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Refinement of Adaptive Dynamical Simulation of Quantum Mechanical Double Slit Interference Phenomenon

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Journal of Modern Physics 2024年第3期15卷 239-249页

作者： Tadashi ando Andrei Khrennikov Ichiro Yamato Department of Applied Electronics Tokyo University of Science Tokyo Japan International Center for Mathematical Modelling in Physics and Cognitive Sciences Linnaeus University V&aumlxj&oum Sweden Department of Biological Science and Technology Tokyo University of Science Tokyo Japan

We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. Several properties such as concave single slit pattern and large influence of slight displacement of the emission position were different from the experimental results. In this study we tried other slit conditions and obtained consistent patterns with experiments. We do not claim that the adaptive dynamics is the principle of quantum mechanics, but the present results support the probability of adaptive dynamics as the candidate of the basis of quantum mechanics. We discuss the advantages of the adaptive dynamical view for foundations of quantum mechanics.

关键词： Double Slit Interference Adaptive Dynamics Quantum Mechanics Particle Model Simulation

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

Hydrocarbon Potential of the Triassic-Jurassic Sediments in Southeast Sulawesi, Indonesia, Based on Lithofacies and Geochemical Analysis

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Open Journal of Geology 2024年第8期14卷 723-745页

作者： Muhammad Sulhuzair Burhanuddin Shun Chiyonobu Takuto ando Anggi Yusriani Ratna Husain Suryawan Asfar Graduate School of International Resources Sciences Akita University Akita Japan Geological Department of Hasanuddin University Makassar Indonesia Geoservices Laboratory South Jakarta Indonesia Geological Department of Haluoleo University Kendari Indonesia

Triassic-Jurassic carbonates widely distributed in Eastern Indonesia are believed as oils source rock. The Mesozoic Tokala Formation exhibit source rock potential, as evidenced by high contents of organic matter. Recent exploration has been conducted in southeastern Sulawesi, targeting the Mesozoic intervals. Therefore, in this study, we attempted to determine source rock potential of Tokala Formation outcropped in southeastern Sulawesi area and its capability to generate hydrocarbon. Five distinct lithofacies were delineated, emphasizing lithological and mineralogical features: foraminifera wackestone (FW), lime mudstone (LM), massive bioturbated calcareous-argillaceous shale (MBCAS), weakly laminated argillaceous-calcareous shale (WLACS), and strongly laminated calcareous-argillaceous shale (SLCAS). Subsequent analyses showed that carbonate-rich samples (FW and LM facies, >50% CaO) had poor source rock potential. Conversely, shale facies with moderate carbonate content (WLACS, MBCAS, and SLCAS, 15% - 50% CaO) had good to excellent source rock characteristics, qualifying them as preferable source rock. In addition, levels of SiO2 and Al2O3 should not be neglected, as these constituents play important roles in clay mineral adsorption. Laminated shale facies with moderate CaO content tended to be more promising as source rock than bioturbated facies. The shale facies of Tokala Formation indicate prospective source rock horizon.

关键词： Source Rock Triassic-Jurassic Source Rock Lithofacies Southeastern Sulawesi Tokala Formation

Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cyclosporine treatment in Japan

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World Journal of Gastroenterology 2007年第5期13卷 754-760页

作者： Masaaki Minami Michio Ohta Teruko Ohkura Takafumi ando naoki Ohmiya Yasumasa Niwa Hidemi Goto Department of Gastroenterology Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan Department of Bacteriology Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan

