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Case Study on Focal Retrograde Amnesia due to Limbic Encephalitis

World Journal of Neuroscience 2020年第2期10卷 91-100页

作者： Nobuhiro Takahashi Mimpei Kawamura naoki tanihara Mamiko Sato Yasutaka Kobayashi Department of Rehabilitation Speech-Language-Hearing Therapy Fukui Health Science University Fukui Japan Fukui Higher Brain Dysfunction Support Center Fukui Japan Department of Rehabilitation Speech-Language-Hearing Therapy Fukui General Hospital Fukui Japan Department of Rehabilitation Medicine Fukui General Hospital Fukui Japan

This case study addresses episodic memory impairment or focal retrograde amnesia related to limbic encephalitis. The patient in question was a right-handed man in his 60s who developed focal retrograde amnesia due to limbic encephalitis. An abnormal MRI signal was observed in the right medial temporal lobe. Immediately after the encephalitis onset, mental symptoms—including impaired consciousness, disorientation, hallucinations, and delusions—appeared;however, his condition improved with medical treatment. After transfer to a convalescent and rehabilitation hospital, various neuropsychological tests were conducted but no apparent functional decline was observed in intellectual function, attention, memorization, or retention. However, the patient exhibited impairments related to autobiographical memory and memory of events 4?-?5 years before the onset of limbic encephalitis. Based on these observations, the patient was considered to exhibit focal retrograde amnesia due to limbic encephalitis. Despite exhibiting retrograde amnesia, he had no difficulty in his daily life in the ward. Moreover, after discharge from hospital, smooth work reinstatement was possible. This case demonstrates that, even after exhibiting retrograde amnesia, if its duration is relatively short and physical function and other higher-order brain functions are sustained, social rehabilitation—including work reinstatement—is feasible.

关键词： Limbic Encephalitis Focal Retrograde Amnesia Medial Temporal Lobe Topographic Disorientation Social Rehabilitation

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Selective ROCK inhibitor as a novel drug for the treatment of glaucoma

Selective ROCK inhibitor as a novel drug for the treatment o...

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中华医学会第十二届全国眼科学术大会

作者： Hidenobu tanihara Kumamoto University Graduate School of Medicine

Rho GTPase participates in signaling pathways that lead to formation of actin stress fibers and focal adhesions,and is involved in diverse physiological functions associated with cy-

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MOLECULAR MECHANISMS ASSOCIATED WITH DEVELOPMENTAL ANOMALY IN THE ANGLE STRUCTURE

MOLECULAR MECHANISMS ASSOCIATED WITH DEVELOPMENTAL ANOMALY I...

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第十八届国际眼科研究大会

作者： Hideobu.tanihara Kumamoto University Graduate School of Medicine

＜正＞It has been well known that developmental anomaly in the angle structure of the eye results in elevated intraocular *** many cases of developmental glaucoma, developmental anomalies in the angle structure are as...

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应用经Tenon囊球后注射曲安奈德治疗玻璃体切除术后顽固性糖尿病性黄斑水肿

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 42-43页

作者： Koga T. Mawatari Y. Inumaru J. H.tanihara 曹绪胜 Department of Ophthalmology and Visual Science Kumamoto University Graduate School of Medical Sciences 1-1-1 Honjo 860-8556 Kumamoto Japan

Purpose: To evaluate the efficacy and safety of trans-Tenon’s retrobulbar triamcinolone acetonide (TA) infusion for the treatment of refractory diabetic macular edema (DME) after vitrectomy. Methods: After topical anesthesia, 20 eyes from 20 patients with persistent DME after pars plana vitrectomy were treated with trans-Tenon’s retrobulbar infusion of 40 mg TA through an inferotemporal approach. The mean duration (±SD) between vitrectomy and trans-Tenon’s retrobulbar TA infusion was 11.4±7.9 months. The mean follow-up period (±SD) after trans-Tenon’s retrobulbar TA infusion was 13.3±2.8 months. Results: At 1 week after trans-Tenon’s retrobulbar TA infusion, the mean central retinal thickness (±SD) measured by optical coherence tomography was 381±99 μm, which was a statistically significant decrease in comparisonwith the preoperative thickness (555±112 μm) (P < 0.001). Additional trans-Tenon’s retrobulbar TA infusions were performed in ten eyes (50%), due to the recurrence of DME at 6.6±3.0 months after the first TA infusion. At the final examination, macular edema resolved in 13 (65%), improved in four (20%), and remained unchanged in three (15%) of the 20 eyes. At 1 month after trans-Tenon’s retrobulbar TA infusion, the mean laser flare value (±SD) was 9.6±3.0 photon/ms, which was a statistically significant decrease in comparison with the preoperative value (15.5±5.9 photon/ms) (P < 0.01). Furthermore, in ten eyes (50%) with recurrent DME, re-elevated laser flare values were observed prior to the recurrence of DME. The final best-corrected Snellen visual acuity improved by two or more lines in nine eyes (45%), and remained unchanged in 11 eyes (55.0%). IOP elevation equal to or higher than 21 mmHg was observed in three (15%) of the 20 eyes with TA infusion, and was controlled by topical medications. No other injection-related complications were observed. Conclusion: Trans-Tenon’s retrobulbar TA infusion is an effective and safe method for the treatment of refract

