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Coupling of plasmonic nanopore pairs: facing dipoles attract each other

Light(Science & Applications) 2016年第1期5卷 492-498页

作者： Takumi Sannomiya Hikaru Saito Juliane Junesch naoki yamamoto Department of Innovative and Engineered Materials Tokyo Institute of TechnologyYokohama 226-8503Japan Center of Advanced Instrumental Analysis Kyushu UniversityKasuga 816-8580Japan Department of Physics Chalmers University of TechnologyGothenburg 41296Sweden

Control of the optical properties of nano-plasmonic structures is essential for next-generation optical circuits and high-throughput biosensing *** of such nano-optical devices requires optical couplings of various nanostructured elements and field confinement at the *** particular,symmetric coupling modes,also referred to as dark modes,have recently received considerable attention because these modes can confine light energy to small *** the coupling behavior of plasmonic nanoparticles has been relatively well studied,couplings of inverse structures,that is,holes and pores,remain partially *** for the most fundamental coupling system of two dipolar holes,comparison of the symmetric and antisymmetric coupling modes has not been *** we present,for the first time,a systematic study of the symmetric and anti-symmetric coupling of nanopore pairs using cathodoluminescence by scanning transmission electron microscopy and electromagnetic *** symmetric coupling mode,approximated as a pair of facing dipoles,is observed at a lower energy than that of the anti-symmetric coupling mode,indicating that the facing dipoles attract each *** anti-symmetric coupling mode splits into the inner-and outer-edge localized modes as the coupling distance *** coupling behaviors cannot be fully explained as inverses of coupled *** and anti-symmetric coupling modes are also observed in a short-range ordered pore array,where one pore supports multiple local resonance modes,depending on the distance to the neighboring *** to the observed symmetric modes by far field is also discussed,which is important for nanophotonic device applications.

关键词： cathodoluminescence plasmonic nanopore short-range order surface plasmon transmission electron microscopy

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Partial stent-in-stent placement of biliary metallic stents using a short double-balloon enteroscopy

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World Journal of Gastroenterology 2012年第45期18卷 6674-6676页

作者： Koichiro Tsutsumi Hironari Kato Takeshi Tomoda Kazuyuki Matsumoto Ichiro Sakakihara naoki yamamoto Yasuhiro Noma Takayuki Sonoyama Hiroyuki Okada Kazuhide yamamoto Department of Gastroenterology and Hepatology Dentistry and Pharmaceutical SciencesOkayama University Graduate School of MedicineOkayama 700-8558Japan

Endoscopic intervention is less invasive than percutaneous or surgical approaches and should be considered the primary drainage procedure in most cases with obstructive ***,therapeutic endoscopic retrograde cholangiopancreatography(ERCP) using double-balloon enteroscopy(DBE) has been shown to be feasible and effective,even in patients with surgically altered *** the other hand,endoscopic partial stent-in-stent(PSIS) placement of selfexpandable metallic stents(SEMSs) for malignant hilar biliary obstruction in conventional ERCP has also been shown to be feasible,safe and *** performed PSIS placement of SEMSs for malignant hilar biliary obstruction due to liver metastasis using a short DBE in a patient with Roux-en-Y anastomosis and achieved technical and clinical *** procedure can result in quick relief from obstructive jaundice in a single session and with short-term hospitalization,even in patients with surgically altered anatomies.

关键词：金属支架双气囊小肠胆道外科手术住院治疗内镜自膨胀

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Activity of superior interferon α against HIV-1 in severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes

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Chinese Medical Journal 2011年第3期124卷 396-400页

作者： ZHANG Wei TONG Xiao Tadashi Nakasone YUE Xue-tian naoki yamamoto LIU Xin-yuan YANG Rong-ge Laboratory of HIV Molecular Epidemiology and Virology State Key Laboratory of Virology Wuhan Institution of VirologyChinese Academy of Sciences Wuhan Hubei 430071 China AIDS Research Center National Institute of Infectious Diseases1-23-1 Toyama Shinjuku-ku Tokyo 162-8640 Japan Zhejiang Sci-Tech University Hangzhou Zhejiang 310018 China Zhejiang Sci-Tech University Hangzhou Zhejiang 310018 China Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of Sciences Shanghai 200031 China

