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Modeling the fate of paddy field pesticide in surface water and environmental risk assessment

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Journal of Environmental Sciences 2000年第3期12卷 337-343页

作者： LI Shi\|yu 1, Tohru Morioka 2 (1. Institute of Environmental Science, Zhongshan University, Guangzhou 510275, China. E-mail: eeslsy@*** 2.Department of Environmental Engineering, Osaka University, Yamada oka 2 1, Suita, Osaka 565, Japan. E- 中山大学广东广州 51 0 2 75 Osaka University 日本 Osaka 56 5

The risk of drinking water is greatly concerned because of the large amount of pesticide applied to paddy field and the contamination of drinking water sources due to the runoff. A mathematical model is developed, based on the mass balance, to predict the fate of paddy field pesticides from application, runoff and mixing in a river, taking account of the physical chemical properties and processes of volatilization, degradation, adsorption and desorption. The model is applied to a river basin in Japan to estimate the contaminant level of several popularly used pesticides at the water intakes. The health risk in drinking water induced by each pesticide concerned is estimated and evaluated by comparing with the acceptable daily intake values(ADI) and with that induced by trihalomethanes. An index to evaluate the total risk of all pesticides appearing in water is proposed. The methods for risk management are also discussed.

关键词： modeling pesticide paddy field environmental risk assessment drinking water

Clinical Evaluation of New Biomarkers including IFN-<i>γ</i>for the Diagnosis of Active Tuberculosis Disease

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Journal of Tuberculosis Research 2015年第4期3卷 136-148页

作者： Yoshihiro Kobashi Keiji Mouri Shigeki Kato Mikio oka Department of Respiratory Medicine Kawasaki Medical School Kurashiki Japan

Background: The aim of this study was to evaluate the clinical potential of new biomarkers such as IL-2, TNF-α, MCP-1, MIP-1β including IFN-γ for the diagnosis of active tuberculosis (TB) disease. Materials and Methods: The subjects consisted of 31 patients with active TB disease and 62 patients with non-TB disease. We measured IFN-γ using QuantiFERON-TB Gold In Tube, and IL-2, TNF-α, MCP-1, and MIP-1β using the supernatant from whole blood stimulated with MTB (Mycobacterium tuberculosis)-specific antigens. Results: In the patient group with active TB disease, while the positive response rate of IFN-γ was 74%, that of IL-2 using the supernatant was 61%, TNF-α was 71%, MCP-1 was 81% and MIP-1β was 81%. In the patient group with non-TB disease, while the positive response rate of IFN-γ was 11%, that of IL-2using the supernatant was 32%, TNF-α was 26%, MCP-1 was 23% and MIP-1β was 19%. All biomarker levels of the patients with active TB disease using the supernatant were significantly higher than those of the patients with non-TB disease. While MIP-1β was the most sensitive of all the biomarkers (sensitivity: 80.6%), IFN-γ was the best in terms of specificity (specificity: 87.0%). Conclusions: Several biomarkers, apart from IL-2, showed similar results compared to IFN-γ. The combination of IFN-γ and other new biomarkers may increase the diagnostic accuracy of active TB.

关键词： Mycobacterium tuberculosis (MTB) Disease Interferon-γ (IFN-γ) New Biomarkers Interleukin-2 (IL-2)

Colorectal neuroendocrine carcinoma: A case report and review of the literature

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World Journal of Clinical Cases 2019年第14期7卷 1865-1875页

作者： Tomoaki Yoshida Kenya Kamimura Kazunori Hosaka Koji Doumori Hiromitsu oka Akito Sato Yasuo Fukuhara Shoji Watanabe Tomomi Sato Akira Yoshikawa Takashi Tomidokoro Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Division of Gastroenterology and Hepatology Nagaoka Chuo General HospitalNiigata 940-0861Japan

BACKGROUND Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs;these clinical characteristics result in poor prognosis. Surgical resection appears as an effective approach;however, because it is difficult to accurately diagnose NEC during the early stage and owing to its aggressive growth pattern, development of a reliable standard chemotherapy regimen and management strategies are essential. CASE SUMMARY Here, we report the case of patient with NEC showing an aggressive growth pattern that resulted in the rupture of the tumor to the outside the colon after stenting of the internal colonic stenosis. In addition, the tumor invaded into the duodenum, thereby causing duodenal stenosis that required an additional stent in the duodenum. This aggressive growth pattern is one of the main features of the NEC that is different from adenocarcinoma. To clarify the clinical characteristics, we reviewed 60 recently reported cases, including data on tumor location, size, treatment, and prognosis. CONCLUSION We consider that the information presented here is of great significance for the diagnosis, treatment, and management of symptoms of the patients with NEC.

