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Mucosal patterns change after Helicobacter pylori eradication:Evaluation using blue laser imaging in patients with atrophic gastritis

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World Journal of Gastroenterology 2023年第17期29卷 2657-2665页

作者： Yoshiyuki Nishikawa Yoshio ikeda Hidehiro Murakami Shin-Ichiro Hori Megumi Yoshimatsu naoki Nishikawa Department of Gastroenterology Nishikawa Gastrointestinal ClinicMatsuyama 790-0878EhimeJapan Endoscopy Center Ehime University HospitalToon 791-0295EhimeJapan Department of Internal Medicine Saiseikai Matsuyama HospitalMatsuyama 791-8026EhimeJapan Department of Gastroenterology Himeji Red Cross HospitalHimeji 670-8540HyogoJapan Department of Gastroenterology National Hospital Organization Shikoku Cancer CenterMatsuyama 791-0280EhimeJapan Department of Gastroenterology Matsuyama Shimin HospitalMatsuyama 790-0067EhimeJapan

BACKGROUND Mucosal patterns(MPs)observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty,cracked,and ***,we hypothesized that the spotty pattern may change to the cracked pattern after Helicobacter pylori(***)*** To further substantiate and comprehensively investigate MP changes after *** eradication in a larger number of *** We included 768 patients who were diagnosed with atrophic gastritis with evaluable MP using upper gastrointestinal endoscopy at the Nishikawa Gastrointestinal Clinic,*** them,325 patients were ***-positive,and of them,101 patients who underwent upper gastrointestinal endoscopy before and after *** eradication were evaluated for post-eradication MP *** patients’MPs were interpreted by three experienced endoscopists who were blinded to their clinical *** Among 76 patients with the spotty pattern before or after *** eradication,the pattern disappeared or decreased in 67 patients[88.2%,95%confidence interval(CI):79.0%-93.6%),appeared or increased in 8 patients(10.5%,95%CI:5.4%-19.4%),and showed no change in 1 patient(1.3%,95%CI:0.2%-7.1%).In 90 patients with the cracked pattern before or after *** eradication,the pattern disappeared or decreased in 7 patients(7.8%,95%CI:3.8%-15.2%),appeared or increased in 79 patients(87.8%,95%CI:79.4%-93.0%),and showed no change in 4 patients(4.4%,95%CI:1.7%-10.9%).In 70 patients with the mottled pattern before or after *** eradication,the pattern disappeared or decreased in 28 patients(40.0%,95%CI:29.3%-51.7%),appeared or increased in 35 patients(50.0%,95%CI:38.6%-61.4%),and showed no change in 7 patients(10.0%,95%CI:4.9%-19.2%).CONCLUSION After *** eradication,MPs changed from spotty to cracked in most patients,which may help endoscopists easily and precisely evaluate ***-related gastritis status.

关键词： Atrophic gastritis Helicobacter pylori Gastrointestinal endoscopy Image enhancement Classification

CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda naoki Hama Masanori Tsujie Masataka ikeda Mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer CA19-9 Para-aortic lymph node

Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3726-3732页

作者： naoki Shijubou Toshiyuki Sumi Koki Kamada Takeyuki Sawai Yuichi Yamada Tatsuru ikeda HisashiNakata Yuji Mori Hirofumi Chiba Department of Respiratory Medicine Hakodate Goryoukaku HospitalHakodate 040-8611Japan Department of Respiratory Medicine and Allergology Sapporo Medical University School of MedicineSapporo 060-8556Japan Department of Pathology and Diagnosis Hakodate Goryoukaku HospitalHakodate 040-8611Japan

BACKGROUND Amebic colitis is an infection caused by Entamoeba histolytica and most commonly observed in regions with poor *** is also seen as a sexually transmitted disease in developed *** amebic colitis usually has a chronic course with repeated exacerbations and remissions,it may also manifest as a fulminant form that rapidly progresses and leads to severe,life-threatening complications,such as intestinal perforation,peritonitis,and sepsis,that have a high mortality *** SUMMARY A 68-year-old man was admitted to our hospital with chest pain and acute *** was diagnosed with acute coronary syndrome,acute heart failure,and bacterial *** respiratory condition worsened despite receiving intensive care and intravenous *** the fifth day of hospitalization,he was diagnosed with acute respiratory distress syndrome and was started on steroid *** subsequently developed bloody stools and was diagnosed with cytomegalovirus(CMV)enterocolitis based on biopsy results and a peripheral blood CMV pp65 antigenemia test *** we started antiviral therapy with ganciclovir,which was successful in reducing his antigen titers,he continued to have bloody *** weeks after initiation of ganciclovir therapy and six weeks after his admission,the patient died from intestinal *** only posthumously diagnosed him with amebic colitis and CMV enterocolitis based on autopsy findings of transmural necrosis of the entire colon with massive ameba *** We urge clinicians to consider Entamoeba histolytica infection if severe colitis progresses after steroid *** treatment is recommended then.

