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The Crop Journal 2015年第6期3卷 481-488页

作者： Kenji Fukunaga naoko izuka Takehiro Hachiken Satoshi Mizuguchi Hidemi Ito Katsuyuki Ichitani Faculty of Life and Environmental Sciences Prefectural University of Hiroshima Faculty of Agriculture Kagoshima University

We investigated genetic variation of a rice HEADING DATE 1(HD1) homolog in foxtail ***, we searched for a rice HD1 homolog in a foxtail millet genome sequence and designed primers to amplify the entire coding sequence of the gene. We compared full HD1 gene sequences of 11 accessions(including Yugu 1, a Chinese cultivar used for genome sequencing) from various regions in Europe and Asia, found a nucleotide substitution at a putative splice site of intron 1, and designated the accessions with the nucleotide substitution as carrying a splicing variant. We verified by RT-PCR that this single nucleotide substitution causes aberrant splicing of intron 1. We investigated the geographical distribution of the splicing variant in 480 accessions of foxtail millet from various regions of Europe and Asia and part of Africa by d CAPS and found that the splicing variant is broadly distributed in Europe and Asia. Differences of heading times between accessions with wild type allele of the HD1 gene and those with the splicing variant allele were unclear. We also investigated variation in 13 accessions of ssp. viridis, the wild ancestor, and the results suggested that the wild type is predominant in the wild ancestor.

关键词： Foxtail millet Geographical distribution HD1(HEADING DATE 1) homolog Setaria italica Splice site

Advances in titanium alloys and orthopedic implants:new titanium alloys and future research directions

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Bio-Design and Manufacturing 2024年第6期7卷 1053-1054页

作者： Yu Mori naoko Mori Department of Orthopaedic Surgery Tohoku University Graduate School of MedicineSendai 980-8574Japan Department of Radiology Akita University Graduate School of MedicineAkita 010-8543Japan

Dear Editor,We read with great interest the article by Tan et ***“Accelerated fracture healing by osteogenic Ti45Nb implants through the PI3K-Akt signaling pathway”[1].This research thoroughly examines the bone-forming capabilities of the Ti45Nb *** in vitro studies revealed that the Ti45Nb alloy enhances the osteogenic differentiation of MC3T3-E1 cells more effectively than Ti6Al4V alloy controls,showing no noticeable cytotoxic effects.

关键词： Ti6Al4V alloy

Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration

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Neural Regeneration Research 2018年第6期13卷 979-980页

作者： naoko Niimi Kazunori Sango Diabetic Neuropathy Project Department of Sensory and Motor Systems Tokyo Metropolitan Institute of Medical Science

Diabetic peripheral neuropathy（DPN）is one of the most common and intractable complications of diabetes *** irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and depression;whereas its progression to more advanced stages can result in serious consequences,such as lower limb amputations and lethal arrhythmias.

关键词： DPN Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration NGF NCV AR PNS

A fate model of pathogenic viruses in a composting toilet based on coliphage inactivation

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Journal of Environmental Sciences 2011年第7期23卷 1194-1198页

作者： Shinobu Kazama Narue Tameike naoko Nakagawa Masahiro Otaki Department of Human Environmental Science Ochanomizu University INAX Co. 1-23-6 Yoshino-cho Kita-ku Satiama 331-0811 Japan Department of Civil and Environmental Engineering Tokyo Metropolitan University 1-1 Minamiosawa Hachioji City Tokyo 192-0397 Japan

A composting toilet using sawdust as a matrix has the potential to trap pathogens that might occasionally be contained in human feces. Therefore, care should be taken when handling the sawdust. It should also be noted that pathogenic viruses tend to have stronger tolerance than pathogenic bacteria. The fates of several species of coliphages, T4, λ, Qβ and MS2, in sawdust were investigated as a viral model. The fates of coliphages were significantly different among them, and they changed in response to temperature and the water content of the sawdust. As the results, T4 coliphage had the strongest tolerance and Qβ had the weakest one in sawdust. It was estimated the days required to decrease virus to a safe level based on a risk assessment. According to the rates of Qβ and T4, 15 days and 167 days were required respectively for a safe level of infection risk based on actually operated composting toilet condition. Thus, it was significantly different depending on the species and sawdust conditions.

