Development Directorate Japan Aerospace Exploration AgencySagamihara252-5210Japan Research and Development Directorate Japan Aerospace Exploration AgencyTsukuba305-8505Japan Seoul National University Seoul08826Republic of Korea Okayama Observatory Kyoto UniversityAsakuchi719-0232Japan Japan Spaceguard Association Bisei714-1411Japan 不详

This paper describes the guidance and navigation technique used by Hayabusa2 for the asteroid rendezvous operation to reach *** operation results,including the achieved guidance and navigation performance,are also *** assessment and navigation teams worked closely to provide reliable navigation solutions with a short solution delivery *** the uncertainty of the Ryugu’s ephemeris was considerable before Hayabusa2’s arrival,a combination of radiometric-optical hybrid navigation and a stochastic-constrained optimum guidance method was able to achieve an accuracy of less than 100 m and 1 cm/s,and the arrival was precisely timed.

关键词： solar system exploration sample return optical navigation trajectory optimization spacecraft guidance

Sizes of Anode and Cathode Affect Electricity Generation in Rice Paddy-Field Microbial Fuel Cells

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Journal of Sustainable Bioenergy Systems 2016年第1期6卷 10-15页

作者： Nagayoshi Ueoka naoko Sese Mayu Sue Atsushi Kouzuma Kazuya Watanabe School of Life Sciences Tokyo University of Pharmacy and Life Sciences Tokyo Japan Technical Research Institute Maeda Corporation Tokyo Japan

Rice paddy-field microbial fuel cells (RPF-MFCs) are devices that exploit rhizosphere bacteria to generate electricity from soil organic matter, including those excreted from roots. Previous studies have examined factors affecting electric outputs from RPF-MFCs and demonstrated that RPFMFC was able to generate electricity up to 80 mW·m-2 (based on the projected area of anode). The present study operated RPF-MFCs with different sizes of anodes and cathodes and examined how electrode sizes affected electricity generation. We show that anodes are the limiting factor for electricity generation immediately after commencing the operation, while cathodes become the limiting factor after anode performances are sufficiently increased. RPF-MFC achieved the maximum power density of 140 mW·m-2 (based on the projected area of anode), when the cathode is sufficiently larger than the anode. Results suggest that the cathode needs to be improved for eliciting the maximum capacity of rhizosphere bacteria for electricity generation in RPF-MFC.

关键词： Root Exudates Polarization Analyses Pyrosequencing 16S rRNA Gene Geobacter

Relative Monocytosis in Patients with Erythrocytosis

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Open Journal of Blood Diseases 2013年第1期3卷 21-24页

作者： Hiroshi Fujita Akira Ohwada naoko Handa Shigeko Nishimura Department of Internal Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan. Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Polycythemia vera (PV) is characterized by leukocytosis, thrombocytosis, and low mean capsular volume (MCV). No specific hematological findings are observed in patients with erythrocytosis of other origins. However, recombinant erythropoietin (EPO) increases the number of mononuclear cells in the peripheral blood. Therefore, we hematologically examined monocytes in patients with erythrocytosis. The medical records of 48 erythrocytosis patients (hemoglobin: men, >18.5 g/dL;women, >16.5 g/dL) collected between August 2005 and July 2012 were reviewed for age, gender, hematology, and serum erythropoietin level. Patients were divided into 3 groups: PV (N = 17), reactive erythrocytosis (RE, N = 25), and EPO-elevated erythrocytosis (EPO-E, N = 6). We compared monocytes in the hemogram among the 3 groups and examined the correlation between hematological data and serum EPO level. The percent monocytes in the hemogram were 3.4% ± 0.3%, 7.4% ± 0.4%, and 12.3% ± 1.1% for the PV, RE, and EPO-E groups, respectively, which were significant (p 1.0 ′ 109/L) in the PV, RE, and EPO-E groups, respectively. A significant correlation was observed between percent monocyte or absolute monocyte count and serum EPO level. In conclusion, monocyte count in hemograms may be useful for diagnosing EPO-elevated erythrocytosis.

