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Effects of Lifestyle Intervention Performed by Community Pharmacists on Glycemic Control in Patients with Type 2 Diabetes: The Community Pharmacists Assist (Compass) Project, a Pragmatic Cluster Randomized Trial

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Pharmacology & Pharmacy 2016年第3期7卷 124-132页

作者： Hiroshi Okada Mitsuko Onda Masaki Shoji Kazuhiko Kotani Takeo Nakayama Yasushi Nakagawa naoki sakane Department of Preventive Medicine Clinical Research Institute for Endocrine and Metabolic Disease National Hospital Organization Kyoto Medical Center Kyoto Japan Department of Health Informatics Kyoto University School of Public Health Kyoto Japan Clinical Laboratory of Practical Pharmacy Osaka University of Pharmaceutical Sciences Osaka Japan Division of Community and Family Medicine Jichi Medical University Tochigi Japan Polon Company Kobe Japan

Background: Community pharmacists should be involved in diabetes care, while there has been less evidence about whether a brief lifestyle intervention is effective for diabetes care in community pharmacies. Objectives: To examine the effects of brief lifestyle intervention on glycemic control in patients with type 2 diabetes mellitus (T2D) by using a coaching style, provided by community pharmacists. Methods: A prospective, cluster-randomized, controlled trial was conducted in 50 groups of community pharmacies in Japan. In all, 132 patients with T2D (age, 20 - 75 years, ≥8.0% of hemoglobin A1c (HbA1c)) were assigned to the intervention group (n = 90) or the usual care group (n = 42). The intervention group (IG) underwent brief lifestyle coaching for self-care of T2D for 6 months. The standard care group (CG) received usual care by pharmacists and was given a general newsletter. The primary outcome was changes in HbA1c levels. Results: After 6 months, the IG had significantly improved HbA1c (IG: -0.6 ± 0.9 vs. CG: -0.2% ± 0.9%;p = 0.021 using the last observation carried forward analysis). Although the number of drugs reduced from 2.3 ± 0.8 to 2.0 ± 1.2 in the IG, the number increased from 2.3 ± 1.1 to 2.5 ± 1.1 in the CG (-0.2 ± 0.9 in IG vs. 0.2 ± 0.6 in CG;p = 0.023). Conclusions: The brief lifestyle intervention by community pharmacists improved glycemic control in patients with T2D. Community pharmacists may more positively participate as lifestyle coaches for diabetes care.

关键词： Diabetes Care HbA1c Drug Adherence Community Pharmacy Lifestyle Intervention

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A CHALLENGE FOR BIAXIAL AND TRIAXIAL CREEP TESTING

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Acta Metallurgica Sinica(English Letters) 1998年第6期11卷 429-436页

作者： M.sakane S.Mukai Ritsumeikan Univ Shiga Japan

This paper describes new methods for biaxial and triaxial creep testing. Biaxial tension and triaxial tension creep testers were developed. The performance of the machines was described and some test results were discussed. Stress biaxiality had almost no effect on the creep deformation and Mises potential was suitable for describing the creep deformation under biaxial and triaxial stress states. Stress biaxiality had a small influence on prolonging creep rupture time under the constant Mises stress condition.A new triaxial tension creep testing method was discussed together with the shape of the triaxial creep specimen.

关键词： creep creep rupture stress multiaxiality stainless steel high temperature

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Chinese Yuan after Chinese Exchange Rate System Reform

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China & World Economy 2006年第6期14卷 39-57页

作者： Eiji Ogawa Michiru sakane Graduate Student Graduate School of Commerce and Management Hitotsubashi University Kunitachi Tokyo and Research Assistant of RIETI.

In this paper, the actual exchange rate policy conducted by the Chinese government after the Chinese exchange rate system reform on 21 July 2005 is investigated. Also, the long-run effect is investigated, including the Balassa-Samuelson effect on the Chinese yuan. It was found that the Chinese government generated a statistically significant but small change in exchange rate policy during the sample period until 25 January 2006. It was not identified that the Chinese monetary authority is adopting the currency basket system because the change is too small in the economic sense. It is indicated that the Chinese government should take account of the productivity growth of countries composing the currency basket in order to operate a currency basket regime.

关键词： Chinese exchange rate system reform currency basket system productivity Balassa-Samuelson effect

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Mechanisms of the autophagosome-lysosome fusion step and its relation to non-alcoholic fatty liver disease

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Liver Research 2018年第3期2卷 120-124页

作者： Hayato Hikita Sadatsugu sakane Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuitaJapan

Macroautophagy(hereafter autophagy)is a catabolic process by which autophagosomes arising from an isolation membrane fuse with lysosomes to degrade components in the *** fusion step is one of the key steps during the process of *** step is extremely complicated and its detailed mechanisms remain *** consists of two phases:first phase is autophagosome migration phase and second phase is fusion of autophagosomes and lysosomes ***,various molecules have been reported to be involved in each *** the first phase,microtubules and actin remodeling mechanism are *** the second phase,soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE)proteins,Rab family proteins,phosphoinositide 3-kinase(PI3K)complex and Rubicon are *** the present review,we introduce recent findings related to autophagosome-lysosome fusion step and discuss liver diseases possibly associated with autophagosome-lysosome fusion dysfunction.

