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Simultaneous Measurement of Neural Activities of Acute Mouse Hippocampal Slices Using Multi-Electrode Array System and Laser Confocal Calcium Imaging

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Journal of Behavioral and Brain Science 2017年第2期7卷 68-78页

作者： Yuuta Hamasaki Natsumi Haba naoki iwata Yoshiki Uno Minoru Saito Department of Biosciences College of Humanities and Sciences Nihon University Tokyo Japan Department of Correlative Study in Physics and Chemistry Graduate School of Integrated Basic Sciences Nihon University Tokyo Japan

Recently, non-invasive, real-time and multi-point measurement of neural activities has become possible by using a multi-electrode array (MEA). Another method for multi-point measurement is the fluorescent imaging technique using voltage indicator dyes or calcium indicator dyes. Especially, calcium imaging using fluorescent calcium indicator dyes is often more useful, because they exhibit larger changes in the fluorescence intensity than voltage indicator dyes and their fluorescence changes can be detect easily. Additionally, calcium signals play key roles in the brain function, such as the long-term potentiation (LTP) in the hippocampus, and calcium imaging can be a powerful tool to elucidate the brain function. In this study, we constructed a measurement apparatus combining the MEA system and laser confocal calcium imaging and simultaneously measured electric signals and calcium signals in acute mouse hippocampal slices. The obtained results showed the availability of the present method.

关键词： Multi-Electrode Array Laser Confocal Calcium Imaging Hippocampus Acute Slice Long-Term Potentiation

Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer

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World Journal of Gastroenterology 2017年第14期23卷 2519-2526页

作者： Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami naoki iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine Division of Biostatistics Clinical Research Center Aichi Medical University Hospital

AIMTo identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative ***-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy (distal gastrectomy or total gastrectomy) were included in the analysis. Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications (grade II or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease ***-six patients (21.1%) experienced grade II or higher postoperative complications. The platelet-lymphocyte ratio (PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value (0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71 (sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94 (95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications (OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative *** preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer.

关键词： Gastric cancer Gastrectomy Platelet-lymphocyte ratio Postoperative complication Prediction

Acetylene Vacuum Carburizing

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材料热处理学报 2004年第5期25卷 370-374页

作者： Hitoshi iwata JH CORPORATION Aichi Japan

Almost 30 years has passed since the publication of materials on vacuum carburizing technology, and is attracting a great deal of attention as a technology capable of being used as a substitute for gas carburizing technology. However, the technology was not popular except in specific fields. The main reason for this is due to a variety of harmful influences accompanying the sooting problems caused by CH4 or C3H8. We have succeeded in that the occurrence of sooting was suppressed by utilizing acetylene, at extremely low pressure for carburizing (below 1 kPa). This process is now showing the excellent quality and prospects for this technology in terms of quality, economy and safety. At present almost 70 practical mass production furnaces are used in production lines, in Japan and abroad. At this time, we will report summary of the present acetylene vacuum carburizing process and the actual results obtained by these acetylene vacuum carburizing furnaces for mass production.

关键词：乙炔真空渗碳大量生产低压

Nonlinear Magnetic Response of Superconducting Flux Arrays with Random Pinning

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Chinese Physics Letters 1997年第3期14卷 217-220页

作者： NI Jun GU Bing-lin Shuichi iwata Department of Physics Tsinghua UniversityBeijing 100084 Research into Artifacts Center for EngineeringThe University of TokyoKamaba 4-6-1Meguro-kuTokyo 153Japan

The static nonlinear magnetic response of randomly pinned flux-line lattice in a type-Ⅱ super-conductor has been investigated using variational replica-symmetry-broken method.A peak in the curve of susceptibility as a function of external magnetic field is *** the magnetic field is low,there is a softening in the susceptibility as an effect of pinning potential with nonzero correlation *** some critical magnetic field,the softening changes into *** reaching the maximum in hardening,the susceptibility decreases to its value of piire states with the increase of magnetic field.

关键词： method. field. susceptibility

First-principles calculation of phase equilibria and phase separation of the Fe-Ni alloy system

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Rare Metals 2006年第5期25卷 437-440页

作者： Ying Chen Shuichi iwata Tetsuo Mohri Department of Quantum Engineering and System Science School of Engineering The University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo113-8656 Japan Graduate School of Frontier Sciences The University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-8656 Japan Division of Materials Science and Engineering Graduate School of Engineering Hokkaido University Kita-13 Nishi-8 Kita-ku Sapporo060-8628 Japan

Theoretical investigation of the phase equilibria of the Fe-Ni alloy has been performed by combining the FLAPW total energy calculations and the Cluster Variation Method through the Cluster Expansion Method. The calculations have proved the stabilization of the LIE phase at 1：3 stoichiometry, which is in agreement with the experimental result, and predicted the existence of L1 0 as a stable phase below 550 K; this L1 0 phase has been missing in the conventional phase diagram. The calculations are extended to the Fe-rich region that is characterized by a wide range phase separation and has drawn considerable attention because of the intriguing Invar property associated with a Fe concentration of 65%. To reveal the origin of the phase separation, a P-V curve in an entire concentration range is derived by the second derivative of free energy functional of the disordered phase with respect to the volume. The calculation confirmed that the phase separation is caused by the breakdown of the mechanical-stability criterion. The newly calculated phase separation line combined with the L1 0 and L12Eorder-disordered phase boundaries provides phase equilibria in the wider concentration range of the system. Furthermore, a coefficient of thermal expansion （CTE） is attempted by incorporating the thermal vibration effect through harmonic approximation of the Debye-Gruneisen model. The Invar behavior has been reproduced, and the origin of this anomalous volume change has been discussed.

