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Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation: Case report

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World Journal of Gastroenterology 2015年第25期21卷 7911-7915页

作者： Kohei Mishima Hideaki Obara Kayoko Sugita Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Kentaro Matsubara Takehiko Mori Yaoko Takano Hiroshi Fujiwara Osamu Itano naoki hasegawa Satoshi Iwata Yuko Kitagawa Department of Surgery Keio University School of Medicine Center for Infectious Diseases and Infection Control Keio University School of Medicine Division of Hematology the Department of Medicine Keio University School of Medicine Department of Infectious Diseases Keio University School of Medicine

Helicobacter cinaedi(H. cinaedi), a Gram-negative spiral-shaped bacterium, is an enterohepatic nonHelicobacter pylori Helicobacter species. We report the first case of H. cinaedi bacteremia with cellulitis after liver transplantation. A 48-year-old male, who had been a dog breeder for 15 years, underwent ABO-incompatible living-donor liver transplantation for hepatitis C virus-induced decompensated cirrhosis using an anti-hepatitis B core antibody-positive graft. The patient was preoperatively administered rituximab and underwent plasma exchange twice to overcome blood type incompatibility. After discharge, he had been doing well with immunosuppression therapy comprising cyclosporine, mycophenolate mofetil, and steroid according to the ABO-incompatible protocol of our institution. However, 7 mo after transplantation, he was admitted to our hospital with a diagnosis of recurrent cellulitis on the left lower extremity, and H. cinaedi was detected by both blood culture and polymerase chain reaction analysis. Antibiotics improved his symptoms, and he was discharged at day 30 after admission. Clinicians should be more aware of H. cinaedi in immunocompromised patients, such as ABO-incompatible transplant recipients.

关键词： Helicobacter cinaedi Bacteremia Cellulitis Liver transplantation Hepatitis C Living-donor ABOincompatible HBc-Ab-positive donor

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Differential Mechanisms of the Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonists on Bleomycin-Induced Lung Fibrosis

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Open Journal of Respiratory Diseases 2013年第2期3卷 31-38页

作者： Keisuke Miyamoto Sadatomo Tasaka Yasushi Nakano Hiromi Shinoda Hirofumi Kamata Wakako Yamasawa Makoto Ishii naoki hasegawa Tomoko Betsuyaku Center for Infectious Diseases and Infection Control Keio University School of Medicine Tokyo Japan Department of Laboratory Medicine Keio University School of Medicine Tokyo Japan Division of Pulmonary Medicine Keio University School of Medicine Tokyo Japan

Background and Objectives: Peroxisome proliferator-activated receptor-g (PPAR-g) is a nuclear receptor whose activation regulates inflammation and fibrosis in various organs. We aimed to investigate the effect of two PPAR-g ligands, telmisartan and rosiglitazone, on lung injury and fibrosis induced by intratracheal bleomycin (BLM). Methods: Lung injury and fibrosis was induced in female C57Bl/6 mice by intratracheal instillation of 1.0 mg/kg of BLM. Some of the animals received rosiglitazone intraperitoneally or telmisartan in drinking water. Bronchoalveolar lavage (BAL) was performed 2, 7, 14 or 21 days after BLM instillation for cell counting and measurement of mediators in the lung. In a separate series, the lungs were sampled for collagen assay and histopathological evaluation. Results: Treatment with rosiglitazone or telmisartan significantly attenuated the BLM-induced increases in lung collagen content, pathological score, and inflammatory cells in BAL fluid. Rosiglitazone significantly suppressed BLM-induced elevation of TGF-b1, MCP-1, and IL-6 levels in the lung. In contrast, telmisartan made no changes in these cytokines, whereas it mitigated the BLM-induced increase in prostaglandin F2a in the lung. Higher concentrations of rosiglitazone and telmisartan attenuated proliferation of lung fibroblasts in vitro. Conclusions: Two PPAR-g ligands, rosiglitazone and telmisartan, exert protective effects on BLM-induced lung fibrosis through the suppression of different profibrotic mediators.

关键词： Peroxisome Proliferator-Activated Receptor-γ Bleomycin Pulmonary Fibrosis Transforming Growth Factor-β1 Prostaglandin F2α

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北京养老服务机构入住理由及位置选择的初探——关于合理布局建设养老服务机构

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城市规划 2012年第9期36卷 77-84页

作者：戴维铃木博志长谷川直树中铁置业亳州投资发展有限公司日本名城大学

通过对北京市养老服务机构的入住老人进行问卷调研,解析老人的入住理由。老人在机构选择意向中重视"离子女居住地近"的要素,并在实际选择入住时,呈现选择离子女居住地较近机构的趋势。根据该倾向,研究通过整理各功能区特征,为解决北京... 详细信息

通过对北京市养老服务机构的入住老人进行问卷调研,解析老人的入住理由。老人在机构选择意向中重视"离子女居住地近"的要素,并在实际选择入住时,呈现选择离子女居住地较近机构的趋势。根据该倾向,研究通过整理各功能区特征,为解决北京市养老服务机构入住率分布不均衡的现状,提出各功能区养老机构的规划建设见解。

