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Clinical impact of endoscopy position detecting unit(UPD-3) for a non-sedated colonoscopy

World Journal of Gastroenterology 2015年第16期21卷 4903-4910页

作者： Masakatsu Fukuzawa Junichi Uematsu Shin Kono Sho Suzuki Takemasa Sato naoko Yagi Yuichiro Tsuji Kenji Yagi Chika Kusano Takuji Gotoda Takashi Kawai Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University Endoscopy Center Tokyo Medical University Hospital

AIM:To evaluate whether an endoscopy position detecting unit(UPD-3) can improve cecal intubation rates, cecal intubation times and visual analog scale(VAS) pain scores, regardless of the colonoscopist's level of ***:A total of 260 patients(170 men and 90women)who underwent a colonoscopy were divided into the UPD-3-guided group or the conventional group(no UPD-3 guidance).Colonoscopies were performed by experts(experience of more than 1000colonoscopies)or trainees(experience of less than 100colonoscopies).Cecal intubation rates,cecal intubation times,insertion methods(straight insertion:shortening the colonic fold through the bending technique;roping insertion:right turn shortening technique)and patient discomfort were *** discomfort during the endoscope insertion was scored by the VAS that was divided into 6 degrees of ***:The cecum intubation rates,cecal intubation times,number of cecal intubations that were performed in<15 min and insertion methods were not significantly different between the conventional group and the UPD-3-guided *** number of patients who experienced pain during the insertion was markedly less in the UPD-3-guided group than in the conventional *** and multivariate analysis showed that the following factors were associated with lower VAS pain scores during endoscope insertion:insertion method(straight insertion)and UPD-3guidance in the trainee *** the experts group,univariate analysis showed that only the insertion method(straight insertion)was associated with lower VAS pain ***:Although UPD-3 guidance did not shorten intubation times,it resulted in less patient painduring endoscope insertion compared with conventional endoscopy for the procedures performed by trainees.

关键词： Colonoscopy Training Endoscopy positiondetecting unit

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Ablation margin assessment of liver tumors with intravenous contrast-enhanced C-arm computed tomography

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World Journal of Radiology 2012年第3期4卷 109-114页

作者： Jin Iwazawa Shoichi Ohue naoko Hashimoto Takashi Mitani Department of Radiology Nissay Hospital6-3-8 ItachiboriNishikuOsaka 550-0012Japan Department of Radiology Komatsu Hospital11-6 KawakatsuchoNeyagawa 572-8567Japan

AIM:To evaluate the feasibility of intravenous contrast-enhanced C-arm computed tomography (CT) for assessing ablative areas and margins of liver tumors. METHODS: Twelve patients (5 men, 7 women; mean age, 69.5 years) who had liver tumors (8 hepatocellular carcinomas, 4 metastatic liver tumors; mean size, 16.3 mm; size range, 8-20 mm) and who underwent percutaneous radiofrequency ablations (RFAs) with a flat-detector C-arm system were retrospectively reviewed. Intravenously enhanced C-arm CT and multidetector computed tomography (MDCT) images were obtained at the end of the RFA sessions and 3-7 d after RFA to evaluate the ablative areas and margins. The ablated areas and margins were measured using axial plane images acquired by both imaging techniques, with prior contrast-enhanced MDCT images as the reference. The sensitivity, specificity, and positive and negative predictive values of C-arm CT for detecting insufficient ablative margins (< 5 mm) were calculated. Statistical differences in the ablative areas and margins evaluated with both imaging techniques were compared using a paired t-test. RESULTS: All RFA procedures were technically successful. Of 48 total ablative margins, 19 (39.6%) and 20 (41.6%) margins were found to be insufficient with C-arm CT and MDCT, respectively. Moreover, there were no significant differences between these 2 imaging techniques in the detection of these insufficient ablative margins. The sensitivity, specificity, and positive and negative predictive values for detecting insufficient margins by C-arm CT were 90.0%, 96.4%, 94.7% and 93.1%, respectively. The mean estimated ablative areas calculated from C-arm CT (462.5 ± 202.1 mm2) and from MDCT (441.2 ± 212.5 mm2) were not significantly different. The mean ablative margins evaluated by C-arm CT (6.4 ± 2.2 mm) and by MDCT (6.0 ± 2.4 mm) were also not significantly different. CONCLUSION: The efficacy of intravenous contrast-enhanced C-arm CT in assessing the ablative areas and margins

