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World Journal of Hepatology 2018年第1期10卷 166-171页

作者： Manabu Hayashi Satoshi Kawana Hirofumi Sekino Kazumichi Abe naoki matsuoka Masahito Kashiwagi Ken Okai Yukiko Kanno Atsushi Takahashi Hiroshi Ito Yuko Hashimoto Hiromasa Ohira Department of Gastroenterology Fukushima Medical University School of Medicine Department of Diagnostic Pathology Fukushima Medical University School of Medicine Department of Radiology Fukushima Medical University School of Medicine

Primary hepatic angiosarcoma is the most common malignant mesenchymal tumor of the liver. It has a poor prognosis and various appearances on magnetic resonance(MR) images. We report a case of hepatic angiosarcoma with a characteristic appearance on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)-enhanced MR imaging in the hepatobiliary phase. A 72-year-old man was admitted with a complaint of abdominal pain. Gd-EOBDTPA-enhanced MR imaging revealed a liver tumor that showed slight hyperintensity in the hepatobiliary phase. These findings suggested Gd-EOB-DTPA uptake in the tumor. An autopsy revealed the solid proliferation and sinusoidal spreading of hepatic angiosarcoma cells. Immunohistochemistry indicated that the tumor was negative for OATP1B3. Gd-EOB-DTPA uptake in the liver tumor in the hepatobiliary phase suggested sinusoidal tumor invasion with residual normal hepatocytes.

关键词： Hepatic angiosarcoma Gadoliniumethoxybenzyl-diethylenetriamine pentaacetic acid Cirrhosis Hepatocellular carcinoma

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.Lee Ryota L.matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Retreatment of patients with treatment failure of directacting antivirals: Focus on hepatitis C virus genotype 1b

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World Journal of Gastroenterology 2017年第46期23卷 8120-8127页

作者： Tatsuo Kanda Kazushige Nirei naoki Matsumoto Teruhisa Higuchi Hitomi Nakamura Hiroaki Yamagami Shunichi matsuoka Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of Internal MedicineNihon University School of Medicine

The recent development of direct-acting antiviral agents(DAAs) against hepatitis C virus(HCV) infection could lead to higher sustained virological response(SVR) rates, with shorter treatment durations and fewer adverse events compared with regimens that include interferon. However, a relatively small proportion of patients cannot achieve SVR in the first treatment, including DAAs with or without peginterferon and/or ribavirin. Although retreatment with a combination of DAAs should be conducted for these patients, it is more difficult to achieve SVR when retreating these patients because of resistance-associated substitutions(RASs) or treatment-emergent substitutions. In Japan, HCV genotype 1 b(GT1 b) is founded in 70% of HCVinfected individuals. In this minireview, we summarize the retreatment regimens and their SVR rates for HCV GT1 b. It is important to avoid drugs that target the regions targeted by initial drugs, but next-generation combinations of DAAs, such as sofosbuvir/velpatasvir/voxilaprevir for 12 wk or glecaprevir/pibrentasvir for 12 wk, are proposed to be potential solution for the HCV GT1 b-infected patients with treatment failure, mainly on a basis of targeting distinctive regions. Clinicians should follow the new information and resources for DAAs and select the proper combination of DAAs for the retreatment of HCV GT1 b-infected patients with treatment failure.

关键词： Direct-acting antiviral agent Genotype 1b Hepatitis C virus Resistance-associated substitutions

Extraction,classification and visualization of 3-dimensional clouds simulated by cloud-resolving atmospheric model

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International Journal of Modeling, Simulation, and Scientific Computing 2017年第4期8卷 190-204页

作者： Daisuke matsuoka Center for Earth Information Science and Technology(CEIST)Japan Agency for Marine-Earth Science and Technology(JAMSTEC)3173-25 Showa-Machi Kanazawa-kuYokohama 236-0001Japan