AIM： TO investigate active cytomegalovirus （CMV） infection following the cydosporine A （CyA） treatment of steroid-refractory ulcerative colitis （UC）. METHODS： Twenty-three patients with severe UC not responding to steroid therapy （male 14, and female 9） enrolled at Nagoya University Hospital from 1999 to 2005. They received continuous intravenous infusion of CyA （average 4 mg/kg per day） for 1 mo. Serum and colonic biopsy samples were collected before CyA treatment and 4 d, 10 d, 20 d, and 30 d after treatment. Patients were evaluated for CMV by using serology （IgM antibody by ELISA）, quantitative real-time PCR for CMV DNA, and histopathological assessment of hematoxylin and eosin （HE）-stained colonic biopsies. CMV infection was indicated by positive results in any test. RESULTS： No patients had active CMV infection before CyA treatment. Eighteen of 23 UC patients treated with CyA were infected with active CMV （IgM antibody in 16/23 patients, 69.6%; CMV DNA in 18/23 patients, 78.2%; and inclusion bodies in 4/23 patients, 17.3%）. There was no difference in the active CMV-infection rate between males and females. Active CMV infection was observed after approximately 8 d of CyA treatment, leading to an exacerbation of colitis. Fifteen of these 18 patients with active CMV infection （83.3%） required surgical treatment because of severe deteriorating colitis. Treatment with ganciclovir rendered surgery avoidable in three patients. CONCLUSION： Our results suggest that active CMV infection in severe UC patients treated with CyA is associated with poor outcome. Further, ganciclovir is useful for treatment of CMV-associated UC after immunosuppressive therapy.

关键词： Cytomegalovirus Cyclosporine Ulcerative colitis Ganciclovir

Impact of blanching pretreatment on the drying rate and energy consumption during far-infrared drying of Paprika(Capsicum annuum L.)

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Food Quality and Safety 2018年第2期2卷 97-103页

作者： Takahiro Orikasa naoki Ono Takashi Watanabe Yasumasa ando Takeo Shiina Shoji Koide Faculty of Agriculture Iwate UniversityMorioka IARC Kenpoku Agricultural Research Institute KunoheIwate Food Research Institute NAROTsukubaIbaraki Graduate School of Horticulture Chiba UniversityMatsudoJapan

We incorporated a superheated steam blanching pretreatment step into a paprika drying process and compared the far-infrared(FIR)drying rates,hardness of the sample surfaces,cell membrane stabilities,and energy consumption of blanched and non-blanched *** average drying rate of blanched paprika samples during FIR drying was higher than that of non-blanched *** hardness and cell membrane stability of dried blanched samples were lower than those of non-blanched *** estimated that the softening of the sample surfaces and injury to the cell membranes caused the drying rate to *** total energy consumption of the FIR drying of paprika was reduced by approximately 30%by introducing the blanching *** findings contribute to the development of environmentally friendly FIR drying techniques for paprika.

关键词： blanching cell membrane stability,energy consumption far-infrared drying hardness.

Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

Direct visualization of postoperative aortobronchial fistula on computed tomography

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World Journal of Radiology 2024年第8期16卷 337-347页

作者： Nanae Tsuchiya Hitoshi Inafuku Satoko Yogi Yuko Iraha Gyo Iida Mizuki ando Takaaki Nagano Shotaro Higa Tatsuya Maeda Yuya Kise Kojiro Furukawa Koji Yonemoto Akihiro Nishie Department of Radiology Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Thoracic and Cardiovascular Surgery Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Biostatistics School of Health SciencesFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan

BACKGROUND Postoperative aortobronchial fistula(ABF)is a rare complication that can occur in 0.3%-5.0%of patients over an extended period of time after thoracic aortic *** visualization of the fistula via imaging is *** To investigate the relationship between computed tomography(CT)findings and the clinical signs/symptoms of ABF after thoracic aortic *** Six patients(mean age 71 years,including 4 men and 2 women)with suspected ABF on CT(air around the graft)at our hospital were included in this retrospective study between January 2004 and September *** CT findings included direct confirmation of ABF,peri-graft fluid,ring enhancement,dirty fat sign,atelectasis,pulmonary hemorrhage,and bronchodilation,and the clinical course were retrospectively *** proportion of each type of CT finding was *** ABF detection after surgery was found to have a mean and median of 14 and 13 years,*** signs and symptoms were asymptomatic in 4 patients,bloody sputum was found in 1 patient,and fever was present in 1 *** complications of ABF included graft infection in 2 patients and graft infection with hemoptysis in 2 *** the 6 patients,3 survived,2 died,and 1 was lost to *** locations of the ABFs were as follows:1 in the ascending aorta;1 in the aortic arch;2 in the aortic arch leading to the descending aorta;and 2 in the descending *** were directly confirmed by CT in 4/6(67%)***-graft dirty fat(4/6,67%)and peri-graft ring enhancement(3/6,50%)were associated with graft infection,endoleaks and pseudoaneurysms were associated with hemoptysis(2/6,33%).CONCLUSION Asymptomatic ABF after thoracic aortic surgery can be confirmed on chest *** is useful for the diagnosis of ABF and its complications.

