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Ligand density-dependent influence of arginine-glycine- aspartate functionalized gold nanoparticles on osteogenic and adipogenic differentiation of mesenchymal stem cells

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Nano Research 2018年第3期11卷 1247-1261页

作者： Jingchao Li Ying Chen naoki Kawazoe Guoping Chen Intemational Center for Materials Nanoarchitectonics National lnstitute for Materials Science 1-1 Namiki Tsukuba Ibaraki 305-0044Japan Department of Materials Science and Engineering Graduate School of Pure and Applied Sciences University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki 305-8577 Japan Research Center for Functional Materials National Institute for Materials Science 1- 1 Namiki Tsukuba Ibaraki 305-0044 Japan

Extracellular matrix （ECM） plays a very important role in regulating cell function and fate. It is highly desirable to fabricate biomimetic models to investigate the role of ECM in stem cell differentiation. In this study, arginine- glycine--aspartate （RGD）-modified gold nanoparticles （Au NPs） with tunable surface ligand density were prepared to mimic the ECM microenvironment. Their effect on osteogenic and adipogenic differentiation of human mesenchymal stem cells （MSCs） was investigated. The biomimetic Au NPs were taken up by MSCs in a ligand density-dependent manner. The biomimetic NPs with a high RGD density had an inhibitive effect on the alkaline phosphatase （ALP） activity, calcium deposition, and osteogenic marker gene expression of MSCs. Their effect on oil droplet formation and adipogenic marker gene expression was negative when RGD density was low, while their effect was promotive when RGD density was high. The biomimetic Au NPs regulated the osteogenic and adipogenic differentiation of MSCs mainly through affecting the focal adhesion and cytoskeleton. This study highlights the roles of biomimetic NPs on stem cell differentiation that could provide a meaningful strategy in fabricating functional biomaterials for tissue engineering and biomedical applications.

关键词： arginine-glycine--aspartate(RGD) density biomimetic goldnanopartides (Au NPs) osteogenic differentiation adipogenic differentiation mesenchymal stem cells

Gastrointestinal stromal tumor of the stomach with axillary lymph node metastasis: A case report

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World Journal of Gastroenterology 2017年第9期23卷 1720-1724页

作者： naoki Kubo Nobumichi Takeuchi Department of Surgery Ina central HospitalInashiNagano 396-8555Japan

Gastrointestinal stromal tumors (GISTs) are the most common type of gastrointestinal mesenchymal tumors, although metastasis to the perigastric lymph nodes is relatively rare, compared with liver or peritoneal metastasis. In this report, we describe a case of stomach GIST with a solitary simultaneous metastasis in the left axillary lymph node. A 68-year-old man was diagnosed with a large upper-stomach GIST, and computed tomography and positron emission tomography revealed masses in the left axilla and right mediastinum. We did not detect evidence of metastases to the liver, or other sites including the perigastric lymph nodes, although findings from the surgically resected axillary lymph nodes were compatible with GIST metastasis. Treatment using imatinib markedly reduced the gastric and mediastinal lesions, and this response persisted for 3 years. The patient subsequently experienced rapid growth of the gastric lesion without mediastinal or axilla recurrence, which required palliative surgery. Despite continuing medical treatment(sunitinib and regorafenib), the patient died of liver metastases 23 mo after the surgery. Based on our findings, it appears that the axillary lymph nodes can be a potential metastatic site for GIST metastasis.

关键词：胃肠的 stromal 肿瘤腋淋巴节点转移 Imatinib

Development of a Mobile Sensing Unit and Its Prototype Implementation

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Tsinghua Science and Technology 2008年第S1期13卷 223-227页

作者： Yusuke Mizuno Yozo Fujino Keita kataoka Yoshihiro Matsumoto Research Center for Environmental Safety Yamaguchi University Department of Civil Engineering The University of Tokyo Research and Development Center East Japan Railway Company Kansai Electric Power Co. Inc.

This paper represents a design and development of a mobile sensing unit as well as its prototype implementation for railway track monitoring. The unit consists of an ultra-small personal computer (PC), a global positioning system (GPS) receiver, an accelerometer and an ADC (Analog/Digital Converter) so that the unit can trace the route while capturing an acceleration response of a passenger vehicle. The unit enables more frequent and qualitative data acquisition compared with traditional and the state of the practice railway track inspection equipments. Locating disorder is the key of our unit, which has a reasonable accuracy of positioning with GPS data, existing facilities landmarks, and car acceleration responses. The proposed unit is a promising device for efficient properties management of railway agencies. The prototype implementation shows a result that car acceleration responses are related with the track displacements in low frequencies. The results also imply that sensor settlement on a vehicle floor, not axes or bogies, is effective for capturing track vertical displacements.