关键词： Amebiasis Intestinal Colitis Cytomegalovirus Glucocorticoids Perforation Case report

Quantum Fibrations:Quantum Computation on an Arbitrary Topological Space

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Acta Mathematica Sinica,English Series 2024年第11期40卷 2693-2718页

作者： Kazuki ikeda Co-design Center for Quantum Advantage(C2QA)&Center For Nuclear Theory Department of Physics and AstronomyStony Brook UniversityStony BrookUSA Department of Mathematics and Statistics&Centre for Quantum Topology and Its Applications(quanTA) University of SaskatchewanSaskatoonCanada

Using operator algebras,we extend the theory of quantum computation on a graph to a theory of computation on an arbitrary topological *** computation is usually implemented on finite discrete sets,and the purpose of this study is to extend this to theories on arbitrary *** conventional theory of quantum computers can be viewed as a simplified algebraic geometry theory in which the action of SU(2)is defined on each point of a discrete *** this study,we extend this in general as a theory of quantum fibrations in which the action of the von Neumann algebra is defined on an arbitrary topological *** quantum channel is then naturally extended as a net of von Neumann *** allows for a more mathematically rigorous discussion of general theories,including physics and chemistry,which are defined on sets that are not necessarily discrete,from the perspective of quantum computer science.

关键词： Quantum computation operator algebra von Neumann algebra fibration quantum computational chemistry complexity theory

3D reconstruction size effect on the quantification of solid oxide fuel cell nickel-yttria-stabilized-zirconia anode microstructural information using scanning electron microscopy-focused ion beam technique

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Science Bulletin 2016年第17期61卷 1317-1323页

作者： Zhenjun Jiao naoki Shikazono Institute of Industrial Science The University of Tokyo

Self-made conventional nickel-yttria-stabilized zirconia composite anodes after reduction and 500 h operation were analyzed by three-dimensional microstructure reconstruction based on focused ion beam-scanning electron microscopy *** area,threephases-boundary density and phase volume fraction were measured based on the three-dimensional microstructure reconstruction to quantitatively study the statistical characterization of solid oxide fuel cell nickel-yttria-stabilizedzirconia anode microstructure before and after *** is found that for anode operated with long time,it is necessary to increase the corresponding three-dimensional reconstruction size to suppress the influence of microstructure variation caused by Ni agglomeration in order to obtain more accurate microstructural quantification information.

关键词： FIB-SEM 3D reconstruction TPB density Tetragonal mesh

Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis

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World Journal of Gastroenterology 2014年第21期20卷 6541-6546页

作者： naoki Hashimoto Department of Surgery Kinki UniversityOsaka 589-8511Japan

AIM: To examine the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in rat esophageal lesions induced by reflux of duodenal contents.

关键词： Bile acids Cyclooxygenase-2 Prostaglandin E2 Esophageal cancer Esophagoduodenal anastomosis

Novel Phase Transition in BaPr_2Mn_2O_7

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Journal of Rare Earths 2006年第z2期24卷 1-3页

作者： Hiromi Nakano naoki Kamegashira Ryukoku University SetaOtsu 520-2194Japan Toyohashi University of Technology Tenpaku-choToyohashi 441-8580Japan

The rare earth manganite BaLn2Mn2O7(Ln = rare earth element) has a Sr3Ti2O7-type layered perovskite structure with double-block oxygen octahedra belonging to the Ruddlesden-Popper-type homologous series AO(ABO3)2. In Pr-manganite, a novel phase transition was first observed in situ at 1040 K by a thermal transmission electron microscope. At 1040 K, reflections began to split along the c-direction in the selected area diffraction pattern. This indicates that a new phase appears in the original phase matrix; the c length of the new phase is 1.5% longer than that of the original phase. After about 5 min, the original phase disappears. No change in the crystal symmetry (space group 14/mmm) is observed above 1040 K.

关键词： rare earth manganite phase transition transmission electron microscope (TEM)

Magic sheets:Visual cryptography with common shares

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Computational Visual Media 2018年第2期4卷 185-195页

作者： naoki Kita Kazunori Miyata Japan Advanced Institute of Science and Technology Nomi923-1292Japan.

Visual cryptography(VC) is an encryption technique for hiding a secret image in distributed and shared images(referred to as shares). VC schemes are employed to encrypt multiple images as meaningless,noisy patterns or meaningful images. However,decrypting multiple secret images using a unique share is difficult with traditional VC. We propose an approach to hide multiple images in meaningful shares. We can decrypt multiple images simultaneously using a common share, which we refer to as a magic sheet. The magic sheet decrypts multiple secret images depending on a given share. The shares are printed on transparencies, and decryption is performed by physically superimposing the transparencies. We evaluate the proposed method using binary, grayscale,and color images.

关键词： visual cryptography (VC) information hiding secret sharing

Unveiling the anticancer effect of traditional Chinese herbal medicine

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World Journal of Gastroenterology 2024年第30期30卷 3625-3627页

作者： naoki Asano Division of Carcinogenesis and Senescence Biology Tohoku University Graduate School of MedicineNatori 981-1293MiyagiJapan Division of Cancer Stem Cell Miyagi Cancer Center Research InstituteNatori 981-1293MiyagiJapan

In this issue of World Journal of Gastroenterology,Huang et al reported that Calculus bovis(CB),a traditional Chinese herbal medicine,impedes the growth of liver cancers in *** further in vitro studies,they showed that CB suppressed the M2 polarization of tumor-associated macrophages by suppressing the Wnt signaling pathway,which consequently inhibited the growth of liver *** the effects of traditional Chinese herbal medicine are often not scientifically proven,Huang et al successfully identified the molecular mechanism involved in the anticancer effect of CB,and it is anticipated that the molecular mechanisms involved in the effects of other traditional Chinese herbal medicines will be scientifically elucidated,as demonstrated in this article.

关键词： Calculus bovis Chinese herbal medicine Wnt Hepatocellular carcinoma Liver cancer Tumor-associated macrophages M2 polarization