关键词： Peri-graft air Aortobronchial fistula Chest computed tomography Postoperative Thoracic endovascular aortic repair Complication Thoracic aorta surgery

Epidemiology,clinical characteristics,and management of chronic kidney disease in human immunodeficiency virusinfected patients

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World Journal of Nephrology 2015年第3期4卷 388-395页

作者： Minoru ando naoki Yanagisawa Division of Nephrology Department of MedicineTokyo Metropolitan Komagome Hospital Division of Infectious Diseases Department of MedicineTokyo Metropolitan Komagome Hospital

Antiretroviral therapy has markedly reduced acquired immune deficiency syndrome-related deaths and opportunistic infectious diseases. This has resulted in prolonged survival of individuals infected with the human immunodefciency virus （HIV）. However, this improvement in survival has been accompanied by an increase in the incidence of chronic kidney disease （CKD） and end-stage renal disease. CKD is now epidemic among HIV-infected populations in both Western and Eastern countries. Risk factors associated with CKD in HIV-infected populations include aging, hypertension, diabetes mellitus, co-infection with hepatitis C virus, a low CD4 cell count, and a high HIV viral load. Clinical experience has shown that HIV-infected individuals often have one or more concurrent risk factors for CKD. The cumulative effect of multiple risk factors on the development of CKD should be noted in this population. Glomerular disease directly related to HIV infection, so-called HIV-associated nephropathy, remains an important cause of CKD among a limited HIV population of African descent, but is less likely to be common among other urban HIV populations. The impact of exposure to nephrotoxic antiretroviral agents on the development of kidney disease is both an old and a new concern. In particular, the association of tenofovir with kidney tubular injury has been an area of great interest. The fndings regarding tenofovir’s adverse effect on long-term kidney function vary among studies. The early identifcation and treatment of CKD is recommended for reducing the burden of patients requiring dialysis in HIV-infected populations. Periodic monitoring of urinary concentrations of albumin, protein, and tubular injury markers such as low-molecular-weight proteins may be useful for the early diagnosis of patients at risk for incident CKD. This review focuses on recent epidemiology, clinical characteristics, and management of CKD in a contemporary HIV-infected population.

关键词： Antiretroviral therapy Tenofovir Human immunodeficiency virus-associated nephropathy Albuminuria Renal tubular biomarkers Cystatin C Diabetes mellitus Hypertension

Magnifying chromoscopy, a novel and useful technique for colonoscopy in ulcerative colitis

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World Journal of Gastroenterology 2007年第18期13卷 2523-2528页

作者： Takafumi ando Hironao Takahashi Osamu Watanabe Osamu Maeda Kazuhiro Ishiguro Daisuke Ishikawa Motofusa Hasegawa naoki Ohmiya Yasumasa Niwa Hidemi Goto naoki Ohmiya Yasumasa Niwa Hidemi Goto Department of Gastroenterology Nagoya University Graduate School of Medicine Nagoya Japan

Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by exacerbations and remissions. The degree of inflammation as assessed by conventional colonoscopy is a reliable parameter of disease activity. However, even when conventional colonoscopy suggests remission and normal mucosal findings, microscopic abnormalities may persist, and relapse may occur later. Patients with long-standing, extensive ulcerative colitis have an increased risk of developing colorectal cancer. Ulcerative colitis-associated colorectal cancer is characterized by an early age at onset, poorly differentiated tumor cells, mucinous carcinoma, and multiple lesions. Early detection of dysplasia and colitic cancer is thus a prerequisite for survival. A relatively new method, magnifying chromoscopy, is thought to be useful for the early detection and diagnosis of dysplasia and colitic cancer, as well as the prediction of relapse.

关键词： Ulcerative colitis Histopathology Conventionalcolonoscopy Magnifying colonoscopy Ulcerative colitis-associated colorectal cancer