关键词： Radiofrequency ablation Cone-beam computed tomography Safety margin Liver Neoplasms

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Factors Determining the Detection Time to Flavor in Healthy Adults

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Journal of Behavioral and Brain Science 2014年第3期4卷 114-119页

作者： Satomi Miyaoka Takako Yamazaki naoko Ito Yozo Miyaoka Department of Eating Disorder and Dysphagia Graduate School of Rehabilitation Niigata University of Rehabilitation 2-16 Kaminoyama Murakami Japan Department of Health and Nutrition Niigata University of Health and Welfare 1398 Shimami-cho Kita-ku Niigata Japan

This study analyzed the factors responsible for determining the flavor detection time for chewed semi-solid foods. Thirteen healthy young adults (eight males and five females) were asked to chew gummy candies with five different fruit flavors (i.e., apple, grape, orange, pear, and strawberry) in a random order. The detection time to flavor was measured using an electromyography-based system, which was recently developed by the authors. Briefly, each participant was recorded with surface masseter electromyograms on both sides to determine the start of chewing. Each participant was asked to press a button as soon as possible with his/her preferred hand after detecting the flavor. The time elapsed between the start of chewing and the button press was measured. Two taste components, sugars and organic acids, of the gummy candies were chemically analyzed, and two major sugars and organic acid were individually detected. The odor intensity was also analyzed for the gummy candies. The average detection time significantly differed among the five gummy candies and among the participants. Simple regression analyses revealed that the intensity of the odors was significantly associated with the average time intervals, but the amounts of the two major sugars and the organic acids were not. The analysis yielded the following equation for the regression estimation:?? (y = the time interval, x = the intensity of odors). The results suggest that the intensity of odors of the gummy candies, not the taste components, is responsible for determining the flavor detection time.

关键词： Flavor Detection Time Semi-Solid Food Masseter Electromyogram Chewing Human

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Reading impairment after neonatal hypoglycemia with parietotemporo-occipital injury without cortical blindness:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3899-3906页

作者： naoko Kurahashi Shunsuke Ogaya Yuki Maki Norie Nonobe Sumire Kumai Yosuke Hosokawa Chikako Ogawa Keitaro Yamada Koichi Maruyama Kiyokuni Miura Miho Nakamura Department of Pediatric Neurology Central HospitalAichi Developmental Disability CenterKasugai 480-0392AichiJapan Department of Pediatrics Nagoya University Graduate School of MedicineNagoya 466-8560AichiJapan Division of Neonatology Center for Maternal-Neonatal Care Nagoya University HospitalNagoya 466-8560AichiJapan Department of Pediatrics Tokyo Metropolitan Fuchu Medical Center for the DisabledFuchu 183-0042TokyoJapan Department of Functioning and Disability Institute for Developmental ResearchAichi Developmental Disability CenterKasugai 480-0392AichiJapan Okazaki Medical Center for Child Development Okazaki 444-0011AichiJapan