Background Interferon （IFN） can inhibit human immunodeficiency virus type 1 （HIV-1） replication in vitro and in ***, IFN therapy for HIV infection was limited by its moderate antiviral efficacy and its frequent adverse effects. In the present study we evaluated the anti-HIV efficacy of a novel synthesized superior interferon α （slFNα）.Methods We performed in vitro experiments with HIV-1 IIB infected MT4 cells, and evaluated in vivo anti-HIV efficacy of slFNα in severe combined immunodeficient （SClD） mice reconstituted with human peripheral blood leukocytes （hu-PBL-SClD mice）.Results We found that the 50% effective concentrations （EC5o） of slFNα against the replication of HIV-1 in MT4 cells was 0.06 ng/ml, representing stronger antiviral activity than interferon-α in vitro. In the hu-PBL-SCID mice, a dose-dependent protection pattern was observed： with 0.45 μg and 1.35 μg slFNα daily treatments, parts of SCID mice were protected from HIV infection, whereas 2.25 μg sIFNα daily treatments resulted in a terminally complete *** slFNα shows good anti-HIV activity both in vitro and in SCID mice, may be a promising anti-HIV agent deserving clinical investigation, especially considering the potential of IFN-α to inhibit HIV replication in patients infected with drug-resistant variants or co-infected with hepatitis C virus （HCV）.

关键词： human immunodeficiency virus type 1 severe combined immunodeficient mouse interferon-α

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Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

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npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao Gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao Kobayashi Eriko Watanabe Yu-ya Ohnishi Hajime Nakamura naoki yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

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Higher levels of the lipophilic antioxidants coenzyme Q_(10) and vitamin E in long-lived termite queens than in short-lived workers

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Insect Science 2024年第1期31卷 201-210页

作者： Eisuke Tasaki Yorihiro yamamoto Yoshihito Iuchi Department of Biological Chemistry Graduate School of Sciences and Technology for InnovationYamaguchi UniversityYamaguchiJapan School of Bioscience and Biotechnology Tokyo University of TechnologyHachiojiTokyoJapan

Termite queens and kings live longer than nonreproductive *** molecular mechanisms contributing to their long lifespan have been investigated;however,the underlying biochemical explanation remains *** Q(CoQ),a component of the mitochondrial electron transport chain,plays an essential role in the lipophilic antioxidant defense *** beneficial effects on health and longevity have been well studied in several ***,we demonstrated that long-lived termite queens have significantly higher levels of the lipophilic antioxidant CoQ_(10) than *** chromatography analysis revealed that the levels of the reduced form of CoQ_(10) were 4 fold higher in the queen's body than in the worker's *** addition,queens showed 7 fold higher levels of vitamin E,which plays a role in antilipid peroxidation along with CoQ,than ***,the oral administration of CoQ_(10) to termites increased the CoQ_(10) redox state in the body and their survival rate under oxidative *** findings suggest that CoQ_(10) acts as an efficient lipophilic antioxidant along with vitamin E in long-lived termite *** study provides essential biochemical and evolutionary insights into the relationship between CoQ_(10) concentrations and termite lifespan extension.

关键词： antioxidant defense system coenzyme Q termite queens vitamin E

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Concomitant Increases of the Developing Seed Phosph<i>oenol</i>pyruvate Carboxylase Ac-tivity and the Seed Protein Content of Field-Grown Wheat with Nitrogen Supply

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Agricultural Sciences 2014年第14期5卷 1558-1565页

作者： naoki yamamoto Toshio Sugimoto Takehiro Masumura Plant Nutrition Laboratory Department of Biological and Environmental Science Faculty of Agriculture Graduate School of Agricultural Science Kobe University Kobe Japan Laboratory of Genetic Engineering Graduate School of Life and Environmental Sciences Kyoto Prefectural University Kyoto Japan Kyoto Prefectural Institute of Agricultural Biotechnology Kyoto Japan

Wheat seed storage protein is of great importance for human food. To increase the contents of storage proteins effectively, nitrogen fertilizer at flowering stages is commonly applied. In our previous study, rice phosphoenolpyruvate carboxylase (PEPCase) activity in developing seeds was observed in response to nitrogen application at a flowering stage and was positively correlated to the response of the protein content in seeds of six cultivars. This observation might indicate that the seeds have a biological system for accepting nitrogen in seeds by using PEPCase. To test whether this physiological event occurs in wheat, we examined the PEPCase activity and protein content in field-grown wheat seeds under different nitrogen supply conditions. With only basal dressing, seeds showed lower PEPCase activity and protein content (both 0.90-fold) compared to seeds without basal fertilizer. With ammonium sulfate application at 8.3 and 25 g/m2 at a flowering stage, seeds showed higher PEPCase activity (1.08- and 1.17-fold, respectively) and protein content (1.15- and 1.42-fold, respectively), depending on the nitrogen level. We investigated the relationship between PEPCase activity and protein content in the seeds among four conditions. The effect of the nitrogen supply on PEPCase activity during grain-filling stages was validated by the results of a hydroponic culture experiment. Together the results demonstrate that our hypothesis seems to apply to field-grown wheat.