关键词： composting toilet viral indicator coliphage risk assessment

Role of stereotactic body radiotherapy for oligometastasis from colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4220-4229页

作者： Atsuya Takeda naoko Sanuki Etsuo Kunieda Radiation Oncology Center Ofuna Chuo HospitalKanagawa 247-0056Japan Department of Radiation Oncology Tokai UniversityKanagawa 259-1193Japan

Systemic chemotherapy has enabled prolongation of survival in patients with stage IV colorectal cancer. This has subsequently increased the relative significance of local therapy for patients with oligometastases because they can be cured by removal of oligometastatic lesions. One of the most frequently reported tumor histologies for oligometastases is colorectal cancer. Resection is the standard therapy in most settings of oligometastases. Recently, studies have shown that stereotactic body radiotherapy (SBRT) may become a treatment option that provides high local control with minimal morbidity. Two-year local control rates following SBRT for hepatic and pulmonary oligometastases are almost over 80% and are even higher for patients treated with high-dose regimens. The indications of SBRT for other metastatic sites or conditions include isolated lymph nodes, spinal and adrenal metastasis, and post-surgical pelvic recurrence. Many retrospective studies have indicated that SBRT for various lesions results in good outcomes with low morbidity, both in the curative and palliative setting. However, few reports with a high level of evidence have indicated the efficacy of SBRT compared to standard therapy. Hereafter, the optimal indication of SBRT needs to be prospectively investigated to obtain convincing evidence.

关键词： Oligometastasis Colorectal cancer Radiation therapy Stereotactic ablation body radiation therapy Local therapy

Role of stereotactic body radiation therapy for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第12期20卷 3100-3111页

作者： naoko Sanuki Atsuya Takeda Etsuo Kunieda Radiation Oncology Center Ofuna Chuo Hospital Department of Radiation Oncology Tokai University

The integration of new technologies has raised an interest in liver tumor radiotherapy,with literature evolving to support its *** advances,particularly stereotactic body radiation therapy(SBRT),have been critical in improving local control or potential cure in liver lesions not amenable to first-line surgical resection or radiofrequency *** investigation of SBRT,particularly for hepatocellular carcinoma(HCC),has recently started,yielding promising local control *** addition,data suggest a possibility that SBRT can be an alternative option for HCC unfit for other local ***,information on optimal treatment indications,doses,and methods remains *** HCC,significant differences in patient characteristics and treatment availability exist by *** addition,the prognosis of HCC is greatly influenced by underlying liver dysfunction and treatment itself in addition to tumor *** they are closely linked to treatment approach,it is important to understand these differences in interpreting outcomes from various *** studies are required to validate and maximize the efficacy of SBRT by a large,multi-institutional setting.

关键词： Hepatocellular carcinoma Liver cirrhosis Liver neoplasms Radiation therapy Stereotactic body radiation therapy

Field survey of a sustainable sanitation system in a residential house

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Journal of Environmental Sciences 2006年第6期18卷 1088-1093页

作者： naoko NAKAGAWA Masahiro OTAKI Shinji MIURA Hironobu HAMASUNA Katsuyoshi ISHIZAKI Department of Human Environmental Sciences Ochanomizu University2-1-1OtsukaBunkyo-KuTokyo 112-8610Japan. City Maintenance Technical Research Center 2-9-23ShinjuShinjuku-KuTokyo 160-0023Japan Nagasaki Institute of Applied Science 536Abama-choNagasaki-shiNagasaki Pref.851-0123Japan Research Institute for a Sustainable Future Waseda University513 Tsurumaki-ChouWasedaShinjuku-KuTokyo 169-8050Japan

Sustainable sanitation is an approach for more ecological and sustainable water resources management. In this paper, we proposed one of the new integrated waste treatment systems： an ＂sustainable sanitation system＂ that includes separation of the black water from water system by a non-flushing toilet （bio-toilet）, and a gray water treatment based on a biological and ecological concept. Sustainable sanitation system also converts the domestic waste to soil conditioners and fertilizers, for farmland use. As one of the case studies, Environmentally Symbiotic Housing in which people actually live using the bio-toilet for the black water treatment and the household wastewater treatment facility for the gray water was introduced. The availability of this system was investigated by analyzing the sawdust used in the bio-toilet and the quality of the effluent in the household wastewater treatment facility. As the result, the water content of the sawdust did not exceed 60% in any of the sampling points and the BOD and COD of the effluent of the household wastewater treatment facility were below 10 and 20 mg/L respectively, due to the low loading. Compared to the pollution load on the water environment created by the conventional system, it was found that the effluent of the house has a lower load than the tertiary treatment and the volume of the water consumption is 75% of the conventional system.