关键词： Neuroendocrine carcinoma Colon Colorectal mixed adenoneuroendocrine carcinoma Growth Case report

Morel-Lavallée Lesion: A Case Report of a Large Post-Traumatic Subcutaneous Lumbar Hematoma and Literature Review

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Open Journal of Modern Neurosurgery 2016年第1期6卷 29-36页

作者： Dominique N’Dri oka Daouda Sissoko Alban Slim Mbende Neurosurgery Unit Yopougon Teaching Hospital Abidjan Cote d’Ivoire

Morel-Lavallée Lesions (MLL), described in 1863 by French surgeon Victor-Auguste-Francois Morel-Lavallée, are rare posttraumatic closed degloving injuries, occurring as a result of tangential sheer forces, in which the skin and subcutaneous tissue separate abruptly from the underlying deep fascia, causing fluid collection with liquefied fat. A 31-year-old policeman involved in a road traffic accident, presented with a gradually expanding lumbar swelling, which was soft, fluctuant and painful with contused skinon examination. Computed Tomography (CT) scan of the lumbar spine revealed a large subcutaneous hematoma on axial view, extending from the 12th thoracic vertebra down to the first sacral vertebra. There was no skeletal lesion. The treatment consisted of surgical excision/drainage of the collection followed by continuous suction with drainage tubes for two days. The collection is completely resolved;the patient made a full recovery and has been asymptomatic. Since there was a history of blunt trauma and given the nature and the location of the collection over osseous prominences, we report this rare case of a large posttraumatic lumbar hematoma diagnosed on clinical and CT scanning grounds as a Morel-Lavallée lesion. The patient was informed that non-identifying information from the case would be submitted for publication, and he provided consent.

关键词： Morel-Lavallée Lesions (MLL) Subcutaneous Hematoma Lumbar Trauma

Direction without speed information process in the human brain: a magnetoencephalographic study using random dots apparent motion stimulus

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Open Journal of Molecular and Integrative Physiology 2011年第2期1卷 17-22页

作者： Sachiko oka Tomokazu Urakawa Ryusuke Kakigi Yoshiki Kaneoke Department of Integrative Physiology National Institute for Physiological Sciences Myodaiji-cho Okazaki Japan

Apparent motion stimulus induces visual perception of smooth motion even though there is no speed information. We examined whether human brain response as measured by magnetoencephalography carries direction information in the visually presented apparent motion of a randomdot pattern in a similar manner as continuous motions that have speed and direction information. Although there was no significant effect of motion direction on the peak response latency and amplitude, mutual information entropy (IE) significantly increased after the motion onset at approximately 36 ms after the response latency in 41% of the evaluations. Detailed analysis of the data from five subjects who participated in both the present apparent motion and our previous coherent motion studies revealed that the maximum IE latency (delay) for apparent motion was significantly longer than that for coherent motion, although the mean maximum IE was the same. The results indicate that direction is represented in the response waveform evoked by apparent motion but the manner is different from that for coherent motion probably due to the distinct neural processes engaged only for the apparent motion perception. We consider that direction and speed can be processed separately in the human brain because direction information was generated without speed information for the perception of apparent motion.

关键词： Apparent Motion Random Dot Kinematogram Direction Information Entropy Magnetoencephalography

IC models for the simulation of the emission radiated from PCB

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IC models for the simulation of the emission radiated from P...

Vehicle Speed Observation Models Based on the Data on the Smartphone GPS

1997 International Symposium on Electromagnetic Compatibility

作者： Chiharu Miyazaki Naoto oka Takeshi Uchida Shuichi Nitta Information Technology R&D Center Mitsubishi Electric Corporation 5-1-1 OfunaKamakura.Kanagawa 247 Japan Faculty of Technology Tokyo University of Agriculture and Technology 2-24-16 Naka-cho.Koganei.Tokyo 184 Japan

＜正＞The authors are developing the technology that can simulate normal-mode emission radiated from printed circuit *** describe the driver and the receiver IC models which are needed to simulate radiated *** have derived the driver and the receiver IC *** validity of these models was confirmed by comparing measured data with the results of the simulation.