关键词： Autophagy Autophagosome-lysosome fusion Rubicon Non-alcoholic fatty liver disease(NAFLD) Hepatitis B virus(HBV) Hepatitis C virus(HCV)Liver cancer

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A Robust Deadbeat Control Method for UPS Inverters

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电工电能新技术 2007年第4期26卷 31-35,64页

作者：汪孟李方正黄立培 sakane Makoto State Key Lab of Power Systems Dept. of Electrical Engineering Tsinghua University GS Yuasa Power Electronics Ltd. Osaka 569-1115 Japan

The traditional deadbeat control for UPS inverters has a robustness problem. The parametric imprecision can greatly harm the stability of the system, which restricts the application. A novel robust deadbeat control method is proposed in this paper to deal with the problem. In the proposed control method, a proportional element is added to the traditional deadbeat control in order to improve the robustness to parametric imprecision. To eliminate the error between output voltage and voltage reference caused by environmental noise and parametric deviation, a model reference adaptive regulator is also added to the control method. A 1kVA prototype is built based on DSP. Theoretical analysis and experimental results show that the robustness for parametric variation of the proposed method is much better than the traditional deadbeat control. The system can remain stable even when the systemic parameters have a large deviation from calculating parameters. The system has small static error and fast dynamic response with the new control method. This method is easy to realize in DSP and is suitable for full digital realization of UPS.

关键词：不间断电源逆变器懒散控制模型参考自适应控制鲁棒性

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Anand模型预测63Sn37Pb焊锡钎料的应力应变行为

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机械强度 2004年第4期26卷 447-450页

作者：张莉陈旭 Nose H sakane M 天津大学化工学院天津300072 日本立命馆大学机械工程系

通过在温度 3 13K～ 3 98K、应变率 10 - 3% s～ 10 % s内的一系列恒应变率拉伸实验 ,研究 63Sn3 7Pb焊锡钎料的力学行为 ,发现该材料的应力应变关系与温度和应变率有很大的相关性。采用统一型Anand粘塑性本构方程对该材料在较大温度... 详细信息

通过在温度 3 13K～ 3 98K、应变率 10 - 3% s～ 10 % s内的一系列恒应变率拉伸实验 ,研究 63Sn3 7Pb焊锡钎料的力学行为 ,发现该材料的应力应变关系与温度和应变率有很大的相关性。采用统一型Anand粘塑性本构方程对该材料在较大温度和应变率范围内的应力应变行为进行数值模拟。结果表明Anand粘塑性方程可以有效地描述 63Sn3 7Pb焊锡钎料在 10 %应变下的温度和应变率相关粘塑性本构行为。

关键词： 63Sn37Pb焊锡钎料 Anand粘塑性模型应力应变行为

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Ultra-large-scale phase-field simulation study of ideal grain growth

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npj Computational Materials 2017年第1期3卷 247-252页

作者： Eisuke Miyoshi Tomohiro Takaki Munekazu Ohno Yasushi Shibuta Shinji sakane Takashi Shimokawabe Takayuki Aoki Graduate School of Science and Technology Kyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan Faculty of Mechanical Engineering Kyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan Division of Materials Science and Engineering Faculty of EngineeringHokkaido UniversityKita 13 Nishi 8Kita-kuSapporoHokkaido 060-8628Japan Department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan The Supercomputing Division Information Technology CenterThe University of Tokyo2-11-16 YayoiBunkyo-kuTokyo 113-8658Japan Global Scientific Information and Computing Center Tokyo Institute of Technology2-12-1 i7-3 O-okayamaMeguro-kuTokyo 152-8550Japan

Grain growth,a competitive growth of crystal grains accompanied by curvature-driven boundary migration,is one of the most fundamental phenomena in the context of metallurgy and other scientific ***,the true picture of grain growth is still controversial,even for the simplest(or‘ideal’)*** problem can be addressed only by large-scale numerical ***,we analyze ideal grain growth via ultra-large-scale phase-field simulations on a supercomputer for elucidating the corresponding authentic statistical *** performed simulations are more than ten times larger in time and space than the ones previously considered as the largest;this computational scale gives a strong indication of the achievement of true steady-state growth with statistically sufficient number of ***,we provide a comprehensive theoretical description of ideal grain growth behaviors correctly quantified by the present *** findings provide conclusive knowledge on ideal grain growth,establishing a platform for studying more realistic growth processes.