关键词：北京市养老服务机构入住理由子女居住地

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我国与日本住宅区公园绿地建设体制的对比--兼述北京市住宅区公园绿地的建设现状

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城市规划 2010年第12期34卷 71-76页

作者：戴维长谷川直树铃木博志日本名城大学理工学研究科日本名城大学

本文阐述了我国住宅区的基本形态及构成、住宅区公园绿地建设的相关体制,通过对北京市住宅区中心绿地的建设现状实地调研,整理出了北京市住宅区中心绿地的现状和问题,并借鉴日本住宅区中心绿地的规划建设方法,对我国住宅区中心绿地规划... 详细信息

本文阐述了我国住宅区的基本形态及构成、住宅区公园绿地建设的相关体制,通过对北京市住宅区中心绿地的建设现状实地调研,整理出了北京市住宅区中心绿地的现状和问题,并借鉴日本住宅区中心绿地的规划建设方法,对我国住宅区中心绿地规划建设提出建议。

关键词：北京市住宅区公园绿地中心绿地

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北京养老服务机构建设布局及使用状况的初探——关于合理布局建设养老服务机构

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城市规划 2011年第9期35卷 60-67页

作者：戴维长谷川直树铃木博志日本名城大学

随着北京市老龄率的不断增加,市政府通过增建养老服务机构、推行居家养老政策等措施努力改善提高养老服务水平。本文从城市规划的角度着眼于养老服务机构的建设布局,通过分析其建设布局与使用状况(床位使用率)的关系,探讨建设现状的合理... 详细信息

随着北京市老龄率的不断增加,市政府通过增建养老服务机构、推行居家养老政策等措施努力改善提高养老服务水平。本文从城市规划的角度着眼于养老服务机构的建设布局,通过分析其建设布局与使用状况(床位使用率)的关系,探讨建设现状的合理性,并提出相关改善方案。

关键词：北京市养老服务机构建设布局床位使用率

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Cytomegalovirus colitis followed by ischemic colitis in a non-immunocompromised adult:A case report

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World Journal of Gastroenterology 2015年第12期21卷 3750-3754页

作者： Tsuyoshi hasegawa Kazuki Aomatsu Masanori Nakamura naoki Aomatsu Keiho Aomatsu Department of Surgery Aomatsu Memorial Hospital Izumisano Department of Gastroenterology Izumiohtsu City Hospital Izumiohtsu Department of Surgery Fuchu Hospital

We report a rare case of cytomegalovirus(CMV) colitis followed by severe ischemic colitis in a nonimmunocompromised patient. An 86-year-old woman was admitted after experiencing episodes of vomiting and diarrhea. The next day, hematochezia was detected without abdominal pain. The initial diagnosis of ischemic colitis was based on colonoscopy and histological findings. The follow-up colonoscopy revealed a prolonged colitis. Immunohistochemical staining detected CMVpositive cells following conservative therapy. Intravenous ganciclovir therapy led to successful healing of ulcers and disappearance of CMV-positive cells. The prevalence of CMV infection is common in adults. CMV colitis is relatively common in immunocompromised patients; however, it is rare in immunocompetent patients. In our case, CMV infection was allowed to be established due to the disruption of the colonic mucosa by the prior severe ischemic colitis. Our experience suggests that biopsies may be necessary to detect CMV and the prompt management of CMV colitis should be instituted when intractable ischemic colitis is observed.

关键词： Cytomegalovirus infection Colitis Ischemic colitis

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Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding

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World Journal of Gastroenterology 2015年第24期21卷 7500-7505页

作者： Minoru Tomizawa Fuminobu Shinozaki Rumiko hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto naoki Ishige Department of Gastroenterology National Hospital Organization Shimoshizu Hospital Department of Radiology National Hospital Organization Shimoshizu Hospital Yotsukaido City Department of Surgery National Hospital Organization Shimoshizu Hospital Department of Neurology National Hospital Organization Shimoshizu Hospital Department of Rheumatology National Hospital Organization Shimoshizu Hospital Department of Pediatrics National Hospital Organization Shimoshizu Hospital Department of Neurosurgery National Hospital Organization Shimoshizu Hospital

AIM: To examine characteristics of patients with blood urea nitrogen(BUN) levels higher and lower than the normal ***: Patient records between April 2011 and March 2014 were analyzed retrospectively. During this time, 3296 patients underwent upper endoscopy. In total, 50 male(69.2 ± 13.2 years) and 26 female(72.3 ± 10.2 years) patients were assessed. Patients were divided into two groups based on BUN levels: higher than the normal limit(21.0 mg/d L)(H) and lower thanthe normal limit(L). One-way analysis of variance was performed to reveal differences in the variables between the H and L groups. Fisher's exact test was used to compare the percentage of patients with gastric ulcer or gastric cancer in the H and L ***: White blood cell count was higher in the H group than in the L group(P = 0.0047). Hemoglobin level was lower in the H group than in the L group(P = 0.0307). Glycated hemoglobin was higher in the H group than in the L group(P = 0.0264). The percentage of patients with gastric ulcer was higher in the H group(P = 0.0002). The H group contained no patients with gastric ***: Patients with BUN ≥ 21 mg/d L might have more severe upper gastrointestinal bleeding.

