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Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma

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World Journal of Gastroenterology 2017年第31期23卷 5764-5772页

作者： Kohei Nishio Kenjiro Kimura Ryosuke Amano Bunzo Nakata Sadaaki Yamazoe Go Ohira Kotaro Miura naoki kametani Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Masaichi Ohira Department of Surgical Oncology Osaka City University Graduate School of Medicine Department of Surgery Kashiwara Municipal Hospital

AIM To elucidate the effect of expression of doublecortin and Ca M kinase-like-1(DCLK1) in patients with pancreatic ductal adenocarcinoma(PDAC). METHODS Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition(EMT) marker expression, and cancer stem cell(CSC) marker expression. Univariate and multivariate survival analyses were performed and we assessed the association between DCLK1 expression and clinicopathological factors, including the EMT marker and CSC marker.RESULTS In total, 48.5%(66/136) of the pancreatic cancer samples were positive for DCLK1. Patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors(median, 18.7 mo vs 49.5 mo, respectively; P < 0.0001). Positive DCLK1 expression correlated with histological grade(P = 0.0290), preoperative CA19-9 level(P = 0.0060), epithelial cell adhesion molecule(Ep CAM) expression(P = 0.0235), and the triple-positive expression of CD44/CD24/Ep CAM(P = 0.0139). On univariate survival analysis, five factors were significantly associated with worse overall survival: histological grade of G2 to G4(P = 0.0091), high preoperative serum SPan-1 level(P = 0.0034), R1/2(P < 0.0001), positive expression of DCLK1(P < 0.0001) or CD44(P = 0.0245). On multivariate survival analysis, R1/2 [odds ratio(OR) = 2.019, 95% confidence interval(CI): 1.380-2.933; P = 0.0004] and positive DCLK1 expression(OR = 1.848, 95%CI: 1.2854-2.661; P = 0.0009) were independent prognostic factors. CONCLUSION DCLK1 expression was found to be an independent prognostic factor and it may play a crucial prognostic role by promoting acquisition of stemness.

关键词： Doublecortin 和凸轮 kinase-like-1 胰腺的癌症上皮的间充质的转变癌症干细胞预示的因素

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Water-resistant organic thermoelectric generator with >10μW output

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Carbon Energy 2023年第4期5卷 55-67页

作者： Shinichi Hata Kanto Maeshiro Misaki Shiraishi Soichiro Yasuda Yuta Shiozaki Koudai kametani Yukou Du Yukihide Shiraishi naoki Toshima Department of Applied Chemistry Faculty of EngineeringSanyo‐Onoda City UniversityYamaguchiJapan Graduate School of Engineering Sanyo‐Onoda City UniversityYamaguchiJapan College of Chemistry Chemical Engineeringand Materials ScienceSoochow UniversitySuzhouPeople's Republic of China

Flexible p–n thermoelectric generator(TEG)technology has rapidly advanced with power enhancement and size reduction.To achieve a stable power supply and highly efficient energy conversion,absolute chemical stability of n-type materials is essential to ensuring large temperature differences between device terminals and ambient stability.With the aim of improving the long-term stability of the n-type operation of carbon nanotubes(CNTs)in air and water,this study uses cationic surfactants,such as octylene-1,8-bis(dimethyldodecylammonium bromide)(12-8-12),a gemini surfactant,to stabilize the nanotubes in a coating,which retains the n-doped state for more than 28 days after exposure to air and water in experiments.TEGs with 10 p-n units of 12-8-12/CNT(n-type)and sodium dodecylbenzene sulfonate/CNT(p-type)layers are manufactured,and their water stability is evaluated.The initial maximum output of 16.1μW(75 K temperature difference)is retained after water immersion for 40 days without using a sealant to prevent TEG module degradation.The excellent stability of these CNT-based TEGs makes them suitable for underwater applications,such as battery-free health monitoring and information gathering systems,and facilitates the development of soft electronics.

关键词： gemini surfactant n-type carbon nanotube surfactant doping thermoelectric properties water-resistant generators water stability

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Comparison between Conventional and Improved Gas Engine-Driven VRF under Same Climate Conditions

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Journal of Energy and Power Engineering 2014年第2期8卷 326-330页

作者： Taku Shimizu Kyosuke Yamada Shigeki kametani Tatsuo Nobe Department of Architecture Kogakuin University To~o 163-8677 Japan Tokyo University of Marine Science and Technology Tokyo 108-8477 Japan

This paper reports the on-site performance evaluation of conventional and improved gas engine-driven VRF (variable refrigerant flow) units and (abbreviated as GHP) units. The study aims to elucidate two actual GHP units by using the probe insertion method. There is a tendency to decrease energy efficiency compared to a high loading factor. GHP operation was almost all part load operation. This on-site evaluation indicates a clear difference between conventional and improved GHP.

关键词：燃气发动机传统气候条件驱动变制冷剂流量地源热泵性能评估热泵机组

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复杂地质构造地区的地震技术问题

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石油物探 1975年第4期 49-57页

作者： T.kametani A.Umedo Y.Ishii N.Asakura 林民瑞

在复杂地质构造地区,为了提高构造和岩性信息的可靠性,用常规方法已作过各种各样的尝试。这些改进的效果已通过对给出构造所作的射线路径模型来证实。层速度的推导和反射波的时间—深度转换可通过考虑倾角的影响而有效地进行。与时间有... 详细信息

在复杂地质构造地区,为了提高构造和岩性信息的可靠性,用常规方法已作过各种各样的尝试。这些改进的效果已通过对给出构造所作的射线路径模型来证实。层速度的推导和反射波的时间—深度转换可通过考虑倾角的影响而有效地进行。与时间有关的振幅衰减也作为一个岩性信息的标志而加以研究。

关键词：迭加速度迪克反射面层速度射线路径射线轨迹射线理论反射波时间剖面地震剖面反射点地质构造

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