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Coupling of plasmonic nanopore pairs: facing dipoles attract each other

Light(Science & Applications) 2016年第1期5卷 492-498页

作者： Takumi Sannomiya Hikaru Saito Juliane Junesch naoki yamamoto Department of Innovative and Engineered Materials Tokyo Institute of TechnologyYokohama 226-8503Japan Center of Advanced Instrumental Analysis Kyushu UniversityKasuga 816-8580Japan Department of Physics Chalmers University of TechnologyGothenburg 41296Sweden

Control of the optical properties of nano-plasmonic structures is essential for next-generation optical circuits and high-throughput biosensing *** of such nano-optical devices requires optical couplings of various nanostructured elements and field confinement at the *** particular,symmetric coupling modes,also referred to as dark modes,have recently received considerable attention because these modes can confine light energy to small *** the coupling behavior of plasmonic nanoparticles has been relatively well studied,couplings of inverse structures,that is,holes and pores,remain partially *** for the most fundamental coupling system of two dipolar holes,comparison of the symmetric and antisymmetric coupling modes has not been *** we present,for the first time,a systematic study of the symmetric and anti-symmetric coupling of nanopore pairs using cathodoluminescence by scanning transmission electron microscopy and electromagnetic *** symmetric coupling mode,approximated as a pair of facing dipoles,is observed at a lower energy than that of the anti-symmetric coupling mode,indicating that the facing dipoles attract each *** anti-symmetric coupling mode splits into the inner-and outer-edge localized modes as the coupling distance *** coupling behaviors cannot be fully explained as inverses of coupled *** and anti-symmetric coupling modes are also observed in a short-range ordered pore array,where one pore supports multiple local resonance modes,depending on the distance to the neighboring *** to the observed symmetric modes by far field is also discussed,which is important for nanophotonic device applications.

关键词： cathodoluminescence plasmonic nanopore short-range order surface plasmon transmission electron microscopy

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Partial stent-in-stent placement of biliary metallic stents using a short double-balloon enteroscopy

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World Journal of Gastroenterology 2012年第45期18卷 6674-6676页

作者： Koichiro Tsutsumi Hironari Kato Takeshi Tomoda Kazuyuki Matsumoto Ichiro Sakakihara naoki yamamoto Yasuhiro Noma Takayuki Sonoyama Hiroyuki Okada Kazuhide yamamoto Department of Gastroenterology and Hepatology Dentistry and Pharmaceutical SciencesOkayama University Graduate School of MedicineOkayama 700-8558Japan

Endoscopic intervention is less invasive than percutaneous or surgical approaches and should be considered the primary drainage procedure in most cases with obstructive ***,therapeutic endoscopic retrograde cholangiopancreatography(ERCP) using double-balloon enteroscopy(DBE) has been shown to be feasible and effective,even in patients with surgically altered *** the other hand,endoscopic partial stent-in-stent(PSIS) placement of selfexpandable metallic stents(SEMSs) for malignant hilar biliary obstruction in conventional ERCP has also been shown to be feasible,safe and *** performed PSIS placement of SEMSs for malignant hilar biliary obstruction due to liver metastasis using a short DBE in a patient with Roux-en-Y anastomosis and achieved technical and clinical *** procedure can result in quick relief from obstructive jaundice in a single session and with short-term hospitalization,even in patients with surgically altered anatomies.

关键词： Double-balloon enteroscopy Malignant hi-lar biliary obstruction Self-expandable metallic stent Partial stent in stent Roux-en-Y anastomosis

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Successful biliary drainage using a metal stent through the gastric stoma

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World Journal of Gastroenterology 2015年第24期21卷 7594-7597页

作者： Kazuyuki Matsumoto Hironari Kato Koichiro Tsutsumi Yutaka Akimoto Daisuke Uchida Takeshi Tomoda naoki yamamoto Yasuhiro Noma Shigeru Horiguchi Hiroyuki Okada Kazuhide yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

We report a case of biliary drainage for malignant stricture using a metal stent with an ultrathin endoscope through the gastric stoma. A 78-year-old female was referred to our hospital for jaundice and fever. She had undergone percutaneous endoscopic gastrostomy(PEG) for esophageal obstruction after radiation therapy for cancer of the pharynx. Abdominal contrast-enhanced computed tomography showed a 3-cm enhanced mass in the middle bile duct and dilatation of the intrahepatic bile duct. We initially performed endoscopic retrograde cholangiopancreatography(ERCP) with a trans-oral approach. However, neither the side-viewing endoscope nor the ultrathin endoscope passed through the esophageal orifice. Thus, we eventually performed ERCP via the PEG stoma using an ultrathin endoscope. We performed biliary drainage with a 6F introducer selfexpanding metal stent. The cytology findings obtained by brush cytology showed malignancy. Her laboratory results were restored to normal levels after drainage and no complication occurred.