关键词： mobile sensing railway track monitoring instrumentation data acquisition passenger vehicle global positioning system (GPS)

Selective extraction of In(Ⅲ),Ga(Ⅲ) and Zn(Ⅱ) using a novel extractant with phenylphosphinic acid

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Chinese Journal of Chemical Engineering 2016年第2期24卷 232-236页

作者： Yuji Sasaki naoki Matsuo Tatsuya Oshima Yoshinari Baba Department of Applied Chemistry Faculty of EngineeringUniversity of Miyazaki

A new extractant,[N,N-di(2-ethylhexyl)amino]methylphenylphosphinic acid(DEAPP),was synthesized to develop the mutual separation techniques of In(III),Ga(III) and Zn(II).The extraction selectivity for In(III),Ga(III)and Zn(II) with DEAPP was higher than that of the commercial phosphorus acid extractants such as D2 EHPA and PC-88 *** extraction selectivity for metal ions in 1 mol·L-1aqueous ammonium nitrate solution with DEAPP was in the following order:In(III) N Ga(III) N Zn(II).These selective extraction behaviors indicate that the amino moiety of DEAPP plays an important role in the mutual separation of In(III),Ga(III) and Zn(II).The extraction equilibria of In(III),Ga(III) and Zn(II) with DEAPP(=HR) were expressed by the following reactions:In3++ 2HRT2In R3HRT + 3H+,Ga3++ 1.5HRT-2+ NO3 GaR 2eHRT N O3T + 2H+,and Zn2++ 2HRT2 Zn R2HRT2+ 2H+.The extraction equilibrium constants of In(III),Ga(III) and Zn(II) with DEAPP were determined to be Kex,M= 1.7 × 104[dm3·mol-1],4.17 [(dm3·mol-1)0.5],and 1.55 x 10-2[–],respectively.

关键词：选择性提取锌(Ⅱ) 乙基己基 GA3 萃取剂化学工业出版社次膦酸萃取平衡常数

Evaluation of gut dysbiosis using serum and fecal bile acid profiles

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World Journal of Clinical Cases 2022年第34期10卷 12484-12493页

作者： Tadakuni Monma Junichi Iwamoto Hajime Ueda Makoto Tamamushi Fumio Kakizaki naoki Konishi Shoichiro Yara Teruo Miyazaki Takeshi Hirayama Tadashi Ikegami Akira Honda Department of Gastroenterology and Hepatology Tokyo Medical University Ibaraki Medical CenterInashiki-Gun 300-0395Japan Joint Research Center Tokyo Medical University Ibaraki Medical CenterInashiki-Gun 300-0395Japan

Dysbiosis in the intestinal microflora can affect the gut production of microbial metabolites,and toxic substances can disrupt the barrier function of the intestinal wall,leading to the development of various *** levels of Clostridium subcluster XIVa(XIVa)are associated with the intestinal dysbiosis found in inflammatory bowel disease(IBD)and Clostridium difficile infection(CDI).Since XIVa is a bacterial group responsible for the conversion of primary bile acids(BAs)to secondary BAs,the proportion of intestinal XIVa can be predicted by determining the ratio of deoxycholic acid(DCA)/[DCA+cholic acid(CA)]in feces *** example,serum DCA/(DCA+CA)was significantly lower in IBD patients than in healthy controls,even in the remission *** results suggest that a low proportion of intestinal XIVa in IBD patients might be a precondition for IBD onset but not a consequence of intestinal *** report showed that a reduced serum DCA/(DCA+CA)ratio could predict susceptibility to ***,the BA profile,particularly the ratio of secondary to primary BAs,can serve as a surrogate marker of the intestinal dysbiosis caused by decreased XIVa.