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Computer Technology and Application 2016年第6期7卷 300-307页

作者： Gede Herdian Setiawan I Made oka Widyantara Made Sudarma Magister Electrical Engineering Department Engineering Faculty and Udayana University Denpasar Bali Indonesia

The development of GPS （global positioning system） receiver now can be integrated on a smartphone. GPS receiver on smartphones has been developed for location-based applications. Smartphones are very suitable to be used as an experimental tool, because smartphones are usually equipped with various types of sensors. This paper proposes a model observation vehicle speed on a road section based on the GPS data on the smartphone. Observations made by calculating the speed of the speed of vehicles moving through the data transfer at the GPS location of the smartphone, the data are then sent periodically to the server and server processing and storage of vehicle speed data. After tested with test reliability indicators use RMSE, observations with model observations speed, speed based on GPS data on a smartphone are relevant when compared with the speed directly from the vehicle＇s speedometer with the difference between the value of the difference of speed that is 3.1785 km/h.

关键词： GPS smartphone vehicle speed observations.

Additional attention to combination antiretroviral therapy-related lipodystrophy

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World Journal of Virology 2017年第3期6卷 49-52页

作者： Norihiko Kobayashi Masako Nakahara Masako oka Kumiko Saeki Department of Disease Control Research Institute National Center for Global Health and Medicine

The occurrence of lipodystrophy in patients taking antihuman immunodeficiency virus(HIV) medications is a serious problem as it is irreversible even after drug withdrawal. Although it was first recognized in patients taking proteinase inhibitors, other types of anti-HIV agents can also cause lipodystrophy. In a recent publication by Jones et al entitled "Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes" in World Journal of Virology, it was reported that simultaneous treatment of human subcutaneous adipocytes with anti-HIV drugs with different mechanisms of action synergistically exerted antiadipogenesis effects in vitro, warning us to take utmost care in every case receiving combination antiretroviral therapy(cART). For elucidation of the molecular basis for cART-related lipodystrophy, multi-faceted approaches should be taken, based on a deeper understanding of the development and organization of adipose tissues.

关键词： Combination antiretroviral therapy Lipodystrophy Protease inhibitor Reverse transcriptase inhibitor Human immunodeficiency virus

Clinical Analysis of Pulmonary Nontuberculous Mycobacterial Disease Complicated by Lung Cancer during the Follow-Up Periods

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Open Journal of Respiratory Diseases 2016年第4期6卷 59-66页

作者： Yoshihiro Kobashi Makoto Kittaka Keiji Mouri Shigeki Kato Mikio oka Department of Respiratory Medicine Kawasaki Medical School Kurashiki Japan

Introduction: The objective of this study was the estimation of the clinical characteristics of patients with pulmonary nontuberculous mycobacterial (NTM) disease complicated by lung cancer during the follow-up periods. Methods: We analyzed the clinical findings of four patients (2.0%) complicated by lung cancer during the follow-up periods of over six months at least after the definite diagnosis of pulmonary NTM disease of 202 patients with pulmonary NTM disease experienced in our hospital in the last decade. Results: There were four patients with pulmonary NTM disease complicated by lung cancer and all of them were caused by Mycobacterium avium complex (MAC). They were all elderly male patients and had underlying diseases. Three patients were diagnosed with primary lung cancer and one diagnosed with metastatic lung cancer from colon cancer within 3 years after the diagnosis of pulmonary NTM disease. The treatments for lung cancer were surgical resection for all patients with localized lesions. One patient died due to the worsening of underlying disease and the remaining three survived except for the recurrence of one patient. Conclusion: Although the complication rate of pulmonary NTM disease and lung cancer was a lower percentage (2.0%) than in previous reports, the careful follow-up for patients with pulmonary NTM disease without forgetting the possible complication of lung cancer is necessary.

关键词： Pulmonary Nontuberculous Mycobacterial (NTM) Disease Lung Cancer Solitary Nodular Type