Cloud-resolving atmospheric general circulation models using large-scale supercomputers reproduce realistic behavior of 3-dimensional atmospheric field on a global *** understand the simulation result for scientists,conventional visualization methods based on 2-dimensional cloud classification are not enough for understanding individual clouds and their physical *** this study,we propose a new 3-dimensional extraction and classification method of simulated clouds based on their 3-dimensional shape and physical *** proposed method extracts individual clouds by cloud water and cloud ice,and classifies them into six types by their altitude and upward *** applied the method to time-varying atmospheric simulation data,and attempted to visualize atmospheric phenomena on the tropics such as developing cumulonimbus and tropical *** case studies clearly visualize the behavior of individual cloud type and clarify that some cloud types have a relationship with rainfall during active weather *** proposed method has the potential to analyze such phenomena that develop in the vertical direction as well as the horizontal direction.

关键词： Atmospheric simulation cloud visualization

Imbricate structure of the Otakeyama area, Okayama Permian Yoshii Group in the Prefecture, southwest Japan

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Frontiers of Earth Science 2015年第1期9卷 152-163页

作者： Tsuyoshi ITO Atsushi matsuoka State Key Laboratory of Geo-processes and Mineral Resources China University of Geosciences Wuhan 430074 China Department of Geology Faculty of Science Niigata University Niigata 950-2181 Japan

The Yoshii Group of the Akiyoshi terrane is distributed over the Otakeyama area, Okayama Prefecture, southwest Japan. The Yoshii Group is composed of siliceous rocks and clastics, comprising chert-clastic sequences. The Yoshii Group is divided into four structural units （Units Ot 1, Ot 2, Ot 3, and Ot 4） in structurally ascending order. Lithological similarities and radiolarian age suggest that these units exhibit almost identical ocean plate stratigraphy. These units are structurally-repeated to form an imbricate structure. This structure was possibly formed by off-scrape accretion at a toe of an accretionary complex. Additionally, a review of previous studies indicates that an imbricate structure is common in the Akiyoshi terrane. The presence of an imbricate structure in the Akiyoshi terrane, Permian accretionary complex, indicates the possibility that a specific horizon of Permian pelagic sequences acted as a drcollement zone.

关键词： accretionary complex imbricate structure,Permian radiolafia Yoshii Group Okayama Prefecture,southwest Japan

Formation and Annealing of BaTiO_3 and SrTiO_3 Nanoparticles in KOH Solution

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Journal of Materials Science & Technology 2010年第1期26卷 33-38页

作者： Tomoki Tsumura Keiichi matsuoka Masahiro Toyoda Department of Applied Chemistry Faculty of EngineeringOita University

Barium titanate （BaTiO3） and strontium titanate （SrTiO3） nanoparticles were synthesized separately through hydrothermal reaction of crystalline TiO2 particles and corresponding alkaline earth hydroxides, Ba（OH）2 and St（OH）2 respectively, in 50 mol·dm^-3 KOH solution at 150℃. Each structural evolution of BaTiO3 and SrTiO3 during the hydrothermal treatment was investigated by X-ray diffraction （XRD）, field emission scanning electron microscopy （FE-SEM）, field emission transmission electron microscopy （FE-TEM） and thermogravimetry- differential analysis （TG-DTA）. In the BaTiO3 system, round particles with cubic perovskite-type structure were obtained within 1 h. However, these particles were gradually dissolved and then were re-precipitated in the form of cube-shape BaTiO3 particles with a smaller lattice constant ac than that of the former phase. After the BaTiO3 particles formed firstly have disappeared completely, or the two phases coexistence stage with different lattice constant ac passed, lattice constant ac of BaTiO3 phase re-precipitated continuously decreased with annealing time. In contrast, once SrTiO3 particles are formed, the lattice constant ac decreased continuously throughout the reaction. The result indicates that SrTiO3 particles were annealed without dissolution and precipitation process under the present condition.

