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The chemical structures,biosynthesis,and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium:a review

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Chinese Journal of Natural Medicines 2024年第8期22卷 676-698页

作者： QI Jianzhao WU Jing KANG Shijie GAO Jingming Hirokazu kawagishi LIU Hongwei LIU Chengwei Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life ScienceNortheast Forestry UniversityHarbin 150040China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China Faculty of Agriculture Shizuoka UniversityShizuoka 422-8529Japan State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Fungal phytochemicals derived from higher fungi,particularly those from the culinary-medicinal genus Hericium,have gained significant attention in drug discovery and *** review aims to provide a comprehensive analysis of the chemical structures,biosynthetic pathways,biological activities,and pharmacological properties of monomeric compounds isolated from Hericium *** the past 34 years,253 metabolites have been identified from various Hericium species,including cyathane diterpenes,alkaloids,benzofurans,chromenes,phenols,pyrones,steroids,and other miscellaneous *** investigations into the biosynthesis of erinacines,a type of cyathane diterpene,have led to the discovery of novel cyathane *** research has highlighted the biological activities and pharmacological properties of Hericium-derived compounds,with particular emphasis on their neuroprotective and neurotrophic effects,immunomodulatory capabilities,anti-cancer activity,antioxidant properties,and antimicrobial *** A,in particular,has been extensively ***,transcriptomic,and proteomic analyses of Hericium species have facilitated the discovery of new compounds and provided insights into enzymatic reactions through genome *** diverse chemical structures and biological activities of Hericium compounds underpin their potential applications in medicine and as dietary *** review not only advances our understanding of Hericium compounds but also encourages further research into Hericium species within the realms of medicine,health,functional foods,and agricultural *** broad spectrum of compound types and their diverse biological activities present promising opportunities for the development of new pharmaceuticals and edible products.

关键词： Hericium Secondary metabolites Biological activity Biosynthesis

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Polyarteritis nodosa clinically mimicking nonocclusive mesenteric ischemia

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World Journal of Gastroenterology 2013年第23期19卷 3693-3698页

作者： Tsuyoshi Shirai Hiroshi Fujii Shinichiro Saito Tomonori Ishii Hideyuki Yamaya Shigehito Miyagi Satoshi Sekiguchi naoki kawagishi Masato Nose Hideo Harigae Department of Hematology and Rheumatology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Department of Histopathology Tohoku University Graduate School of MedicineSendai 980-8574 Japan

Here, we present the case of a 74-year-old Japanese man with segmental intestinal necrosis, which developed after treatment with pulsed methylprednisolone for mononeuritis multiplex. The patient was weakly positive for myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA). Computed tomography and surgical findings were compatible with nonocclusive mesenteric ischemia (NOMI). He underwent small intestinal resection by emergency surgery and an intestinal fistula was made. Pathologically, necrotizing vasculitis with fibrinoid necrosis was present in medium to small-sized arteries, which was equivalent to Arkin's classification Ⅱ-Ⅳ. Most of the arteries had fibrous intimal thickening, which was considered to obstruct the arteries and thus cause segmental intestinal necrosis. A diagnosis of polyarteritis nodosa (PAN) was made, and intravenous cyclophosphamide pulse therapy was added to the therapeutic regimen. This patient was successfully treated with these multidisciplinary therapies and his stoma was finally closed. This is a very rare and indicative case of PAN weakly positive for MPO-ANCA and clinically mimicking NOMI, which occurred even after treatment with pulsed methylprednisolone.

关键词： Anti-neutrophil cytoplasmic antibody Intestinal necrosis Myeloperoxidase Nonocclusive mesenteric ischemia Polyarteritis nodosa

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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

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World Journal of Gastroenterology 2005年第44期11卷 6954-6959页

作者： Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi naoki kawagishi Akira Sato Susumu Satomi Division of Advanced Surgical Science and Technology Department of Surgery

AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in ***: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were ***: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P＜0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval ***: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury.