关键词： bio-toilet pollution load sustainable sanitation system water consumption

Structure properties of pyrolytic lignin extracted from aged bio-oil

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Chinese Science Bulletin 2011年第14期56卷 1417-1421页

作者： JIANG XiaoXiang naoko Ellis ZHONG ZhaoPing Thermoenergy Engineering Research Institute Southeast University Nanjing 210096 China Department of Chemical and Biological Engineering University of British Columbia Vancouver V6T 1Z3 Canada

Fast pyrolysis is a promising technology that can convert biomass into ***-oil is one such product,known not only as a greenhouse gas-neutral energy source,but also an opportunity to reduce reliance on fossil *** lignin,a fine homogeneous powder,is the water-insoluble fraction of bio-oil and it contributes to the instability of ***,pyrolytic lignin can be used in commercial materials such as adhesives in the wood-based panel *** paper presents the structural characterization of pyrolytic lignin extracted from aged bio-oil and the relationship between its properties and the treatment temperature of the aged *** lignin samples were characterized by Fourier transform infrared spectroscopy,gel permeation chromatography,differential scanning calorimetry,thermogravimetric analysis and proton nuclear magnetic resonance *** average molecular weight of pyrolytic lignin increased from 700 to 1000 g/mol with increasing aging temperature (6-50°C).Differential scanning calorimetry showed that the glass transition temperature of pyrolytic lignin increases with lower heating rate and higher treatment temperature of *** increase in the initial decomposition temperature and the temperature at 95 wt% weight loss of the aged pyrolytic lignin in thermogravimetry were observed for the bio-oil aged at higher *** increase in residue weight of aged pyrolytic lignin was found in bio-oil aged at higher temperatures.

关键词：快速热解木质素生物油年龄结构特性提取差示扫描量热法傅立叶变换红外光谱

Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China

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World Journal of Gastroenterology 2000年第5期6卷 750-753页

作者： naoko lida Hideaki Oda Shigetoshi Aiso Takatoshi Ishikawa Department of Molecular Pathology Faculty of Medicinethe University of TokyoHongoTokyo 113Japan

INTRODUCTIONAdenocarcinomas of the cardia are the lesionsarising from the proximal stomach or within 3 cm ofthe gastroesophageal *** cancerstended to be advanced at the time of presentation,usually with poor *** recent decade,the incidence of adenocarcinoma of gastric eardiaand esophagus are increasing steadily,while therehas been a decrease in the proportion of the cancersarising from the distal ***

关键词： cardia adenocarcinoma/etiology protein P53 gene expression mutation genes p53 polymerase chain reaction DNA risk factors

Degradation rates and products of fluticasone propionate in alkaline solutions

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Journal of Pharmaceutical Analysis 2017年第5期7卷 297-302页

作者： Tadakazu Tokumura naoko Yoshida Kanami Mori-Yasumoto Osamu Shirota Takuro Kurita Laboratory of Pharmaceutics Kagawa School of Pharmaceutical Sciences Tokushima Bunri University Department of Pharmaceutical Sciences School of Pharmacy International University of Health and Welfare Laboratory of Pharmacognosy and Natural Products Chemistry Kagawa School of Pharmaceutical Sciences Tokushima Bunri University

The apparent degradation rate constant of fluticasone propionate(FLT) in 0.1 M NaOH:methanol=1:1 at 37 °C was previously reported to be 0.169 ± 0.003 h^(-1), and four degradation products(products 1–4) were observed in the solution. The aims of the present study were to assess the degradation rates of FLT in other alkaline solutions and clarify the chemical structures of the four degradation products in order to obtain basic data for designing an enema for inflammatory bowel disease. The apparent degradation rate constants in 0.05 M NaOH and 0.1 M NaOH:CH_3CN=1:1 were 0.472 ± 0.013 h^(-1) and 0.154 ± 0.000 h^(-1)(n=3), respectively. The chemical structures of products 1–4 in 0.1 M NaOH:methanol=1:1 were revealed by nuclear magnetic resonance(NMR)and mass spectrometry data. The chemical structure of products 2 was that the 17-position of the thioester moiety of FLT was substituted by a carboxylic acid. The degradation product in 0.1 M NaOH:CH_3CN=1:1 was found to be product 2 based on ~1H NMR data. The degradation product in 0.05 M NaOH was considered to be product 2 based on the retention time of HPLC. These results are useful for detecting the degradation products of FLT by enzymes of the intestinal bacterial flora in the large intestine after dosing FLT as an enema.

关键词： Fluticasone propionate Degradation rate Degradation products Chemical structure Alkaline solution