关键词： Nitrogen Application Phosphoenolpyruvate Carboxylase Seed Storage Protein Wheat

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Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 1-3页

作者： Kazuaki Shimada Kenichi Nakamura Noboru yamamoto Department of Hepatobiliary and Pancreatic Surgery National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan

Precision medicine is a growing field *** its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical *** main obstacles are associated... 详细信息

关键词： clinical Cancer overcome

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Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第40期22卷 8967-8977页

作者： Issei Saeki naoki yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Yamaguchi University Health Administration Center Yamaguchi 755-8511 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Department of Human Nutrition Faculty of Nursing and Human Nutrition Yamaguchi 755-8502 Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of Medicine Yamaguchi Prefectural University Yamaguchi 755-8505 Japan Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi 755-8511 Japan

AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical *** In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was *** Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities.

关键词：肝肿瘤 Hepatocellular 癌先进舞台 Iron-chelator Deferasirox

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A new electric field mill array with each of the mill’s rotor controlled precisely by a GPS module:Equipment and initial results

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Earth and Planetary Physics 2024年第2期8卷 423-435页

作者： Kozo Yamashita Hironobu Fujisaka DaoHong Wang Hiroyuki Iwasaki Kazuo yamamoto Koichiro Michimoto Masashi Hayakawa Department of Production Systems Engineering and Sciences Komatsu UniversityNu 1-3 Shicho-machiKomatsuIshikawa 923-8511Japan Fujisaka Technology Office 1058-5 Yoshizawa-choOhta-shiGunma 373-0019Japan Department of Electrical Electronic and Computer EngineeringGifu University1-1 YanagidoGifu CityGifu 501-1193Japan Cooperative Faculty of Education Gunma University4-2-Aramaki-machiMaebashiGunma 371-8510Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugaiAichi 487-8501Japan Independent Researcher Kosenba Town 2-44-11-406Kawagoe CitySaitama350-0036Japan Advanced Wireless&Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofuTokyo 182-8585Japan

We have newly designed an electrostatic sensor,called an electric field mill(EFM),to simplify the estimation of the charge position and charge amount transferred by lightning *** is necessary for this remote estimation of the transferred charge to measure electric field changes caused by charge loss at the time of a lightning strike at multiple *** multiple-station measurement of electric field changes,not only speed but also phase for exposure and shielding of the sensing plates inside each EFM of the array should be synchronized to maintain the sensitivities of the deployed ***,there is no such EFM with specified speed and phase control performance of the rotary ***,we developed a new EFM in which the rotary mechanism was controlled consistently to within 3%error by a GPS *** EFMs had been distributed in the Hokuriku area of Japan during the winter season of 2022-2023 for a test *** we describe the design and a simple calibration method for our new EFM *** analysis method based on the assumption of a simple monopole charge structure is also *** validation,locations of assumed point charges were compared with three-dimensional lightning mapping data estimated by radio observations in the MF-HF *** results indicated the validity to estimate transferred charge amounts and positions of winter cloud-to-ground lightning discharges with our new EFM array.

关键词： lightning electrostatic field electric field mill electric field change

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Hadron-quark continuity induced by the axial anomaly in dense QCD

Hadron-quark continuity induced by the axial anomaly in dens...

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The 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions

作者： naoki yamamoto Tetsuo Hatsuda Motoi Tachibana Gordon Baym Department of Physics University of TokyoTokyo 113-0033Japan Department of Physics University of TokyoTokyo 113-0033Japan Department of Physics Saga UniversitySaga 840-8502Japan Department of Physics University of IllinoisIllinois 61801

＜正＞The transition from the hadronic Nambu-Goldstone （NG） phase of dense matter to the deconfined color-superconducting （CSC） phase is relevant to heavy ion collisions to be explored in the future at moderate energies at GSI, and of interest in the interiors of neutron and quark stars. The NG-to-CSC transition depends critically on the interplay between two competing phenomena: quark-anti-quark pairing, characterized by a chiral condensate ＜（q|-）q ＞ hq-qi, and quark-quark

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