关键词： Percutaneous endoscopic gastrostomy Transgastrostomic endoscopy Ultrathin endoscope Malignant biliary obstruction Metal stent

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Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

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npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao Gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao Kobayashi Eriko Watanabe Yu-ya Ohnishi Hajime Nakamura naoki yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

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Concomitant Increases of the Developing Seed Phosph<i>oenol</i>pyruvate Carboxylase Ac-tivity and the Seed Protein Content of Field-Grown Wheat with Nitrogen Supply

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Agricultural Sciences 2014年第14期5卷 1558-1565页

作者： naoki yamamoto Toshio Sugimoto Takehiro Masumura Plant Nutrition Laboratory Department of Biological and Environmental Science Faculty of Agriculture Graduate School of Agricultural Science Kobe University Kobe Japan Laboratory of Genetic Engineering Graduate School of Life and Environmental Sciences Kyoto Prefectural University Kyoto Japan Kyoto Prefectural Institute of Agricultural Biotechnology Kyoto Japan

Wheat seed storage protein is of great importance for human food. To increase the contents of storage proteins effectively, nitrogen fertilizer at flowering stages is commonly applied. In our previous study, rice phosphoenolpyruvate carboxylase (PEPCase) activity in developing seeds was observed in response to nitrogen application at a flowering stage and was positively correlated to the response of the protein content in seeds of six cultivars. This observation might indicate that the seeds have a biological system for accepting nitrogen in seeds by using PEPCase. To test whether this physiological event occurs in wheat, we examined the PEPCase activity and protein content in field-grown wheat seeds under different nitrogen supply conditions. With only basal dressing, seeds showed lower PEPCase activity and protein content (both 0.90-fold) compared to seeds without basal fertilizer. With ammonium sulfate application at 8.3 and 25 g/m2 at a flowering stage, seeds showed higher PEPCase activity (1.08- and 1.17-fold, respectively) and protein content (1.15- and 1.42-fold, respectively), depending on the nitrogen level. We investigated the relationship between PEPCase activity and protein content in the seeds among four conditions. The effect of the nitrogen supply on PEPCase activity during grain-filling stages was validated by the results of a hydroponic culture experiment. Together the results demonstrate that our hypothesis seems to apply to field-grown wheat.

关键词： Nitrogen Application Phosphoenolpyruvate Carboxylase Seed Storage Protein Wheat

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In vitro evaluation of the anti-diabetic potential of soymilk yogurt and identification of inhibitory compounds on the formation of advanced glycation end-products

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Food Bioscience 2022年第6期50卷 668-675页

作者： Yuki Nakashima naoki yamamoto Ryosuke Tsukioka Hikari Sugawa Rina Ohshima Kaede Aoki Tomoyuki Hibi Kotone Onuki Yudai Fukuchi Shin Yasuda Ryoji Nagai Hideki Kinoshita Graduate School of Bioscience Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan School of Agriculture Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan Graduate School of Agriculture Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan Probio LLC. 1330-1 FutaNishihara-muraAso-gunKumamotoJapan

In this study, we aimed to identify starter strains of lactic acid bacteria (LAB) to produce soymilk yogurt that can decrease the risk of diabetes mellitus (DM) and its complications. The inhibition assays of the dipeptidyl peptidase IV (DPP- IV) and advanced glycation end products (AGEs) formation were conducted using 70% ethanol (EtOH) extraction of freeze-dried soymilk yogurt. Soymilk yogurt produced using Weissella confusa TOKAI 2 showed the highest inhibition rate in the α-amylase inhibition assay, while soymilk yogurt produced using Lactiplantibacillus plantarum TOKAI 17 showed the highest inhibition rates in the α-glucosidase and DPP-Ⅳ inhibition assays, respectively. Soymilk yogurt produced using Streptococcus macedonicus TOKAI 4 showed the highest inhibitory activities in Nω-(carboxymethyl) arginine (CMA) and Nε-(carboxymethyl) lysine (CML) formation, respectively. Furthermore, soymilk yogurt prepared using Lb. plantarum TOKAI 17 and Lactiplantibacillus pentosus TOKAI 35 exhibited higher proportions of aglycone isoflavones than soymilk and showed a higher fluorescent AGEs inhibitory activity than that of soymilk (p < 0.05). Interestingly, the inhibition assay assessing fluorescent AGEs formation using isoflavones indicated that aglycone-type isoflavones, such as genistein and daidzein, had higher inhibitory activities than that of glycosides (p < 0.05). These results indicate that soymilk yogurt produced using Lb. plantarum TOKAI 17 and Lb. pentosus TOKAI 35 had inhibitory effects on α-glucosidase, DPP-Ⅳ, and AGEs formation in vitro, and that aglycone isoflavones might inhibit the formation of fluorescent AGEs.