关键词： grain field establishing

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新型免疫抑制剂FK—506对T淋巴细胞活化增殖的影响

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中华微生物学和免疫学杂志 1991年第3期11卷 165-168页

作者：刘佳佳孤根刚泸州医学院微生物学教研室日本岛根医科大学第三内科

本文报道研究新型免疫抑制剂FK-506对T淋巴细胞活化增殖的影响。经过纯化的静止T淋巴细胞在单一的植物血凝素（PHA）刺激下不发生增殖反应。同时加入IL-2，诱发了明显的增殖反应。但这种增殖反应完全被FK-506所抑制。若预先用单一的PHA... 详细信息

本文报道研究新型免疫抑制剂FK-506对T淋巴细胞活化增殖的影响。经过纯化的静止T淋巴细胞在单一的植物血凝素（PHA）刺激下不发生增殖反应。同时加入IL-2，诱发了明显的增殖反应。但这种增殖反应完全被FK-506所抑制。若预先用单一的PHA刺激T淋巴细胞48小时，然后加入IL-2所引起的增殖反应则不为FK-506所阻断。佛波脂（PMA）是一种不影响细胞内Ca 2+ 浓度的蛋白激酶C （PKC）激活剂，由它联合IL-2所引起的T淋巴细胞的增殖反应也不被FK-506所阻断。这些结果表明，FK-506抑制了由pHA所诱导的IL-2R的表达，从而影响T淋巴细胞的活化增殖，这可能是由于FK-506阻断了T淋巴细胞活化早期的同Ca 2+ 有关的信号传递而致。

关键词：免疫抑制剂 FK-506 淋巴细胞增殖

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采用死区补偿和输出电流补偿的数控UPS逆变器

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清华大学学报（自然科学版） 2006年第1期46卷 17-20页

作者：刘亚东邢岩黄立培坂根诚清华大学电机工程与应用电子技术系电力系统及大型发电设备安全控制和仿真国家重点实验室北京100084 南京航天航空大学自动化学院南京2100163 杰士汤浅公司日本国大阪府5691115

为在不增加传感器的情况下,改善不间断电源(U PS)逆变器的输出动静态性能,提出了一种数字控制策略。该策略利用面积等效原理,将线性负载下的死区等效为方波扰动,利用前馈对其补偿;将输出电流视为对控制系统的扰动,并利用前馈补偿,通过... 详细信息

为在不增加传感器的情况下,改善不间断电源(U PS)逆变器的输出动静态性能,提出了一种数字控制策略。该策略利用面积等效原理,将线性负载下的死区等效为方波扰动,利用前馈对其补偿;将输出电流视为对控制系统的扰动,并利用前馈补偿,通过对输出电压的微分运算获得输出滤波电容电流值,从而在不使用电流传感器的情况下,实现了对U PS逆变器的准双环控制。在1 kVA的样机上进行实验研究,其结果在额定阻性负载下的稳态总谐波畸变率(THD)为2.49%,空载与额定负载间阶越变化下的电压调整率为6.75%。结果表明:死区补偿和输出电流补偿有效,整个控制策略的可行。

关键词：不间断电源数字控制死区多环控制

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304型不锈钢蠕变-疲劳损伤预测和剩余寿命评定

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锅炉技术 1988年第2期 11-17页

作者： SEHCHI NISHINO ,MASAO sakane ,MASATERU OHNAMI ,宋勤余 ,范崇义

前言最近几年来,火力发电厂延长寿命的紧迫问题是对用于高温、长时的结构材料的损伤预测和剩余寿命评定。高温服役的材料,不仅承受纯蠕变或纯疲劳损伤,而且还承受机械应力和热应力造成的更复杂的蠕变—疲劳交互作用损伤。由于蠕变或疲... 详细信息

前言最近几年来,火力发电厂延长寿命的紧迫问题是对用于高温、长时的结构材料的损伤预测和剩余寿命评定。高温服役的材料,不仅承受纯蠕变或纯疲劳损伤,而且还承受机械应力和热应力造成的更复杂的蠕变—疲劳交互作用损伤。由于蠕变或疲劳作用下断裂和变形具有不旧样式,所以在蠕变—疲劳交互作用下的剩余寿命及损伤的精确评定相当复杂。为了精确评定蠕变—疲劳损伤,设法使用一些有损和无损试验方法,然而至

关键词：蠕变损伤半高宽微应变晶粒尺寸晶粒度晶粒规格寿命评定蠕变断裂试验剩余寿命蠕变试验机材料试验机疲劳损伤低周疲劳试验短寿命试验损伤预测

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