关键词： Gut dysbiosis Clostridium subcluster XIVa Bile acids HPLC-MS/MS Inflammatory bowel diseases Clostridium difficile infection

Van Vleck paramagnetism of europium oxyhydroxide

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Journal of Rare Earths 2015年第2期33卷 177-181页

作者： Hiroaki Samata naoki Wada Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University FukaeminamiHigashinada Kobe Hyogo 658-0022 Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceNamiki Tsukuba Ibaraki 305-0044 Japan

Europium oxyhydroxide crystals were synthesized by the flux method. The as-grown crystals were transparent and had a plate-like shape with natural flat surfaces. The powder XRD data were refined by assuming a monoclinic structure of the space group P21/m and lattice parameters of a=0.4346 nm, b=0.3744 nm, c=0.6107 nm, and β=108.62°. The magnetic susceptibility of the EuOOH crystals exhibited typical Van Vleck temperature-independent paramagnetism below 120 K. The calculated susceptibility, based on Van Vleck＇s theory, agreed with the experimental data to some extent, with the coupling constant λ=458±10 K. The experimental results were in close agreement with the results calculated using a modified formula with λ=505±2 K and a constant term C=4.6×10^-4 emu/（mol·Oe）.

关键词： europium oxyhydroxide magnetic measurement Van Vleck paramagnetism rare earths

Effects of blue light on gametophyte development of Laminaria japonica (Laminariales, Phaeophyta)

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Chinese Journal of Oceanology and Limnology 2005年第3期23卷 323-329页

作者：史翠娟 kataoka Hironao 段德麟 Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Graduate School of Life Sciences Tohoku University Sendai 980-8577 Japan

Laminaria gametophyte was greatly influenced by light in its growth and development. Using light-emitting diodes (LED) as blue and red light sources, we analyzed the light effect on gametophytes devel- opment of Laminaria japonica Aresch. The gametophytes were obtained from zoospores collected in April, May, July, 2003 and September, 2004. We found that the growth of gametophytes was stimulated by increasing inten- sity of blue light (BL) and red light (RL) illumination, of which BL was obviously stronger than that of RL. The fertilization of gametophytes depended largely on BL, and only sufficient BL illumination could take the repro- ductive effect. In addition, we noticed that there was a significant difference in light responses for gametophytes developed from zoospore collected in different times. For zoospores released in April, under BL1 (73.90 μmol photons/m·s), the unicellular female gametophytes and multi-cellular male gametophytes produced eggs and sperms respectively, and further developed towards sporophytes. However, for gametophytes developed in May, July or September, they became multi-cellular and never formed oogonia or antheridia. It is believed that the Laminaria sporangium maturation stage could affect the gametophytes reaction to BL under laboratory culture conditions. Therefore, cryptochrome- or phototropin-like BL photoreceptors is probably involved in BL-induced development of Laminaria gametophytes.

关键词：配偶体蓝光光周期植物生长速度

Low-Driving-Voltage Optical Modulation Utilizing FWM for High-Speed Transmission Systems

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光学学报 2003年第S1期23卷 562-563页

作者： Akihiko Matsuura Toshiya Matsuda Tomoyoshi kataoka NTT Network Service Systems Laboratories 1-1 Hikarinooka Yokosuka-Shi Kanagawa 239-0847 JapanNTT Network Service Systems Laboratories 1-1 Hikarinooka Yokosuka-Shi Kanagawa 239-0847 JapanNTT Network Service Systems Laboratories 1-1 Hikarinooka Yokosuka-Shi Kanagawa 239-0847 Japan

We propose an optical transmitter with reduced modulator driving voltage. This reduction is achieved through an on-off ratio improvement technique based on FWM. We confirmed the feasibility of the method in a 43-Gbit/... 详细信息

关键词： FWM on in for Low-Driving-Voltage Optical Modulation Utilizing FWM for High-Speed Transmission Systems

Proposal of Rip-up &Re-allocate Algorithm for Optical Layer-2 Switch Network

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光子学报 2014年第7期43卷 34-41页

作者： Masahiro NAKAGAWA Kyota HATTORI naoki KIMISHIMA Masaru KATAYAMA Akira MISAWA NTT Network Service Systems Laboratories NTT Corporation

We are developing an optical layer-2s witch network that uses both wavelength-division multiplexing and time-division multiplexing technologies for efficient traffic aggregation in metro *** efficient traffic aggregation,path bandwidth control is key because it strongly affects bandwidth *** this paper,we propose a dynamic time-slot allocation method that uses periodic information of difference values of traffic *** method can derive near-optimal allocation with lower computational cost,which enlarges the maximum available network size compared with conventional time-slot allocation *** results show that the proposed method enables dynamic path control in 1K-node-scale optical layer-2s witch network,which leads to cost-effective metro networks.

关键词：交通聚集技术地铁网络成本效益交通管理