关键词： Erythropoietin Monocyte Erythrocytosis

Observation of Reciprocal Induced CD between Colloidal Gold Nanoparticles and Chiral Schiff Base Zn （11） Complexes with Parallel Dipole Moments

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Journal of Chemistry and Chemical Engineering 2013年第5期7卷 390-394页

作者： naoko Kimura Hitoe Nishizuru Yoshikazu Aritake Takashiro Akitsu Department of Chemistry Faculty of Science Tokyo University of Science Tokyo 162-8601 Japan

The authors have prepared suprameolecular systems of chiral Schiffbase ZnAZSB （Zn（II） complexes with azo-groups） or without ZnSB （azo-groups） and colloidal AuNP （gold nanoparticles） of 10, 40 and 80 nm diameters. They exhibited gradual shifts of surface plasmon bands as well as fluorescence bands. The authors observed and discussed induced CD bands on gold nanoparticles from chiral ZnAZSB or ZnSB. Absence of cis-trans photoisomerization of ZnAZSB with AuNP also supported direct contact near the surface of AuNP. Quenching and splitting of fluorescence bands of ZnSB （λex = 550 nm and λem = 400 nm） depending on concentration of ZnSB and size of AuNP also suggested intermolecular （electric） interaction on the surface of AuNE Decrease of the intensity of the CD band around 380 nm resulted from reciprocal induced CD effect due to parallel arrangement of electric transition moments of ZnAZSB or ZnSB and surface of AuNP.

关键词： Induced CD colloidal gold Schiffbase Zinc (II) complexes chirality.

Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection

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World Journal of Gastroenterology 2019年第12期25卷 1502-1512页

作者： Yoriaki Komeda Tomohiro Watanabe Toshiharu Sakurai Masashi Kono Kazuki Okamoto Tomoyuki Nagai Mamoru Takenaka Satoru Hagiwara Shigenaga Matsui Naoshi Nishida naoko Tsuji Hiroshi Kashida Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine

BACKGROUND Risk factors for local recurrence after polypectomy, endoscopic mucosal resection(EMR), and endoscopic submucosal dissection(ESD) have not been ***, the appropriate interval for endoscopic surveillance of colorectal tumors at high-risk of local recurrence has not been *** To clarify the clinicopathological characteristics of recurrent lesions after endoscopic colorectal tumor resection and determine the appropriate *** Three hundred and sixty patients(1412 colorectal tumors) who underwent polypectomy, EMR, or ESD and received endoscopic surveillance subsequently for more than one year to detect local recurrence were enrolled in this study. The clinicopathological factors associated with local recurrence were determined via univariate and multivariate *** Local recurrence was observed in 31 of 360(8.6%) patients [31 of 1412(2.2%)lesions] after colorectal tumor resection. Piecemeal resection, tumor size of more than 2 cm, and the presence of villous components were associated with colorectal tumor recurrence after endoscopic resection. Of these three factors, the piecemeal resection procedure was identified as an independent risk factor for recurrence. Colorectal tumors resected into more than five pieces were associated with a high risk of recurrence since the average period from resection torecurrence in these cases was approximately 3 mo. The period to recurrence in cases resected into more than 5 pieces was much shorter than that in those resected into less than 4 pieces(3.8 ± 1.9 mo vs 7.9 ± 5.0 mo, P < 0.05).CONCLUSION Local recurrence of endoscopically treated colorectal tumors depends upon the outcome of first endoscopic procedure. Piecemeal resection was the only significant risk factor associated with local recurrence after endoscopic resection.