关键词： Fe-Ni alloy system order-disorder separation magnetism first-principles calculations cluster variation method cluster expansion method Debye-Gruneisen model

3D reconstruction size effect on the quantification of solid oxide fuel cell nickel-yttria-stabilized-zirconia anode microstructural information using scanning electron microscopy-focused ion beam technique

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Science Bulletin 2016年第17期61卷 1317-1323页

作者： Zhenjun Jiao naoki Shikazono Institute of Industrial Science The University of Tokyo

Self-made conventional nickel-yttria-stabilized zirconia composite anodes after reduction and 500 h operation were analyzed by three-dimensional microstructure reconstruction based on focused ion beam-scanning electron microscopy *** area,threephases-boundary density and phase volume fraction were measured based on the three-dimensional microstructure reconstruction to quantitatively study the statistical characterization of solid oxide fuel cell nickel-yttria-stabilizedzirconia anode microstructure before and after *** is found that for anode operated with long time,it is necessary to increase the corresponding three-dimensional reconstruction size to suppress the influence of microstructure variation caused by Ni agglomeration in order to obtain more accurate microstructural quantification information.

关键词： FIB-SEM 3D reconstruction TPB density Tetragonal mesh

Use of family structure information in interaction with environments for leveraging genomic prediction models

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The Crop Journal 2020年第5期8卷 843-854页

作者： Reyna Persa Hiroyoshi iwata Diego Jarquin Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68583USA Graduate School of Agricultural and Life Sciences The University of TokyoBunkyoTokyo 113-8657Japan

The characterization of genomes with great detail offered by the modern genotyping platforms have opened a venue for accurately predicting the genotype-by-environment interaction(GE)effects of untested genotypes in different environmental *** developed statistical models have shown the advantages of including the GE interaction component in the prediction context using molecular markers,pedigree,or *** order to leverage the family information of highly structured populations when pedigree data is not available,we developed a model that uses the family membership *** proposed model extends the reaction norm model by including the interaction between families and environments(FE).A representative fraction of a soybean Nested Association Mapping population(16,187 grain yield records)comprising 38 bi-parental families(1358 genotypes)observed in 18 environments(2011,2012,and 2013)was used to contrast the proposed model with three conventional prediction *** crossvalidation scenarios(prediction of tested[CV2]and untested[CV1]genotypes)with a twofold design(50%for training and testing sets)were used for mimicking prediction situations that breeders face in *** showed that the family factor in interaction with environments explains a sizable amount of the phenotypic *** helped to improve the predictive ability with respect to the main effects model(GBLUP)around 41%(CV2)and 49%(CV1),and about 17%with respect to the conventional reaction norm *** inclusion of the FE term not only improved the global results but also significantly increased the prediction accuracy of those environments where the conventional models showed a very poor *** results show the importance of taking into consideration the family structure existing in breeding programs for improving the selection strategies in multi-parental populations.

关键词： interaction structure instead

Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis

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World Journal of Gastroenterology 2014年第21期20卷 6541-6546页

作者： naoki Hashimoto Department of Surgery Kinki UniversityOsaka 589-8511Japan

AIM: To examine the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in rat esophageal lesions induced by reflux of duodenal contents.

关键词： Bile acids Cyclooxygenase-2 Prostaglandin E2 Esophageal cancer Esophagoduodenal anastomosis

Novel Phase Transition in BaPr_2Mn_2O_7

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Journal of Rare Earths 2006年第z2期24卷 1-3页

作者： Hiromi Nakano naoki Kamegashira Ryukoku University SetaOtsu 520-2194Japan Toyohashi University of Technology Tenpaku-choToyohashi 441-8580Japan

The rare earth manganite BaLn2Mn2O7(Ln = rare earth element) has a Sr3Ti2O7-type layered perovskite structure with double-block oxygen octahedra belonging to the Ruddlesden-Popper-type homologous series AO(ABO3)2. In Pr-manganite, a novel phase transition was first observed in situ at 1040 K by a thermal transmission electron microscope. At 1040 K, reflections began to split along the c-direction in the selected area diffraction pattern. This indicates that a new phase appears in the original phase matrix; the c length of the new phase is 1.5% longer than that of the original phase. After about 5 min, the original phase disappears. No change in the crystal symmetry (space group 14/mmm) is observed above 1040 K.

关键词： rare earth manganite phase transition transmission electron microscope (TEM)