关键词：白内障肝移植猪动物实验

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Comparative experiment on treating digested piggery wastewater with a biofilm MBR and conventional MBR： simultaneous removal of nitrogen and antibiotics

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 123-131页

作者： Xiaoyan Song Rui Liu Lujun Chen Tomoki kawagishi Zhejiang Provincial Key Laboratory of Water Science and Technology Department of Environment in Yangtze Delta Region Institute of Tsinghua University-Zhejiang Jiaxing 314006 China School of Environment Tsinghua University Beijing 100084 China Aqua Development Center Mitsubishi Rayon Co. Ltd. Toyohashi 4408601 Japan

A biofilm membrane bioreactor （BF-MBR） and a conventional membrane bioreactor （MBR） were parallelly operated for treating digested piggery wastewater. The removal performance of COD, TN, NH4＋-N, TP as well as antibiotics were simultaneously studied when the hydraulic retention time （HRT） was gradually shortened from 9 d to 1 d and when the ratio ofinfluent COD to TN was changed. The results showed that the effluent quality in both reactors was poor and unstable at an influent COD/ TN ratio of 1.0±0.2. The effluent quality was signifcantly improved as the influent COD/TN ratio was increased to 2.3±0.5. The averaged removal rates of COD, NH4＋-N, TN and TP were 92.1%, 97.1%, 35.6% and 54.2%, respectively, in the BF-MBR, significantly higher than the corresponding values of 91.7%, 90.9%, 17.4% and 31.9% in the MBR. Analysis of 11 typical veterinary antibiotics （from the tetracycline, sulfonamide, quinolone, and macrolide families） revealed that the BF-MBR removed more antibiotics than the MBR. Although the antibiotics removal decreased with a shortened HRT, high antibiotics removals of 86.8%, 80.2% and 45.3% were observed in the BF-MBR at HRT of 5~4 d, 3-2 d and 1 d, respectively, while the corresponding values were only 83.8%, 57.0% and 25.5% in the MBR. Moreover, the BF-MBR showed a 15% higher retention rate of antibiotics and consumed 40% less alkalinity than the MBR. Results above suggest that the BF-MBR was more suitable for digested piggery wastewater treatment.

关键词： AlkalinityAntibioticsBiofilmDigested piggery wastewater (DPW)Membrane bioreactor

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Comparative study on microbial community in intermittently aerated sequencing batch reactors （SBR） and a traditional SBR treating digested piggery wastewater

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Frontiers of Environmental Science & Engineering 2017年第3期11卷 97-106页

作者： Xiaolin Sheng Rui Liu Xiaoyan Song Lujun Chen kawagishi Tomoki Zhejiang Provincial Key Laboratory of Water Science and Technology Department of Environment in Yangtze Delta Region Institute of Tsinghua University Zhejiang Jiaxing 314006 China School of Environment Tsinghua University Beijing 100084 China Aqua Development Center Mitsubishi Rayon Co. Ltd. Toyohashi 4408601 Japan

A traditional sequencing batch reactor （SBR） and two intermittently aerated sequencing batch reactors （IASBRs） were parallelly operated for treating digested piggery wastewater. Their microbial communities were analyzed, and the nitrogen removal performance was compared during the long term run. IASBRs demonstrated higher removal rates of total nitrogen （TN） and ammonium nitrogen （NH4＋ -N） than the SBR, and also demonstrated higher resistance against TN shock load. It was found that the more switch times between aerobic/anoxic in an IASBR, the higher the removal rates of TN and NH4＋ N. All the reactors were predominated by Thauera, Nitrosomonas and Nitrobacter, which were considered to be species of denitrifiers, ammonium oxidizing bacteria （AOB） and nitrite oxidizing bacteria （NOB）, respectively. However, the abundance and diversity was of great difference. Compared with SBR, IASBRs achieved higher abundance of denitrification related bacteria. IASBR 1# with four aerobic/anoxic switch times was detected with 25.63% of Thauera, higher than that in IASBR 2# with two aerobic/anoxic switch times （l 1.57% of Thauera）, and much higher than that in the SBR （only 6.19% of Thauera）. IASBR 2# had the highest percentage of AOB, while 1ASBR 1# had the lowest percentage. The denitrifiers abundance was significantly positive correlated with the TN removal rate. However, the NH4＋ N removal rate showed no significant correlation with the AOB abundance, but might relate to the AOB activity which was influenced by the average free ammonium （FA） concentration. Nitrobacter was the only NOB genus detectable in all reactors, and were less than 0.03%.