关键词： BaTiO3 SrTiO3 Nanoparticle Hydrothermal reaction

Metal-free catalytic reduction of aldehydes,ketones,aldimines,and ketimines

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Chinese Chemical Letters 2010年第11期21卷 1314-1317页

作者： Hiroaki matsuoka Kazuhiro Kondo Graduate School of Medical Sciences Nagoya City University Graduate School of Pharmaceutical Sciences Nagoya City University

The metal-free combination of catalytic amounts of PPh3,B（C6F5）3,and PhSiH_3 can efficiently hydrosilylate aldehydes, ketones,aldimines and ketimines to afford the corresponding reduction products in good yields.

关键词： Metal-free hydrosilylation Reduction Ketone Ketimine

Experimental Study on Shock Wave Structures in Constant-area Passage of Cold Spray Nozzle

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Journal of Thermal Science 2007年第1期16卷 40-45页

作者： Hiroshi KATANODA Takeshi matsuoka Kazuyasu MATSUO Dept.Mechanical Engineering Kagoshima University1-21-40 KorimotoKagoshima890-0065 Japan Takagi Precision Dies Co. Ltd.2-4-1 Ishida-MinamiMinami-kuKitakyushuFukuoka802-0836 Japan Dept.Mechanical Systems and Environmental Engineering The University of Kitakyushu1-1 HibikinoWakamatsukuKitakyushuFukuoka808-0135 Japan

Cold spray is a technique to make a coating on a wide variety of mechanical or electric parts by spraying solid particles accelerated through a high-speed gas flow in a converging-diverging nozzle. In this study, pseudo-shock waves in a modeled cold spray nozzle as well as high-speed gas jets are visualized by schlieren technique. The schlieren photographs reveals the supersonic flow with shock train in the nozzle. Static pressure along the barrel wall is also measured. The location of the head of pseudo-shock wave and its pressure distribution along the nozzle wall are analytically explained by using a formula of pseudo-shock wave. The analytical results show that the supersonic flow accompanying shock wave in the nozzle should be treated as pseudo-shock wave instead of normal shock wave.

关键词： Supersonic Flow Pseudo-Shock Wave Jet Flow Cold Spray

Molecular targets for the treatment of pancreatic cancer:Clinical and experimental studies

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World Journal of Gastroenterology 2016年第2期22卷 776-789页

作者： Tasuku matsuoka Masakazu Yashiro Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Pancreatic cancer is the fourth most common cause of cancer deaths worldwide. Although recent therapeutic developments for patients with pancreatic cancer have provided survival benefits, the outcomes for patients with pancreatic cancer remain unsatisfactory. Molecularly targeted cancer therapy has advanced in the past decade with the use of a number of pathways as candidates of therapeutic targets. This review summarizes the molecular features of this refractory disease while focusing on the recent clinical and experimental findings on pancreatic cancer. It also discusses the data supporting current standard clinical outcomes, and offers conclusions that may improve the management of pancreatic cancer in the future.

关键词： Pancreatic cancer Targeted therapy Tyrosinekinase inhibitors Microenvironment Cancer stem cell

Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer

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World Journal of Gastroenterology 2016年第8期22卷 2415-2423页

作者： Masakazu Yashiro Tasuku matsuoka Department of Surgical Oncology Osaka City University Graduate School of Medicine Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of Medicine

Fibroblast growth factor receptors(FGFRs) regulate a variety of cellular functions, from embryogenesis to adult tissue homeostasis. FGFR signaling also plays significant roles in the proliferation, invasion, and survival of several types of tumor cells. FGFR-induced alterations, including gene amplification, chromosomal translocation, and mutations, have been shown to be associated with the tumor initiation and progression of gastric cancer, especially in diffuse-type cancers. Therefore, the FGFR signaling pathway might be one of the therapeutic targets in gastric cancer. This review aims to provide an overview of the role of FGFR signaling in tumorigenesis, tumor progression, proliferation, and chemoresistance. We also discuss the accumulating evidence that demonstrates the effectiveness of using clinical therapeutic agents to inhibit FGFR signaling for the treatment of gastric cancer.

关键词： Fibroblast growth factor receptor Gastric cancer Signaling pathway Targeted therapy