BACKGROUND Perinatal brain injury may lead to later neurodevelopmental disorders,whose outcomes may vary due to neuroplasticity in young *** neuroimaging studies have shown that the left parietotemporal area(which includes the left inferior parietal lobe)is associated with phonological awareness and decoding skills,which are essential skills for reading acquisition in ***,the literature on the effect of perinatal cerebral injury on the development of phonological awareness or decoding ability in childhood is *** SUMMARY We report the case of an 8-year-old boy who presented with reading difficulty following a perinatal injury in the parieto-temporal-occipital *** patient was born at term and was treated for hypoglycemia and seizures during the neonatal ***-weighted brain magnetic resonance imaging on postnatal day 4 revealed cortical and subcortical hyperintensities in the parieto-temporo-occipital *** the age of 8 years,physical examination was unremarkable,aside from mild *** occipital lobe injury,the patient had adequate visual acuity,normal eye movement,and no visual field ***-scale intelligence quotient and verbal comprehension index on Wechsler Intelligence Scale for Children-Fourth Edition were 75 and 90,*** assessment revealed adequate recognition of Japanese Hiragana ***,he had significantly slower reading speed in the Hiragana reading test than control *** phonological awareness test revealed significant errors(standard deviation+2.7)in the mora reversal *** Patients with perinatal brain injuries in the parietotemporal area require attention and may benefit from additional reading instructions.

关键词： Brain diseases Hypoglycemia Dyslexia Long-term care Education Case report

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Water-Soluble Gd(III)−Porphyrin Complexes Capable of Both Photosensitization and Relaxation Enhancement

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Chemical & Biomedical Imaging 2023年第2期1卷 157-167页

作者： Tamas Nemeth naoko Yoshizawa-Sugata Agnes Pallier Youichi Tajima Yue Ma Éva Tóth Hisao Masai Yoko Yamakoshi Department of Chemistry and Applied Biosciences ETH ZürichCH8093 ZürichSwitzerland Research Center for Genome&Medical Sciences Tokyo Metropolitan Institute of Medical ScienceSetagayaTokyo 156-8506Japan Centre de Biophysique Moléculaire CNRS UPR 4301University of Orléans45071 Cedex 2 OrléansFrance Department of Basic Medical Sciences Tokyo Metropolitan Institute of Medical ScienceSetagayaTokyo 156-8506Japan

With the aim of developing more stable Gd(III)−porphyrin complexes,two types of ligands 1 and 2 with carboxylic acid anchors were *** to the N-substituted pyridyl cation attached to the porphyrin core,these porphyrin ligands were highly water-soluble and formed the corresponding Gd(III)chelates,Gd-1 and ***-1 was sufficiently stable in neutral buffer,presumably due to the preferred conformation of the carboxylateterminated anchors connected to nitrogen in the meta position of the pyridyl group helping to stabilize Gd(III)complexation by the porphyrin center.1H NMRD(nuclear magnetic relaxation dispersion)measurements on Gd-1 revealed high longitudinal water proton relaxivity(r1=21.2 mM^(−1)s^(−1)at 60 MHz and 25℃),which originates from slow rotational motion resulting from aggregation in aqueous *** visible light irradiation,Gd-1 showed extensive photoinduced DNA cleavage in line with efficient photoinduced singlet oxygen ***-based assays revealed no significant dark cytotoxicity of Gd-1,while it showed sufficient photocytotoxicity on cancer cell lines under visible light *** results indicate the potential of this Gd(III)−porphyrin complex(Gd-1)as a core for the development of bifunctional systems acting as an efficient photodynamic therapy photosensitizer(PDT-PS)with magnetic resonance imaging(MRI)detection capabilities.

关键词： Singlet oxygen generation relaxivity Gd(III)chelate water-soluble porphyrin photocytotoxicity

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Biological Effects of Cloth Containing Specific Ore Powder in Patients with Pollen Allergy

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Biomedical and Environmental Sciences 2016年第8期29卷 563-573页

作者： Suni LEE Hitoshi OKAMOTO Shoko YAMAMOTO Tamayo HATAYAMA Hidenori MATSUZAKI naoko KUMAGAI-TAKEI Kei YOSHI-TOME Yasumitsu N1SHIMURA Toshiaki SATO Yasuzo KIRITA Yoshio FUJII Takemi OTSUKI Biological Sciences Universidad De Los Andes Bogota 111711 Col. Department of Hygiene Kawasaki Medical School 577 Mastushima Kurashiki 701-0192 Japan Cosmic Garden Co. Ltd. 1-2-25 Ima Kita-Ku Okayama 700-0975 Japan Coordinator Specified Nonprofit Organiztion MEDICAL TECHNO OKA YAMA 1st Floor General Education Research Building Shikata Campus 2-5-1 Shikata Kita-ku Okayama 700-8558 Japan Okayama University Organization for Research Promotion and Collaboration 3rd Floor Basie Medicine Building Shikata Campus 2-5-1 Shikata Kita-ku Okayama 700-8558 Japan