关键词： Lactic acid bacteria Soymilk yogurt Diabetes Advanced glycation end products

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Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第40期22卷 8967-8977页

作者： Issei Saeki naoki yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Yamaguchi University Health Administration Center Yamaguchi 755-8511 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Department of Human Nutrition Faculty of Nursing and Human Nutrition Yamaguchi 755-8502 Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of Medicine Yamaguchi Prefectural University Yamaguchi 755-8505 Japan Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi 755-8511 Japan

AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical *** In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was *** Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities.

关键词： Liver tumor Hepatocellular carcinoma Advanced stage Iron-chelator Deferasirox

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Hadron-quark continuity induced by the axial anomaly in dense QCD

Hadron-quark continuity induced by the axial anomaly in dens...

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The 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions

作者： naoki yamamoto Tetsuo Hatsuda Motoi Tachibana Gordon Baym Department of Physics University of TokyoTokyo 113-0033Japan Department of Physics University of TokyoTokyo 113-0033Japan Department of Physics Saga UniversitySaga 840-8502Japan Department of Physics University of IllinoisIllinois 61801

＜正＞The transition from the hadronic Nambu-Goldstone （NG） phase of dense matter to the deconfined color-superconducting （CSC） phase is relevant to heavy ion collisions to be explored in the future at moderate energies at GSI, and of interest in the interiors of neutron and quark stars. The NG-to-CSC transition depends critically on the interplay between two competing phenomena: quark-anti-quark pairing, characterized by a chiral condensate ＜（q|-）q ＞ hq-qi, and quark-quark

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Activity of superior interferon α against HIV-1 in severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes

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Chinese Medical Journal 2011年第3期124卷 396-400页

作者： ZHANG Wei TONG Xiao Tadashi Nakasone YUE Xue-tian naoki yamamoto LIU Xin-yuan YANG Rong-ge Laboratory of HIV Molecular Epidemiology and Virology State Key Laboratory of Virology Wuhan Institution of VirologyChinese Academy of Sciences Wuhan Hubei 430071 China AIDS Research Center National Institute of Infectious Diseases1-23-1 Toyama Shinjuku-ku Tokyo 162-8640 Japan Zhejiang Sci-Tech University Hangzhou Zhejiang 310018 China Zhejiang Sci-Tech University Hangzhou Zhejiang 310018 China Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of Sciences Shanghai 200031 China

Background Interferon （IFN） can inhibit human immunodeficiency virus type 1 （HIV-1） replication in vitro and in ***, IFN therapy for HIV infection was limited by its moderate antiviral efficacy and its frequent adverse effects. In the present study we evaluated the anti-HIV efficacy of a novel synthesized superior interferon α （slFNα）.Methods We performed in vitro experiments with HIV-1 IIB infected MT4 cells, and evaluated in vivo anti-HIV efficacy of slFNα in severe combined immunodeficient （SClD） mice reconstituted with human peripheral blood leukocytes （hu-PBL-SClD mice）.Results We found that the 50% effective concentrations （EC5o） of slFNα against the replication of HIV-1 in MT4 cells was 0.06 ng/ml, representing stronger antiviral activity than interferon-α in vitro. In the hu-PBL-SCID mice, a dose-dependent protection pattern was observed： with 0.45 μg and 1.35 μg slFNα daily treatments, parts of SCID mice were protected from HIV infection, whereas 2.25 μg sIFNα daily treatments resulted in a terminally complete *** slFNα shows good anti-HIV activity both in vitro and in SCID mice, may be a promising anti-HIV agent deserving clinical investigation, especially considering the potential of IFN-α to inhibit HIV replication in patients infected with drug-resistant variants or co-infected with hepatitis C virus （HCV）.

关键词： human immunodeficiency virus type 1 severe combined immunodeficient mouse interferon-α

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Dilation of a severe bilioenteric or pancreatoenteric anastomotic stricture using a Soehendra Stent Retriever

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World Journal of Gastrointestinal Endoscopy 2013年第8期5卷 412-416页

作者： Koichiro Tsutsumi Hironari Kato Ichiro Sakakihara naoki yamamoto Yasuhiro Noma Shigeru Horiguchi Ryo Harada Hiroyuki Okada Kazuhide yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Department of Endoscopy Okayama University Hospital

Bilioenteric or pancreatoenteric anastomotic stric-tures often occur after surgery for a pancreaticobiliary disorder. Therapeutic endoscopic retrograde cholan-giopancreatography using balloon enteroscopy has been shown to be feasible and effective in patients with such strictures. However, when a benign anas-tomotic stricture is severe, a dilation catheter cannot pass through the stricture despite successful insertion of the guidewire. We report on the usefulness of the Soehendra Stent Retriever over a guidewire for dilating a severe bilioenteric or pancreatoenteric anastomotic stricture under short double-balloon enteroscopy, in two patients with surgically altered anatomies.

关键词： Bilioenteric anastomotic stricture Soehen-dra Stent Retriever Dilation Pancreatoenteric anasto-motic stricture Double-balloon enteroscopy

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