关键词： Local recurrence Colorectal tumor Endoscopic surveillance Piecemeal resection Risk factors

Modeling and analysis of Hayabusa2 touchdown

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Astrodynamics 2020年第2期4卷 119-135页

作者： Kent Yoshikawa Hirotaka Sawada Shota Kikuchi naoko Ogawa Yuya Mimasu Go Ono Yuto Takei Fuyuto Terui Takanao Saiki Seiji Yasuda Kota Matsushima Tetsuya Masuda Yuichi Tsuda Japan Aerospace Exploration Agency Sagamihara252-5210Japan NEC Corporation Fuchu183-8501Japan

The Hayabusa2 asteroid explorer mission focuses principally on the touchdown and sampling on near-Earth asteroid 162173 ***2 successfully landed on its surface and ejected a projectile for sample collection on February 22,***2 later landed near a crater formed by an impactor and executed the sampling sequence again on July 11,*** a successful mission,a thorough understanding and evaluation of spacecraft dynamics during touchdown were *** most challenging aspect of this study was the modeling of such spacecraft phenomena as the dynamics of landing on a surface with unknown *** particular,a Monte Carlo analysis was used to determine the parameters of the operational design for the final descent and touchdown *** paper discusses the dynamical modeling of the simulation during the touchdown of Hayabusa2.

关键词： contact dynamics resistive force theory(RFT) astrodynamics Hayabusa2 planetary exploration

Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan

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World Journal of Gastroenterology 2017年第29期23卷 5364-5370页

作者： Tomiyasu Arisawa Masakatsu Nakamura Toshimi Otsuka Wu Jing naoko Sakurai Hikaru Takano Tasuku Hayashi Masafumi Ota Tomoe Nomura Ranji Hayashi Takeo Shimasaki Tomomitsu Tahara Tomoyuki Shibata Department of Gastroenterology Kanazawa Medical University Department of Gastroenterology Fujita Health University

To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODSThis case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). RESULTSThe genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. CONCLUSIONOur results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.

关键词： Maf protein K Genetic polymorphism Reactive oxygen species Ulcerative colitis Nuclear factor-erythroid 2-related factor 2

Refractory ulcerative colitis accompanied with cytomegalovirus colitis and multiple liver abscesses: A case report

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World Journal of Gastroenterology 2005年第33期11卷 5241-5244页

作者： Takuya Inoue Ichiro Hirata Yutaro Egashira Kumi Ishida Ken Kawakami Eijiro Morita naoko Murano Shingo Yasumoto Mitsuyuki Murano Ken Toshina Takashi Nishikawa Norihiro Hamamoto Ken Nakagawa Ken-Ichi Katsu The Second Department of Internal Medicine Osaka Medical College 2-7 DaigakuchoTakatsuki City Osaka 569-8686 Japan Department of Pathology Osaka Medical College Takatsuki City Osaka 569-8686 Japan The Second Department of Internal Medicine Osaka Medical College 2-7 Daigakucho Takatsuki City Osaka 569-8686 Japan

Various hepato-biliary complications are an increased incidence in patients with inflammatory bowel disease,and portal bacteremia is well documented in patients with ulcerative colitis (UC). However, few reports mention UC in association with liver abscesses. Recently, there are several reports describing cytomegalovirus (CMV) infection in association with disease exacerbation and steroid refractoriness in patients with UC. Here we present a case of refractory UC accompanied with multiple liver abscesses and CMV colitis. The patient, a 72-year-old male, with a five-year history of repeated admissions to our hospital for UC, presented with an exacerbation of his *** performed on admission suggested that his UC was exacerbated, then he was given prednisolone and mesalazine orally, and betamethasone ***, he had exacerbated symptoms. Repeat sigmoidoscopy revealed multiple longitudinal ulcers and pseudopolyps in the rectosigmoid colon. Although immunohistochemical staining of biopsy specimens and the serum testing for antigenemia were negative on admission and after the repeat sigmoidoscopy, they became histologically positive for CMV. Nonetheless, the patient developed spiking fevers, soon after ganciclovir was administered. Laboratory studies revealed an increased white cell count with left shift, and Enterococcus fecalis grew in blood cultures. An abdominal computed tomography (CT) scan was obtained and the diagnosis of liver abscesses associated with UC was made, based on CT results. The hepatic abscesses were successfully treated with intravenous meropenem for 6 wk, without further percutaneous drainage. To our knowledge, this is the first reported case of multiple liver abscesses that develop during UC exacerbation complicated by CMV colitis.

关键词： Uver abscess Ulcerative colitis Cytomegalovirusinfection Inflammatory bowel disease