Objective The custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder （SNOP） in wall materials and surveys customers in order to improve allergic symptoms. Methods To investigate the biological effects of SNOP, patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP （CCSNOP）, and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth （NWC）. Each stay lasted 60 min. Before and immediately after the stay, a questionnaire regarding allergic symptoms, as well as POMS （Profile of Mood Status） and blood sampling, was performed. Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups. Results Results indicated that some symptoms, such as nasal obstruction and lacrimation, improved, and POMS evaluation showed that patients were calmer following a stay in CCSNOP. Relative eosinophils, non-specific Ig E, epidermal growth factor, monocyte chemotactic protein-I, and tumor necrosis factor-a increased following a stay in CCSNOP. Conclusion This ore powder improved allergic symptoms, and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients.

关键词： Specific Mineral Cloth, Indoor air Immunological effects Pollen allergy

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3D Numerical Simulation of Hair Formation Process Using a Particle Model

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Open Journal of Regenerative Medicine 2015年第1期4卷 1-5页

作者： Katsuya Nagayama Shogo Matsuoka naoko Morisaki Hiroyuki Taguchi Kyushu Institute of Technology Fukuoka Japan Kao Corporation Tochigi Japan

Hair is very important in determining human appearance. Although there are numerous observed data and experimental recordings for hair, a detailed mechanism of hair formation has not yet been elucidated. Therefore, in this study, a simulation of the method of formative process of hair roots was done using a 3D particle model. The model contains details of the cell growth from the hair matrix cells and changes from spherical to non-spherical oval shape. Simulation results were able to exhibit the hair formation process from the base of the hair follicle. Furthermore, at the surface opening of the follicle, the hair structure was recorded. Therefore, this model can be used to clarify the mechanism of hair root formation.

关键词： Numerical Simulation Hair Formation Particle Model

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Validation of general linear modeling for identifying factors associated with Quality of Life: A comparison with structural equation modeling

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Health 2013年第11期5卷 1884-1888页

作者： naoko Kumagai Motonori Hatta Yashiyasu Okuhara Hideki Origasa Center of Medical Information Science Kochi Medical School Kochi Japan Data Management Actelion Pharmaceuticals Japan Ltd. Tokyo Japan Division of Biostatistics and Clinical Epidemiology School of Medicine University of Toyama Toyama Japan Integrated Center for Advanced Medical Technologies Kochi Medical School Kochi Japan Center of Medical Information Science Kochi Medical School Kochi Japan

Purpose: General linear modeling (GLM) is usually applied to investigate factors associated with the domains of Quality of Life (QOL). A summation score in a specific sub-domain is regressed by a statistical model including factors that are associated with the sub-domain. However, using the summation score ignores the influence of individual questions. Structural equation modeling (SEM) can account for the influence of each question’s score by compositing a latent variable from each question of a sub-domain. The objective of this study is to determine whether a conventional approach such as GLM, with its use of the summation score, is valid from the standpoint of the SEM approach. Method: We used the Japanese version of the Maugeri Foundation Respiratory Failure Questionnaire, a QOL measure, on 94 patients with heart failure. The daily activity sub-domain of the questionnaire was selected together with its four accompanying factors, namely, living together, occupation, gender, and the New York Heart Association’s cardiac function scale (NYHA). The association level between individual factors and the daily activity sub-domain was estimated using SEM?and GLM, respectively. The standard partial regression coefficients of GLM and standardized path coefficients of SEM were compared. If?these coefficients were similar (absolute value of the difference -0.06 and -0.07 for the GLM and SEM. Likewise, the estimates of occupation, gender, and NYHA were -0.18 and -0.20, -0.08 and -0.08, 0.51 and 0.54, respectively. The absolute values of the difference for each factor were 0.01, 0.02, 0.00, and 0.03, respectively. All differences were less than 0.05. This means that these two approaches lead to similar conclusions. Conclusion: GLM is a valid method for exploring association factors with a domain in QOL.