关键词：玻璃体切除术球后注射 Tenon 曲安奈德糖尿病性黄斑水肿顽固性

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小梁切开术治疗进展期青光眼的长期结果

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美国医学会眼科杂志（中文版） 2005年第2期17卷 120-121页

作者： Hanako Ikeda Hitoshi Ishigooka Tonmyuki Muto Hidenobu tanihara Makoto Nagata 陆遥（译）

目的：说明小梁切开术治疗原发性和继发性进展期青光眼的长期结果。方法：89例进展期青光眼患者的149只眼进行了小梁切除术，对这些患者进行回顾性研究。在随访和最后检查时测定眼压、成功率、视力和视野。

关键词：青光眼患者小梁切开术长期结果进展期治疗小梁切除术继发性原发性回顾性检查时

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眼钝挫伤时吲哚青绿着色显示内界膜破裂

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 45-45页

作者： Hirata A tanihara H Dept.of Oph-thalmol

Purpose:Description of cases of tra umatic macular hole that appeared concomitant with a rup tured internal limiting membrane(ILM)that was apparent during vitrectomy only after staining with indocyanine gre en(ICG).Methods:Vitrectomy with ILM peeling was performed on a 20-year-old man and a 13-year-old boy for treatment of traumaticmacular ***:D uring vitrectomy,the ILM was found to be ruptured along the area of an identi-fied macular hole only after ICG *** the vit-rectomy,the macular holes were closed and visual acuity ***,visual field defect associated with apparent inner-layer retinal damage ***:Blunt trauma can cause severe inner-layer retinal damage with rupture of the ILM as well as fran k macular hole for-mation and choroidal rupture.

关键词：内界膜钝挫伤吲哚青绿黄斑裂孔玻璃体切割术内层视网膜玻璃体切割手术脉络膜破裂视野缺损男性儿童

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经Tenon囊球后注射曲安西龙治疗玻璃体切除术后与视网膜分支静脉阻塞相关的黄斑水肿

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 14-14页

作者： Kawaji T. Hirata A. Awai N. H. tanihara 桑延智 Department of Ophthalmology and Visual Science Graduate School of Medical Sciences Kumamoto University 1-1-1 Honjo Kumamoto 860-8556 Japan Dr

PURPOSE: To evaluate the effectiveness and safety of trans-Tenon retrobulbar triamcinolone injection for macular edema associated with branch retinal vein occlusion (BRVO) after vitrectomy. DESIGN: Prospective interventional case series. METHODS: The study included 20 eyes of 20 patients with BRVO, characterized by macular edema lasting more than 3 months after vitrectomy. Trans-Tenon retrobulbar injection of 40 mg triamcinolone was performed, and visual and anatomic responses were evaluated. RESULTS: Mean foveal thickness was 499.4± 209.1 μ m preoperatively, 281.8± 110.1 μ m at 2-week follow-up, and 196.9± 92.1 μ m at 6-month follow-up (P < .0001, at 2 weeks and 6 months, paired t test). Improvement of visual acuity by at least 0.2 logMAR (logarithm of the minimum angle of resolution) was seen in 14 (70% ) of the 20 eyes. CONCLUSIONS: Trans-Tenon retrobulbar injection of triamcinolone may be an alternative for additional treatment of eyes with BRVO that remains after vitrectomy.

关键词：玻璃体切除术 Tenon 曲安西龙黄斑水肿视网膜疾病视网膜分支静脉阻塞球后注射

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