关键词： Digested piggery wastewater Intermittent aeration aeration Microbial community Partial nitrification^lenitrification processSequencing batch reactor (SBR)

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Advantages of intermittently aerated SBR over conventional SBR on nitrogen removal for the treatment of digested piggery wastewater

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Frontiers of Environmental Science & Engineering 2017年第3期11卷 131-140页

作者： Xiaoyan Song Rui Liu Lujun Chen Baogang Dong Tomoki kawagishi Zhejiang Provincial Key Laboratory of Water Science and Technology Department of Environment in Yangtze Delta Region Institute of Tsinghua University-Zhejiang Jiaxing 314006 China School of Environment Tsinghua University Beijing 100084 China Aqua Development Center Mitsubishi Rayon Co. Ltd. Toyohashi 4408601 Japan

An intermittently aerated sequencing batch reactor （IASBR） and a traditional sequencing batch reactor （SBR） were parallelly constructed to treat digested piggery wastewater, which was in high NH4＋ -N concentration but in a low COD/TN ratio. Their pollutant removal perfonnance was compared under COD/TN ratios of 1.6-3.4 d and hydraulic retention times of 5 3 d. The results showed that the IASBR removed TN, NH4＋-N and TOC more efficiently than the SBR. The average removal rates of TN, NH4＋-N and TOC were 83.1%, 96.5%, and 89.0%, respectively, in the IASBR, significantly higher than the corresponding values of 74.8%, 82.0%, and 86.2%. in the SBR. Mass balance of organic carbon revealed that the higher TN removal in the IASBR might be attributed to its efficient utilization of the organic carbon for denitrification, since that 48.7%- 52.2% of COD was used for denitrification in the IASBR, higher than the corresponding proportion of 43.1%-47.4% in the SBR. A prc-anoxic process in the IASBR would enhance the ammonium oxidation while restrict the nitrite oxidation. Anoxic duration of 40-80 min should be beneficial for achieving stable nitritation.

关键词： Anoxic stress Carbon source Digested piggery wastewater Intermittently aerated SBR (IASBR)Total nitrogen

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Treatment strategy for pancreatic head cancer with celiac axis stenosis in pancreaticoduodenectomy:A case report and review of literature

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World Journal of Gastroenterology 2022年第8期28卷 868-877页

作者： Eiji Yoshida Yasutoshi Kimura Takuro Kyuno Ryoko kawagishi Kei Sato Tsuyoshi Kono Takehiro Chiba Toshimoto Kimura Hitoshi Yonezawa Osamu Funato Makoto Kobayashi Kenji Murakami Akinori Takagane Ichiro Takemasa Department of Surgery Hakodate Goryoukaku HospitalHakodate City 040-8611Japan Department of Surgery Surgical Oncology and ScienceSapporo Medical UniversitySapporo City 060-8543HokkaidoJapan Department of Diagnostic Radiology Hakodate Goryoukaku HospitalHakodate City 040-8611Japan

BACKGROUND During pancreaticoduodenectomy in patients with celiac axis(CA)stenosis due to compression by the median arcuate ligament(MAL),the MAL has to be divided to maintain hepatic blood flow in many ***,MAL division often fails,and success can only be determined *** overcome this problem,we performed endovascular CA stenting preoperatively,and thereafter safely performed *** present this case as a new preoperative treatment strategy that was *** SUMMARY A 77-year-old man with a diagnosis of pancreatic head cancer presented to our department for *** assessment revealed CA stenosis caused by *** performed endovascular stenting in the CA preoperatively because we knew that going into the operation without a strategy could lead to ischemic ***-antiplatelet therapy(DAPT)–which is needed when a stent is inserted–was then administered in parallel with neoadjuvant chemotherapy(NAC).This allowed us to administer DAPT for a sufficient period before the main pancreaticoduodenectomy procedure while obtaining therapeutic effects from *** stomach-preserving pancreaticoduodenectomy was *** operation did not require any unusual techniques and was performed ***,the patient progressed well,without any ischemic ***,curative resection was confirmed,and the patient had no recurrence or complications due to ischemia up to six months *** Preoperative endovascular stenting,with NAC and DAPT,is effective and safe prior to pancreaticoduodenectomy in potentially resectable pancreatic cancer.