关键词： General Liner Modeling Latent Variable Standardized Path Coefficient Standard Partial Regression Coefficient Structural Equation Modeling

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Relationship between Road Traffic Accidents and Drinking Habits in All 47 Prefectures of Japan

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Journal of Transportation Technologies 2013年第3期3卷 190-193页

作者： Nobuyuki Miyatake naoko Tanaka Noriko Sakano Hiroshi Kinoshita Department of Forensic Medicine Faculty of Medicine Kagawa University Kagawa Japan Department of Hygiene Faculty of Medicine Kagawa University Kagawa Japan

We evaluated the road traffic accidents and drinking habits in all 47 prefectures of Japanby ecological study. Data on traffic accidents were obtained from Ministry of Internal Affairs and Communications,Japan. Drinking habits were also obtained from Ministry of Health Labour and Welfare and The General Insurance Association of Japan. The effect of drinking on road traffic accidents was evaluated by ecological study. Road traffic accidents were 15442.0 ± 14404.9 deaths due to road traffic accidents were 103.5 ± 57.5 and injured subjects due to road traffic accidents were 19068.3 ± 17433.6 in 2010 inall 47 prefectures of Japan. Drinking habits was significantly and negatively correlated with injured subjects due to road traffic accidents. However, road traffic accidents due to drinking was positively correlated with injured subjects due to road traffic accidents (r = 0.492, p = 0.0004). In conclusion, drinking habits and road traffic accidents due to drunk driving were closely linked to injured subjects due to road traffic accidents inJapan.

关键词： Road Traffic Accidents Drinking Habits Ecological Study Japan

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Investigation of Antibiotic Use at a Dental Teaching Hospital in Yogyakarta, Indonesia: A Review from Guidelines

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Pharmacology & Pharmacy 2014年第5期5卷 524-531页

作者： Mayu Winnie Rachmawati naoko Yoshida Hirohito Tsuboi Kazuko Kimura Department of Drug Management and Policy Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan

Objective: To investigate prescription of antibiotics by dental practitioners at a dental teaching hospital in Yogyakarta, Indonesia, and to establish whether it conforms to major guidelines. Methods: A cross-sectional study of adult outpatients’ medical records was conducted in order to scrutinize antibiotic prescriptions. The results were compared with recommendations in four published guidelines. Results: Dental practitioners prescribed a wide range of antibiotics to treat 121 diagnoses. Amoxicillin (78.8%) was most commonly prescribed, followed by clindamycin (9.9%), metronidazole (5.0%), and lincomycin (2.1%). Among all prescriptions, 79.5% were for generic antibiotics. The most common diagnoses were dental pulp gangrene followed by dental pulp necrosis (26.7% and 8.8%, respectively). According to guidelines-1 through-4, the percentages of antibiotic prescriptions that were evaluated as appropriate for the reported diagnosis were 15.1%, 7.2%, 7.5%, and 16.3%, respectively. However, 9.9%, 84.0%, 83.7% and 67.8% of prescriptions could not be classified as appropriate or inappropriate because the respective guidelines neither listed the antibiotic nor gave statement regarding appropriate indications. Conclusion: Our results suggest that significant inappropriate antibiotic prescribing occurred at a dental teaching hospital in Yogyakarta, Indonesia, according to major antibiotics guidelines. However, the four guidelines failed to list some antibiotics, failed to list indications for prescription in some cases, and were inconsistent in their recommendations. There is a need to introduce specific institutional guidelines. Our findings should be helpful for developing public health policy guidelines to minimize inappropriate antibiotic prescribing at dental hospitals.

关键词： Appropriateness Antibiotics Prescriptions Dental Teaching Hospital Guidelines

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