关键词： Blood urea nitrogen Forrest classification Hemoglobin White blood cell count

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Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding

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World Journal of Gastroenterology 2015年第20期21卷 6246-6251页

作者： Minoru Tomizawa Fuminobu Shinozaki Rumiko hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto naoki Ishige Department of Gastroenterology National Hospital Organization Shimoshizu Hospital Department of Radiology National Hospital Organization Shimoshizu Hospital Department of Surgery National Hospital Organization Shimoshizu Hospital Department of Neurology National Hospital Organization Shimoshizu Hospital Department of Rheumatology National Hospital Organization Shimoshizu Hospital Department of Pediatrics National Hospital Organization Shimoshizu Hospital Department of Neurosurgery National Hospital Organization Shimoshizu Hospital

AIM: To distinguish upper from lower gastrointestinal(GI) bleeding. METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively(3296 upper endoscopy, and 1520 colonoscopy). Seventysix patients had upper GI bleeding(Upper group) and 65 had lower GI bleeding(Lower group). Variables were compared between the groups using one-way analysis of variance. Logistic regression was performed to identify variables significantly associated with the diagnosis of upper vs lower GI bleeding. Receiveroperator characteristic(ROC) analysis was performed to determine the threshold value that could distinguish upper from lower GI bleeding. RESULTS: Hemoglobin(P = 0.023), total protein(P = 0.0002), and lactate dehydrogenase(P = 0.009) were significantly lower in the Upper group than in the Lower group. Blood urea nitrogen(BUN) was higher in the Upper group than in the Lower group(P = 0.0065). Logistic regression analysis revealed that BUN was most strongly associated with the diagnosis of upper vslower GI bleeding. ROC analysis revealed a threshold BUN value of 21.0 mg/d L, with a specificity of 93.0%.CONCLUSION: The threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/d L.

关键词： Logistic regression analysis Likelihoodanalysis Receiver-operator characteristic analysis Blood urine nitrogen Hemoglobin

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Magnifying chromoscopy, a novel and useful technique for colonoscopy in ulcerative colitis

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World Journal of Gastroenterology 2007年第18期13卷 2523-2528页

作者： Takafumi Ando Hironao Takahashi Osamu Watanabe Osamu Maeda Kazuhiro Ishiguro Daisuke Ishikawa Motofusa hasegawa naoki Ohmiya Yasumasa Niwa Hidemi Goto naoki Ohmiya Yasumasa Niwa Hidemi Goto Department of Gastroenterology Nagoya University Graduate School of Medicine Nagoya Japan

Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by exacerbations and remissions. The degree of inflammation as assessed by conventional colonoscopy is a reliable parameter of disease activity. However, even when conventional colonoscopy suggests remission and normal mucosal findings, microscopic abnormalities may persist, and relapse may occur later. Patients with long-standing, extensive ulcerative colitis have an increased risk of developing colorectal cancer. Ulcerative colitis-associated colorectal cancer is characterized by an early age at onset, poorly differentiated tumor cells, mucinous carcinoma, and multiple lesions. Early detection of dysplasia and colitic cancer is thus a prerequisite for survival. A relatively new method, magnifying chromoscopy, is thought to be useful for the early detection and diagnosis of dysplasia and colitic cancer, as well as the prediction of relapse.

关键词： Ulcerative colitis Histopathology Conventionalcolonoscopy Magnifying colonoscopy Ulcerative colitis-associated colorectal cancer

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Complex-Valued Neural Networks:A Comprehensive Survey

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1406-1426页

作者： ChiYan Lee Hideyuki hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama 930-8555Japan

Complex-valued neural networks(CVNNs)have shown their excellent efficiency compared to their real counterparts in speech enhancement,image and signal *** throughout the years have made many efforts to improve the learning algorithms and activation functions of *** CVNNs have proven to have better performance in handling the naturally complex-valued data and signals,this area of study will grow and expect the arrival of some effective improvements in the ***,there exists an obvious reason to provide a comprehensive survey paper that systematically collects and categorizes the advancement of *** this paper,we discuss and summarize the recent advances based on their learning algorithms,activation functions,which is the most challenging part of building a CVNN,and ***,we outline the structure and applications of complex-valued convolutional,residual and recurrent neural ***,we also present some challenges and future research directions to facilitate the exploration of the ability of CVNNs.

关键词： Complex activation function complex backpropagation algorithm complex-valued learning algorithm complex-valued neural network deep learning

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