关键词： Pancreaticoduodenectomy Celiac axis stenosis Median arcuate ligament Endovascular stenting Pancreatic head cancer Case report

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A robust homogeneous binding assay for α4β2 nicotinic acetylcholine receptor

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Acta Pharmacologica Sinica 2005年第10期26卷 1175-1180页

作者： naoki SUTO Tsuyoshi OGIKU Discovery and Pharmacology Research Laboratories Tanabe Seiyaku Co 2-50 kawagishi 2-Chome Toda Saitama 335-8505 Japan Discovery and Pharmacology Research Laboratories Tanabe Seiyaku Co 2-50 kawagishi 2-Chome Toda Saitama 335-8505 Japan

Aim: To develop a homogeneous high-throughput screening （HTS） assay based on scintillation proximity assay （SPA） technology for identification of novel α4β2 nicotinic acetylcholine receptor （nAChR） modulators. Methods: Membrane preparation of HEK293 cells expressing α4β2 nAChR, [3H]cytisine and wheat germ agglutinin （WGA）-coupled microbeads were used to develop an HTS assay based on SPA technology. This method was validated against a conventional filter binding approach and applied to large-scale screening of a library containing 32000 synthetic compounds. Intracellular calcium measurement was carried out to verify the bioactivities of the hits found by the SPA assay. Results: IC50values of 2 reference compounds （epibatidine and RJR 2403） determined by SPA and filter binding methods were comparable and consistent with those reported elsewhere. A total of 54 compounds, showing more than 60% competitive inhibition on [3H]cytisine binding to α4β2 nAChR, were identified initially following an HTS campaign. Secondary screening confirmed that 17 compounds with novel chemical structures possessed relatively high binding affinity to α4β2 nAChR （Ki50% inhibition on ABT-594-induced calcium mobilization while none showed any agonistactivity. Conclusions: This homogeneous binding assay is a highly efficient, amenable to automation and robust tool to screen potential α4β2 nAChR modulators in an HTS setting. Its application may be expanded to other membrane receptors and ion channels.

关键词： nicotinic acetylcholine receptor: scintillation proximity assay high-throughput screening

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Development of superalloys and coatings for next generation gas turbines

Development of superalloys and coatings for next generation ...

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2011中国材料研讨会

作者： H.Harada K.kawagishi High Temperature Materials Center National Institute for Materials Science （NIMS）

＜正＞In order to achieve the Japanese Government target for CO 2 emission reduction,that is,25% reduction by the year 2020 from the emission level in 1990,the thermal efficiency improvement in fossil power

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Clinical usefulness of endoscopic ultrasonography for the evaluation of ulcerative colitis-associated tumors

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World Journal of Gastroenterology 2015年第9期21卷 2693-2699页

作者： Kiyonori Kobayashi Kana kawagishi Shouhei Ooka Kaoru Yokoyama Miwa Sada Wasaburo Koizumi Research and Development Center for New Medical Frontiers Kitasato UniversitySchool of MedicineSagamiharaKanagawa 252-0380Japan Department of Gastroenterology Kitasato UniversitySchool of MedicineSagamihara 252-0380Japan

AIM:To evaluate the clinical usefulness of endoscopic ultrasonography(EUS) for the diagnosis of the invasion depth of ulcerative colitis-associated ***:The study group comprised 13 patients with 16 ulcerative colitis(UC)-associated tumors for which the depth of invasion was preoperatively estimated by *** lesions were then resected endoscopically or by surgical colectomy and were examined *** mean age of the subjects was 48.2 ± 17.1 years,and the mean duration of UC was 15.8 ± 8.3 *** lesions were treated by endoscopic resection and the other 14 lesions by surgical *** depth of invasion of UCassociated tumors was estimated by EUS using an ultrasonic probe and was evaluated on the basis of the deepest layer with narrowing or rupture of the colonic ***:The diagnosis of UC-associated tumors by EUS was carcinoma for 13 lesions and dysplasia for 3 *** invasion depth of the carcinomas was intramucosal for 8 lesions,submucosal for 2,the muscularis propria for 2,and subserosal for ***(69%) of the 16 lesions arose in the *** macroscopic appearance was the laterally spreading tumor-non-granular type for 4 lesions,sessile type for 4,laterally spreading tumor-granular type for 3,semipedunculated type(Isp) for 2,type 1 for 2,and type 3 for *** depth of invasion was correctly estimated by EUS for 15 lesions(94%) but was misdiagnosed as intramucosal for 1 carcinoma with high-grade submucosal *** 2 lesions treated by endoscopic resection were intramucosal carcinoma and dysplasia,and both were diagnosed as intramucosal lesions by ***:EUS provides a good estimation of the invasion depth of UC-associated tumors and may thus facilitate the selection of treatment.

关键词： Ulcerative colitis Colitis-associated tumor Diagno

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